Production of ACE inhibitory peptides via ultrasonic-assisted enzymatic hydrolysis of microalgal Chlorella protein: Process improvement, fractionation, identification, and in silic... by Jeeraporn Pekkoh, Apiwit Kamngoen, Antira Wichaphian, May Thu Zin, Supakit Chaipoot, Kamon Yakul, Wasu Pathom-aree, Wageeporn Maneechote, Benjamas Cheirsilp, Kuan Shiong Khoo, Sirasit Srinuanpan

“…More importantly, in silico structure-activity relationship analysis proved the non-toxicity of the identified LMW peptides. The result indicates a potential link between 47 LMW peptides and the inhibition of ACE activity, suggesting that microalgae protein hydrolysate and peptides could be developed into new treatments for CVD and hypertension. …”
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Comprehensive identification, characterization and expression analyses of the class III POD gene family in water lily (Nymphaea colorata) by Wasi Ullah Khan, Wasi Ullah Khan, Latif Ullah Khan, Noor Muhammad Khan, Ji Zhang, Wang Wenquan, Wang Wenquan, Fei Chen, Fei Chen

“…Class III peroxidases are plant-specific glycoproteins and widely distributed among plant species, that play a crucial role in plant resistance to different stresses, such as salt, heat, cold and metal toxicity. The present study is the first comprehensive and systematic report to characterize the NcPOD gene family in water lily (Nymphaea colorata). …”
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Metal Biomonitoring Through Arboreal Species in Riparian Ecosystems: <i>Pithecellobium dulce</i> as a Bioindicator Species by Sayuri Hernández-Maravilla, María Luisa Castrejón-Godínez, Efraín Tovar-Sánchez, Hugo Albeiro Saldarriaga-Noreña, Alexis Rodríguez, Marcos Eduardo Rosas-Ramírez, Patricia Mussali-Galante

“…However, it is polluted by multiple wastewater discharges from different origins, with toxic metals being the main pollutants. Therefore, environmental monitoring strategies based on bioindicator species are necessary to evaluate the ecosystem health of riparian ecosystems. …”
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Lymphocyte Oxidative Stress/Genotoxic Effects Are Related to Serum IgG and IgA Levels in Coke Oven Workers by Meili Gao, Yongfei Li, Aqun Zheng, Xiaochang Xue, Lan Chen, Yu Kong

“…These data suggest that oxidative stress/DNA damage induced by PAHs may play a role in toxic responses for PAHs in immunological functions.…”
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Assessment of cardio-oncology knowledge and practice among healthcare providers in Saudi Arabia: a comprehensive nationwide survey by Hisham A. Badreldin, Nada Alsuhebany, Lama Alfehaid, Mohammed Alzahrani, Maha Aldoughaim, Abdullah M. Alrajhi, Jumanah Alsufyani, Dania Elsherif, Kanan Alshammari

“…In Saudi Arabia, the incidence of cancer is rising, and there is a critical need for cardio-oncology services to address cancer treatment-related cardiovascular toxicity. This study aimed to evaluate the knowledge and practices of healthcare providers (HCPs) in Saudi Arabia regarding cardio-oncology. …”
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Spatial-Temporal Patterns of Litterfall Mercury Concentration and Flux in Typical Vegetation in China by Shuyu Han, Xiang Niu, Bing Wang, Zhangwei Wang, Xiaoshan Zhang, Qiang Wang, Jiajie Du, Pingping Liu, Donghuan Liu, Fengshi Pan, Tingyu Xu

“…Mercury is one of the most toxic heavy metal pollutants, and mercury absorbed by plant leaves accumulates in forests in the form of litterfall. …”
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The Fungi-specific histone Acetyltransferase Rtt109 mediates morphogenesis, Aflatoxin synthesis and pathogenicity in Aspergillus flavus by acetylating H3K9 by Ruilin Sun, Meifang Wen, Lianghuan Wu, Huahui Lan, Jun Yuan, Shihua Wang

“…Abstract Aspergillus flavus is a common saprophytic filamentous fungus that produces the highly toxic natural compound aflatoxin during its growth process. …”
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Non-small cell lung cancer and the tumor microenvironment: making headway from targeted therapies to advanced immunotherapy by Anna De Lucia, Lucia Mazzotti, Lucia Mazzotti, Anna Gaimari, Anna Gaimari, Matteo Zurlo, Roberta Maltoni, Claudio Cerchione, Sara Bravaccini, Angelo Delmonte, Lucio Crinò, Patricia Borges de Souza, Luigi Pasini, Fabio Nicolini, Fabrizio Bianchi, Manel Juan, Hugo Calderon, Chiara Magnoni, Chiara Magnoni, Luca Gazzola, Luca Gazzola, Paola Ulivi, Massimiliano Mazza

“…Nowadays, targeted therapies remain the gold standard for many patients, but still they suffer from many adverse effects, including unexpected toxicity and intrinsic acquired resistance mutations, which lead to relapse. …”
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Development of Collagen-Based 3D Matrix for Gastrointestinal Tract-Derived Organoid Culture by Joo Hyun Jee, Dong Hyeon Lee, Jisu Ko, Soojung Hahn, Sang Yun Jeong, Han Kyung Kim, Enoch Park, Seon Young Choi, Sukin Jeong, Joong Woon Lee, Han-Jun Cho, Min-Soo Kwon, Jongman Yoo

“…On the other hand, natural characteristics of collagen emphasize toxic-free friendly niche to both organoid and normal tissue. …”
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Effectiveness of purple leaves (Graptophyllum pictum L. Griff) and hydroxyapatite as socket preservation biomaterials by Ratri Maya Sitalaksmi, Rizkipriyanto Azharpratomo, Shafira Ninditya Irsan, Primanda Nur Rahmania, Sisca Meida Wati, Syafira Salsabila Adam, Kavanila Bilbalqish, Khairul Anuar bin Shariff, Harry Laksono, Agus Dahlan, Devi Rianti

“…Purple leaves contains flavonoids, steroids, tannins, saponins,and non-toxic alkaloids. These compounds play roles as antimicrobials, immunomodulators, antioxidants, anti-inflammatories, analgesics. …”
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Significant role of anionic behavior of cocoyl glutamate on lead(II) ion adsorption towards activated carbon adsorbent from cigarette butts by Moh Zeinur Ridho, Retno Pertiwi, Eldo Delta Bagaskara, Raya Rambu Rambani, Chika Synthia Pitaloka, Fanta Mei Wahyuni, Istiqomah Rahmawati, Muhammad Reza

“…Cigarette butts are one of the most abundant waste in the world, being dangerous due to non-biodegradable behavior and highly toxic. Cigarette butts can be converted to activated carbon (CA) which can be used as an adsorbent. …”
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Switch of phosphorylation to O-GlcNAcylation of AhR contributes to vascular oxidative stress induced by benzo[a]pyrene by Rong Wang, Yun Huang, Xiaoruo Gan, Chenghao Fu, Yuemin Li, Ning Chen, Hao Xi, Huishan Guo, Wei Zhang, Yuhong Lü, Yan Zhang, Pin Lü

“…Benzo[a]pyrene (B[a]P) is a food contaminant toxic for cardiovascular diseases. The nuclear translocation of Arylhydrocarbon receptor (AhR) plays an important role in B[a]P-induced oxidative stress and vascular diseases. …”
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Cytopenia among CML Patients on Imatinib in Kenya: Types, Grades, and Time Course by Angela McLigeyo, Jamilla Rajab, Mohammed Ezzi, Peter Oyiro, Yatich Bett, Andrew Odhiambo, Matilda Ong’ondi, Sitna Mwanzi, Mercy Gatua, NAOthieno- Abinya

“…Patients on imatinib treatment may develop cytopenia due to drug toxicity. This study aimed to determine the types, grades, and time course of cytopenia in CML patients on imatinib at a Nairobi hospital. …”
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Sun-Drying and Melatonin Treatment Effects on Apricot Color, Phytochemical, and Antioxidant Properties by Rukiye Zengin, Yılmaz Uğur, Yasemin Levent, Selim Erdoğan, Harlene Hatterman-Valenti, Ozkan Kaya

“…These findings suggest promising applications for commercial-scale implementation through either dipping or spraying methods. The non-toxic nature of melatonin and its demonstrated efficacy in preserving fruit quality parameters position it as a valuable post-harvest treatment option in the fruit supply chain. …”
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Deep learning on CT scans to predict checkpoint inhibitor treatment outcomes in advanced melanoma by Laurens S. Ter Maat, Rob A. J. De Mooij, Isabella A. J. Van Duin, Joost J. C. Verhoeff, Sjoerd G. Elias, Tim Leiner, Wouter A. C. van Amsterdam, Max F. Troenokarso, Eran R. A. N. Arntz, Franchette W. P. J. Van den Berkmortel, Marye J. Boers-Sonderen, Martijn F. Boomsma, Fons J. M. Van den Eertwegh, Jan Willem de Groot, Geke A. P. Hospers, Djura Piersma, Art Vreugdenhil, Hans M. Westgeest, Ellen Kapiteijn, Ardine A. De Wit, Willeke A. M. Blokx, Paul J. Van Diest, Pim A. De Jong, Josien P. W. Pluim, Karijn P. M. Suijkerbuijk, Mitko Veta

“…Abstract Immune checkpoint inhibitor (ICI) treatment has proven successful for advanced melanoma, but is associated with potentially severe toxicity and high costs. Accurate biomarkers for response are lacking. …”
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An integrated strategy for sequential nitrite removal and methane recovery: Sludge fermentation driven by nitrite reduction by Xiaodi Li, Mengxue Sun, Bo Wang, Wei Zeng, Yongzhen Peng

“…With the nitrite concentrations increasing from 200 to 800 mg/L methane production decreased from 128.7 to 0 mg/L at the digestion time of 15 d. The toxicity of nitrite to methanogenic microorganisms and the nitrite reduction process competing with methanogens for carbon sources may lead to the inhibition of methane production by excessive nitrite. …”
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Adsorption of phenol and methylene blue contaminants onto high-performance catalytic activated carbon from biomass residues by Numfor Linda Bih, Mwemezi J. Rwiza, Asha S. Ripanda, Assia Aboubakar Mahamat, Revocatus L. Machunda, Joon Weon Choi

“…Organic contaminants from wastewater toxicity to the environment has increased during the last few decades and, therefore, there is an urgent need to decontaminate wastewater prior to disposal. …”
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Effect of Nano-Silica on Mechanical Properties and Cytotoxicity of Calcium-Silicate-Based Root Canal Filling Materials by Hao He, Bolang Hao, Xiang Xiong, Yi Cheng, Jia Lou, Zheyu He, Dongyang Li, Zhihuan Wang, Jian Qin

“…The findings of this study demonstrate that the early compressive strength of calcium-silicate-based root canal filling materials exhibits a substantial increase in response to the incorporation of NS, and that calcium-silicate-based root canal filling materials do not manifest significant levels of toxicity. NS improved hydration product formation and made efficient pore filling possible.…”
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Combined exposure to mixed brominated flame retardants on obstructive sleep apnea syndrome in US adults by Junping Liu, Zhaoyue Liu, Xinru Liu, Nan Wang, Lin Wu, Xiaoxue Xu, Wei Liu, Yajie Feng, Huanyu Zhang, Yue Zhou, Xinle Yin, Yaping Liu, Qunhong Wu, Ning Ning, Libo Liang

“…Results Serum BFRs, including PBDE28, PBDE47, PBDE99, PBDE100, and PBB153, showed positive correlations with the OSAS risk. The toxic effect of serum BFRs co-exposure on OSAS risk was consistently demonstrated through the results of WQS regression, QGC and BKMR models. …”
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Neurovascular bundle sparing in hypofractionated radiotherapy maintained with realistic treatment uncertainties by Roel C. Kwakernaak, Victor J. Brand, Jesús Rojo-Santiago, Femke E. Froklage, Mischa S. Hoogeman, Steven J.M. Habraken, Maaike T.W. Milder

“…Background and purpose: Erectile dysfunction is a common side effect of radiotherapy for prostate cancer. To mitigate this toxicity, it has been suggested to limit the dose to critical nerves and vessels. …”
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