From invasive species to agricultural resource: evaluation of Phragmites australis from Zarivar Lake as an organic amendment for the release of phosphorus, potassium, micronutrients and toxic metals by Shno Karimi, Zahra Kolahchi, Mahboube Zarrabi, Safoora Nahidan, Taqi Raza

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Mitigation of PFOA/PFOS toxicity in zebrafish (Danio rerio) by oxidative stress modulation and gut microbial metabolism through the use of aquatic probiotic Lactobacillus rhamnosus by Chun Wang, Guanyi Li, Sibao Chen, Ruixuan Li, Mengyan Wang, Xia Wang, Ning Ding, Yingxue Sun

“…However, the potential ameliorative effects of probiotics on the toxic effects caused by PFOA and PFOS in zebrafish have not been studied. …”
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Selective toxicity of a novel antimicrobial peptide Acidocin 4356 against Pseudomonas aeruginosa and Acinetobacter baumannii in human cell-based in vitro infection models by Mahbubeh Talaee, Sima Modiri, Marzieh Rajabi, Fatemeh Saadati, Ali Akbari, Sahar Javadi, Shuaiqi Guo, Hojatollah Vali, Kambiz Akbari Noghabi

“…Fluorescent microscopy and flow cytometry analysis confirmed the MTT results, showing ACD’s potent antimicrobial effects and minimal toxicity to human cells, even after 12 h of treatment. …”
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Exploring the power of spectrophotometric technique in determination of oxytetracycline and lidocaine in their pharmaceutical dosage form as well as in the presence of toxic lidocaine impurity: univariate versus multivariate analysis by Naglaa Ahmed, Ahmed Hemdan, Hala ZaaZaa, Maha Galal

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Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPARγ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease by Merilin Al Sharif, Petko Alov, Vessela Vitcheva, Ilza Pajeva, Ivanka Tsakovska

“…Comprehensive understanding of the precise mode of action/adverse outcome pathway (MoA/AOP) of chemicals becomes a key step towards superseding the current repeated dose toxicity testing methodology with new generation predictive toxicology tools. …”
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Real-World Characterization of Toxicities and Medication Management in Recipients of CAR T-Cell Therapy for Relapsed or Refractory Large B-Cell Lymphoma in Nova Scotia, Canada by Jenna Shaw, Mahmoud Elsawy, Rachel Nielsen, Amye Michelle Harrigan, Tara T. DiCostanzo, Laura V. Minard

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Analysis of toxicity and mechanisms of busulfan in non-obstructive azoospermia: A genomic and toxicological approach integrating molecular docking, single-cell sequencing, and experimentation in vivo by Yanggang Hong, Qichao Yuan, Yi Wang, Deqi Wang, Xiaoju Guan, Congde Chen

“…Busulfan, an alkylating chemotherapeutic agent widely used to treat chronic myelogenous leukemia, is known to induce NOA through its toxic effects on spermatogonial stem cells (SSCs). …”
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Mitigation of doxorubicin-induced liver toxicity in mice breast cancer model by green tea and Moringa oleifera combination: Targeting apoptosis, inflammation, and oxidative stress by Abdulrahman H. Laftah, Nawfal Alhelfi, Sadeq K. Al Salait, Ammar B. Altemimi, Mohammad Reza Tabandeh, Efstathia Tsakali, Jan F.M. Van Impe, Ahmed A. Abd El-Maksoud, Tarek Gamal Abedelmaksoud

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Cancer Burden Disease Attributable to PM2.5 and Health Risk by PM2.5-bound Toxic Species in Two Urban Chilean Municipalities by Ye Li, Franz Muñoz-lbañéz, Ana Maldonado-Alcaíno, Darby Jack, Beizhan Yan, Li Xu, Marco Acuña, Manuel Leiva-Guzman, Ana Valdés, Dante D. Cáceres

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Exploring Chemical Basis of Toxicity Reduction for Processed Roots of Stellera chamaejasme L.... by Wei Yang, Xiaoli Ma, Ludi Wang, Mengmeng Wei, Shuyao Wang, Siyang Wu, Chen Kang, Yingfei Li

“…Stellera chamaejasme L., particularly the root (ruixianglangdu), is toxic. Thus, ruixianglangdu is commonly processed with vinegar or milk to reduce toxicity. …”
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And the Oscar Goes to Peripheral Blood Film for the Detection of Lead Poisoning in a Complicated Toxic Patient: A Case Report with a Review of Laboratory Clues by Amir Zamani, Ehsan Sarraf Kazerooni, S. Saeed Kasaee, Mohammad Hossein Anbardar, Sahand Mohammadzadeh, Golsa Shekarkhar, Neda Soleimani

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Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide by Xie Y, Zhu M, Bao H, Chen K, Wang S, Dai J, Chen H, Li H, Song Q, Wang X, Yu L, Pei J

“…Additionally, in vivo studies revealed substantial tumor growth suppression and reduced tumor-associated fibroblasts (TAFs) and collagen. Acute toxicity studies indicated that Rg3-Lip-OXA/CaO2 markedly reduced the toxicity of chemotherapeutic drugs.Conclusion: This multifunctional nanosystem enhances chemotherapy efficacy and reduces toxicity, offering a promising approach for optimizing CRC treatment and potential clinical application. …”
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Paeonol Attenuates Methotrexate-Induced Cardiac Toxicity in Rats by Inhibiting Oxidative Stress and Suppressing TLR4-Induced NF-κB Inflammatory Pathway by Abdulla Y. Al-Taher, Mohamed A. Morsy, Rehab A. Rifaai, Nagwa M. Zenhom, Seham A. Abdel-Gaber

“…Oxidative stress and inflammation have been proved in the development of MTX toxicity. Paeonol is a natural phenolic compound with various pharmacological activities including antioxidant and anti-inflammatory properties. …”
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Real-world pharmacovigilance analysis unveils the toxicity profile of amivantamab targeting EGFR exon 20 insertion mutations in non-small cell lung cancer by Jing Zhang, Wenjie Li

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Alkali metal salt modulated visible photocatalytic degradation of tetracycline hydrochloride by g-C3N4: Degradation pathway, mechanism and toxicity assessment by Yujie Jiao, Sujin Lu, Ru Li, Qikai Liu, Yongxia Ma, Fei Fu, Yaqi Mao, Yang Liu

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The Effect of the Concurrent Use of Angiotensin-Converting Enzyme Inhibitors or Receptor Blockers on Toxicity and Outcomes in Patients Treated with Radiotherapy: A Systematic Review and Meta-Analysis by Wan-Chuen Liao, Hala Shokr, Corinne Faivre-Finn, Clare Dempsey, Kaye Janine Williams, Li-Chia Chen

“…<b>Conclusions</b>: ACEI use is associated with a reduction in radiation pneumonitis, but evidence for other radiotherapy-related toxicity and survival outcomes remains inconsistent across cancer types and severities. …”
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Cucumeropsis mannii seed oil shields against cyclophosphamide-induced hepatorenal toxicity by modulating redox imbalance and iNOS/IL-β1 signalling in rats by Amaka Cecilia Agbara, Ejike Daniel Eze, Christian Emeka Offor, Adam Moyosore Afodun, Ezebuilo Ugbala Ekpono, Peter Chinedu Agu, Chinyere Aloke, Nkeiru Nwaamaka Ezeani, Emmanuel Orire Ikuomola, Ekom Monday Etukudo, Ilemobayo Victor Fasogbon, Angela Mumbua Musyoka, Patrick Maduabuchi Aja

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A Case of Severe Hydroxychloroquine-Induced Retinal Toxicity in a Patient with Recent Onset of Renal Impairment: A Review of the Literature on the Use of Hydroxychloroquine in Renal Impairment by Rajen Tailor, Ibrahim Elaraoud, Peter Good, Monique Hope-Ross, Robert A. H. Scott

“…Although retinal toxicity at this dose has been documented, the development of renal impairment without dose adjustment or close monitoring of visual function is likely to have potentiated retinal toxicity. …”
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Mononuclear Aluminum–Fluoride Ions, AlF<i>_x</i>^(+/−)—Study of Plausible Frameworks of Complexes with Biomolecules and Their In Vitro Toxicity by Anja Pavlovič, Larisa Janžič, Lucija Sršen, Andreja Nataša Kopitar, Kathleen F. Edwards, Joel F. Liebman, Maja Ponikvar-Svet

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Sub-toxic cisplatin concentrations induce extensive chromosomal, nuclear and nucleolar abnormalities associated with high malignancy before acquired resistance develops: Implications for clinical caution. by John G Delinassios, Robert M Hoffman, George Koumakis, Dimitrios Palitskaris, Kyriaki-Nefelli Poulatsidou, George J Delinasios

“…<h4>Aim</h4>This study investigates the impact of sub-toxic cisplatin levels on nuclear and nucleolar abnormalities and chromosome instability in HeLa cells since our current knowledge of cisplatin effects on these parameters is based on studies with high concentrations of cisplatin.…”
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