Phytomedicinal armamentarium: A review of inula racemosa-derived alantolactones and isoalantolactones in anticancer therapy by Joshi Gaurav Santoshrao, Smriti Jamwal, Rakesh Kumar, Ekta Bisht, Bisen Harsh Krishnakumar, Shreya Katoch, R.K. Asrani

“…The compounds have demonstrated efficacy in vitro and in vivo, affecting various cancer cell lines with minimal toxicity to normal cells. Conclusion: Alantolactone and isoalantolactone from Inula racemosa show promising potential as anti-cancer agents. …”
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Oncolytic vaccinia virus armed with anti-CD47 nanobody elicit potent antitumor effects on multiple tumor models via enhancing innate and adoptive immunity by Jie Chen, Liu Yang, Mengyuan Li, Qian Ye, Shibing Wang, Zengpeng Li, Wenbin Qian

“…However, this therapeutic approach is often hampered by on-target side effects, physical barriers, and immunosuppressive tumor microenvironment (TME).Methods To improve therapeutic efficacy while minimizing toxicities, we engineered an oncolytic vaccinia virus (OVV) encoding an anti-CD47 nanobody (OVV-αCD47nb). …”
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Magnesium extraction of ferronickel slag processed by alkali fusion and hydrochloric acid leaching by Prasetyo A.B., Khaerul A., Mayangsari W., Febriana E., Maksum A., Andinie J., Firdiyono F., Soedarsono J.W.

“…Moreover, the accumulation due to increasing ferronickel demand as well as the environmental contamination due to various potentially toxic elements contained in the ferronickel slag could be prevented. …”
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Characterization of the Phosphotransferase from <i>Bacillus subtilis</i> 1101 That Is Responsible for the Biotransformation of Zearalenone by Yuzhuo Wu, Qiuyu Zhou, Junqiang Hu, Yunfan Shan, Jinyue Liu, Gang Wang, Yin-Won Lee, Jianrong Shi, Jianhong Xu

“…The experiments conducted on MCF-7 cells demonstrated that ZEA-P exhibited a lower level of estrogenic toxicity than ZEA. The optimal reaction conditions for ZPH1101 were determined to be 45 °C and pH 8.0. …”
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Analysis of different therapeutic schemes combining cyclophosphamide and doublestranded DNA preparation for eradication of Krebs-2 primary ascites in mice by E. A. Potter, E. V. Dolgova, A. M. Minkevich, V. P. Nikolin, N. A. Popova, Ya. R. Efremov, S. I. Baiborodin, V. A. Rogachev, A. S. Proskurina, A. V. Kozel, O. S. Taranov, V. V. Omigov, E. I. Vereschagin, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…We show that combining CP with cross-linked human and salmon dsDNA results in a synergistic toxicity for ascites-bearing mice, an observation supported by the histopathology analysis of organs and tissues of experimental animals. …”
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Resveratrol-Based Carbamates as Selective Butyrylcholinesterase Inhibitors: Design, Synthesis, Computational Study and Biometal Complexation Capability by Maja Sviben, Ilijana Odak, Danijela Barić, Milena Mlakić, Ottó Horváth, Lajos Fodor, Sunčica Roca, Ivana Šagud, Irena Škorić

“…Considering our previous experience in the design of new cholinesterase inhibitors, especially resveratrol analogs, in this research, the basic stilbene skeleton was used as a structural unit for new carbamates designed as potentially highly selective butyrylcholinesterase (BChE) inhibitors with excellent absorption, distribution, metabolism, excretion and toxicity ADMET properties. The inhibitory activity of newly prepared carbamates <b>1</b>–<b>13</b> was tested toward the enzymes acetylcholinesterase (AChE) and BChE. …”
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Fluralaner systemic treatment of chickens results in mortality in Triatoma gerstaeckeri, vector of the agent of Chagas disease by Cassandra Durden, Yuexun Tian, Koyle Knape, Cory Klemashevich, Keri N. Norman, John B. Carey, Sarah A. Hamer, Gabriel L. Hamer

“…As an alternative to environmental sprays, host-targeted systemic insecticides (or endectocides) allow for application of chemicals to vertebrate hosts, resulting in toxic blood meals for arthropods (xenointoxication). …”
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Newer Generation of Scooters: Polychlorinated Dibenzo-p-dioxin and Dibenzofuran and Polychlorinated Biphenyl Reductions by Hung-Hong Chen, Yun-Hwei Shen, Hsi-Hsien Yang, Jau-Huai Lu, Lin-Chi Wang, Yen-Kung Hsieh, Chia-Fon Lee, Sheng-Lun Lin

“…Abstract Scooter emissions have attracted attention in recent years because of human exposure to their direct effects in urban areas. Trace toxics, such as polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) have thus become important in scooter emissions. …”
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Intra-Arterial Chemotherapy with Doxorubicin and Cisplatin Is Effective for Advanced Hepatocellular Cell Carcinoma by Ming-Chun Ma, Yen-Yang Chen, Shau-Hsuan Li, Yu-Fan Cheng, Chih-Chi Wang, Tai-Jan Chiu, Sung-Nan Pei, Chien-Ting Liu, Tai-Lin Huang, Chen-Hua Huang, Yu-Li Su, Yen-Hao Chen, Sheng-Nan Lu, Kun-Ming Rau

“…The median overall survival was 8.3 months for all patients and was 3.1 months and 12.0 months in groups I and II, respectively (P<0.0001). The most common toxicity was alopecia. Four patients developed grade 3 or 4 leukopenia. …”
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Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications by Alina Mihaela Leustean, Manuela Ciocoiu, Anca Sava, Claudia Florida Costea, Mariana Floria, Claudia Cristina Tarniceriu, Daniela Maria Tanase

“…Dysbiosis causes activation of proinflammatory mechanisms, metabolic toxicity, and insulin resistance. Trimethylamine N-oxide (TMAO) is a microbial organic compound generated by the large intestine, and its concentration increases in the blood after ingestion of foods rich in L-carnitine and choline, such as red meat, eggs, and fish. …”
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Heat-not-burn technology affects plasma testosterone levels and markers of inflammation, oxidative stress in the testes of rats by Silvia Granata, Camilla Morosini, Maria Chiara Valerii, Ivan Fagiolino, Stefano Sangiorgi, Severino Ghini, Enzo Spisni, Fabio Vivarelli, Lucy C. Fairclough, Moreno Paolini, Donatella Canistro

“…Although the levels of toxicants in the mainstream are significantly lower than those observed in tobacco smoke, some recent studies have raised concerns about potential health risks associated with their use, particularly regarding their effects on male gonadal function, which remain largely unexplored.MethodsAdult male Sprague-Dawley rats were exposed, whole body, 5 days/week for 4 weeks to HnB mainstream.ResultsThe expression of the cell cycle regulators Bax/Bcl-2 ratio is not affected, along with no changes in p-38. …”
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Cytotoxic and Apoptosis-Inducing Activity of Plants from the Family Asparagaceae in Relation to Human Alveolar Adenocarcinoma Cells by Y.N. Kamalova, V.V. Shtyreva, Essam Abdul-Hafeez, Omer H.M. Ibrahim, P.V. Zelenikhin, N.S. Karamova, O.N. Ilinskaya

“…It is known that some plant metabolites exhibit antioxidant, cytotoxic, and antitumor activity, while at the same time being less toxic than modern allopathic drugs. In this work, we have investigated the cytotoxic and apoptosis-inducing effects of extracts obtained from plants of the family Asparagaceae on A549 human lung adenocarcinoma cells. …”
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Use of hazardous barium slag as a supplementary cementitious material in calcium aluminate cement: Evolution of engineering properties and microstructure by Chen-xi Dong, Zhao Duan, Jiang-shan Li, Xin Chen, Wei Zhang, Haitao Cao, Nianqin Wang

“…The disposal of barium slag (BS), a hazardous industrial by-product, presents a significant environmental challenge, particularly because of its potential toxicity and underuse. Because of its thermodynamic history of rapid water quenching at high temperatures, BS exhibits high reactivity and alkali-activation potential, making it a promising supplementary cementitious material (SCM). …”
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Synthesis, Molecular Docking, MEP and SAR Analysis, ADME-Tox Predictions, and Antimicrobial Evaluation of Novel Mono- and Tetra-Alkylated Pyrazole and Triazole Ligands by Y. Kaddouri, B. Bouchal, F. Abrigach, M. El Kodadi, M. Bellaoui, R. Touzani

“…ADME-Tox studies suggested that compounds 12 and 13 exhibit better toxicity profiles than the commercial antibiotic streptomycin. …”
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Hypericin-Mediated Photodynamic Therapy for Head and Neck Cancers: A Systematic Review by Jakub Fiegler-Rudol, Natalia Zięba, Radosław Turski, Maciej Misiołek, Rafał Wiench

“…<b>Conclusions</b>: HY-PDT emerges as a highly promising and minimally toxic treatment modality for head and neck cancers, demonstrating efficacy in inducing selective tumour cell death and modulating the immune microenvironment. …”
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Patient-centered outcomes for gastrointestinal cancer care: a scoping review protocol by Natalie G Coburn, Frances C Wright, Alyson L Mahar, Lesley Gotlib Conn, Julie Hallet, Amy T Hsu, Paul D James, Joanna Yang, Tori Barabash, Luckshi Rajendran, Claire Ludwig, Ekaterina Kosyachkova, Julie Deleemans

“…Traditionally, clinical studies have largely focused on a few concrete and easily measurable outcomes such as survival, disease progression and immediate treatment toxicities. These outcomes do not capture other important factors that patients consider when making treatment decisions. …”
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Effect of nanocurcumin (Curcuma longa) on lung histopathology in rats exposed to carbon black by El Roy Achmad Rahmaniabdi, Imam Mustofa, Eka Pramyrtha Hestianah, Widjiati Widjiati, Rochmah Kurnijasanti, Hani Plumeriastuti

“… Background Exposure to carbon black can induce respiratory toxicity, leading to tissue remodeling, inflammation, and fibrosis. …”
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Cerebellar lipid dysregulation in SCA3: A comparative study in patients and mice by Alexandra F. Putka, Varshasnata Mohanty, Stephanie M. Cologna, Hayley S. McLoughlin

“…In contrast, Atxn3-Knock-out mice showed mild lipid upregulation, emphasizing a toxic gain-of-function mechanism underlying lipid downregulation in SCA3.We conclude that lipids are significantly altered in SCA3 and establish a platform for continued exploration of lipids in disease through interactive data visualization websites. …”
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Synergistic Effect of Sugarcane Bagasse and Zinc Oxide Nanoparticles on Eco-Remediation of Cadmium-Contaminated Saline Soils in Wheat Cultivation by Emad M. Hafez, Khadiga Alharbi, Hany S. Gharib, Alaa El-Dein Omara, Essam Elatafi, Maha M. Hamada, Emadelden Rashwan, Tarek Alshaal

“…This study explores the combined application of sugarcane bagasse (SCB) and zinc oxide nanoparticles (ZnO NPs) to mitigate the toxic effects of Cd and salinity in wheat plants. …”
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Cellular EMT-status governs contact guidance in an electrospun TACS-mimicking in vitro model by Lorenz Isert, Mehak Passi, Benedikt Freystetter, Maximilian Grab, Andreas Roidl, Christoph Müller, Aditi Mehta, Harini G. Sundararaghavan, Stefan Zahler, Olivia M. Merkel

“…The biocompatibility of these fibers was enhanced by collagen coating, ensuring minimal toxicity and improved cell attachment. Various breast cancer cell lines (MCF7, HCC1954, MDA-MB-468, and MDA-MB-231) were cultured on these fibers to assess epithelial-to-mesenchymal transition (EMT) markers, cellular morphology, and migration.Aligned fibers (TACS5) significantly influenced EMT-related changes, promoting cellular alignment, spindle-shaped morphology and a highly migratory phenotype in mesenchymal and hybrid EMT cells (MDA-MB-468, MDA-MB-231). …”
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