Microplastic pollution of the Zrafshan river tributary in Samarkand and Navoi regions of the Republic of Uzbekistan by Alijon Khusanov, Ozodbek Sabirov, Yulia Frank, Danil Vorobev, Egor Vorobev, Svetlana Rakhmatullina, Sherzodbek Tashbaev, Sarvinoz Mamatkarimova, Abdumukhtar Yakhyoyev, Mukhammadyusuf Juraev, Ilyas Isakov, Dilyor Karimjonov, Islomjon Zokirov, Ikrom Abdullaev

“…Microplastics pose a serious threat to aquatic ecosystems due to their ubiquity and ability to accumulate toxic substances. In the Central Asian context, the problem of microplastics remains poorly understood, complicating the development of mitigation strategies. …”
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A detoxified TLR4 agonist inhibits tumour growth and lung metastasis of osteosarcoma by promoting CD8+ cytotoxic lymphocyte infiltration by Ryunosuke Oyama, Akira Nabeshima, Makoto Endo, Alexey Novikov, Toshifumi Fujiwara, Capucine Phelip, Nobuhiko Yokoyama, Yoshinao Oda, Martine Caroff, Yoshihiro Matsumoto, Jerome Kerzerho, Yasuharu Nakashima

“…Systemic immune activation by Toll-like receptor 4 (TLR4) immunostimulants has shown great promise; however, current TLR4 agonists’ toxicity hinders this systemic approach in patients with osteosarcoma. …”
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Luffa–Ni/Al layered double hydroxide bio-nanocomposite for efficient ibuprofen removal from aqueous solution: Kinetic, equilibrium, thermodynamic studies and GEP modeling by Soheil Tavassoli, Afsaneh Mollahosseini, Saeed Damiri, Mehrshad Samadi

“…Luffa is a robust, renewable biomaterial known for its low mass, high specific strength, and non-toxicity, making it ideal for composite development. …”
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<i>In Vitro</i> and <i>In Vivo</i> Evaluation of the Antischistosomal Activity of Polygodial and 9-Deoxymuzigadial Isolated from <i>Drimys brasiliensis</i> Branches by Eric Umehara, Rayssa A. Cajas, Gabriel B. Conceição, Guilherme M. Antar, Adriano D. Andricopulo, Josué de Moraes, João Henrique G. Lago

“…Cytotoxicity assays against Vero cells revealed no toxicity for either compound (CC₅₀ > 200 μM). …”
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Assessing carbon emissions of facility agriculture involving photovoltaic greenhouses – insights from table grapes cultivation by Yichun Li, Shuyue Li, Yaru Luo, Xuecai Wang, Hengcheng Zhang, Yuquan W. Zhang, Shiren Song

“…Moreover, improved greenhouse utilizing photovoltaic power (1.26 × 103kgCO2-eq/mu-year) exhibits higher carbon emissions, however with lower levels of environmental toxicity due to utilizing grapevines for organic fertilizers. …”
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Biochemical Constituents of Phaleria macrocarpa (Leaf) Methanolic Extract Inhibit ROS Production in SH-SY5Y Cells Model by Ibrahim Maina Hassan, Wan Norhamidah Wan Ibrahim, Ferdaus Binti Mohamat Yusuf, Siti Aqlima Ahmad, Syahida Ahmad

“…High antioxidant activities and low toxicity effect of this crude revealed its high benefit to be used as natural medicine/supplements.…”
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Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women by Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, Sophie Besser, Daria Geilen, Tim Kaden, Tim Kaden, Anne-Katrin Bothe, Diana Maria Morales-Prieto, Behnam Amiri, Behnam Amiri, Stephan Schaller, Ligaya Kaufmann, Martin Raasch, Ramy M. Ammar, Ramy M. Ammar, Christian Maass, Christian Maass

“…Long-term exposure simulations confirmed the value of this integrated system for predicting the non-toxic metabolization of prednisone.ConclusionThis approach may provide a potential non-animal alternative that could contribute to our understanding of drug behavior during pregnancy and may support early-stage drug safety assessment for vulnerable populations.…”
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In vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species by M. Karkhane Yousefi, M. Seyed Hashtroudi, A. Mashinchian Moradi, A.R. Ghasempour

“…The results showed that fucoxanthin extract from Dictyota. indica at 24-hour treatment and 50 µg/ml concentration has the most effective anticancer activity on the breast cancer cells line, without toxic effects to the normal cells. According to the obtained results, it seems that Dictyota. …”
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Pharmacophore-based approach for the identification of prospective UDP-2,3-diacylglucosamine hydrolase (LpxH) inhibitor from natural product database against Salmonella Typhi by Divyapriya Karthikeyan, Sanjit Kumar, NS Jayaprakash

“…Both compounds underwent toxicity prediction and ADMET analysis, showing favorable drug-like properties, with compound 1615 emerging as the most promising inhibitor due to its optimal electronic energy and minimal chemical potential. …”
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Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair by Penghui Wang, Zaifeng Chen, Ping Li, Abdullah Al Mamun, Shaoxia Ning, Jinjing Zhang, Chonghui Tang, Tianmiao Sun, Jian Xiao, Xiaojie Wei, Fenzan Wu

“…Our results demonstrate that encapsulating Que in LipTC (QLipTC) enhances solubility, minimizes toxic side effects, facilitates lesion targeting, and aids in crossing the blood-spinal cord barrier. …”
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Safety assessment of a novel marine multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 according to phenotype and whole genome-sequencing analysis by Xueyan Mo, Mengcheng Zhou, Yanmei Li, Lili Yu, Huashang Bai, Peihong Shen, Xing Zhou, Haojun Zhu, Huijie Sun, Ru Bu, Chengjian Jiang

“…Virulence enzymes, such as gelatinase, DNase, hemolytic, lecithinase, and thrombin were absent. Acute toxicity test with mice demonstrated that GXDK6 is safe. …”
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Bifunctional copper ion/melittin incorporated hydrogel with antimicrobial and antioxidant capabilities for infected skin wound healing by Jun Yao, Xiao Li, Minjie Lin, Zhuoqi Han, Xiaonan Wang, Jingjing Guo, Bing Wu, Jiajie Xia

“…The optimised hydrogel not only reduces MEL toxicity but also amplifies its antibacterial and anti-inflammatory effects. …”
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Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid by Elizabeth Henao, Ezequiel Delgado, Héctor Contreras, Germán Quintana

“…Those materials are commercially available, have low toxicity, and are widely used in the area. These compounds interact through physical crosslinks, which are affected by physical changes of the medium. …”
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Determination of Pendimethalin Dynamic Residual Distribution in Crucian Carp Tissues and Associated Risk Assessment by Lu Qiao, Na Yuan, Gang Han, Bo Cheng, Defu Zhang, Jinlong Song, Yingchun Mu

“…Pendimethalin has been considered a moderately to extremely toxic compound for fish and aquatic organism. This study developed the determination of dynamic residual distribution for pendimethalin in crucian carp tissues (muscle, liver, kidney, gill, and blood) under semistatic exposure system by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method. …”
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Transcriptome response in a marine copepod under multigenerational exposure to ocean warming and Ni at an environmentally realistic concentration by Yunlei Zhang, Shiru Lin, Yaolu Niu, Xiaoping Zhou, Qingxian Lin

“…Overall, this study indicates that both ocean warming and Ni pollution adversely affect the marine copepod T. japonicus from multigenerational transcriptome analysis, especially warming increased Ni toxicity to marine copepods, and our results also provide references to the mechanism concerning the effects of Ni and warming on marine copepods.…”
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Linking Endotoxins, African Dust PM10 and Asthma in an Urban and Rural Environment of Puerto Rico by Mario G. Ortiz-Martínez, Rosa I. Rodríguez-Cotto, Mónica A. Ortiz-Rivera, Cedric W. Pluguez-Turull, Braulio D. Jiménez-Vélez

“…Urban extracts were highly toxic, proinflammatory (IL-6/IL-8 secretion), and induced higher TLR4 expression and NF-κB activation compared to rural extracts. …”
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Anti-cancer and antimicrobial efficacy of ZnO nanoparticles synthesized via green route using Amaranthus dubius (Spleen Amaranth) leaves extract by Faaiza Naaz K, Alavya Tiwari, Aabid Hussain Shaik, Indumathi P, Brianna Brianna, Ayaz Anwar, Mohammed Rehaan Chandan

“…The results demonstrated that ZnO nanoparticles were non-toxic to the normal cell line. At a concentration of 7.82 μg/mL, there was a 15.4% decrease in cell viability relative to the control in HCT116 cell lines, indicating cytotoxicity. …”
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Customizing the optical, electronic and transport attributes of lead-free hybrid FASnBr3 perovskites triggered by spin-orbit coupling and strains by Nusrat Jahan, Farah B.H. Pritu, Md Rasidul Islam, Budrun Neher, M Mahbubur Rahman, Farid Ahmed

“…However, the commonly studied MAPbI3 and FAPbI3 are toxic and less stable, prompting the necessity for safer replacements. …”
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Spireoside Controls Blast Disease by Disrupting Membrane Integrity of Magnaporthe oryzae by Xu Liting, He Kaiwei, Guo Chunyu, Quan Cantao, Ma Yahuan, Zhang Wei, Ren Lifen, Wang Long, Song Li, Ouyang Qing, Yin Junjie, Zhu Xiaobo, Tang Yongyan, He Min, Chen Xuewei, Li Weitao

“…Plant secondary metabolites typically exhibit broad-spectrum antifungal activity without selective toxicity against pathogens. However, only a small fraction of antifungal metabolites have been identified from the tens of thousands of known plant secondary metabolites. …”
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Status Epilepticus due to Intraperitoneal Injection of Vehicle Containing Propylene Glycol in Sprague Dawley Rats by Evon S. Ereifej, Seth M. Meade, Cara S. Smith, Keying Chen, Nanette Kleinman, Jeffrey R. Capadona

“…These findings are consistent with oral and intravenous administration of propylene glycol toxicity as previously reported in other species, including humans. …”
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