Ovario- protective effect of Moringa oleifera leaf extract against cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats by Seham Samir Soliman, Ahmed A. Suliman, Khaled Fathy, Ahmed A. Sedik

“…Abstract It is crucial to develop new tactics to prevent ovarian tissue damage in women whose reproductive toxicity is caused by chemotherapy. The present investigation was performed to assess the protective effects of Moringa oleifera (M. oleifera) leaf extract on cyclophosphamide (CP)-induced ovarian damage and reproductive dysfunction. …”
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Comparative efficacy and safety of neoadjuvant radiotherapy for patients with borderline resectable, and locally advanced pancreatic ductal adenocarcinoma: a systematic review and... by Xin Wang, Dan Cao, Qingfeng Wang, Qiancheng Hu, Wanrui Lv

“…Secondary outcomes include overall survival, disease-free survival and acute and late grade 3 and grade 4 toxicities. For randomised control trials, the risk of bias will be assessed using the Cochrane Risk of Bias Tool, while the risk of bias for non-randomised, observational studies will be evaluated using the Risk Of Bias In Non-randomised Studies-of Interventions. …”
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Cardiovascular and Metabolic Adverse Events of Endocrine Therapies in Women with Breast Cancer: A Disproportionality Analysis of Reports in the FDA Adverse Event Reporting System by Shaimaa Elshafie, Lorenzo Villa‐Zapata, Randall L. Tackett, Iman Y. Zaghloul, Henry N. Young

“…ABSTRACT Introduction Emerging evidence suggests potential cardiovascular toxicities from oral endocrine therapies (ETs); however, results are conflicting. …”
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Peptide Design for Enhanced Anti-Melanogenesis: Optimizing Molecular Weight, Polarity, and Cyclization by Putri SA, Maharani R, Maksum IP, Siahaan TJ

“…Cyclization of peptides enhances their structural stability, serum resistance, and binding affinity while reducing toxicity. This process increases resistance to enzymatic degradation and improves target specificity by limiting conformational flexibility. …”
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RETRACTED: Efficacy of Vanadyl Sulfate and Selenium Tetrachloride as Anti-Diabetic Agents against Hyperglycemia and Oxidative Stress Induced by Diabetes Mellitus in Male Rats by Fawziah A. Al-Salmi, Reham Z. Hamza

“…Histological sections in pancreas tissues were treated as indicators of both VOSO₄ and selenium tetrachloride efficacy, either alone or combined, for the alleviation of STZ toxicity. The genotoxicity of diabetes mellitus was assessed, and the possible therapeutic roles of VOSO₄ or selenium tetrachloride, or both, on antioxidant enzymes were studied. …”
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FEATURES OF BIOELEMENTS ACCUMULATION BY FUNGI L. EDODES DURING CULTIVATION IN SUBSTRATES ENRICHED WITH Cr, Se, Ge, Fe CITRATES by I. Andrusyshyna, O. Velikanov, D. Bakhlukov

“…According to the research results, the enrichment of the substrate with citrates Cr, Se, Ge, Fe leads to their accumulation by shiitake mushrooms and also affects the trace element composition of mushrooms in general, but modification of the trace element composition of the substrate does not lead to the accumulation of bioelements and toxicants above the level of the maximum permissible concentration. …”
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Efficacy of caerulomycin A in modulating macrophage polarization and cytokine response in a murine model of lipopolysaccharide-induced sepsis by Jun Zhang, Shiyue Tang

“…For in-vitro assays using the RAW264.7 macrophage cell line, the concentration of caeA that was non-toxic to cell survival was screened using the MTT assay, followed by the analyses by qRT-PCR, ELISA, Western blot and flow cytometry for M1/M2 type macrophage markers (CD86, NOS2, CD206, ARG1) and inflammatory factors (IL-1β, IL-6, TNF-α, IL-4, and IL-10) expression. …”
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Effect of Nigella sativa extract on nasal mucosal inflammation in rats exposed to cigarette smoke by Fathika Alamanda, Anna Mailasari Kusuma Dewi, Dwi Marliyawati, Yanuar Iman Santosa

“…Cigarette smoke contains toxic compounds that can initiate an inflammatory reaction and infiltrate inflammatory cells. …”
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Pain in pancreatitis: issue and ways out by A. V. Okhlobystin

“…Medical treatment of pain includes, first of all, elimination of toxic factors and stimulations of pancreatic secretion. …”
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Dietary Exposure to Aflatoxins in Some Randomly Selected Foods and Cancer Risk Estimations of Cereals Consumed on a Ghanaian Market by Nii Korley Kortei, Theophilus Annan, Seidu A. Richard, Adjoa A. Boakye, Clement O. Tettey, Edward Ken Essuman, Enoch Aninagyei, Precious Agbemeseli

“…By using the model prescribed by Joint FAO/WHO Expert Committee on Food Additives (JECFA), the risks posed by the food and feed samples were determined. The degrees of toxicity were in the ranges of 0.78–234.73 μg/kg, 0.47–21.6 μg/kg, 1.01–13.75 μg/kg, and 0.66–5.51 μg/kg, respectively, for AFB1, AFB2, AFG1, and AFG2. …”
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Autologous haematopoiesis stem cell transplantation (AHSCT) for treatment-refractory autoimmune diseases in children by Jasmin Beate Kuemmerle-Deschner, Susanne Benseler, Joerg C Henes, Özlem Satirer, Michaela Döring, Till Lesk

“…Safety: Three experienced infections, including HHV6, Candida and Ralstonia sepsis; one developed a systemic inflammatory response syndrome; two new onset secondary autoimmune diseases including autoimmune haemolytic anaemia, Graves’ disease and one was found to have a breast fibroadenoma. Treatment toxicity: one cyclophosphamide-associated transient renal failure and pericardial effusion, one patient with amenorrhoea/infertility.Conclusions AHSCT was an effective and safe approach for children and adolescents with treatment-refractory autoimmune diseases. …”
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The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques. by Alexander M Cole, Dorothy L Patton, Lisa C Rohan, Amy L Cole, Yvonne Cosgrove-Sweeney, Nicole A Rogers, Deena Ratner, Alexandra B Sassi, Carol Lackman-Smith, Patrick Tarwater, Bharat Ramratnam, Piotr Ruchala, Robert I Lehrer, Alan J Waring, Phalguni Gupta

“…<h4>Background</h4>RC-101 is a congener of the antiretroviral peptide retrocyclin, which we and others have reported is active against clinical HIV-1 isolates from all major clades, does not hemagglutinate, and is non-toxic and non-inflammatory in cervicovaginal cell culture. …”
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Liposomal Formulations: A Recent Update by Surendra S. Agrawal, Vrinda Baliga, Vaishali Y. Londhe

“…To improve therapeutic efficacy and reduce systemic toxicity, researchers added stimuli-responsive components to liposomal membranes to precisely control drug release kinetics. …”
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Nano-chitosan-coated, green-synthesized selenium nanoparticles as a novel antifungal agent against Sclerotinia sclerotiorum: in vitro study by Mohamed M. Desouky, Radwa H. Abou-Saleh, Tarek A. A. Moussa, Heba M. Fahmy

“…These fungicides must be restricted because of their toxicity and the development of resistance strains. …”
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An in-vivo herb-drug interaction study of IME-9 and glimepiride in nicotinamide-STZ-induced diabetic rats by Archana K. Thikekar, Asha B. Thomas, Sohan S. Chitlange

“…In silico molecular docking investigations were conducted using Autodock Vina 1.2.3 to assess the binding affinity of the 46 primary phytoconstituents present in IME 9 with CYP2C9 enzymes. Toxicity assessments were carried out utilizing the MTT assay. …”
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Release of tumour necrosis factor alpha into bronchial alveolar lavage fluid following antigen challenge in passively sensitized guinea-pigs by D. E. Kelly, M. Denis, D. F. Biggs

“…BAL fluid from OA sensitized animals that inhaled OA aerosols contained no detectable TNF-α at 30 min, but it was found in increasing amounts at 60, 90 and 120 min; TNF-α was not detected in fluid from any of the animals that inhaled saline. As BAL fluids were toxic to the cells used in the assays, neither IL-1 nor IL-6 could be measured. …”
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Ecological and genetic assessment of the consequences of radiation influence on contaminated areas by A. B. Bigaliev, K. Z. Shalabaeva, B. E. Shimshikov, S. S. Kobegenova, L. M. Adilova, A. N. Kozhakhmetova, S. Sharakhmetov, M. N. Burkhanova

“…A reconnaissance and radioecological examination of environmental objects was carried out using analytical methods, which made it possible to determine the quantitative content of toxic components, the content of priority pollutants and radioactive isotopes. …”
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The evolving roles of geophysics in environmental assessment, monitoring, and management of landfill leachate contaminant plumes: An overview by Joseph Omeiza Alao

“…Landfill leachate, a toxic brew of pollutants, poses a silent threat to water resources, ecosystems, and public health. …”
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Comparative analysis of the efficacy and safety of fixed-dose combinations versus their individual components for open-angle glaucoma by Z.M. Nagornova, A.V. Kuroyedov, A.V. Seleznev

“…Moreover, IOP-lowering effect of fixed-dose combinations is similar or even greater than that of individual components due to the lack of washout phenomenon and less toxic effect of preservatives on the ocular surface. …”
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3-Acetyldeoxynivalenol induces pyroptosis in leydig cells via METTL3-mediated N6-methyladenosine modification of NLRP3 by Yangyun Wang, Chaoliang Shi, Wei Jiao, Xiaoxiang Wan

“…Collectively, our findings reveal a novel mechanism by which 3-ADON exerts its reproductive toxicity, underscoring the pivotal role of METTL3-mediated m6A modifications in regulating Leydig cell dysfunction.…”
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