Radiation decreases bronchial epithelial progenitor function as assessed by organoid formation by Merian E. Kuipers, Dennis K. Ninaber, Krista C.J. van Doorn-Wink, Annelies M. Slats, Pieter S. Hiemstra

“…Results and discussion IR increased the number of γH2Ax-foci (marker of double stranded DNA breaks) in ALI-PBEC, but did not affect markers of toxicity (LDH-release or TEER). IR did also not affect mRNA markers for inflammation or epithelial-mesenchymal transition (EMT), but did increase mRNA levels of the cell cycle inhibitor P21/CDKN1A and resulted in downregulation of the proliferation markers MKI67 and E2F1. …”
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Short bouts and long-term exercise reduce sedentary-induced bone loss and microstructural changes by modulating bone formation and resorption in healthy young male rats by L.Y. Wang, L.M. Liang, X.X. Zhang, H. Chi, F. L. Peng

“…Abstract Although the toxic effect of Sedentary behavior (SED) on bone health has been demonstrated in the previous study, the underlying mechanisms of SED, or break SED to bone health remain unclear. …”
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Value of Plasma NGAL and Creatinine on First Day of Admission in the Diagnosis of Cardiorenal Syndrome Type 1 by Hao Phan Thai, Bao Hoang Bui, Tien Hoang Anh, Minh Huynh Van

“…Neutrophil gelatinase-associated lipocalin (NGAL) in the blood and urine is one of the earliest biomarkers of acute kidney injury due to ischemia or renal toxicity. This study was aimed to evaluate the diagnostic efficacy of plasma NGAL in the diagnosis of CRS1. …”
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Effect of phycocyanin and phycoerythrin on antioxidant and antimicrobial activity of refrigerated low-fat yogurt and cream cheese by Azadeh Ahmadi, Seyed Amir Ali Anvar, Bahareh Nowruzi, Leila Golestan

“…Additionally, we confirmed that PE and PC are not toxic to Caenorhabditis elegans at concentrations up to 1 mg/mL. …”
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Usefulness of Measuring Thiopurine Metabolites in Children with Inflammatory Bowel Disease and Autoimmunological Hepatitis, Treated with Azathioprine by Katarzyna Bąk-Drabik, Piotr Adamczyk, Justyna Duda-Wrońska, Dominika Dąbrowska-Piechota, Anna Jarzumbek, Jarosław Kwiecień

“…Measurements of thiopurine metabolites may allow identifying patients at risk for toxicity and nonadherence. It can also provide an explanation for the ineffectiveness of the treatment, observed in some patients. …”
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Constructing adverse outcome pathway for per- and polyfluoroalkyl substances and retinoblastoma based on PI3K-AKT/MAPK signaling pathway by Yuyan GUI, Tingji WANG, Minghao WANG, Yaqi XU, Yunhui ZHANG

“…The Pathview package in R was employed to predict molecular initiating events, key events, and their associated phenotypes, for further understanding the relevant gene-molecule interaction toxicity pathway network. Molecular docking techniques were utilized to validate the affinity of PFAS for these molecular initiating events. …”
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Retrospective trend analysis of biocides in suspended particulate matter of major German rivers by Georg Dierkes, Susanne Schmidt, Christiane Meier, Korinna Ziegler, Jan Koschorreck, Arne Wick

“…The pyrethroid permethrin, which is highly toxic to aquatic organisms (invertebrates: NOEC = 0.0047 µg/L; fish: NOEC = 0.41 µg/L) as well as to sediment-dwelling organisms (Chironomidae: LC50 = 2.1 mg/kg and NOEC 0.1 mg/kg), was detected at several sampling sites (up to 11.2 ng/g). …”
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Rational design of novel phenol ether derivatives as non-covalent proteasome inhibitors through 3D-QSAR, molecular docking and ADMET prediction by Miao Yuan, Hanwen Ji, Fengxin Sun, Qiang Chen, Ping Cheng

“…Therefore, potentially attractive non-covalent proteasome inhibitors with low toxicity could be found as anticancer drugs. Methods: In this work, computer-aided drug design methods, including quantitative structure-activity relationship (QSAR), molecular docking, absorption, distribution, metabolism, excretion, and toxicology (ADMET) prediction, and drug-likeness prediction methods were performed. …”
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Biofabrication of zinc oxide nanoparticles using Moringa oleifera, characterization and statistical optimization for their application in crystal violet adsorption by Meshayil M. Alsolmi, Noura El-Ahmady El-Naggar, Mashael I. Alqurashi, Ragaa A. Hamouda

“…Despite its various applications, crystal violet has been recognized as a biohazard dye due to its toxic and carcinogenic properties. It persists in the environment with long-lasting effects and has detrimental impacts. …”
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Potential and Comparative Tablet Disintegrant Properties of Pectin Obtained from Five Okra Genotypes in Ghana by Frederick William Akuffo Owusu, Mariam El Boakye-Gyasi, Jacob Kwaku Agbenorhevi, Marcel Tunkumgnen Bayor, Kwabena Ofori-Kwakye

“…Elemental analysis of the extracted pectin from the various genotypes revealed very low levels of toxic metals and micronutrients. Pectin from the various genotypes was evaluated as disintegrants within concentrations of 5–10% w/w (F1–F18). …”
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Changes of Ammonia, Nitrite and Nitrate at Recirculation System of Red Tilapia (Oreochromis sp.) Rearing by D. Djokosetiyanto, A. Sunarma, . Widanarni

“…The accumulation of organic materials can  be toxic for fish, generate mineralization of nutrient from organic materials and cause high oxygen expenditure.  …”
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Copper Super-Dosing Improves Performance of Heat-Stressed Broiler Chickens through Modulation of Expression of Proinflammatory Cytokine Genes by Sudipto Haldar, Amrita Kumar Dhara, Sayantani Sihi Arora, Arpana Verma Mukherjee, Arup Nayak

“…It was concluded from the present experiment that during conditions of impending HS, dietary supplementation of 112.5 to 150 mg Cu/kg diet as Cu-P may be a novel strategy to alleviate the negative effects of HS without involving any apparent risk of Cu toxicity.…”
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Engineered Perfluorochemical Cancer-Derived Exosomes Loaded with Indocyanine Green and Camptothecin Provide Targeted Photochemotherapy for Effective Cancer Treatment by Lee YH, Huang CY

“…Moreover, tumor growth was significantly arrested by ICFESs containing 40/40 μM [ICG]/[CPT] in combination with 30 sec of NIR exposure without systemic toxicity, and the resulting tumors were approximately 15-fold smaller than those treated for 14 days with 40 μM free CPT alone.Conclusion: We suggest that the aforementioned anticancer efficacy was achieved via a dual-stage mechanism, phototherapy followed by chemotherapy. …”
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Replacement of fishmeal with Quinoa Husk (Chenopodium quinoa) for mitigating multiple stresses in Pangasianodon Hypophthalmus by Neeraj Kumar, Paritosh Kumar, Aliza Pradhan, Dilip Kumar Singh, Tarkeshwar Kumar, Jagadish Rane, Kotha Sammi Reddy

“…The oxidative enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST) and glutathione peroxidase (GPx) in gill, kidney and liver tissues were significantly lowered by replacement of fishmeal by QH at 25% in fish reared under arsenic and ammonia toxicity and high temperature stress (NH3+As+T). The neurotransmitter enzyme (AChE) in brain tissue was noticeably enhanced by QH at 25%. …”
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Particle-bound PAHs and Chemical Composition, Sources and Health Risk of PM2.5 in a Highly Industrialized Area by Elizabeth Vega, Diego López-Veneroni, Omar Ramírez, Judith C. Chow, John G. Watson

“…., tires and industrial waste) of the recycling cement kilns and incinerators resulted in elevated toxic species such as, Cd, and Sb in the range of 0.02–0.3 µg m−3. …”
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Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4 by Hui Gao, Kunming Tian, Xiaojun Feng, Mengqing Yan, Chen Gao, Yisheng Jiang, Chenhao Zhu, Huzhe Zhu, Xueping Liu, Yingfu Peng

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Therapeutic potential of brentuximab vedotin in breast cancer and lymphoma via targeted apoptosis and gene regulation by Abeer Ezzat, Mohga Shafiek, Shimaa Shawki, Shaimaa Abdel-Ghany, Mahmoud Nazih, Hussein Sabit

“…HSF cells, serving as controls, exhibited minimal viability loss (above 70%), indicating limited toxicity in normal fibroblasts. In contrast, MCF-7 and MDA-MB-231 cells demonstrated time-dependent reductions in viability, with a pronounced decline by 72 h, suggesting Brentuximab’s efficacy in both ER-positive and triple-negative breast cancer. …”
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Synthesis and Evaluation of PCL/Chitosan/CQD‐Fe Magnetic Nanocomposite for Wound Healing: Emphasis on Gene Expression by Elham Maghareh Abed, Fatemeh Yazdian, Abbas Akhavan Sepahi, Behnam Rasekh

“…Our findings indicated that PCL/Cs/CQD‐Fe can improve skin regeneration due to its antibacterial effect, biocompatibility, and non‐toxicity. This biocompatible nanocomposite is a scaffold that can be used for covering the skin.…”
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Negative Association of Gulf War Illness Symptomatology with Predicted Binding Affinity of Anthrax Vaccine Antigen to Human Leukocyte (HLA) Class II Molecules by Lisa M. James, Apostolos P. Georgopoulos

“…Conclusions: Reduced HLA protection against the toxic anthrax vaccine may underlie GWI.…”
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Haemophagocytic lymphohistiocytosis in patients treated with immune checkpoint inhibitors: analysis of WHO global database of individual case safety reports by Alessandro Ceschi, Roberta Noseda, Raffaela Bertoli, Laura Müller

“…ICI-related haemophagocytic lymphohistiocytosis (HLH) has been recently outlined in single case reports, raising a concern about the need of increasing our knowledge on this rare yet life threatening ICI haematological toxicity.Methods To determine ICI-related HLH clinical, haematological, and coagulation features, its timing and outcome, concurrent irAEs and concomitant infections, we performed a retrospective observational cross-sectional study and queried VigiBase, the WHO global database of suspected adverse drug reactions (ADRs), on September 30th, 2018. …”
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