Sorafenib-Loaded Silica-Containing Redox Nanoparticle Decreases Tumorigenic Potential of Lewis Lung Carcinoma by Babita Shashni, Hao Thi Tran, Long Binh Vong, Ren-Jei Chung, Yukio Nagasaki

“…<b>Background:</b> Orally administered sorafenib has shown limited improvement in overall survival for non-small-cell lung cancer patients, likely due to poor pharmacokinetics and adverse effects, including gastrointestinal toxicity. To address these issues, we developed silica-containing antioxidant nanoparticles (siRNP) as a carrier to enhance the therapeutic efficacy of lipophilic sorafenib. …”
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Cancer Cachexia: Innovations in Pharmacotherapy for Terminal-Stage Patients - Review of the latest reports by Kinga Witowska, Karolina Sacher, Negar Hosseinnejad, Mikolaj Biskupski, Mariola Turemka, Aneta Mandziuk, Urszula Korotko, Krystyna Zabojska, Aneta Klaudia Wojtas, Aleksandra Cygnarowicz

“…Pentoxifylline declined inflammation and chemotherapy toxicity, and improved body weight and survival. Cannabinoids alleviated chemotherapy-induced nausea but were ineffective for weight and quality of life. …”
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Antimicrobial Activity of Aspergillus sp. from the Amazon Biome: Isolation of Kojic Acid by Josy Caldas Rodrigues, Weison Lima da Silva, David Ribeiro da Silva, Carolina Rabelo Maia, Clarice Virginia Santos Goiabeira, Haile Dean Figueiredo Chagas, Gigliola Mayara Ayres D’Elia, Gleica Soyan Barbosa Alves, Viviane Zahner, Cecilia Veronica Nunez, Ormezinda Celeste Cristo Fernandes

“…., with antibacterial activity and moderate toxicity at the concentrations tested, is a promising prototype of an alternative active principle of an antimicrobial drug.…”
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Liquid chromatography-high resolution mass spectrometry based analysis of persistent mobile organic compounds in aqueous samples: Method development and optimization by Kyriaki Anagnostopoulou, Vasileios Alampanos, Eleni Evgenidou, Dimitra A. Lambropoulou

“…Persistent Mobile Organic Compounds (PMOCs) represent a critical threat to water resources due to their high solubility, resistance to degradation, and potential toxicity, posing risks to human health and ecosystems. …”
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Sorption behavior of pomegranate polyphenols on surfactant-modified clays in aqueous solution by Houda Saad, Thouraya Turki, Mondher Srasra, Ezzeddine Srasra

“…They can be present at high concentrations in the bulk effluents generated by the agro-food industries which can be toxic and have an impact on microbial processing in wastewater treatment plants. …”
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Unravelling the outcome of L-glutaminase produced by Streptomyces sp. strain 5 M as an anti-neoplasm activity by Mervat G. Hassan, Gharieb S. El-Sayyad, Mohamed O. Abdel-Monem, Mohamed N. Malash, Mona A. Kishk, Mohamed E. El Awady, Mohamed I. El-khonezy

“…The isolated enzyme’s Km and Vmax values were 2.62 mM and 10.20 U/ml, respectively. Strong toxicity against HepG-2, HeLa, and MCF-7 was observed due to the anticancer properties of the isolated L-glutaminase. …”
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Species of Sulfur in Sour Gas Reservoir: Insights from In Situ Raman Spectroscopy of S–H2S–CH4–H2O System and Its Subsystems from 20 to 250°C by Yifan Yu, Wenxuan Hu, I-Ming Chou, Lei Jiang, Ye Wan, Yiqun Li, Yang Xin, Xiaolin Wang

“…However, experimental studies on S species in sour gas are limited due to the toxicity and corrosion of S and H2S. Fused silica capillary capsules (FSCCs) are inert to S and H2S and, therefore, were employed in this study as microreactors containing the S–H2S–CH4–H2O system and its subsystems, representing the composition of sour gas. …”
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Antiviral Activity of Pistacia atlantica subsp. Kurdica Extract Against Herpes Simplex Virus Type 1 by Shahin Gavanji, Hojjat Baghshahi, Azizollah Bakhtari, Ali Mohamadi, Zahra Hamami Chamgordani, Mojtaba Khandan, Javaher Sinaei

“…Kurdica was tested for toxicity. Furthermore, 50% cytotoxic and inhibitory concentrations (CC50 and IC50) were identified. …”
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UEF-HOCUrdu: Unified Embeddings Ensemble Framework for Hate and Offensive Text Classification in Urdu by Kifayat Ullah, Muhammad Aslam, Muhammad Usman Ghani Khan, Faten S. Alamri, Amjad Rehman Khan

“…Hate speech and other forms of hostile communication on social media have several implications such as; fostering violence, promoting social divide, and negative psychological effects. Since such toxic language is becoming more and more common, it is imperative to have a proper way of identifying it, especially in low resource language like Urdu. …”
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Sub-ppb H₂S Sensing with Screen-Printed Porous ZnO/SnO₂ Nanocomposite by Mehdi Akbari-Saatlu, Masoumeh Heidari, Claes Mattsson, Renyun Zhang, Göran Thungström

“…Hydrogen sulfide (H₂S) is a highly toxic and corrosive gas commonly found in industrial emissions and natural gas processing, posing serious risks to human health and environmental safety even at low concentrations. …”
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Inhibitory Effect of PRMT5/MTA Inhibitor on MTAP‐Deficient Glioma May Be Influenced by Surrounding Normal Cells by Yunjie Wang, Xiaohui Sun, Runchen Ma, Xiaofan Zhang, Shengmin Ji, Zhaofeng Liu, Gangqiang Yang, Hongbo Wang, Peng Zhang, Jianzhao Zhang, Jingwei Tian

“…In vitro and in vivo experiments have demonstrated that MRTX1719, a small molecule that selectively binds PRMT5/MTA complex, significantly inhibits the proliferation of MTAP‐deficient tumors and has a weak toxic effect on normal cells. However, it has been reported that MTAP‐deleted tumors did not significantly accumulate MTA in vivo due to metabolism of MTA by MTAP‐expressing stroma, which might lead to a diminished anti‐cancer effect of MRTX1719. …”
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BTS1-knockout Saccharomyces cerevisiae with broad-spectrum antimicrobial activity through lactic acid accumulation by Liu Cong, Yuan Zhou, Yu Zhang, Shanshan Mao, Chaoqun Chen, Liying Wang, Xiao Li, Zuo Zhang, Zuobin Zhu, Ying Li

“…In summary, our study underscores the probiotic potential of BTS1-KO S. cerevisiae, offering broad-spectrum antibacterial activity in vitro and in vivo with low toxicity. This highlights BTS1-KO S. cerevisiae as a promising probiotic candidate for clinical prevention and control of bacterial infection.…”
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Sustainability assessment of pectin extraction from Citrus paradisi peel to support the encapsulation of lactic acid bacteria by Natalia A. Di Clemente, Enzo La Cava, Sonia Sgroppo, Andrea Gomez-Zavaglia, Esteban Gerbino

“…The main impact categories were climate change, human toxicity with carcinogenic effects and depletion of water resources contributing to deionized water and electricity consumption. …”
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Exploration of the anti-inflammatory potential of Polygonum bistorta L.: protection against LPS-induced acute lung injury in rats via NF-ĸβ pathway inhibition by Sajida Parveen, Kashif ur Rehman Khan, Shahid Muhammad Iqbal, Hanan Y. Aati, Areej M. Al-taweel, Liaqat Hussain, Musaddique Hussain, Musaddique Hussain

“…Crude extract possesses a maximum inhibitory potential of 81.77% ± 0.62% for acetylcholinesterase against eserine. Acute oral toxicity study revealed LD50 beyond 7 g/kg. Plant extract markedly restored LPS-induced hypoxemia, pulmonary edema, histopathological alterations, and leukocyte infiltration in the lung. …”
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Propylene glycol-based deep eutectic solvent as an alternative to Ethaline for electrometallurgy by Bertoloni, Calogera, Mba Ekomo, Vitalys, Villemejeanne, Benoît, Lemoine, Charly, Duwald, Romain, Billy, Emmanuel, Mendil-Jakani, Hakima,  Legeai, Sophie

“…However, if ChCl can be considered as a “green” reactant, this is not the case for EG. A DES with a lower toxicity can be obtained by replacing EG by propylene glycol (PG), widely used in cosmetics and pharmacology, yielding a DES called Propeline. …”
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NMR metabolic profiling of the liver following administrationof alcohol andthemushroom Ganoderma lucidum in rats by M. S. Krestina, O. B. Shevelev, I. V. Koptyug, L. A. Gerlinskaya, S. E. Peltek, A. E. Akulov

“…We have evaluated the efficiency of a metabonomic approach to metabolic phenotyping and detection of early metabolic changes under a toxic influence. For this purpose, a metabolic profiling of rat liver was performed with 1H NMR spectroscopy. …”
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ENDOPROSTHESIS OF THE SHOULDER JOINT IN METASTATIC LESIONS OF THE PROXIMAL HUMERUS DURING IMMUNOSUPPRESSIVE THERAPY by M. V. Ivanova, V. Yu. Karpenko, A. V. Bukharov, V. A. Derzhavin

“…This method has significant advantages because of the high local concentrations with minimal risk of systemic toxicity. In this paper we present a clinical case of performing resection of the proximal humerus to the shoulder joint arthroplasty in patient on immunosuppressive therapy.…”
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Anthracyclines disaggregate and restore mutant p63 function: a potential therapeutic approach for AEC syndrome by Fabiana Boncimino, Ludovica D’Auria, Kristina Todorova, Sabina Y. van der Zanden, Jacques Neefjes, Anna Mandinova, Caterina Missero, Stefano Sol

“…A chemical analog of Doxorubicin, diMe-Doxorubicin, which exhibits lower tissue and organ toxicity, was also found to be effective in promoting the disaggregation of mutant p63 and rescuing its transcriptional activity. …”
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Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies by Niloofar Javid, Ali Asadipour, Ehsan Salarkia, Mohammad Amin Langarizadeh, Fatemeh Sharifi, Mohammad Mahdavi, Bagher Amirheidari, Aida Iraji, Hojjat Rezaiezadeh, Gholamreza Hassanpour, Yaghoub Pourshojaei

“…The primary drawbacks of existing treatments include severe side effects, substantial toxicity, high financial costs, extended treatment regimens, and the discomfort associated with injectable forms of administration. …”
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Preventive treatment with guarana powder (Paullinia cupana) mitigates acute paracetamol-induced hepatotoxicity by modulating oxidative stress by Clécia Dias Teixeira, Priscila Oliveira Barbosa, Wanderson Geraldo Lima, Gustavo Silveira Breguez, Miliane Martins de Andrade Fagundes, Daniela Caldeira Costa, Cintia Lopes de Brito Magalhães, Joana Ferreira Amaral, Melina Oliveira de Souza

“…This study assessed the preventive effects of guarana powder on redox status in a rat model of acute hepatotoxicity induced by a toxic dose of paracetamol. Male Wistar rats were divided into four groups: control (C), guarana (G), paracetamol (P), and guarana + paracetamol (GP). …”
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