Mitochondria-Targeting and Oxygen Self-Supplying Eccentric Hollow Nanoplatform for Enhanced Breast Cancer Photodynamic Therapy by Jing Li, Yu Wang, Jun Tao, Xiaodan Su, Feipeng Zhu, Wei Lu, Xiaolin Han, Meng Dang, Lixing Weng

“…Hemolytic assays and in vitro toxicity experiments show that the EHMONs-Ce6-CTPP possesses very good biocompatibility and can target mitochondria of triple-negative breast cancer, thus increasing the accumulation of photosensitizers Ce6 at mitochondria after entering cancer cells. …”
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A Novel Copolymer-Based Functional SPECT/MR Imaging Agent for Asialoglycoprotein Receptor Targeting by Pu Zhang MS, Zhide Guo MS, Deliang Zhang MS, Chang Liu MS, Guibing Chen MM, Rongqiang Zhuang PhD, Manli Song MS, Hua Wu PhD, Xianzhong Zhang PhD

“…After labeling with 99m Tc and Gd simultaneously, the radiochemical purity, toxicity, relaxivity (r 1 ), and in vivo SPECT/MR imaging in mice were evaluated. …”
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Mushroom Intoxication in Türkiye: A Nationwide Cohort Study Based on Demographic Trends, Seasonal Variations, and the Impact of Climate Change on Incidence by Dilara Turan Gökçe, Derya Arı, Naim Ata, Hale Gökcan, Ramazan İdilman, Mustafa Mahir Ülgü, Murat Harputluoglu, Mesut Akarsu, Zeki Karasu, Mustafa Okan Ayvalı, Şuayip Birinci, Meral Akdoğan Kayhan

“…Background/Aims: Mushroom intoxication poses a considerable public health risk due to its potential for severe toxicity and fatality. This study aims to investigate demographic trends, diagnostic locations, and mortality rates of patients with mushroom intoxication. …”
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Immune Thrombocytopenia in a worker exposed to toluene: a case report by Eric Slawka, Margarida Lourenço Castelló, Gabriel Machado Romão da Silva, Angelica dos Santos Vianna

“…Although several substances may cause ITP, little attention has been paid to the role of toxicants such as benzene, a well-known hematotoxic agent.Conclusion: This case highlights the role of benzene-contaminated toluene in ITP. …”
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Isolation and characterization of a novel highly efficient bacterium Lysinibacillus boronitolerans QD4 for quantum dot biosynthesis by Xingyu Gu, Xingyu Gu, Xiaoju Li, Ruijia Zhang, Ruijia Zhang, Ruoli Zheng, Ruoli Zheng, Mingrui Li, Mingrui Li, Rong Huang, Xin Pang

“…The development of environmentally friendly synthesis methods is required due to the toxicity and severe reactions that occur during the chemical synthesis of quantum dots. …”
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Decarboxylase mediated oxalic acid metabolism is important to antioxidation and detoxification rather than pathogenicity in Magnaporthe oryzae by Chang Liu, Yi Wei, Yuejia Dang, Wajjiha Batool, Xiaoning Fan, Yan Hu, Zhengquan He, Shihong Zhang

“…M. oryzae OxdC (MoOxdC) is an oxalate decarboxylase that appears to play a role in relieving oxalic acid toxicity. Loss of Mooxdc does not affect mycelial growth, conidiophore development, or appressorium formation in M. oryzae; however, the antioxidant and pathogenic abilities of the mutant were enhanced. …”
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Chemical, Spectral, Biological, and Toxicological Studies of Some Benzene Derivatives Used in Pharmaceuticals: In Silico Approach by Emranul Kabir, M R O Khan Noyon, Md Rabiul Alam, Mr. Nasiruddin, Sajia Islam, Mahima Akter, Monir Uzzaman

“…All derivatives were predicted by ADMET to have improved pharmacokinetic properties and less acute oral toxicity. …”
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Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids by Su-Jin Lee, Eunji Kim, Yeeun Jeong, Jae Boum Youm, Hyoung Kyu Kim, Jin Han, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Sung Joon Kim, Hyang-Ae Lee

“…EchA treatment induced no significant changes in these parameters, confirming its non-toxic electrophysiological profile. Cellular viability and lactate dehydrogenase (LDH) assays revealed no cytotoxic effects of EchA across tested concentrations. …”
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Assimilation efficiencies and elimination rates of silver, cadmium and zinc accumulated by trophic pathway in Gammarus fossarum by Gestin, Ophélia, Lopes, Christelle, Delorme, Nicolas, Garnero, Laura, Geffard, Olivier, Lacoue-Labarthe, Thomas

“…To improve the assessment of metal toxicity in aquatic organisms, it is important to consider the different uptake pathways (i.e. trophic or aqueous). …”
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Unraveling the spatiotemporal trends and source attribution of polycyclic aromatic hydrocarbons and oxygenated derivatives in Guangzhou agricultural ditch sediment by Shaomin Li, Weisong Chen, Yichen Liu, Haoyu Wang, Yongtao Li, Zhen Zhang, Xingjian Yang

“…Oxygenated polycyclic aromatic hydrocarbons (OPAHs) have garnered significant scientific attention due to their heightened toxicity and mobility compared to their parent PAHs. …”
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Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort by Giehae Choi, Xiaoshuang Xun, Deborah H. Bennett, John D. Meeker, Rachel Morello-Frosch, Sheela Sathyanarayana, Susan L Schantz, Leonardo Trasande, Deborah Watkins, Edo D. Pellizzari, Wenlong Li, Kurunthachalam Kannan, Tracey J. Woodruff, Jessie P. Buckley

“…While these chemicals have identified toxicities, little is known about their influences on fetal development. …”
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Novel (±)-trans-β-lactam ureas: Synthesis, in silico and in vitro biological profiling by Jurin Mladenka, Stepanić Višnja, Bojanić Krunoslav, Vadlja Denis, Kontrec Darko, Dražić Tonko, Roje Marin

“…The tools PASS and SwissTargetPrediction could not predict biological targets for compounds 4a–t with high probability, pointing to the novelty of their structure. Considering low toxicity risk, molecules 4a and 4f can be selected as the most promising candidates for further structure modifications.…”
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Indoor and Outdoor Exposure to PM2.5 during COVID-19 Lockdown in Suburban Malaysia by Eliani Ezani, Peter Brimblecombe, Zulfa Hanan Asha’ari, Amirul Aiman Fazil, Sharifah Norkhadijah Syed Ismail, Zamzam Tuah Ahmad Ramly, Md Firoz Khan

“…Unfortunately, little is known about the toxicity of indoor particles and the types of exposures that result where people increase the amount of time they spend working from home or staying indoors, especially during periods of lockdown.…”
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Transcriptional Systems Vaccinology Approaches for Vaccine Adjuvant Profiling by Diogo Pellegrina, Heather L. Wilson, George K. Mutwiri, Mohamed Helmy

“…Here, we review some of the challenges in adjuvant studies, such as predicting adjuvant activity and toxicity when administered alone or in combination with antigens, or classifying adjuvants in groups with similar properties, while underscoring the significance of transcriptomics in systems vaccinology approaches to propel vaccine development forward.…”
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Staphylococcus aureus nt5 gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion by Xinpeng Liu, Lan Huang, Yang Ye, Haiyi Wang, Min Tang, Fuqiang He, Zijing Xia, Shi Deng, Peng Zhang, Ruiwu Dai, Shufang Liang

“…The nt5 mutant strain was easily swallowed by host immune cells, resulting in weak bacterial toxicity of the S. aureus mutant in the bacterial infection process. …”
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Ibuprofen-Induced Multiple Fixed Drug Eruption Confirmed by Re-Challenge: A Case Report and Literature Review by Yoshihito Mima, Masako Yamamoto, Hiyo Obikane, Yuta Norimatsu, Ken Iozumi

“…However, in multiple FDE, CD8-positive T cell activity may outweigh that of regulatory T cells, causing uncontrolled inflammation and leading to the spread of poorly-demarcated lesions that can progress to severe drug reactions such as Stevens–Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). We reviewed 13 cases of ibuprofen-induced multiple FDE. …”
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Validation of devices for characterization of hybrid 3D printed embroidery TENG for energy harvesting by HASAN TAHIR, Benny Malengier, Carla Hertleer, Lieva Van Langenhove

“…These threads have non-toxic, non-skin irritation properties, which makes them suitable for smart wearable energy harvesting applications. …”
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Enhanced biocidal efficacy of alcohol based disinfectants with salt additives by Euna Oh, Hyerin Shin, Sumin Han, Soo Jee Do, Younseo Shin, Ji Hee Pi, Youngjin Kim, Dae-Hong Ko, Kyu Hyoung Lee, Hyo-Jick Choi

“…This method, which employs mild salt instead of toxic materials, offers a simpler, more cost-effective, and safer alternative to conventional alcohol-based disinfectants. …”
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Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review by Hongcai Li, Jingjing Liang, Mengzhen Han, Zhenpeng Gao

“…Single drug therapy may have toxic side effects and disrupt gut microbiota balance. …”
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Addressing challenges in vector control: a review of current strategies and the imperative for novel tools in India’s combat against vector-borne diseases by Kuldeep Singh, Amit Sharma, Manju Rahi, Sanjeev Kumar Gupta, Gaurav Kumar, Rajendra Baharia, Sam Joy

“…The promising new vector control tools are insecticide-treated nets with synergist and/or pyrrole chlorfenapyr, alternatives/additions to synthetic pyrethroids like neonicotinoids, clothianidin for indoor residual spray, newer formulations such as Bacillus sphaericus for use in larvicides, attractive toxic sugar baits, especially to curtail outdoor transmission, endectocides like ivermectin for use in animals/humans, insecticidal paints, spatial repellents, insecticide-treated wearables and others. …”
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