P(AN-co-MMA) nanofiber membrane decorated with greenly synthesized nanoparticles for heavy metal removal: a competitive study by Abeer Syed, Enshirah Da’na, Amel Taha, Mohamed R El-Aassar, Adnan M Aldughaish

“…Heavy metal contamination is a serious threat to water resources as it has been associated with carcinogenicity, mutagenicity, and toxicity. With the presence of heavy metals in water bodies reported from all over the globe, there is an urgent need for innovative water treatment strategies. …”
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Navigating the Challenges of Sustainable Dental Practices: Opportunities for Green Innovation in Dentistry by Wajiha Qamar

“…Dental practices can drastically reduce their impact on the environment by transitioning to environmentally friendly materials like biodegradable composites and non-toxic sterilization processes.2 The transition is essential to developing a sustainable healthcare system prioritizing human and environmental well-being. …”
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SUCCESSFUL REGISTRATION OF DOMESTIC BIOANALOGUE OF BEVACIZUMAB – NEW OPPORTUNITIES FOR EFFECTIVE TREA TMENT OF PATIENTS WITH NON-SQUAMOUS CELL NON-SMALL CELL LUNG CANCER by S. V. Orlov, S. N. Fogt, M. S. Shustova

“…The treatment lasted for six cycles of three weeks or until progression or until the development of intolerable toxic effects. Based on CT scan assessment performed by an independent specialist, the overall response rate (ORR, partial response rate + complete response rate) defined as a primary endpoint was 42.59% (95% CI 30.33–55.83%) in "Avegra®" arm and 39.29% (95% CI 27.58–52.27%) in "Avastin®" arm, respectively. …”
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DigiLoCS: A leap forward in predictive organ-on-chip simulations. by Manoja Rajalakshmi Aravindakshan, Chittaranjan Mandal, Alex Pothen, Stephan Schaller, Christian Maass

“…Accurate prediction of in vivo clearance from in vitro data is important as inadequate understanding of the clearance of a compound can lead to unexpected and undesirable outcomes in clinical trials, ranging from underdosing to toxicity. Physiologically based pharmacokinetic (PBPK) model estimation of liver clearance is explored. …”
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Development and Characterization of a Hydrogel Containing Chloramphenicol-Loaded Binary Ethosomes for Effective Transdermal Permeation and Treatment Acne in Rat Model by Liu RJ, Li M, Zhu Q, Liu HY, Zhang XX, Han XY, Yu MJ, Zhou JW, Han CY

“…However, because of its toxicity and poor water solubility, its use has been restricted. …”
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NIR Triggered Bionic Bilayer Membrane-Encapsulated Nanoparticles for Synergistic Photodynamic, Photothermal and Chemotherapy of Cervical Cancer by Ding J, Zhang X, Guo L, Xiong J, Zhang C, Du Z, Zhu L, Alifu N, Dong B

“…Both in vitro and in vivo experiments showed well phototherapy-chemotherapy effect of RBC@ICG-DOX NPs with low toxic side effects.Conclusion: Drug delivery, imaging and tumor synergies were accomplished through combinatorial strategies as well as bilayer membrane encapsulation, opening up a new platform for the design of future tumor combination therapies.Keywords: erythrocyte membrane modification, indocyanine green, adriamycin, combination therapy, cervical cancer…”
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IOP-lowering therapy and ocular surface in glaucoma. Part 1. The effects of drug substances of glaucoma medications on the ocular surface by A.V. Antonova, V.P. Nikolaenko, V.V. Brzheskiy

“…Dose- and exposition-dependent loss of goblet cells, corneal epithelial toxicity, meibomian gland dysfunction, increased activity and expansion of fibroblasts, and pro-inflammatory cytokine release from goblet cells account for the development and progression of symptoms and signs of dry eye as demonstrated by progressive deterioration in Ocular Surface Disease Index (OSDI), Norn’s test, and Schirmer’s test. …”
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Antioxidant and Anti-Inflammatory Potential of Cymbopogon nardus Ethanol Extract on 3T3-L1 Cells by Rohmawaty E, Wiraswati HL, Zahra TA, Amalina SN, Ramadhanti J, Rosdianto AM, Laelalugina A, Nasution GTD, Kamisah Y

“…Antioxidant activity of the extract was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide dismutase (SOD) assays. Toxicity was evaluated using the MTT assay. Additionally, the effects of the extract on the gene expression of hypoxia-inducible factor 1α (HIF-1α) in menadione-induced 3T3-L1 cells, as well as interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced 3T3-L1 cells, were investigated.Results: Phytochemical screening revealed the presence of phenolics, tannins, alkaloids, and flavonoids in the ethanolic extracts. …”
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Trace element concentrations, multivariate analysis and health risk potential of soils from urban and peri-urban agriculture by K.M. Hawrami, A.K. Baset

“…The main aim of this study was to assess the levels and sources of trace elements in this specific region and to analyze the potential health hazards linked to toxic elements present in the soil.METHODS: Elemental analyses were conducted on soil samples using the total digestion method, involving the use of Hydrofluoric acid. …”
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Economic TEHES-Tube Material Evaluation by Absorbability Index under O-S-Dimensions for Minimizing Global Warming and Air Pollution by Exploring Dominance Theory: Green Management... by M. Prabhu, Sri Yogi Kottala, A. Anbazhagan, Anoop Kumar Sahu

“…There is a high magnitude of contaminated hot heat (CHH) from hot fluids such as contaminated water, oils, and mixed oils; toxic oils increase the GWAP ON emission. Such GWAP can be controlled by applying the methods-techniques for optimizing the energy processes, evaluating the high energy absorption material among available materials and technological advancement in energy flow devices, optimizing design of energy systems and low heat emission strategy, etc. …”
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Y2O3NPs induce selective cytotoxicity, genomic instability, oxidative stress and ROS mediated mitochondrial apoptosis in human epidermoid skin A-431 Cancer cells by Hanan RH Mohamed, Shrouk H.A Hemdan, Ahmed A. El-Sherif

“…Notably, exposure to five Y2O3NPs concentrations (0.1, 1, 10, 100 and 1000 µg/ml) resulted in a high concentration-dependent reduction in cell viability and a corresponding increase in cell death observed 72 h post-treatment specifically in A-431 cancer cells, while normal skin fibroblast (HSF) cells exhibited minimal toxicity. When A-431 cancer cells were treated with the half-maximal inhibitory concentration (IC50) of Y2O3NPs for 72 h, a significant increase in ROS generation was noted. …”
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Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway by Su Qing, Xu Baolin, Tian Zhoubin, Gong Ziling

“…Moreover, it was also found non-toxic to normal cells (BEAS-2B and MCF 10A). The effect of compound 4e was further determined on apoptosis of Saos-2 cells by Annexin-PI assay, where it significantly amplified the percentage of apoptotic cells. …”
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PARP inhibitor‐based treatment in metastatic, castration‐resistant prostate cancer (mCRPC): A systematic review and meta‐analysis by Michela Roberto, Mattia Alberto Di Civita, Daniele Marinelli, Andrea Torchia, Nertila Cara, Giulia Maltese, Iolanda Speranza, Daniele Santini

“…The arm with PARPi either as monotherapy or in combination with ARTA showed a significantly higher toxicity profile. Conclusions PARPi‐based therapy represents a compelling treatment option for HRR+ mCRPC, mainly BRCA1/2‐mutated patients. …”
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Silver-based plasmonic nanoparticles for biosensor organophosphate pesticides using a single film containing acetylcholinesterase/choline oxidase by D. Hermanto, N. Ismillayli, H. Muliasari, R. Wirawan, S.R. Kamali

“…Therefore, this study aimed to develop a biosensor that can detect organophosphate pesticides highly toxic to humans and the environment. METHODS: Biosensor organophosphate pesticides using a single film containing acetylcholinesterase/choline oxidase have been designed using silver-based plasmonic nanoparticles as a colorimetric indicator. …”
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Nitrification and denitrification in pond by Yuni Puji Pujihastuti

“…Degradation of process metabolic biota culture waste can biologically be nitrat compound one of the forms that are not toxic in the nitrification process.  Five process of nitrogen biogeochemical cycle in the container cultivation is the amonification, nitrification, nitrogen assimilation, denitrification and nitrogen fixation. …”
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Application of organoids in drug screening of gynecological malignant tumors by JIANG Yuanyuan, WEI Wenfei, WU Jingya, LI Huawen

“…However, the actual clinical effectiveness is often influenced by various factors, such as adverse reactions due to drug toxicity and the drug resistance and insensitivity observed in some patients, which limit improvements in patient survival rates. …”
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Tumor Microenvironment Responsive Key Nanomicelles for Effective Against Invasion and Metastasis in Ovarian Cancer Using Mice Model by Liu Y, Kong L, Yu Y, Zang J, Zhang L, Guo RB, Li ST, Cheng L, Li XT, Chen YQ

“…The synergistic effect between docetaxel and triptolide was systematically investigated, the ratio of the two drugs was optimized, and the physicochemical properties of the nano-particles and their ability to inhibit ovarian cancer cell growth and metastasis were evaluated in vitro and in vivo.Results: PVGLIG-MTX-D/T-NMs enhanced the targeting, stability, and bioavailability of the drug, while reducing the dose and toxicity. In addition, by regulating the expression levels of E-Cadherin, N-Cadherin, matrix metalloproteinases (MMPs), hypoxia-inducible factor 1-alpha (HIF-1α), and vascular endothelial growth factor (VEGF), it exhibited an inhibitory effect on epithelial-mesenchymal transformation (EMT) and tumor cell angiogenesis, and effectively inhibited the invasion and metastasis of ovarian cancer cells.Conclusion: PVGLIG-MTX-D/T-NMs achieved passive targeting of tumor sites by enhancing permeability and retention (EPR) effects. …”
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Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis by Zhe Chen, Mingyang Tang, Nan Wang, Jiangjiang Liu, Xiaoyan Tan, Haitao Ma, Jing Luo, Kai Xie

“…PheWAS revealed no significant drug-related toxicities for BRSK2, and its therapeutic potential was further underscored by protein interaction analyses. …”
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Blood Lead Levels among Blood Donors and High-Risk Occupational Groups in a Mining Area in Ghana: Implications for Blood Transfusion among Vulnerable Populations by Veronica Agyemang, Joseph K. Acquaye, Samuel B. E. Harrison, Felix B. Oppong, Stephany Gyaase, Kwaku P. Asante, Edeghonghon Olayemi

“…Children and pregnant women are most vulnerable to the toxic effects of lead and over 40 percent of blood transfused in Ghana is given to children under 5 years. …”
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A characteristic of the species composition of pathogenic fungi of the genus <i>Fusarium</i> in corn biocenoses of the Voronezh region by T. M. Kolomiets, M. I. Kiseleva, N. S. Zhemchuzhina, L. F. Pankratova, S. A. Elizarova

“…The isolates, stable in morphological and cultural characteristics and studied for pathogenicity and toxicity, were placed for long-term storage in the Russian State Collection of Plant Pathogenic Microorganisms and Cultivars for Identif ication of Phytopathogenic Microbial Strains at the All-Russian Scientif ic Research Institute of a Phytopathology.…”
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