Exploring the efficacy of fluorouracil and platinum based chemotherapy in advanced hepatocellular carcinoma to bridge the treatment gap in resource limited settings by Se Jun Park, Kabsoo Shin, In-Ho Kim, MyungAh Lee, Tae Ho Hong, Hyunho Kim

“…A high pretreatment neutrophil-to-lymphocyte ratio (≥ 3.0) adversely affected both PFS (HR = 1.79; 95% CI, 0.99–3.25; p = 0.034) and OS (HR = 2.02; 95% CI, 1.10–3.69; p = 0.011). Hematologic toxicities related to the treatment were substantial, with 62.5% of patients experiencing grade 3 or 4 events, primarily neutropenia, which affected 60.4% of them. …”
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INNOVATION IN BIOCOMPATIBLE MATERIALS FOR DENTAL IMPLANTS: CURRENT PERSPECTIVE AND SITUATIONS by Asaftei Victoria, Ciornei Mădălina, Țabără Eduard Lucian, Agop-Forna Doriana, Maxim Alexandra, Norina Forna

“…However, the main drawback in these approaches is the potential toxicity and accumulative effect of the metals over time. …”
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Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses by Valentina Stock, Rebecca Hofer, Franziska Lochmann, Vera Spanke, Klaus R. Liedl, Jakob Troppmair, Thierry Langer, Hubert Gstach, Christian Dank, Chris A. Mayhew, Sarah Kammerer, Veronika Ruzsanyi

“…For the first time, we identify an isotopically unlabelled CYP3A4 substrate, tolterodine that leads to the formation of a non-toxic volatile metabolite, acetone, which could potentially be applied to monitor CYP3A4 activity in humans. …”
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Prediction of potential drug targets and key inhibitors (ZINC67974679, ZINC67982856, and ZINC05668040) against Rickettsia felis using integrated computational approaches by Sudais Rahman, Hsien Liu, Mohibuallah Shah, Mashal M. Almutairi, Iram Liaqat, Tetsuya Tanaka, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Abdulaziz Alouffi, Abid Ali

“…Absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiling confirmed that most compounds met the preferred pharmacokinetic properties, except for ZINC67895371 and ZINC67847806, which exhibited positive ames test results, and ZINC05670149, ZINC67895371, and ZINC67847806, showed hepatotoxicity. …”
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Lysozyme-based spray for treatment of radiotherapy-induced oral mucositis by Zdenka Gojković, Jelena Rožić, Nataša Gašpar, Aziz Šukalo, Meliha Mehić, Amna Tanović Avdić, Una Glamočlija

“…Methods: A prospective, open-label study was conducted on patients with ulcerative inflammation of the oral cavity and pharynx mucous membranes clinically assessed for oral mucositis according to the World Health Organization (WHO) Oral Toxicity Scale. Patients were randomly divided into a lysozyme group (using a spray containing lysozyme + cetylpyridinium + lidocaine) and a control group (using a compounded preparation containing gentamicin + dexamethasone + lidocaine). …”
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The interplay between RNA m6A modification and radiation biology of cancerous and non-cancerous tissues: a narrative review by Yajia Cheng, Yue Shang, Shuqin Zhang, Saijun Fan

“…Radiation therapy (RT) induces oncological responses, from molecular to phenotypic alterations, while simultaneously exerting toxic effects on healthy tissue. N6-methyladenosine (m6A), a prevalent modification on coding and non-coding RNAs, is a key epigenetic mark established by a set of evolutionarily conserved enzymes. …”
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Kombucha Versus Vegetal Cellulose for Affordable Mucoadhesive (nano)Formulations by Ioana Popa-Tudor, Naomi Tritean, Ștefan-Ovidiu Dima, Bogdan Trică, Marius Ghiurea, Anisoara Cimpean, Florin Oancea, Diana Constantinescu-Aruxandei

“…Cellulose nanofibers gained increasing interest in the production of medical devices such as mucoadhesive nanohydrogels due to their ability to retain moisture (high hydrophilicity), flexibility, superior porosity and durability, biodegradability, non-toxicity, and biocompatibility. In this work, we aimed to compare the suitability of selected bacterial and vegetal nanocellulose to form hydrogels for biomedical applications. …”
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Exploring the Impact of Citric Acid on Mitigating Sweet Potato Soft Rot and Enhancing Postharvest Quality by Yixi Chen, Linjiang Pang, Jiacheng Bai, Wenbao Yu, Yueming Zhu, Melvin Sidikie George, Zunfu Lv, Guoquan Lu

“…Citric acid (CAC) is a ubiquitous, odorless, and non-toxic food additive. Soft rot, caused by the pathogen <i>Rhizopus stolonifer</i>, is a major postharvest disease affecting sweet potato (<i>Ipomoea batatas</i> (L.) …”
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Oxidized alkaline biochar and phosphate solubilizing bacteria mixture enhances direct seeded maize yield in an acid soil by Hachib Mohammad Tusar, Md. Kamal Uddin, Shamim Mia, Susilawati Kasim, Samsuri Bin Abd. Wahid, Tomoyuki Makino, Zakaria Solaiman

“…These improvement in yield might have occurred due to an increase soil pH, P bioavailability (r2= 0.74), and a reduction in Al toxicity (r2= 0.36).Findings of this study could have significant implications for crop production in acidic soil.…”
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Parishin B blocking TRIB3-AKT1 interaction inhibits breast cancer lung metastasis by Xiongtao Cheng, Xiongtao Cheng, Jianguo Sun, Shouhong Chen, Nan Wang, Weijing Tang, Zijian Xia, Yuhong Shu, Shouhong Gao, Zhipeng Wang, Xinxia Wang, Rongzi Shao, Jianxiong Cao, Jianxiong Cao

“…In addition, PB exhibited good anti-BC activity without drug toxicity in normal breast cells by experiments in vitro, and RNA-seq analysis suggested PB could inhibit the proliferation and invasion of BC cells related with cell cycle. …”
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Study on the Therapeutic Effects of Bisdemethoxycurcumin on a Cerebral Amyloid Angiopathy Mouse Model Established via Chronic Treatment With Five Vascular Risk Factors by Shudong Lin, Guanghua Zhu, Juan Xie, Xuanwei Wen, Limin Deng, Sijing Li, Guozhi Liu, Feiyan Wang, Shuangxi Chen, Zijian Xiao

“…Bisdemethoxycurcumin (BDMC) has been demonstrated to exhibit pharmacological effects with anti‐Aβ toxicity properties. Thus, the present study mainly focused on the potential therapeutic effects of BDMC on CAA. …”
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Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial by Jeffrey M. Clarke, George R. Simon, Hirva Mamdani, Lin Gu, James E. Herndon, Thomas E. Stinchcombe, Neal Ready, Jeffrey Crawford, Guru Sonpavde, Stephen Balevic, Andrew B. Nixon, Michael Campa, Elizabeth B. Gottlin, Huihua Li, Ruchi Saxena, You Wen He, Scott Antonia, Edward F. Patz

“…Two dose-limiting adverse events were reported: grade 3 acute kidney injury (0.3 mg/kg) and grade 2 colitis (1 mg/kg). No dose-limiting toxicities were noted at the highest dose levels and the MTD was not reached. …”
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Synthesis, In vitro antimicrobial activity, and In silico bioinformatical approach of xanthone-fatty acid esters against Staphylococcus aureus, Escherichia coli, and Candida albica... by Yehezkiel Steven Kurniawan, Ervan Yudha, Jumina, Harno Dwi Pranowo, Eti Nurwening Sholikhah

“…The in vitro cytotoxicity assay against the NIH3T3 cell line showed that xanthyl laurate was non-toxic at 500 μg/mL with a cell viability percentage of 86.14 ± 1.38 %. …”
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Sustainable Valorization of Rice Straw into Biochar and Carbon Dots Using a Novel One-Pot Approach for Dual Applications in Detection and Removal of Lead Ions by Jagpreet Singh, Monika Bhattu, Meenakshi Verma, Mikhael Bechelany, Satinder Kaur Brar, Rajendrasinh Jadeja

“…Lead (Pb) is a highly toxic heavy metal that causes significant health hazards and environmental damage. …”
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A new luminescent material based on bismuth(III): Synthesis, structural characterization, DFT calculations, Hirshfeld surface, thermal behavior, vibrational and optical properties by Chaima Jridi, Nour Elleuch, Jerome Lhoste, Mohamed Boujelbene

“…Bismuth-halide-based hybrid materials are desirable in luminescent applications due to low toxicity and chemical stability. (C8H12N)4Bi2Cl10, was elaborated by the slow evaporation technique at room temperature. …”
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Identification of plasma proteins binding oxidized phospholipids using pull-down proteomics and OxLDL masking assay‡ by Philipp Jokesch, Lisa Holzer, Lydia Jantscher, Sebastian Guttzeit, Rudolf Übelhart, Olga Oskolkova, Valery Bochkov, Bernd Gesslbauer

“…Oxidized phospholipids (OxPLs) are increasingly recognized as toxic and proinflammatory mediators, which raises interest in the mechanisms of their detoxification. …”
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Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study by Nicolás Tentoni, Miriam Hwang, Gabriela Villanueva, Ryan Combs, Jennifer Lowe, Laura B. Ramsey, Zachary L. Taylor, Thais Murciano Carrillo, María Dolores Aumente, Teresa López‐Viñau López, Carmelo Rizzari, Scott C. Howard

“…Early AKI detection is paramount to prevent further renal injury and irreversible toxicities. This study sought to determine whether early elimination patterns of MTX would be useful as a biomarker of AKI in HDMTX treatment. …”
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Genome sequence and evaluation of safety and probiotic potential of Lacticaseibacillus paracasei LC86 and Lacticaseibacillus casei LC89 by Ting Chen, Yunjiao Zhao, Yunjiao Zhao, Yixuan Fan, Yao Dong, Zhonghui Gai

“…Additionally, we studied the acute toxicity of LC86 and LC89 in mice through a 14-day oral gavage experiment.ResultsThe two strains selected were identified as Lacticaseibacillus paracasei and Lacticaseibacillus casei. …”
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Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer by Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent Dufossé

“…Its derivatives, such as 13p, exhibit enhanced potency by arresting the G2/M phase and targeting drug-resistant cells with minimal toxicity. Advanced nano-delivery systems and combination therapies further enhance oridonin's therapeutic potential. …”
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Immunomodulatory Effect of Phage Depolymerase Dep_kpv74 with Therapeutic Potential Against K2-Hypervirulent <i>Klebsiella pneumoniae</i> by Nikolay V. Volozhantsev, Maria A. Makarova, Alena S. Kartseva, Marina V. Silkina, Valentina M. Krasilnikova, Egor A. Denisenko, Alexander I. Borzilov, Victoria V. Firstova

“…The biochemical results of the studies indicated that Dep_kpv74 did not exert any toxic effects on liver and kidney functions. The results of the analysis of lymphocyte proliferative activity demonstrated that Dep_kpv74 depolymerase has a mild immunomodulatory effect. …”
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