Eco-friendly synthesis of chitosan NPs from Fioria vitifolia (L.) L: Potential to antibacterial, antioxidant, cytotoxicity properties of HepG2 cells and their evaluation of safety... by Mohamed Imath, Chinnasamy Ragavendran, Chinnaperumal Kamaraj, Ramalingam Karthik Raja, Gholamreza abdi

“…Using the MTT Assay, the dose-dependent response of FV-CNPs against HepG2 cells was determined, and an IC50 value of 59.41 µg/mL was obtained. Finally, the toxicity test conducted on zebrafish eggs revealed that bending bodies only became visible at levels exceeding 100 μg/mL. …”
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Olfactory Impairment and Recovery in Zebrafish (<i>Danio rerio</i>) Following Cadmium Exposure by Chiara Maria Motta, Rosa Carotenuto, Chiara Fogliano, Luigi Rosati, Pabitra Denre, Raffaele Panzuto, Rossana Romano, Gianluca Miccoli, Palma Simoniello, Bice Avallone

“…Present in high concentrations across water bodies, cadmium is known to bioaccumulate and biomagnify throughout the food chain. While the toxic effects of cadmium on the organs and tissues of aquatic species are well-documented, little is known about its impact on sensory systems crucial for survival. …”
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Improving drug repositioning with negative data labeling using large language models by Milan Picard, Mickael Leclercq, Antoine Bodein, Marie Pier Scott-Boyer, Olivier Perin, Arnaud Droit

“…Supervised machine learning is commonly used to score drug candidates but is hindered by the lack of reliable negative data—drugs that fail due to inefficacy or toxicity— which is difficult to access, lowering their prediction accuracy and generalization. …”
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Assisted Egg White Biogenic Synthesis for Elaboration of ZnO Nanoparticles by Elena Andreea Vijan, Ecaterina Magdalena Modan, Sorin Georgian Moga, Denis Aurelian Negrea, Adriana-Gabriela Schiopu, Mihai Oproescu, Daniela Istrate

“…ZnO-based nanomaterials especially demonstrate versatility, accessibility, biocompatibility and low toxicity. In recent years, there has been a growing interest in developing eco-friendly and sustainable approaches for synthesizing nanomaterials. …”
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Disulfidptosis-related lncRNA signature to assess the immune microenvironment and drug sensitivity in acute myeloid leukemia by Yuying Zhao, Hai-en Cheng, Jingfei Wang, Yunke Zang, Zhijun Liu, Yanhua Sun, Yanli Sun

“…However, chemotherapy suffers from high toxicity and a shortage of hematopoietic stem cell donors, which significantly shortens patient survival. …”
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Combination of ataxia telangiectasia and Rad3-related inhibition with ablative radiotherapy remodels the tumor microenvironment and enhances immunotherapy response in lung cancer by Jenny Ling-Yu Chen, Chun-Kai Pan, Li-Cheng Lin, Yu-Sen Huang, Tsung-Hsuan Huang, Shu-Jyuan Yang, Sung-Hsin Kuo, Yu-Li Lin

“…Safety analysis showed minimal toxicity. ATR inhibition enhanced the efficacy of ablative radiotherapy and immunotherapy in lung cancer. …”
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Influence of Omega-3 and Green Tea Extract on Alcohol-Induced Liver Injury in Rats by Ridha Hassan Hussein, Zana Hassan Ibrahim

“…Drinking alcoholic beverages recently is common in many parts of the world, liver is a principal organ that involved in toxic effects of alcohol and it remains a serious health problem globally. …”
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In Vitro Antibacterial, Antioxidant, Cytotoxicity Activity, and In Silico Molecular Modelling of Compounds Isolated from Roots of Hydnora johannis by Teshome Degfie, Milkyas Endale, Muhdin Aliye, Rajalakshmanan Eswaramoorthy, Tariku Nefo Duke, Aman Dekebo

“…According to the cytotoxicity study, n-hexane extract exhibited a high level of toxicity with 28.9 ± 5.6% cell viability. Antibacterial activity was tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pyogen. …”
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Programmed neurite degeneration in human central nervous system neurons driven by changes in NAD+ metabolism by Markus Brüll, Selina Multrus, Michael Schäfer, Ivana Celardo, Christiaan Karreman, Marcel Leist

“…The establishment of a CNS axotomy model (using modified 3D LUHMES cultures) allowed us to study metabolic control of ND in human midbrain-derived neurons without the use of toxicants or other direct disturbance of cellular metabolism. …”
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Medicinal plants as alternatives for the management of hypertension and diabetes in Nigeria: Analysis of the structured interview of Nigerian patients by Rosemary A. Sylver-Francis, Olavi Pelkonen

“…Potentially, the use may predispose patients to severe hypotension or hypoglycaemia and other adverse effects e.g. drug interactions and direct toxicities. Also, poor quality and scanty or anecdotal directions of TMPs raises safety concerns. …”
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High Glucose-Induced Oxidative Stress Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances Possibly via p38 MAPK Activation in Rat Nucleus Pulposus Cells by Xiaofei Cheng, Bin Ni, Feng Zhang, Ying Hu, Jie Zhao

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Genotoxic and Mutagenic Assessment Induced by Vinasse, Before and After Being Subjected to Bio-oxidation and Fenton Processes. by Iván Meléndez Gélvez, Diego Alberto Salazar Moncada, Elkín Johan Granados Vega, Jennifer Carolina Soledad Maldonado, Carlos Alberto Peláez Jaramillo

“…Conclusion: The importance of addressing vinasse pollution and treatment methods to reduce its toxicity is emphasised. However, further research is needed to fully understand the risks associated with vinasse exposure and to develop effective mitigation strategies. …”
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Chromosomal Abnormalities in Allium cepa Induced by Treated Textile Effluents: Spatial and Temporal Variations by W. M. Dimuthu Nilmini Wijeyaratne, P. G. Minola Udayangani Wickramasinghe

“…Appropriate effluent treatment processes are expected to significantly reduce the toxicity of effluents before they are released to the natural environment. …”
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Cytotoxicity and genotoxicity of orthodontic bands after aging: an in-vitro study by Maryam Karandish, Bahar Khademi, Golnaz Ziaei, Nasrollah Erfani, Leila Moezi, Zahra Faghih

“…However, AO bands seem to become toxic for gingiva cells in acidic milieu.…”
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How the Suboxone Education Programme presented as a solution to risks in the Canadian opioid crisis: a critical discourse analysis by Quinn Grundy, Fiona Webster, Daniel Z Buchman, Sheryl Spithoff, Ross E G Upshur, Abhimanyu Sud, Matthew Strang

“…Discursive themes were identified through iterative and duplicate analyses using a semistructured data extraction instrument.Results Documents characterised the Programme as addressing iatrogenic risks from overprescribing opioid analgesics, environmental risks from a toxic street drug supply and pharmacological risks relating to the dominant therapeutic alternative of methadone. …”
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PSMA antibody, humanized PSMA.CAR10.3, or Cetuximab increases prostate cancer localization of NF-κB p50-deficient immature myeloid cells (p50-IMC) and phagocytosis by their macroph... by Mohammad A. Alzubi, Theresa Barberi, Alan D. Friedman

“…Nevertheless, this study indicates the potential clinical utility of adding a tumor-directing antibody or CAR, including the novel, fully humanized PSMA.CAR10.3, to proinflammatory p50-IMC to optimize the activation of anti-tumor immunity in prostate cancer and other malignancies, and understanding PSMA toxicity in normal but not malignant prostate epithelium may reveal a novel therapeutic opportunity.…”
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On Farm Evaluation of Eucalyptus globulus Labill Leaf and Chenopodium ambrosioides L. Whole Plant Powder against Storage Insect Pests in Stored Maize at Sokoru District in Jimma Zo... by Lelise Tilahun Dufera, Abebe Yimer Tadesse, Waktole Sori Gobena, Chala Gowe Kuyu

“…It is recommended that further research should be done to check if the increasing rate of application increases protection duration of these botanicals and the toxicity of Chenopodium ambrosioides L. should be further studied to use it as a storage insect protectant of maize grains intended for food purpose.…”
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Cobalt-induced oxidative stress and defense responses of Adhatoda vasica proliferated shoots by Abeer A. Radi, Fatma A. Farghaly, Fatma A. Al-Kahtany, Ahmed M. Zaher, Afaf M. Hamada

“…While cobalt (Co) can be toxic to plants at high levels and isn’t considered essential, it plays a beneficial role in many enzymes and is critical for various biological functions. …”
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Compounds Involved in the Invasive Characteristics of <i>Lantana camara</i> by Hisashi Kato-Noguchi, Midori Kato

“…Lantadenes A and B, oleanonic acid, and icterogenin are highly toxic to herbivore mammals, and β-humulene, isoledene, α-copaene thymol, and hexadecanoic acid have high insecticidal activity. β-Caryophyllene and <i>cis</i>-3-hexen-1-ol may function as herbivore-induced plant volatiles which are involved in sending warning signals to undamaged tissues and the next plants of the same species. …”
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Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients by Lara Marques, Nuno Vale

“…We also identified individual characteristics associated with increased salbutamol toxicity risk, indicating the need for dose adjustment or alternative administration. …”
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