Sequential Therapy of Linezolid and Contezolid to Treat Hematogenous Lung Abscess Caused by Staphylococcus aureus in a Congenital Cerebral Hypoplasia Patient: A Case Report by Zhou S, Xin C, Liu W

“…Contezolid may ameliorate the hematologic toxicity associated with linezolid. Here, we report the case of a patient with congenital cerebral hypoplasia who was hospitalized due to fever and multiple abscesses in both lungs. …”
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Algorithm of management of patient with alcohol-induced liver disease by M. V. Mayevskaya, M. A. Morozova

“…Pathogenesis of ALD is based on direct toxic operation action of ethanol on one hand and on endotoxemia and increased production of proinflammatory cytokines, on another hand. …”
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Hypericum Perforatum-Derived Exosomes-Like Nanovesicles: A Novel Natural Photosensitizer for Effective Tumor Photodynamic Therapy by Ma X, Chen N, Zeng P, He Y, Zhang T, Lu Y, Li Z, Xu J, You J, Zheng Y, Wang L, Luo M, Wu J

“…In vivo, HPDEN-mediated PDT significantly suppressed tumor growth and induced extensive tumor necrosis, with no observable toxicity to major organs.Conclusion: HPDENs represent a novel plant-derived photosensitizer with dual ROS generation pathways and significant therapeutic efficacy, providing a promising platform for enhancing photodynamic therapy.Keywords: Hypericum perforatum-derived exosomes-like nanovesicles, photosensitizer, photodynamic therapy, reactive oxygen species, apoptosis…”
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Investigation of nutritional content and aflatoxin B1 in landraces and varieties of Ethiopian groundnut (Arachis hypogaea L.) by Syraji Yonas, K. Gobikanila, P. R. Jeyaramraja

“…Abstract Aflatoxins, a group of toxic compounds produced by certain Aspergillus species, pose significant health risks due to their strong carcinogenic properties. …”
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Layer-by-Layer Biopolymer-Coated Deformable Liposomes–In Situ Gel: A Hybrid Strategy for Enhanced Ocular Delivery of Itraconazole: In Vitro and In Vivo Appraisal by Mohamed M. Badran, Areej Alsubaie, Mounir M. Salem Bekhit, Abdullah H. Alomrani, Aliyah Almomen

“…Its oral administration is associated with systemic toxicity, and its efficacy in ocular formulations is limited. …”
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Targeted delivery of curcumin and CM11 peptide against hepatocellular carcinoma cells based on binding affinity of PreS1-coated chitosan nanoparticles to SB3 protein by Danial Rahmani, Ramezan Ali Taheri, Mehrdad Moosazadeh Moghaddam

“…The MTT assay showed that PreS1-Cur-CM11-CS NPs act in a targeted and specific manner with the highest toxicity on the HepG2 cells compared to the control by a decrease in viability of about 26% after 48 h based on cell apoptosis. …”
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An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamo... by Vinod K. Ramani, Srimonta Gayen, Radheshyam Naik

“…To evaluate the clinical effectiveness endpoints and toxicity of oral azacytidine when combined with pembrolizumab. ii. …”
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Breaking the shield of solid tumors: a combined approach for enhanced efficacy of CAR-T cells by Marat Khaliulin, Aygul Valiullina, Alexey Petukhov, Youyong Yuan, Sheila Spada, Emil Bulatov

“…Furthermore, concerns exist regarding tumor antigen loss and therapy-associated toxicity. Currently, scientists are working to enhance the structure of the CAR and improve the survival and efficiency of CAR-T cells in recognizing tumor antigens in solid tumors. …”
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Characteristics of PM and PAHs Emitted from Oil-fired Process by Ming Wei Chang, Minh Man Trinh, Chian Kou Lien, Moo Been Chang

“…Regarding the distribution of PAHs species, Nap is the dominant congener of the oil-fired boiler while BcFE is the major contributor for toxic equivalent concentrations. In addition, air pollutant emission factors reported in literatures were compiled and compared those obtained in this study. …”
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Human Exposure Assessment in Air Pollution Systems by Junfeng (Jim) Zhang, Paul J. Lioy

“…Results from many exposure studies indicate that people are very likely to receive the greatest exposure to many toxic air pollutants not outside but inside places such as homes, offices, and automobiles. …”
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A Prospective Study to Assess the Best Optimal Dose of Tacrolimus before Renal Transplantation and Its Impact on Graft Survival and Patient Outcome in Renal Transplant Recipients by Niranjan Gogoi, Charu Jain, Megha Agarwal, Dhananjay Agarwal, Ajay Gupta, Munesh Kumar

“…One patient showed TAC-related toxicity in biopsy. Conclusion: Optimizing the dose of TAC before renal transplantation may facilitate individualization of immunosuppression and can improve graft outcome.…”
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Phytochemical Profiling, Bioactivity, and Insecticidal Effectiveness of <i>Mammea americana</i> L. Leaf Extracts Against <i>Ferrisia</i> sp. by Mike Vázquez-Torres, Nilka Rivera-Portalatín, Irma Cabrera-Asencio

“…Potential cytotoxicity was assessed using brine shrimp lethality tests, where all extracts displayed high toxicity to <i>Artemia salina</i>. The dichloromethane extract (MAD) had the lowest LC₅₀ value (8.39 μg/mL), followed by methanol extract (MAM, 11.66 μg/mL) and chloroform extract (MAC, 12.67 μg/mL). …”
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Indomethacin-Induced Gastric Ulcer in Rats: Gastroprotectivity of <i>Muscari neglectum</i> in Water by Menekse Soydan, Gulnur Arabaci, Necati Utlu, Mesut Bünyami Halici, Esra Aktas Senocak, Metin Kiliçlioglu

“…<b>Methods:</b> 60 male Sprague Dawley rats were utilized for the purposes of evaluating the acute toxicity and gastric ulcer models, with a total of 36 rats employed for these experiments (n = 6). …”
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Adsorption of phenol on activated carbon obtained from date palm branches by Sameh Ahmed, E. S. Gogina, N. A. Makisha

“…However, the discharge of wastewater containing phenol is a priority due to its high toxicity to humans and animals, even at low concentrations. …”
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Lysophosphatidic Acid Induced Apoptosis, DNA Damage, and Oxidative Stress in Spinal Cord Neurons by Upregulating LPA4/LPA6 Receptors by Yifan Yang, Jing Xu, Qingxin Su, Yiran Wu, Qizheng Li, Zongren Ma, Tao Ding

“…Recently, LPA has been reported to be involved in spinal cord neuronal injury and toxicity, promoting the pathogenesis of LSS. However, the exact effects of LPA on spinal cord neurons remain unknown. …”
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Assessment of Inappropriate Dose Adjustment of Antimicrobials and Other Medicines Among Chronic Kidney Disease Patients: A Multicenter Observational Study by Roheena Zafar, Inayat Ur Rehman, Yasar Shah, Khang Wen Goh, Long Chiau Ming

“…Inaccurate dosage adjustments can lead to toxicities, therapeutic failures, and adverse drug reactions. …”
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Comparison of inhaled versus intravenous anesthesia for laryngoscopy and laryngeal electromyography in a rat model by M. Gazzaz, J. Saini, S. Pagliardini, B. Tsui, C. Jeffery, H. El-Hakim

“…Three mortalities were encountered, one of which was due to lidocaine toxicity and two were during anesthetic induction. …”
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Lyophilized powder of calf bone marrow hydrolysate liposomes improved renal anemia: In vitro and in vivo evaluation. by Li Li, Shasha Zhao, Xiaodun Liu, Zhe Xu, Dong Li, Xiaoyu Dai

“…The results of lyophilized powder of CBMHL co-culture with human adipose mesenchymal stem cells (MSCs) and human cytokine-induced killer (CIK) cells showed that the lyophilized powder of CBMHL had no potential toxicity and allergic reaction in vitro. Compared with the Model Group, the red blood cell (RBC) count, hemoglobin (HB) content and hematokrit (HCT) of rats blood routine in the Model+high doses of CBMHL Group (Model+H-CBMHL Group) increased significantly (P < 0.05). …”
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Nonclinical Similarity of the Biosimilar Candidate ABP 938 with Aflibercept Reference Product by Neungseon Seo, Scott Kuhns, Dina A. Andrews, Alexander Colbert, Vincent Chow, Jennifer Liu

“…Additionally, there was no evidence of ocular or systemic toxicity associated with IVT administration of ABP 938 in a repeat-dose, 1-month toxicology study in cynomolgus monkeys; toxicokinetic and toxicology profiles were similar to aflibercept RP. …”
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Assessing Redox Properties of Natural Organic Matters with regard to Electron Exchange Capacity and Redox-Active Functional Groups by Zhiyuan Xu, Zhen Yang, Hongping Wang, Jie Jiang

“…Redox processes in groundwater play an important role in bioavailability, toxicity, and mobility of redox-active elements and contaminants. …”
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