4,6-Disubstituted pyrimidine-based microtubule affinity-regulating kinase 4 (MARK4) inhibitors: synthesis, characterization, in-vitro activity and in-silico studies by Ashanul Haque, Khalaf M. Alenezi, Mohd. Saeed Maulana Abdul Rasheed, Md. Ataur Rahman, Saleha Anwar, Shahzaib Ahamad, Dinesh Gupta

“…The drug-likeness feature and toxicity of the molecules were evaluated using QikProp and other tools.ResultsCompounds were synthesized following a multi-step approach and characterized using multi-nuclear magnetic resonance (1H/13C-NMR) and mass spectrometry. …”
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Modeling and correction of protein conformational disease in iPSC-derived neurons through personalized base editing by Colin T. Konishi, Nancy Mulaiese, Tanvi Butola, Qinkun Zhang, Dana Kagan, Qiaoyan Yang, Mariel Pressler, Brooke G. Dirvin, Orrin Devinsky, Jayeeta Basu, Chengzu Long

“…Using an inducible MUT NS-GFP neuron system, we identified early prevention of toxic protein expression allowed aggregate clearance, while late prevention halted further aggregation. …”
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Monitoring N : P Ratio and Cd, Cu, Pb, and Zn Contents in Different Types of Anaerobic Digestates: A Six-Year Study Case by Christina-Luise Roß, Kerstin Nielsen, Jorita Krieger, Marieke Hoffmann, Karen Sensel-Gunke, Frank Ellmer, Timo Kautz

“…Depending on the quality of the input substrates, process parameters, and postfermentation treatments, digestates may contain a broad spectrum of potentially toxic elements. We suspected that these contents may vary on a broad scale even under seemingly stable process conditions at the biogas plant. …”
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Defect engineering and alloying strategies for tailoring thermoelectric behavior in GeTe and its alloys by Qiyong Chen, Cheng Yang, Tong Xing, Jinyang Xi, Wenqing Zhang, Jiong Yang, Lili Xi

“…GeTe exhibits excellent p-type medium-temperature thermoelectric properties with low toxicity and good mechanical characteristics, making it highly promising for development in the thermoelectric field. …”
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Beneficial arthropods threatened by synthetic agricultural pesticides around the southeast slopes of Mount Cameroon by Daniel Brice Nkontcheu Kenko, Agathe Lambou Fotio, Kenfack Donhachi Aimerance, Derick Atemlefac Acha, Miranda Egbe Awo, Eric Bertrand Fokam

“…Data on pesticide usage (active ingredients, interval, dosage, number of applications), and ecotoxicology (LD50 and environmental behaviour) were collected from field surveys and the IUPAC databases, respectively, then imported into PRIMET to assess the level of risk expressed in Exposure Toxicity Ratio (ETR). Tomato was the main crop of the area while insecticides were the main pesticide category utilised in the study area. …”
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Performance enhancement of full inorganic Sb2S3 solar cells with MnS hole transport layers by Minghong Rui, Hangyu Li, Yuan Li, Wenqi Li, Sumei Wang

“…However, the issue of high cost, poor environmental stability and toxic benzene-based solvents for preparation represent significant challenges for the efficient organic HTLs. …”
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Antibacterial Activity of Rationally Designed Antimicrobial Peptides by Marius B. Tincho, Thureyah Morris, Mervin Meyer, Ashley Pretorius

“…The reasons may either be the antibiotic resistance towards the available therapeutic molecules or the slow rate of producing adequate therapeutic regimens to tackle the rapid growth of new infectious diseases, as well as the toxicity of current treatment regimens. Due to these reasons, there is a need to seek and develop novel therapeutic regimens to reduce the rapid scale of bacterial infections. …”
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Altering the mechanical properties of self-assembled filaments through engineering of EspA bacterial protein by Moran Elias-Mordechai, May Morhaim, Maya Georgia Pelah, Irina Rostovsky, May Nogaoker, Jürgen Jopp, Raz Zarivach, Neta Sal-Man, Ronen Berkovich

“…Protein-based biomaterials are in high demand due to their high biocompatibility, non-toxicity, and biodegradability. In this study, we explore the bacterial E. coli secreted protein A (EspA), which self-assembles into long extracellular filaments, as a potential building block for new protein-based biomaterials. …”
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Evaluation of cellular and physiological alterations of cells from Mytilus galloprovincialis exposed to benzisothiazolinone by Federica Impellitteri, Kristian Riolo, Giorgia Zicarelli, Miriam Porretti, Cristiana Roberta Multisanti, Giuseppe Piccione, Alessia Giannetto, Caterina Faggio

“…This extensive use is reflected in a vast amount of this compound in the environment, which may cause toxic effects in organisms that come in contact with it. …”
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Multimodal lung cancer theranostics via manganese phosphate/quercetin particle by Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang, Yinan Liu, Hongda Liu, Chen Wang, HaiLu Yao, Linying Zhong, Yuanfeng Fu, Pengbo Guo, Weiqi Chen, Xinyu Zhou, Li Zou, Licheng Gan, Jiawei Yan, Yichong Hou, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Guang Han, Xijun Wang, Jigang Wang

“…Mechanistic studies indicated that QCT and Mn2+ exhibited excellent peroxidase-like (POD-like) activity, catalysing the conversion of endogenous hydrogen peroxide into highly toxic hydroxyl radicals through a Fenton-like reaction, depleting glutathione (GSH), promoting reactive oxygen species (ROS) generation in mitochondria and endoplasmic reticulum, and inducing ferroptosis. …”
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Fabrication of metal organic framework/Polyoxometalate-TiO2 based DSCCs with enhanced electron lifetime and reduced recombination of charge carriers sensitized with cabbage/spinach... by William Moloto, Pontsho Mbule, Edward Nxumalo, Bulelwa Ntsendwana

“…However, considering practical requirements of DSSCs, the natural dye-based devices satisfy most of the criteria such as affordability, ease of extraction, multiple wavelengths that can be absorbed with large coefficient, non-toxicity, and wide availability.…”
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Distribution and risk assessment of microplastics in a source water reservoir, Central China by Minghui Shen, Yang Li, Liwen Qin, Xudong Chen, Tianyu Ao, Xishu Liang, Kaibo Jin, Yanyan Dou, Juexiu Li, Xuejun Duan

“…Both the middle and bottom water showed elevated levels of risk due to higher concentrations of polymers with significant toxicity indices. This study presents novel findings on the distribution of microplastics in different water layers, providing crucial data support for understanding the migration patterns of microplastics in source water reservoirs and facilitating pollution prevention efforts.…”
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Health risks evaluation of mycotoxins in plant-based supplements marketed in Malaysia by Rozaini Abdullah, Nur Syazwin Kamarozaman, Siti Soleha Ab Dullah, Mohd Yusmaidie Aziz, Hussein Bakheit Adam Aziza

“…Abstract Mycotoxins are toxic secondary metabolites produced by fungi, pose significant health risks when present in plant-based supplements (PBS), necessitating thorough risk assessment to ensure consumer safety. …”
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Preclinical use of a clinically-relevant scAAV9/SUMF1 vector for the treatment of multiple sulfatase deficiency by Maximiliano Presa, Rachel M. Bailey, Somdatta Ray, Lauren Bailey, Saurabh Tata, Tara Murphy, Pierre-Alexandre Piec, Harold Combs, Steven J. Gray, Cathleen Lutz

“…The treated mice show wide distribution of the SUMF1 gene, no signs of toxicity or neuropathy, improved vision and cardiac function, and no behavioral deficits. …”
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Interspecific differences in the response of autotrophic microorganisms to atrazine and S-metolachlor exposure by Laura Malbezin, Nicolas Mazzella, Sébastien Boutry, Isabelle Lavoie, Soizic Morin

“…Indeed, atrazine seemed to explain the toxicity of the mixture for photosynthetic parameters, while certain lipid classes showed intermediate responses between compounds. …”
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Development of Duloxetine Hydrochloride Tablets for Delayed and Complete Release Using Eudragit L 100 by M. Yasmin Begum, Ali Alqahtani, Mohammed Ghazwani, Noura Abdullah Alhamood, Umme Hani, Avanthi Jajala, Mohamed Rahamathulla

“…Duloxetine HCl produces a toxic substance called alpha-naphthol when duloxetine HCl is in contact with gastric fluid. …”
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Design, synthesis, and anti-inflammatory activity of 2H-1,4-benzoxazin-3(4H)-one derivatives modified with 1,2,3-triazole in LPS-induced BV-2 cells by Xixi Hou, Xixi Hou, Longfei Mao, Huibin Zhang, Lan Wang, Baoyu He, Jingjing Guo, Jianji Wang

“…Additionally, acute toxicity tests in mice demonstrated that compound e16 exhibited favorable safety.…”
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Dose-Dense Epirubicin and Cyclophosphamide Followed by Docetaxel as Adjuvant Chemotherapy in Node-Positive Breast Cancer by Hamid Reza Mirzaei, Parisa Sabet Rasekh, Fatemeh Nasrollahi, Parto Sabet Rasekh, Zahra Akbari Tirabad, Hamid Reza Moein, Taban Ghaffari Pour, Parastoo Hajian

“…Fifty-eight patients with axillary lymph node-positive breast cancer were enrolled in the study, of whom 42 (72.4%) completed the regimen. There were two toxicity-related deaths, one patient due to grade 4 febrile neutropenia and the other due to congestive heart failure. …”
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Effect of Food on the Steady-State Pharmacokinetics of Tenofovir and Emtricitabine plus Efavirenz in Ugandan Adults by Mohammed Lamorde, Pauline Byakika-Kibwika, William S. Tamale, Francis Kiweewa, Mairin Ryan, Alieu Amara, John Tjia, David Back, Saye Khoo, Marta Boffito, Cissy Kityo, Concepta Merry

“…The FDC should be taken without food by patients experiencing central nervous system toxicities.…”
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Computational analysis of Allium sativum compounds to identify thermolabile hemolysin inhibitors against Vibrio alginolyticus in shrimp by Sayed Mashequl Bari, Nafees Bin Reza, Meamaching Marma, Sk. Foisal Ahmed, Md Arif Hussain, Md Naimuddin Jabed, Md Alomgir Hossain, Maria Manzoor, Md Saiful Alam

“…Pharmacokinetic and toxicity analyses showed favorable drug-like properties for gibberellin A7 and gibberellic acid with no violations. …”
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