Review on Synthesis Method, Classification and AdsorptionSeparation and Sensing Application of Metal-Organic Frameworks (MOFs) Based Composites by Aklilu Melese, Kenaegzer Mulate, Abdu Hussen, Afework Hailekiros, Walelign Wubet

“…Because of these properties, MOFs composites can be used for a wide range of applications, including, sensing toxic chemicals, drugs, gases, and trace metals, components of foods and many more and also for detection of different materials. …”
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Self‐Boosting Programmable Release of Multiple Therapeutic Agents by Activatable Heterodimeric Prodrug‐Enzyme Assembly for Antitumor Therapy by Shanshan Jiang, Bhaskar Gurram, Junfei Zhu, Shan Lei, Yifan Zhang, Ting He, Oya Tagit, Hui Fang, Peng Huang, Jing Lin

“…Abstract Endogenous stimuli‐responsive prodrugs, due to their disease lesion specificity and reduced systemic toxicity, have been widely explored for antitumor therapy. …”
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Dynamic non-coding RNA biomarker reveals lung injury and repair induced by polystyrene nanoplastics by Sheng Yang, Yiling Ge, Tianyi Zhang, Lihong Yin, Yuepu Pu, Zaozao Chen, Geyu Liang

“…Therefore, this study aims to provide new insights into the pulmonary toxicity of PS-NPs using mice and organoid models. …”
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Immunotherapy-associated autoimmune hemolytic anemia by Uqba Khan, Tarik Hadid, Farman Ali, Muhammad Siddique Khurram, Awais Zaka

“…When combined, CTLA-4 and PD-1 checkpoint inhibitors work synergistically, but with increased probability of toxicity. The following case represents an unusual adverse effect of combined treatment with ipilimumab and nivolumab used for treatment of metastatic melanoma.Case presentation A 43-year-old woman with metastatic melanoma presented with severe generalized weakness and fatigue. …”
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PSCA-targeted BPX-601 CAR T cells with pharmacological activation by rimiducid in metastatic pancreatic and prostate cancer: a phase 1 dose escalation trial by Mark N. Stein, Ecaterina E. Dumbrava, Benjamin A. Teply, Usama S. Gergis, Martin E. Guiterrez, Ran Reshef, Sumit K. Subudhi, Céline F. Jacquemont, Joseph H. Senesac, J. Henri Bayle, Charity D. Scripture, Monica S. Chatwal, Mehmet A. Bilen, Walter M. Stadler, Carlos R. Becerra

“…Thirty-three patients received BPX-601 with or without rimiducid, 24 patients with mPDAC and 9 with mCRPC. Two dose-limiting toxicities and two treatment-related deaths occurred in the highest-dose mCRPC cohort, after which the study was terminated, without determination of the RP2D. …”
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Discovery of Novel Nav1.7-Selective Inhibitors with the 1H-Indole-3-Propionamide Scaffold for Effective Pain Relief by Gaoang Wang, Hang Wu, Yingying Wang, Xiangying Liu, Shuijiao Peng, Wenxing Wang, Meijing Wu, Yifei Liu, Ercheng Wang, Zhe Wang, Lei Xu, Xiaojian Wang, Wei Yang, Haiyi Chen, Xi Zhou, Tingjun Hou

“…Additionally, it displays favorable subtype selectivity and positive drug safety in acute toxicity studies. Pharmacokinetic studies indicate that WN2-R has high bioavailability (F = 20.29%), highlighting its considerable potential for drug development. …”
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Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gu... by Min Yang, Jia Guo, Jinxian Li, Shuyue Wang, Yuan Sun, Ying Liu, Yinghua Peng

“…In contrast, plant-derived extracellular vesicles (PEVs) exhibit promising potential in cancer therapy due to their negligible systemic toxicity, high bioavailability and cost- effectiveness. …”
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Two Birds With One Stone: A Novel Nanocomposite Combining Silicon Nanoparticles and Carbon‐Doped Titania as the Fluorescence Probe and Visible Light Photocatalyst for Simultaneous... by Liyun Ma, Zhi Li, Yiyi Shi, Yuchen Xie, Ming Jiang, Xu Yu, Li Xu

“…This process is driven by the superoxide radicals, holes and hydroxyl radicals produced by C‐TiO2/SiNPs under visible light irradiation. The total toxicities obviously reduce after OTC is degraded by C‐TiO2/SiNPs. …”
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Investigation of children's toys quality on the Macedonian market: determination of lead, cadmium and chromium levels by Mirvete Abdullahi1, Suzana Angelova, Evgenija Kiroska Petreska, Tatjana Kadifkova Panovska

“…Lead in children's toys originates from toxic lead dyes and can lead to serious health complications of central nervous system, cardiovascular, immune system and kidneys. …”
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Tailored biomimetic nanoreactor improves glioma chemodynamic treatment via triple glutathione depletion and prompt acidity elevation by Ya Wen, Qiansai Qiu, Feng Feng, Yujuan Zhu, Jianquan Zhang, Zesheng Sun, Tuodi Zhang, Wei Shi, Jinlong Shi

“…Chemodynamic therapy (CDT) is an emerging antitumor strategy utilizing iron-initiated Fenton reaction to destroy tumor cells by converting endogenous H2O2 into highly toxic hydroxyl radical (OH). However, the intratumoral overexpressed glutathione (GSH) and deficient acid greatly reduce CDT efficacy because of OH scavenging and decreased OH production efficiency. …”
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Radiation Therapy with Concurrent Chemotherapy for Locally Advanced Cervical Carcinoma: Outcome Analysis with Emphasis on the Impact of Treatment Duration on Outcome by Juan Diaz, Daohai Yu, Bizhan Micaily, J. Stuart Ferriss, Enrique Hernandez

“…To assess the effectiveness and toxicity of carboplatin concurrent with pelvic external beam radiation and low-dose rate brachytherapy and to assess the impact that adherence to the treatment plan has on outcomes. …”
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Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring by Xiu Cheng, Yue Xue, Houpeng Wang, Zhangqiang Ma, Na Hu, Chenchen Zhang, Yu Gao, Ruihong Fan, Liaoliao Hu, Jia Li, Dalei Zhang, Jian Huang, Sitian Fang, Runting Xiao, Yuanqiao He, Tao Luo, Liping Zheng

“…Overall, maternal exposure to PS-NPs induced profound and enduring effects on the reproductive functions of female offspring, raising critical alarms regarding the multigenerational reproductive toxicity risks associated with nanoplastic exposure in mammals.…”
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The identification of a SARs-CoV2 S2 protein derived peptide with super-antigen-like stimulatory properties on T-cells by Thai Hien Tu, Fatima Ezzahra Bennani, Nasser Masroori, Chen Liu, Atena Nemati, Nicholas Rozza, Amichai Meir Grunbaum, Richard Kremer, Catalin Milhalcioiu, Denis-Claude Roy, Christopher E. Rudd

“…Abstract Severe COVID-19 can trigger a cytokine storm, leading to acute respiratory distress syndrome (ARDS) with similarities to superantigen-induced toxic shock syndrome. An outstanding question is whether SARS-CoV-2 protein sequences can directly induce inflammatory responses. …”
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Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects by Zi-Han Xu, Ming-Min Xie, Chun-Lan Xie, Xian-Wen Yang, Jun-Song Wang

“…Compounds derived from deep-sea fungi exhibit low toxicity and potent neuroprotective effects, offering a promising source for drug development. …”
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Design of the Multi-Bioactive Graphene-Oxide/Gelatin/Alginate Scaffolds as Dual ECM-Mimetic and Specific Wound Healing Phase-Target Therapeutic Concept for Advanced Wound Healing by Marko Demenj, Martina Žabčić, Marija Vukomanović, Tatjana Ilić-Tomić, Dušan Milivojević, Simonida Tomić, Dubravka Živanović, Marija M. Babić Radić

“…No mortality was detected among the <i>Caenorhabditis elegans</i> throughout the incubation period, indicating that the scaffolds are not toxic. The results of in vitro release study of allantoin, quercetin, and caffeic acid confirm the scaffolds’ significant potential for simultaneous release. …”
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Environmental and human health impact of recycle concrete powder: an emergy-based LCA approach by Aneel Manan, Zhang Pu, Mohanad Muayad Sabri, Wael Alattyih, Jawad Ahmad, Abdullah Alzlfawi

“…Key indicators analyzed include climate change, human toxicity, ionising radiation, ozone depletion, photochemical oxidant formation, ecosystem quality, and resource depletion. …”
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The abundance of microplastics in coral reef ecosystems in the waters of Krueng Raya, Aceh Besar by Ulfah Maria, Juliani Rika, Agustina Sri, Purnawan Syahrul, Malayana Intan, Muliari, Miswari Nur, Yusrizal, Irfannur

“…Microplastics have the potential to disrupt the balance of marine ecosystems due to their non-degradable and toxic nature to organisms. This study aims to analyze the abundance and types of microplastics in sediment from coral reef ecosystems at three locations in Krueng Raya waters (Inong Bale, Ahmad Rhang Manyang, and Lhok Mee) and evaluate the correlation between microplastic abundance and live coral conditions. …”
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PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy by Yujia Liang, Shufang Ning, Mekhrdod S. Kurboniyon, Khaiyom Rahmonov, Zhengmin Cai, Shirong Li, Jinling Mai, Xiaojing He, Lijuan Liu, Liping Tang, Litu Zhang, Chen Wang

“…In response, the PdRu@PEI bimetallic nanoalloys were constructed with well-catalytic activities and effective separation of charges, which can catalyze hydrogen peroxide (H2O2) to toxic hydroxyl radical (·OH) under near-infrared laser stimulation. …”
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Simultaneously delivery of functional gallium ions and hydrogen sulfide to endow potentiated treatment efficacy in chemo- and PARPi-resistant ovarian cancer by Sangsang Tang, Yangyang Li, Yifeng Fang, Mengyan Tu, Shenglong Wu, Yixuan Cen, Junfen Xu

“…More importantly, the therapeutic efficacy of Ga2S3-BSA NMs and their ability to enhance the sensitivity to carboplatin and fluzoparib with negligible toxicity were further confirmed in a platinum-resistant OC animal model. …”
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Screening of six medicinal plant species for antileishmanial activity by Ferreira Fabiana Borges Padilha, Cabral Márcia Regina Pereira, Sarragiotto Maria Helena, Fernandez Carla Maria Mariano, Gazim Zilda Cristiani, Junior Ranulfo Piau, Demarchi Izabel Galhardo, Silveira Thaís Gomes Verzignassi, Lonardoni Maria Valdrinez Campana

“…After isolation and analysis of chemical components by ultra-high performance liquid chromatography-high-resolution tandem mass spectrometry (UHPLC-HRMS/MS), the extracts were also tested for toxicity in J774.A1 macrophages and human erythrocytes. …”
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