Screening of Active Components and Key Targets of Radix Codonopsis in the Treatment of Gastric Cancer by Lijun Tang, Jinhui Chen, Jin Yin, Mingli Fang

“…However, chemotherapy drugs will cause serious toxic and side effects on other normal tissues and cells. …”
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N-acetylated sugars in clownfish and damselfish skin mucus as messengers involved in chemical recognition by anemone host by Sara Heim, Tony Teav, Fabio Cortesi, Hector Gallart-Ayala, Julijana Ivanisevic, Nicolas Salamin

“…Abstract The clownfish - sea anemone system is a great example of symbiotic mutualism where host «toxicity» does not impact its symbiont partner, although the underlying protection mechanism remains unclear. …”
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Transgenic plants as genetic models for studying functions of plant genes by A. V. Kochetov, V. K. Shumny

“…It was also found that these plants were more tolerant to various abiotic stresses (drought, NaCl, cold, toxic heavy metals), which may result from the protective proline effect early in exposure to stress, preventing the cellular gene expression machinery from damage by stress-generated free radicals.…”
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Dynamics of REL, RELA and IRF1 transcription factor expression in U937 macrophages after dioxin exposure by E. V. Kashina, D. Y. Oshchepkov, E. V. Antontseva, M. Y. Shamanina, D. P. Furman, V. A. Mordvinov

“…The aryl hydrocarbon receptor (AhR), a ligand- activated transcription factor, participates in a wide range of critical cellular events in response to endogenous signals or xenobiotic chemicals. 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) is one of the AhR ligands with a very high binding affinity for the AhR. TCDD is the most toxic among the dioxin xenobiotics and induces a broad spectrum of biological responses, including immunotoxicity and cancer. …”
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Recovery of gold from refractory ore employing pressure oxidation by Flávio de Almeida Lemos, Marisa Nascimento, Gaspar Rodrigues Moreira Júnior, Vanessa Resende de Andrade, Paul Cezanne Pinto, Afonso José Guedes Salles

“…However, it has a high energy cost and environmental issues due to the release of toxic gases containing arsenic. In the treatment of refractory gold ores containing arsenic, pressure oxidation (POX) represents an attractive approach for arsenic immobilization, since the conditions are suitable for both sulfide oxidation and the formation of stable arsenates. …”
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Molecular identification and phylogenetic relationship of Bangladeshi pufferfish based on mitochondrial COI and 16S rRNA genes by Md Sagir Ahmed, Nafisa Islam, Durjoy Raha Antu, Mysha Mahjabin, Sujan Kumar Datta, Osamu Arakawa

“…Pufferfish poisoning sporadically occurs due to the consumption of toxic pufferfish throughout the country. Identification of pufferfish is challenging and/or misleading, based on only morphometric characteristics. …”
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Formulation Design and Cell Cytotoxicity of Curcumin-Loaded Liposomal Solid Gels for Anti-Hepatitis C Virus by Helmy Yusuf, Erlyn K. D. D. Novitasari, Ni L. W. Purnami, Adhe W. Mahbub, Retno Sari, Dwi Setyawan

“…These data confirmed that the developed liposomal solid gels were not cytotoxic to Huh7it cell line, indicating that the anti-HCV activity would be through a specific pathway and not by its toxicity. Conclusion. The CUR-loaded liposomal solid gels exhibited the potential and offered an alternative dosage form to improve the therapeutic efficacy of curcumin as an anti-HCV.…”
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A qualitative exploration of the enablers of and barriers to conformance with antibiotic withdrawal periods on smallholding, peri-urban pig farms in Kiambu County, Kenya. by Claire Scott, Nicholas Bor, Kristen K Reyher, Alex J Tasker, Henry Buller, Irene Bueno, Lian F Thomas

“…Non-conformance with antibiotic withdrawal period guidelines represents a food safety concern, with potential for antibiotic toxicities and allergic reactions as well as selecting for antibiotic resistance. …”
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Genistein Implications in Radiotherapy: Kill Two Birds with One Stone by Xiongxiong Liu, Tong Zheng, Yanyu Bao, Ping Li, Ting Zhao, Yan Liu, Hui Wang, Chao Sun

“…To date, many radioprotectors and radiosensitizers have been investigated in preclinical studies, but their use has been hampered by the high toxicity to normal cells or poor tumor radiosensitization effects. …”
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A parallel bioreactor strategy to rapidly determine growth-coupling relationships for bioproduction: a mevalonate case study by Alec Banner, Joseph Webb, Nigel Scrutton

“…However, this process also led to the formation of the toxic byproduct acetate, which can slow growth and cause problems during downstream processing. …”
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Comparative Pharmacokinetic Profiles of Puerarin in Rat Plasma by UHPLC-MS/MS after Oral Administration of Pueraria lobata Extract and Pure Puerarin by Guozhe Zhang, Jianwei Ji, Mingzhong Sun, Yuqiao Ji, Hongjian Ji

“…Compared with puerarin, the Pueraria lobata extract (PLE) has better water solubility, lower toxicity, and less side effects. In this study, the pharmacokinetics of orally administered puerarin (100 mg/kg) and PLE (763 mg/kg, equivalent to 100.0 mg/kg of puerarin) to rats was investigated by the UHPLC-MS/MS method. …”
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Synthesis, in vitro safety and antioxidant activity of new pyrrole hydrazones by Tzankova Diana, Vladimirova Stanislava, Aluani Denitsa, Yordanov Yordan, Peikova Lily, Georgieva Maya

“…The initial in vitro safety screening for cytotoxicity (on HepG2 cells) and hemocompatibility (hemolysis assay) showed good safety of the new compounds, where ethyl 5-(4-bromophenyl)-1-(1-(2-(4-hydroxy-3-methoxybenzylidene)-hydrazineyl)-1-oxo-3-phenylpropan-2-yl)-2-methyl-1H-pyr-role-3-carboxylate (4d) and ethyl 5-(4-bromophenyl)-1-(1-(2-(2-hydroxybenzylidene)hydrazineyl)-1-oxo-3-phenylpropan--2-yl)-2-methyl-1H-pyrrole-3-carboxylate (4a) were the least toxic. The antioxidant activity in terms of radical scavenging activity (DPPH test) and reducing ability (ABTS) was also evaluated. …”
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Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy by Aziza Rashed Al-Rafiah, Khlood Mohammed Mehdar

“…Sodium valproate (SVP) is a commonly used antiepileptic drug (AED); however, it has toxic effects. Lutein (L), a carotenoid, has potent antioxidant and anti-inflammatory properties. …”
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Characteristics and Clinical Course of Patients with Acute Myocardial Infarction and ST-segment Elevation with and without Interatrial Block by Francisco de Jesús Valladares Carvajal, Verónica Mercedes Carretero Acosta, Raimundo Carmona Puerta, Aymara Marcia Hernández Cardoso, Ernesto Julio Bernal Valladares

“…Demographic variables were analyzed: age, sex, skin color and between clinics: toxic habits; (smoker, ex-smoker); medical history (myocardial infarction, angina, peripheral arterial disease, arterial hypertension, type 2 diabetes mellitus, chronic kidney disease; infarct location (anterior, inferior, left bundle branch block); complications: heart failure, atrial fibrillation, ventricular tachycardia/ventricular fibrillation, atrioventricular conduction disorders, mechanical complication, post infarction angina, arterial embolism) and discharge status (alive or deceased). …”
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Analysis of Benzene-Induced Effects on Rhodococcus sp. 33 Reveals that Constitutive Processes Play a Major Role in Conferring Tolerance by Tony Gutiérrez, Robert Learmonth, Iain Couperwhite

“…Most studies investigating mechanisms that confer microorganisms with tolerance to solvents have often focused on adaptive responses following exposure, while less attention has been given to inherent, or constitutive, processes that prevail at the onset of exposure to a toxic solvent. In this study, we investigated several properties of the highly solvent-tolerant bacterium Rhodococcus sp. 33 that confer it with a tolerance to high concentrations of benzene. …”
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Synthesis of ZrO2:Dy3+ Nanoparticles: Photoluminescent, Photocatalytic, and Electrochemical Sensor Studies by K. Gurushantha, K. S. Anantharaju, Nagaraju Kottam, K. Keshavamurthy, C. R. Ravikumar, B. S. Surendra, A. Murugan, H. C. Ananda Murthy

“…The electrochemical sensor studies on ZrO2:Dy3+ NPs exhibited potentiality towards sensing of highly toxic metals like mercury and lead.…”
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Melanin production and laccase mediated oxidative stress alleviation during fungal-fungal interaction among basidiomycete fungi by Samim Dullah, Dibya Jyoti Hazarika, Gunajit Goswami, Tanushree Borgohain, Alokesh Ghosh, Madhumita Barooah, Ashok Bhattacharyya, Robin Chandra Boro

“…Moreover, the fungal–fungal interaction also led to increase in the production of laccase, a group of multicopper oxidases involved in detoxification of toxic compounds. Further, increased activity of superoxide dismutase, an enzyme that catalyzes the dismutation of the superoxide anion to hydrogen peroxide was also recorded during fungal–fungal interaction. …”
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The different response of PM2.5 stimulated nasal epithelial spheroids in control, asthma and COPD groups by Paulina Misiukiewicz-Stępień, Elwira Zajusz-Zubek, Katarzyna Górska, Rafał Krenke, Magdalena Paplińska-Goryca

“…The impairment of airway epithelium in asthma and COPD changes their response to toxic environmental stimuli. This physiological dysfunction might be associated with diseases exacerbation of obstructive lung diseases.…”
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Elritercept, a modified activin receptor IIA ligand trap, increased erythropoiesis and thrombopoiesis in a phase 1 trial by Jennifer Lachey, Christopher Rovaldi, Suresh Bobba, Jared Tur, Harveen Natarajan, Ben Snyder, Jasbir Seehra

“…Elritercept was generally well tolerated at all dose levels, with no dose-limiting toxicities observed. There were no severe or serious adverse events or clinically significant changes in safety laboratory measures. …”
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Chitosan nanoparticles loaded with Lactobacillus rhamnosus bioactive metabolites: Preparation, characterization, and antifungal activity by Aya Abdel-Nasser, Hayam M. Fathy, Ahmed N. Badr, Olfat S. Barakat, Amal S. Hathout

“…Aspergillus flavus is a severe danger to worldwide maize (Zea mays) cultivation, due to its extreme toxicity of aflatoxins produced by the fungi, and its ability to cause economic losses while also posing a health concern to humans and animals. …”
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