PROTACs: Mechanism and Bioavailability enhancement strategies by nanotechnology, RNA viral infections (vaccine strategy) and Prodrug development by Sanaul Mustafa, Md Sabir Hussain Siddiquee

“…They improve the solubility and stability of PROTACs, allow for targeted delivery to the tumour site and minimize toxicity to healthy cells. Moreover, arguably the most interesting virtue of PROTACs is its applicability for RNA viral infections (new vaccine design) based on the degradation of viral proteins. …”
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New genetic tools for plant defense against parasitic nematodes by A. V. Kochetov, T. A. Gavrilenko, O. S. Afanasenko

“…The biological characteristics of sedentary nematodes makes their agrotechnical control problematic, i.e. the GPCN cysts remain dormant in soil for many years until a susceptible host appears, whereas nematicides are either toxic or inefficient. Introgression of resistance genes (R-genes) from related cultivated or wild species is likely to be the most appropriate way for their biocontrol. …”
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Protective effects of gallic acid against nickel-induced kidney injury: impact of antioxidants and transcription factor on the incidence of nephrotoxicity by Areej I. Alhazmi, Mohamed F. El-Refaei, Eman A. A. Abdallah

“…Gallic acid has a protective role against kidney dysfunction and renal damage in Ni-nanoparticle toxicity.…”
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Pollution Characteristics of Sb, As, Hg, Pb, Cd, and Zn in Soils from Different Zones of Xikuangshan Antimony Mine by Saijun Zhou, Andrew Hursthouse, Tengshu Chen

“…Sixty soil samples from the four zones were taken for experimental work, and the contents and morphological characteristics of the six potentially toxic elements (PTEs) such as Sb, As, Hg, Pb, Cd, and Zn in the soil samples were measured by using a hydride generation atomic fluorescence spectrometer (AFS-9700). …”
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From ex vivo to in vivo chimeric antigen T cells manufacturing: new horizons for CAR T-cell based therapy by E. Pinto, L. Lione, M. Compagnone, M. Paccagnella, E. Salvatori, M. Greco, V. Frezza, E. Marra, L. Aurisicchio, G. Roscilli, A. Conforti

“…Additionally, in vivo production of CAR-T cells might reduce the incidence, or at least the severity, of systemic toxicities frequently occurring with ex vivo produced CAR-T cells, such as cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome. …”
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The effect of COVID-19 lockdown on the air environment in India by N. Gupta, A. Tomar, V. Kumar

“…However, as a blessing in disguise, these measures have a positive effect on the environment in terms of reduction in toxic gasses like nitrogen dioxide, aerosols, atmosphere ozone, particulate matter, and improvement in air quality. …”
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A review of the Bovis Calculus’s intervention mechanism and clinical application in ischemic stroke by Ke Xu, Bowen Deng, Tongtong Jia, Mihong Ren, Hai Chen, Jing Zhang, Jinlin Guo, Yong Li, Jian Wang

“…The active components of BC exert neuroprotective effects by reducing microcirculation disturbance, excitatory amino acid toxicity, and oxidative stress injury in the acute stage; inhibiting inflammatory injury, apoptosis, and blood-brain barrier (BBB) disruption in the subacute stage; and promoting angiogenesis and neurogenesis in the restoration stage. …”
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The Potential of Emergency Medical Response to CBRNE Threats in the Context of Military-Civilian Cooperation by Arkadiusz Trzos, Karol Łyziński

“…Aim: The objective of this study is to present the contemporary response options of civilian medical rescue and healthcare systems to the effects of weapons of mass destruction weapons and civilian toxic agents with mass impact potential. The study also demonstrated the preparation and response potential of medical services with proper additional equipment, training and implementation of new systemic solutions to enable the collaboration and cooperation of military and civilian services. …”
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A review on intrathecal administration of medications for leptomeningeal metastases in solid tumors by Xuemei Wang, Chi Yao, Li Quan, Junxiang Zhou

“…It is hoped that future research will focus on exploring more potentially effective anti-tumor drugs for IT treatment, conducting in-depth pharmacokinetic studies, and developing long-acting and low-toxic IT administration regimens for the treatment of meningeal metastases.…”
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Effect Of Zinc And Ingredients Of Protein Supplement On Sperm Parameters And Male Reproductive Hormones- An RCT Study by Saira Safdar, Irfan Afzal Mughal, Noor Ul Ain, Sidra Jabeen, Muhammad Hassaan Farooq, Asma Irfan

“… Objective: The purpose of this study was to assess the protective effects of zinc against injury to sperm parameters and male reproductive hormones brought on by toxic protein supplement constituents. Methods: 30 male Sprague Dawley rats were used in the study, of which 10 were in Group 1 (given standard laboratory food), 10 were in Group 2, fed standard laboratory food nutritional supplement powder and 10 were in Group 3, fed standard laboratory food, nutritional supplement powder and zinc. …”
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Optimization of the DNA isolation procedure for assessing the genetic diversity of essential oil roses (<i>Rosa</i> L.) by S. B. Seitadzhieva, S. Z. Guchetl, S. V. Didovich, E. V. Gorodnyaya

“…High content of organic compounds that worsen nucleic acid purification in aromatic plants, as well as the use of such toxic substances as phenol and mercaptoethanol in many protocols for plant DNA isolation, make it advisable to take the above disadvantages into account when optimizing the DNA extraction technique for the work with essential oil rose plants. …”
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Fatal intoxication after oral ingestion of amphetamine: Two case reports by Evelyn Pawlik, Felix Mayer, Oliver Temme

“…The amphetamine concentrations of both cases are compared and the distribution in the body is discussed. The toxicity of the amphetamine by-products on the human body remains unclear and is subject of further studies.…”
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Nephroprotective effects of Foeniculum vulgare mill (Apiaceae Family) hydromethanol leaf extract against cisplatin-induced nephrotoxicity on Swiss albino mice by Kibur Hunie Tesfa, Chernet Desalegn Gebeyehu, Tiget Ayelgn Mengstie, Hiwot Tezera Endale

“…Therefore, it is mandatory to seek effective, affordable, and safe drugs for the prevention and curative effects of kidney toxicity caused by cisplatin. Thus, this study evaluated the effects of Foeniculum vulgare Mill hydro-methanolic crude leaf extract on cisplatin-induced nephrotoxicity in Swiss albino mice. …”
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Rapid adsorption of selenium removal using iron manganese-based micro adsorbent by Sundus Saeed Qureshi, Sheeraz Ahmed Memon, Rafi-ul-Zaman, Nanik Ram, Sumbul Saeed, Nabisab Mujawar Mubarak, Rama Rao Karri

“…Abstract Selenium in wastewater is of particular concern due to its increasing concentration, high mobility in water, and toxicity to organisms; therefore, this study was carried out to determine the removal efficiency of selenium using iron and manganese-based bimetallic micro-composite adsorbents. …”
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Lipotoxicity and metabolic disorders at obesity by V. T. Ivashkin, M. V. Mayevskaya

“…It is possible to explain lipotoxicity phenomenon as follows: in conditions of insulin resistance glucose stops to be an energy source and is substituted by lipolysis, therefore a plenty of free fatty acids is formed, having potential of toxicity and realizing metabolic disorders in target organs: the liver, the pancreas, muscles. …”
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Assessment of greenhouse gas emissions and environmental impacts in the manufacturing process of thermoelectric coolers: A life-cycle impact perspective by Hyo Young Kim, Jeong Eun Kim, Daehyun Wee

“…Using the life cycle inventory assessment (LCIA), the environmental impacts of the manufacturing process of TECs were analyzed, including greenhouse gas emissions, human carcinogenic toxicity (HCT), terrestrial ecotoxicity (TE), freshwater ecotoxicity (FE), mineral resource scarcity (MRS), and fossil resource scarcity (FRS). …”
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Application of Nano-Titanium Dioxide in Food Antibacterial Packaging Materials by Jiarui Li, Dequan Zhang, Chengli Hou

“…Nano-titanium dioxide (nano-TiO₂) with PDI characteristics has attracted the interest of many researchers with its elevated efficiency, broad-spectrum antibacterial resistance, low cost, safety, and non-toxicity. Nano-TiO₂ photodynamic antibacterial properties have been studied extensively and has a great application value in the field of food packaging. …”
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Formulation of new drug delivery systems for insulin from natural bioactive biocompatible polymers by Howida A. Fetouh, Engy E. A. Aleem, Najiyah H. Mohammed, Jihad M. Abd-Almajeed Aldesouky, Amel M. Ismail

“…Traces amount additives were below toxicity limits. Guar gum increased the numbers of the functional groups of the polymer carrier. …”
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Preparation of ZnAl layered double hydroxides supported by silica for the treatment of Cr(VI) and Cu(II) in aqueous solution by Fengrong Zhang, Luxing Liu, Cuilan Zhang, Dawei Shang, Lishun Wu

“…The adsorption properties of ZA/SiO2 for the removal of toxic metal ions (Cu(II) and Cr(VI)) from water were evaluated. …”
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The Protective Effect of Naringin against Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats by Nergiz H. Turgut, Haki Kara, Sahende Elagoz, Koksal Deveci, Huseyin Gungor, Emre Arslanbas

“…These results show that naringin has the potential of reducing the toxic effects of bleomycin and may provide supportive therapy for conventional treatment methods for idiopathic pulmonary fibrosis.…”
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