Deciphering the Molecular Mechanism of Peracetic Acid Response in Listeria monocytogenes by Marianna Arvaniti, Ahmed Gaballa, Renato H. Orsi, Panagiotis Skandamis, Martin Wiedmann

“…In detail, the organic peroxide toxicity protection (OhrA-OhrR) system, the metal homeostasis genes fur and zurM, the SbrE-regulated lmo0636-lmo0637 operon and a carbohydrate phosphotransferase system (PTS) operon component were induced under exposure of L. monocytogenes to PAA. …”
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Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons by Calum Harvey, Alicja Nowak, Sai Zhang, Tobias Moll, Annika K Weimer, Aina Mogas Barcons, Cleide Dos Santos Souza, Laura Ferraiuolo, Kevin Kenna, Noah Zaitlen, Christa Caggiano, Pamela J Shaw, Michael P Snyder, Jonathan Mill, Eilis Hannon, Johnathan Cooper-Knock

“…Abstract Amyotrophic lateral sclerosis (ALS) lacks a specific biomarker, but is defined by relatively selective toxicity to motor neurons (MN). As others have highlighted, this offers an opportunity to develop a sensitive and specific biomarker based on detection of DNA released from dying MN within accessible biofluids. …”
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Anthelmintic activity of 1,10-phenanthroline-5,6-dione-based metallodrugs by Maria E. Cirino, Thainá R. Teixeira, Alessandro M. H. Silva, Ana C. C. Borges, Lucas Fukui-Silva, Luis G. Wagner, Christiane Fernandes, Malachy McCann, André L. S. Santos, Josué de Moraes

“…Cytotoxicity assays using Vero cells revealed a low toxicity profile and a high selectivity index. Given the promising biological properties of phendione and its metal complexes, these findings contribute to the growing body of research seeking to address the urgent need for new anthelmintic therapies.…”
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Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment by Tatsuya Usui, Masashi Sakurai, Shuhei Enjoji, Hideyoshi Kawasaki, Koji Umata, Takashi Ohama, Nobuyuki Fujiwara, Ryotaro Yabe, Shunya Tsuji, Hideyuki Yamawaki, Shoichi Hazama, Hiroko Takenouchi, Masao Nakajima, Ryouichi Tsunedomi, Nobuaki Suzuki, Hiroaki Nagano, Koichi Sato

“…Tumor organoids were more resistant to toxicity of 5-fluorouracil and Irinotecan than colorectal cancer cell lines, SW480, SW620, and HCT116. …”
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Effectiveness of Phytomining of Vanadium (V) and Chromium (Cr) Using Cymbopogon citratus and Portulaca grandiflora in Red Mud with Manure Addition by Fitranto Irwan, Voijant Tangahu Bieby, Yulikasari Andriyan, Mashudi, Sulistyaning Titah Harmin, Najib Rizal Moh., Salsabilla Faiza, Ming Lam Yeng, Wang Yamin, In Hurun, Maryanawati Soesilo Mery

“…The study was conducted over a period of 28 days, during which time toxicity testing and the phytomining ability of the two plants were observed. …”
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Sociodemografic and Clinical Characteristics of Suicidal Cases who Attempted to Emergency Services in Ankara by Selma ERCAN, Mustafa AKSOY, Abdussamed YALCIN, A. Cigdem SIMSEK, S. Rahmi ACAR, Tulay ERCIN SAHIN

“…The most applied method of suicide attempted is the usage of drugs and toxic substances with the 96.2%. The increment ratio of the suicide attempts is seen paticularly from January to June. …”
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A phase I study of the CDK4/6 inhibitor ribociclib combined with gemcitabine in patients with advanced solid tumors by Aurora Norman, Mahesh Seetharam, Jacob Allred, Jianping Kong, Mateusz Opyrchal, Wen Wee Ma, Yanyan Lou, Grace K. Dy, Amit Mahipal, S. John Weroha, Andrea E. Wahner Hendrickson, Joel M. Reid, Alex A. Adjei

“…Abstract Background Based on preclinical data showing addition of CDK4/6 inhibitors to gemcitabine was synergistic, ribociclib was evaluated in combination with gemcitabine to determine the maximum tolerated dose (MTD) and dose limiting toxicities (DLT). Methods In this single arm multicohort phase I trial, we evaluated the safety and efficacy of ribociclib plus gemcitabine in patients with advanced solid tumors. …”
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Comparative Transcriptome Analysis Reveals Molecular Defensive Mechanism of Arachis hypogaea in Response to Salt Stress by Hao Zhang, Xiaobo Zhao, Quanxi Sun, Caixia Yan, Juan Wang, Cuiling Yuan, Chunjuan Li, Shihua Shan, Fengzhen Liu

“…Abiotic stresses comprise all nonliving factors, such as soil salinity, drought, extreme temperatures, and metal toxicity, posing a serious threat to agriculture and affecting the plant production around the world. …”
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Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade by Chun-Bing Chen, Shuen-Iu Hung, John Wen-Cheng Chang, Chan-Keng Yang, David Hui-Kang Ma, Yu-Chuan Teng, Chun-Wei Lu, Wei-Ti Chen, Hsiao-Yin Yang, Cheng-Chang Tsai, Chih Liang Wang, Pin-Hsuan Chiang, Jennifer Wu, Ya-Wen Tsai, Lai-Ying Lu, Yang Yu-Wei Lin, Rosaline Chung-Yee Hui, Fu-Mei Hsieh, Chao-Kai Hsu, Chaw-Ning Lee, Yi-Ju Chen, Chih-Chiang Chen, Yilei Cui, Hung-Chih Hsu, Ya-Ching Chang, Chih-Jung Chang, Ho-Chen Lin, Chee Jen Chang, Yu-Jr Lin, Cheng-Lung Ku, Chuang-Wei Wang, Wen-Hung Chung

“…However, ICI can potentially induce life-threatening severe cutaneous adverse reaction (SCAR), such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), hindering continuous ICI therapy. …”
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Tenascin C-Guided Nanosystem for Precision Delivery of Obeticholic Acid in Liver Fibrosis Therapy by Yawen Wang, Lei Yang, Qing Xu, Taiyu Liu, Hongliang He, Lisha Liu, Lifang Yin

“…<b>Methods:</b> We designed a liposomal delivery system functionalized with the GBI-10 aptamer and encapsulating obeticholic acid (OCA lips@Apt) to enhance selective delivery to fibrotic liver tissue while minimizing systemic toxicity. <b>Results:</b> Both in vitro and in vivo studies demonstrated that the aptamer-modified OCA liposomes effectively treated hepatic fibrosis through dual mechanisms: modulation of abnormal bile acid metabolism and attenuation of inflammation. …”
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Pb-free metal oxide-based epoxy resin nanocomposites for radiation protection: Physical evaluation analysis approach by Toni Beth Guatato-Lopez, Alvie Asuncion-Astronomo, Gil Nonato C. Santos

“…Traditional lead-based shields, while effective, have significant drawbacks including toxicity and environmental concerns. This study investigates the potential of lead-free epoxy resin nanocomposites, incorporating bismuth oxide, nickel oxide, and cerium oxide, for mid-energy radiation protection. …”
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<i>Tribulus terrestris</i> Fruit Extract: Bioactive Compounds, ADMET Analysis, and Molecular Docking with Penicillin-Binding Protein 2a Transpeptidase of Methicillin-Resistant <i>S... by Khalid J. Alzahrani

“…Among seventeen compounds, eight have favorable pharmacokinetics and medicinal chemistry; however, on the basis of in silico high water solubility, high GI absorption, blood–brain barrier non-permeability, lack of toxicity, and potential drug-likeness, 1-ethylsulfanylmethyl-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane and phthalimide, N-(1-hydroxy-2-propyl), were processed for molecular docking. 1-ethylsulfanylmethyl-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane formed three hydrogen bonds with Ser-452, Thr-584, and Asn-454 residues of the PBP2a transpeptidase. …”
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Nematicidal potential of Microbacterium maritypicum Sneb159 against Heterodera glycines and the complete genome sequence analysis by Jing Zhao, Jing Zhao, Jing Zhao, Zhifu Xing, Aatika Sikandar, Yuxi Duan

“…The volatiles produced by M. maritypicum Sneb159 are toxic to H. glycines for both juveniles and eggs. …”
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Evaluating the influence of trypanosomiasis on murine model using Corchorus olitorius leaf extract as a trypanocidal agent by Madaki Fatima M., Adamu Kabiru Y., Ogunrombi Clinton D., Sakariyau Waheed A., Yunusa Ibrahim O.

“…This research investigated the impact of trypanosomiasis on a murine model while utilizing Corchorus olitorius leaf extract as a potential trypanocidal agent. An acute toxicity analysis was conducted following Lorke's method, and the antitrypanosomal efficacy was assessed in rats at doses of 100, 200, and 400 mg/kg over three weeks, monitoring changes in parasitemia count, body weight, and hematological parameters. …”
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Microplastics in water, sediment and salts from traditional salt producing ponds by A. Tahir, P. Taba, M.F. Samawi, S. Werorilangi

“…With microplastics abundance reached over 53 microplastics items/kg salt, it is believed that continuous consumption by people will end up with possible accumulation of potentially absorbed of various toxic chemical pollutants which present in sea water as salt raw materials. …”
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Column Study for Adsorption of Copper and Cadmium Using Activated Carbon Derived from Sewage Sludge by Najib Al-mahbashi, S.R.M Kutty, A.H. Jagaba, Ahmed Al-Nini, Mujahid Ali, A.A.H. Saeed, A.A.S Ghaleb, Upaka Rathnayake

“…Among the water-polluting substances, heavy metals stand out due to their carcinogenic and toxic effects on the creatures and environment. This study aimed to scrutinize the effectiveness of sewage sludge-based activated carbon in the removal of copper and cadmium from aqueous solutions in column study. …”
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Nanoemulsion and Encapsulation Strategy of Hydrophobic Oregano Essential Oil Increased Human Prostate Cancer Cell Death via Apoptosis by Attenuating Lipid Metabolism by Haribalan Perumalsamy, Rajeshkumar Shanmugam, Jun-Ran Kim, Gokulanathan Anandapadmanaban, Md. Amdadul Huq, Kamal Dua, Dinesh Kumar Chellappan, Tae Hyun Yoon, Sri Renukadevi Balusamy

“…At first, we have synthesized OENE and characterized using various spectroscopic analyses. The toxicity and inhibitory concentration (IC50) of OENE toward prostate cancer by MTT analysis were performed. …”
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Sawdust as an ameliorant to decontaminate Arsenic in potato soils by Md. Hossain, Tuhin Roy, Maruf Mostofa

“…To produce Potato under Arsenic contaminated soil, an experiment was conducted to find out the effect of sawdust as an adsorbent to decontaminate Arsenic toxicity in soil. Method The research was conducted in pot experiment. …”
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The Effect of the Increasing Doses of Vermicompost Applications to Soil on Some Nutrient Concentrations in Olive (Olea europaea L.) Leaves by Ayşe Nur Coşkun, Ali Sümer

“…Micro nutrient elements remained under the limit of toxic effect upon all the applications. The dose 2 kg tree-1 was determined to be the most suitable one in terms of both macro and micro element concentrations under such trial circumstances.…”
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Severe Cutaneous Adverse Drug Reactions at a Tertiary Care Center in Saudi Arabia by Mohammed I. AlJasser

“…SCARs include drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), and acute generalized exanthematous pustulosis (AGEP). …”
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