Interesting Cytokine Profile Caused by Clinical Strains of Pseudomonas aeruginosa MDR Carrying the exoU Gene by Nallely S. Badillo-Larios, Edgar Alejandro Turrubiartes-Martínez, Esther Layseca-Espinosa, Roberto González-Amaro, Luis Fernando Pérez-González, Perla Niño-Moreno

“…In addition, PBMC exposed to strains of four different categories according to their resistance and toxicity showed a differential pattern of cytokine expression, a decrease in IL-10, IL-6, and IL-8, and an over-secretion of IL-1b. …”
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Immunotherapies to Nano-Immunotherapies: Advances in Immune Targeting in Bladder Cancer by Beatriz Ramos, Dakota Rogers

“…However, challenges such as toxic side-effects, variable response rates and the need for predictive biomarkers persists. …”
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Major Outer Membrane Protein from Legionella pneumophila Inhibits Phagocytosis but Enhances Chemotaxis of RAW 264.7 Macrophages by Regulating the FOXO1/Coronin-1 Axis by Zehui Yang, Yingying Chen, Qiang Zhang, Xiaodong Chen, Ze Deng

“…The chemotactic activity, toxicity, and phagocytosis of RAW 264.7 cocultured with different concentrations of MOMP were determined by Transwell, CCK-8, and neutral red uptake assays, respectively. …”
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Prevalence of Hypertension in Area I Cienfuegos Municipality. Second Measurement of CARMEN Initiative by Hilda María Delgado Acosta, Karelis Lastre Navarro, María Lina Valdés Gómez, Mikhail Benet Rodríguez, Alain Francisco Morejón Giraldoni, Juan Rafael Zerquera Rodríguez

“…<strong>Background:</strong> the prevalence of hypertension has increased, associated to inadequate alimentary patterns, decrease of physical activity, and other behaviour patterns related to toxic habits. <strong><br />Objective:</strong> characterizing the prevalence of hypertension in the Area I Cienfuegos in 2010 - 2011. …”
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Optimization of Conditions for Production of Soluble <i>E. coli</i> Poly(A)-Polymerase for Biotechnological Applications by Igor P. Oscorbin, Maria S. Kunova, Maxim L. Filipenko

“…However, <i>E. coli</i> PAP 1’s toxicity and instability in low-salt buffers complicate its expression and purification. …”
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Spectroscopic, DFT, anti-bacterial, and in-silico investigations of novel semicarbazone and thiosemicarbazone synthesised from asymmetrical chalcones by Nikita Sharma, Har Lal Singh

“…Later, computational tools were utilised for evaluating pharmacological attributes such as bioavailability score, Lipinski rule, absorption, distribution, metabolism, excretion and toxicity. Also, density functional theory (DFT) was used to compute quantum computations such as HOMO, LUMO, and chemical descriptors. …”
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Sirolimus Enhances Cyclosporine A-Induced Cytotoxicity in Human Renal Glomerular Mesangial Cells by Séin O'Connell, Craig Slattery, Michael P. Ryan, Tara McMorrow

“…CsA treatment increased profibrotic TGF-β1 secretion in human mesangial cells whereas SRL did not, indicating a role for TGF-β in CsA toxicity. However we observed a synergistic nephrotoxic effect when CsA and SRL were co-administered. …”
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Advancing Neuroscience and Therapy: Insights into Genetic and Non-Genetic Neuromodulation Approaches by Weijia Zhi, Ying Li, Lifeng Wang, Xiangjun Hu

“…The transformative potential of these neuromodulation techniques in neuroscience research and clinical practice is underscored, emphasizing the need for integration and innovation in technologies, the optimization of delivery methods, the improvement of mediums, and the evaluation of toxicity to fully harness their therapeutic potential.…”
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Giant triple negative pregnancy-associated breast cancer (PABC) in a young woman: From diagnosis to therapy step by step: A case report by Micol Bottalico, Cristiana Boldrini

“…Imaging techniques such as ultrasonography (and mammography as an adjunct) and nonenhanced MRI (due to potential toxicity of gadolinium to the fetus) can be used for staging maternal breast disease during pregnancy. …”
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Mini review of spatially fractionated radiation therapy for cancer management by Shrikant B. Mali

“…Spatially fractionated radiation therapy (SFRT) is a non-uniform dose distribution technique that has shown high rates of clinical response with minimal toxicities in large-volume primary or metastatic malignancies. …”
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Evaluation of aluminum tolerance diversity in <i>Avena sativa</i> L. from the VIR collection by I. G. Loskutov, E. V. Blinova, L. Yu. Novikova

“…Despite the crop’s high environmental plasticity, an important condition for obtaining sustainable oat yields is the development of new cultivars with resistance to adverse environmental factors, including metal toxicity and high soil acidity.The objective of this work was to search for oat cultivars resistant to soil stressors (excess of Н+ and Al3+) for use in breeding for edaphic resistance.Materials and methods. …”
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Comparative Study of Heavy Metal Concentration in Eggs Originating from Industrial Poultry Farms and Free-Range Hens in Kosovo by H. Aliu, S. Dizman, A. Sinani, G. Hodolli

“…Therefore, egg consumption does not exceed the safety levels of toxic metals and does not pose any risk to human health.…”
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Prevalence and Risk Factors of Medication Errors in Enteral Tube Feeding Among ICU Patients: A Comprehensive Cross-Sectional Analysis by Mansooreh Asghari-Varzaneh, Shirinsadat Badri, Shadi Farsaei

“…Some errors during drug gavage can lead to feeding tube blockage, reduced drug effectiveness, or drug toxicity. This study aimed to assess medication errors (MEs) in ICU patients using enteral feeding tubes and identify factors that affect ME incidents. …”
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Petroleum Hydrocarbons Contamination Profile of Ochani Stream in Ejamah Ebubu, Eleme Local Government Area of Rivers State, Nigeria by Akuro Adoki

“…At an estimated average depth of 150mm over an area of 6.05 Ha the total volume of contaminated soil/sediment was 9075m3. The levels of toxic species such as heavy metals, PAH and BTEX compounds were found to be very low and they do not pose a significant environmental hazard. …”
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Fipronil in sub-lethal doses leads to immuno-toxicological effects in broiler birds. by Shafia Tehseen Gul, Muhammad Zergham Tahir, Latif Ahmad, Aisha Khatoon, Muhammad Kashif Saleemi, Farid Shokry Ataya, Riaz Hussain, Bakhtawar Maqbool, Dalia Fouad, Ahrar Khan

“…Results also revealed that the bursa of Fabricius thymus and spleen were also affected due to the toxic effect of fipronil, even at sub-lethal doses.…”
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Biomarkers in Nasopharyngeal Carcinoma (NPC): Clinical relevance and prognostic potential by Madhan Krishnan, Shyamaladevi Babu

“…Clinically, the application of these biomarkers has the potential to transform NPC management, enabling more precise interventions and improving survival rates while minimizing treatment-related toxicity. The integration of these biomarkers into routine clinical practice could facilitate early diagnosis, predict therapeutic responses, and identify patients at higher risk of recurrence. …”
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Genome-wide identification of the ATP-dependent zinc metalloprotease (FtsH) in Triticeae species reveals that TaFtsH-1 regulates cadmium tolerance in Triticum aestivum. by Yuxi Huang, Lifan Cao, Tanxing Chen, Xiaoqiang Chang, Yumei Fang, Liuliu Wu

“…Barley stripe mosaic virus-induced gene silencing (BSMV-VIGS) technology confirmed the function of TaFtsH-1, indicating that silencing TaFtsH-1 enhances common wheat's resistance to cadmium (Cd) toxicity. In summary, this study offers an in-depth understanding of the FtsH gene family in wheat, establishing a solid basis for comprehending its functions, genetic mechanisms, and improving wheat's tolerance to heavy metal contamination.…”
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Cytotoxicity Evaluation of Different Types of CAD/CAM Blocks by Fikret Özgür Coşkun, Semanur Özüdoğru, Mustafa Hayati Atala, Giray Buğra Akbaba

“…It has been shown that all blocks whose cytotoxic effects were investigated did not cause any toxic effects (except VM and LU for 24 h) at different application times (24 h and 48 h). …”
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ON THE ISSUE OF ASSESSING THE ECOLOGICAL STATE OF VARIOUS WATERCOURCES IN THE CONDITIONS OF ANTHROPOGENIC PRESSURE by Elena A. Shashulovskaya, Svetlana A. Mosiyash, Olga V. Shashulovskaya, Irina G. Filimonova, Liliya V. Grishina, Elena G. Kuzina

“…Hydro/chemical studies included indicators of oxygen regime, salt composition, organic matter, biogenic and toxic elements. The calculated SCWPI fluctuated in the range of 3,0–5,4, which corresponds to the quality category “very polluted” - “dirty”. …”

The impact of climate change on the natural dendroflora of the greater caucasus by Baghirova Samira

“…The soil layer of the Kapychay site 0-30 cm was found to have low organic matter (humus) content, and the magnesium level in water samples from the Lakit River was toxic. The data obtained during the study of climatic and anthropogenic impacts on the vegetation cover of the region can contribute to the development of measures aimed at developing scientific research and expanding environmental protection measures to preserve biodiversity in the future.…”
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