A novel two-component system contributing the catabolism of c-di-GMP influences virulence in Aeromonas veronii by Chaolun Liu, Jia Shao, Xiang Ma, Yanqiong Tang, Juanjuan Li, Hong Li, Xue Chi, Zhu Liu

“…In a murine model, ΔarrS exhibited increased pathogenicity, leading to elevated TNF-α and IFN-γ levels in serum, and severer toxicity to spleen and kidney. These effects might be elucidated by the upregulated inflammation-associated proteins in ΔarrS. …”
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Nanoliposomal Coencapsulation of Dorema aucheri Extract and Curcumin; Enhanced Cytotoxicity, Apoptosis Induction, and Inhibition of EGFR Gene Expression in Oral Cancer Cells OCC-02 by Mahshid Azizi, Ghasem Ghalamfarsa, Fatemeh Khosravani, Hassan Bardania, Shahriar Azizi

“…Free curcumin, the extract, and the curcumin-extract combination showed dose-dependent toxicity against cancer cells; yet, the extract (IC50: 86 µg/ml) and curcumin-extract (IC50: 65 µg/ml) activities were much more than curcumin (IC50: 121 µg/ml). …”
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Effects of Metalloporphyrins on Heme Oxygenase-1 Transcription: Correlative Cell Culture Assays Guide in Vivo Imaging by Monica Hajdena-Dawson, Weisheng Zhang, Pamela R. Contag, Ronald J. Wong, Hendrik J. Vreman, David K. Stevenson, Christopher H. Contag

“…Furthermore, serum enzyme assays indicated that neither caused detectable liver toxicity. These findings, and especially those with ZnBG, support the use of selected Mps as therapies for pathologic jaundice. …”
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Automatic tool for the reconciliation of serious adverse events for pharmacovigilance: design and implementation of Reconciliaid by Sara Contu, Renaud Schiappa, Yann Chateau, Emmanuel Chamorey

“…Background: Reporting serious adverse events (SAEs) is crucial to reduce or avoid toxicities that can lead to major consequences for patient’s health due to treatments tested in clinical trials. …”
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Methicillin-Resistant Staphylococcus aureus: Docking-Based Virtual Screening and Molecular Dynamics Simulations to Identify Potential Penicillin-Binding Protein 2a Inhibitors from... by Motahareh Masumi, Fatemeh Noormohammadi, Fatemeh Kianisaba, Fatemeh Nouri, Mohammad Taheri, Amir Taherkhani

“…Staphylococcus aureus (S. aureus) is responsible for several disorders including skin and soft tissue infections, bacteremia, pulmonary infections, septic arthritis, osteomyelitis, meningitis, gastroenteritis, toxic-shock syndrome, and urinary tract infections. …”
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Canagliflozin alleviates acetaminophen-induced renal and hepatic injury in mice by modulating the p-GSK3β/Fyn-kinase/Nrf-2 and p-AMPK-α/STAT-3/SOCS-3 pathways by Abeer Bishr, Bassant M. El-Mokadem, Asmaa A. Gomaa

“…Aim: Our study assessed the novel effect of Cana against APAP-induced toxicities. Main methods: mice were randomized into five groups: negative control, Cana25, APAP, Cana10 + APAP, and Cana25 + APAP. …”
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Hypolipidemic Effect of Chloroform Extract of Lagenaria siceraria: Potential Inhibitory Activity of Phytochemicals Targeting the HMG-CoA Reductase Revealed by Molecular Docking and... by Qudsia Kanwal, Mahmood Ahmed, Atiq Ur-Rehman, Aneela Anwar, Samiah Shahid, Atif Shahzad, Attaullah Shah Bukhari, Muhammad Ahmad, Numan Yousaf, Muhammad Muddassar

“…The experimental animals did not display any acute toxicity. Atorvastatin (10 mg/kg bw) was used as a standard drug. …”
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Postharvest Handling Practices and Perception of Potato Safety among Potato Traders in Nairobi, Kenya by Consolata Nolega Musita, Michael Wandayi Okoth, George Ooko Abong’

“…Exposure of the potato to unfavorable conditions such as light, extreme temperatures, and bruising can result in accumulation of glycoalkaloids, which are toxic substances. This study was a cross-sectional survey which aimed to investigate the postharvest handling practices of potatoes and perception of potato safety among open air market traders in Nairobi County, Kenya. …”
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Quantitative Analysis of Heavy Metals and Organic Compounds in Soil from Deir Kanoun Ras El Ain Dump, Lebanon by Jamilah Borjac, Manal El Joumaa, Lobna Youssef, Rawan Kawach, Diane A. Blake

“…The aim of this study was to determine the levels of some toxic heavy metals and organic compounds in different soil samples collected from the dump and along the canal during winter and summer seasons. …”
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siRNA therapeutics for effective management of rheumatoid arthritis by Vishakha R. Chakole, Tathagata Dutta, Priyankar Sen

“…All these disadvantages engender the need for new therapy. siRNA delivery carriers like liposomes, polymeric nanoparticles, and siRNA polymer bio-conjugates are proving to be particularly effective with less toxicity compared to the traditional treatments. A promising addition to these carriers is wrapsome (WS), which can be used as a favorable carrier for delivery of siRNA to its specific sites, such as inflamed joints or the inflamed synovium. …”
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Selective mPGES-1 Inhibitor Ameliorated Adjuvant-Induced Arthritis in the Rat Model by Min Ji Kim, Hwi-Ho Lee, Choi Kim, Ja Yeon Lee, Kyung-Sook Chung, Kyung-Tae Lee, Jae Yeol Lee

“…MPO-0144 attenuated the inflammatory responses without severe gastrointestinal side effects and organ toxicities. These overall data suggest a possibility that MPO-0144 downregulates PGE2 production by potent mPGES-1 and weak COX-2 inhibitory activities, thus attenuating the paw swelling in AIA (adjuvant-induced arthritis) rat models. …”
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The Importance of Natural Indigo Dye and Its Revitalization and Ethiopian Potential for Indigo Growing by Abera Kechi Kabish, Molla Tadesse Abate, Zelalem Adane Alemar, Solomon Girmay

“…The use of excessive and toxic synthetic dyes in textile and apparel manufacturing processes lineages environment pollution and health hazards to the surroundings where they are sited. …”
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Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats by Salah M. Aly, Hamdy A. Fetaih, Abeer A. I. Hassanin, Mosleh M. Abomughaid, Aliaa A. Ismail

“…The present findings proposed that these natural oils have the ability to improve liver function, significantly reduced the liver toxicity and HCC development. However, further sophisticated studies are recommended before their use as conventional therapeutics for HCC treatment.…”
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Formation of volatile compounds in salt-mediated naturally fermented cassava by Alberta N.A. Aryee, Christabel Tachie, Aleksei Kaleda

“…Fermentation has been used to improve shelf-life, functional properties, nutrient bioavailability, minimize toxic compounds, and alter aroma. In this study, the effect of added salt (5–25 %) on the pH, titratable acidity (TTA), and volatile compounds (VOCs) in cassava fermented was investigated. …”
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Association between Particulate Matter Pollution Concentration and Hospital Admissions for Hypertension in Ganzhou, China by Chenwei Li, Xinye Zhou, Kun Huang, Xiaokang Zhang, Yanfang Gao

“…Fine particulate matter (PM2.5) and respirable particulate matter (PM10) are two major air pollutants with toxic effects on the cardiovascular system. Hypertension, as a chronic noncommunicable cardiovascular disease, is also a risk factor for several diseases. …”
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Biochemical characterization of the human ubiquitous glucose‐6‐phosphatase in neutrophil granulocytes by Zsigmond Lédeczi, Klaudia Németh, Tamás Kardon

“…Recently, G6PC3 has been shown to play an important role in neutrophil granulocytes, eliminating the toxic metabolite 1,5‐anhydroglucitol‐6‐phosphate. …”
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Hereditary Tyrosinemia Type 1 in Jordan: A Retrospective Study by Noor A. Megdadi, Ahmad K. Almigdad, Mo’men O. Alakil, Shahrazad M. Alqiam, Sumaia G. Rababah, Moshera A. Dwiari

“…The accumulation of tyrosine toxic metabolites leads to progressive hepatic, renal, and neurological manifestations. …”
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Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents by null Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al Harrasi, Renu Saharan, Geeta Aggarwal, Suresh Kumar, Renu Sehrawat, Chanchal Rani

“…The future of hypertension management using LBDDS is promising, with ongoing reviews focusing on precision medicine approaches, improved biocompatibility, and reduced toxicity. As we delve deeper into understanding the intricate mechanisms underlying hypertension, LBDDS offers a pathway to develop next-generation antihypertensive therapies that are safer, more effective, and tailored to individual patient needs.…”
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PD-1 Blockade in Advanced Melanoma in Patients with Hepatitis C and/or HIV by Diwakar Davar, Melissa Wilson, Chelsea Pruckner, John M. Kirkwood

“…In both patients, no significant toxicities were observed when pembrolizumab was initiated. …”
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Effect of Short-Term Stress and Interaction of Salinity and Ammonia-N Levels, Associated With Food Deprivation on Fatty Acid Profile and Body Composition in Nile Tilapia (Oreochrom... by Eisa Ebrahimi, Javad Motamedi-Tehrani, Rahim Peyghan

“…High levels of nitrogen compounds can lead to acute toxicity in aquatic organisms. Ammonia, a by-product of protein breakdown, is the most prevalent contaminant in freshwater environments. …”
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