Malathion-Induced Hematoxicity and Its Recovery Pattern in Barbonymus gonionotus by Cynthia E. Mrong, Md. R. Islam, Kamrunnaher Kole, Nusrat N. Neepa, Md. J. Alam, Md. R. Haque, Umme O. Rahman, Golam M. Mostakim

“…The study thus confirms that hematology is a sensitive indicator for fish to detect toxicity caused by different chemicals. Changes in these parameters can provide useful information about environmental conditions and risk assessment of aquatic organisms.…”
Get full text

Supplementation with Branched-Chain Amino Acids Induces Unexpected Deleterious Effects on Astrocyte Survival and Intracellular Metabolism with or without Hyperammonemia: A Prelimin... by Ting Wang, Kazuyuki Suzuki, Toshimi Chiba, Keisuke Kakisaka, Yasuhiro Takikawa

“…Branched-chain amino acids (BCAA) have been reported to improve the symptoms of HE induced by hyperammonemia; however, we recently reported that ammonia increases intracellular levels of BCAA and exerts toxic effects on astrocytes. Objectives. This follow-up study was designed to confirm the direct effects of BCAA on human astrocytes and clarify their underlying mechanisms using metabolome analysis and evaluation of associated signaling. …”
Get full text

Chemical Characterization and Biological Activities of Essential Oil Obtained from Mint Timija Cultivated under Mineral and Biological Fertilizers by Ayoub Kasrati, Chaima Alaoui Jamali, Robert Spooner-Hart, Laurent Legendre, David Leach, Abdelaziz Abbad

“…Both treatments enhanced the antioxidant activity of the investigated EOs in all assays (IC50 ranged from 2.34 ± 0.03 mg/mL to 6.82 ± 0.25 mg/mL), while no significant difference in the toxicities of these oils against Tribolium confusum du Val. has been observed. …”
Get full text

24-epibrassinolide regulates oxytetracycline-induced phytotoxicity and its detoxification mechanism by Suya Chen, Shanshan Zhou, Xuan Xuan, Lili Niu, Lu Zhao, Jingjie Guo, Dongmei Xu

“…Conversely, 24-epibrassinolide (EBL), a plant growth hormone, mitigates the toxic effects of various pollutants on plants. However, the mechanism by which exogenous EBL affects the growth of rape seedlings exposed to OTC remains largely unknown. …”
Get full text

A Combined Computational and Experimental Study on Nanoparticle Transport and Partitioning in the Human Trachea and Upper Bronchial Airways by Jiawei Ma, Wei-Chung Su, Yi Chen, Yidan Shang, Jingliang Dong, Jiyuan Tu, Lin Tian

“…Abstract In the past few decades, the transport and deposition of aerosol in the human respiratory tract has been a crucial area of research, resulting in the identification of the toxicity pathways of inhaled pollutants and facilitating the design of efficient drug delivery systems for targeted treatment. …”
Get full text

Safety assessment of preventive pressurized intraperitoneal aerosol chemotherapy in combined treatment of gastric cancer: preliminary results by N. Ya. Muratova, I.  V. Kolobaev, D.  D. Kudryavtsev, E. I. Smolenov, A. B. Ryabov, V. M. Khomyakov, L. O. Petrov, S. A. Ivanov, A. D. Kaprin

“…The safety assessment was carried out according to the classification of surgical complications according to Clavien-D indo and the international scale for toxicity scaling NCI–CTCAE v5.0.Results. Postoperative complications were diagnosed in 25 %, >III grade complications were revealed in 11 % of cases according to the Clavien-D indo classification. …”
Get full text

Optic Chiasmitis as an Isolated Manifestation of Myelin Oligodendrocyte Glycoprotein-Associated Disease – a Case Report by Nina Barankiewicz-Tyc, Karolina Kania, Wojciech Kozubski

“…Rare, non-compressive causes of chiasmopathy include, among others, infectious, post-infectious, inflammatory, autoimmune, demyelinating, toxic and ischaemic processes. Chiasmopathy can also occur due to trauma and radiation treatment. …”
Get full text

Low-Dose Amphotericin B and Murine Dialyzable Spleen Extracts Protect against Systemic Candida Infection in Mice by F. Robledo-Ávila, M. Pérez-Tapia, A. Limón-Flores, L. Pavon, R. Hernández-Pando, I. Wong-Baeza, G. González-González, C. Tovar, S. Estrada-Parra, I. Estrada-García

“…Low-dose AmB and mDSE synergized to clear the infectious agent and reduced tissue damage, confirming the efficacy of a low dose of AmB, which might decrease the risk of drug toxicity. Further studies are necessary to explore these findings and its implications in future therapeutic approaches.…”
Get full text

Life cycle assessment of heat, CO2 from composting for greenhouse applications by Jiamin Wang, BiChen Tian, Rui Li, Jianming Li

“…Sensitivity analysis revealed that the system is most sensitive to freshwater ecotoxicity, toxicity equivalent, and marine ecotoxicity. The impact of AW processing is minimal, contributing only 1.09 % of the total impact. …”
Get full text

Risk Factors Related to Low Birth Weight in Cienfuegos Municipality by Juan Rafael Zerquera Rodriguez, Yusimi Cabada Martínez, Delia Zerquera Rodríguez, Hilda María María Delgado Acosta

“…In addition to the socio-demographic characteristics, the nutritional state, numbers of pregnancies, heavy profit during pregnancy, age, toxic habits and diseases correlated to pregnancy were analyzed.…”
Get full text

Protective Effect of Aqueous Crude Extract of Neem (Azadirachta indica) Leaves on Plasmodium berghei-Induced Renal Damage in Mice by Voravuth Somsak, Sukanya Chachiyo, Ubonwan Jaihan, Somrudee Nakinchat

“…However, the oral administration of neem leaf extract to PbANKA infected mice for 4 days brought back BUN and creatinine levels to near normalcy, and the highest activity was observed at doses of 1,000 and 2,000 mg/kg. Additionally, no toxic effects were found in normal mice treated with this extract. …”
Get full text

Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells by Mara C. Inniss, Sean G. Smith, Dan Jun Li, Benjamin Primack, Dexue Sun, Grace Y. Olinger, Kerri-Lynn Sheahan, Theresa Ross, Meghan Langley, Violet Young, Andres Alvarado, Shabnam Davoodi, Jiefei Geng, Michael Schebesta, Michelle L. Ols, Jeremy Tchaicha, Jan ter Meulen, Dhruv K. Sethi

“…ACT efficacy may be enhanced with pleiotropic cytokines that remodel the TME; however, their expression needs to be tightly controlled to avoid systemic toxicities. Here we show T cells can be armored with membrane-bound cytokines with surface expression regulated using drug-responsive domains (DRDs) developed from the 260-amino acid protein human carbonic anhydrase 2 (CA2). …”
Get full text

Methimazole disrupted skeletal ossification and muscle fiber transition in Bufo gargarizans larvae by Fei Wei, Xueyi Wu, Hongyuan Wang, Yongpu Zhang, Lei Xie

“…Future studies should address the toxicity of EDCs to wildlife and inform aquatic ecosystem conservation strategies.…”
Get full text

Impact of Zootechnical Additive of the Nitrooxypropanol to Minimize Methane Emission in Cattle: A Review by Ghasaq Sami Mshary, Cristina Castillo, Joaquin Hernandez, Rodrigo Muiño

“…Designed and produced around 2012, 3-Nitrooxypropanol is a synthetic, non-toxic chemical molecule that inhibits the CH4 pathway. …”
Get full text

Inhibitory effects of cadmium and hydrophilic cadmium telluride quantum dots on the white rot fungus Phanerochaete velutina by Florian Part, Christian Zafiu, Eva-Kathrin Ehmoser, Mika A. Kähkönen

“…The different EC50 values indicate that the nanoparticle coatings have a strong influence on the inhibitory effects, as the organic ligands used for surface passivation prevented the leaching of acute toxic Cd ions from the metallic QD core. Compared to CdCl2, the CdTe QDs were less inhibitory to the formation of fungal metabolites and their decolorization ability on co-exposed textile dyes. …”
Get full text

Photo-Fenton and Fenton Oxidation of Recalcitrant Industrial Wastewater Using Nanoscale Zero-Valent Iron by Henrik Hansson, Fabio Kaczala, Marcia Marques, William Hogland

“…Future investigations should focus on optimizing treatment processes and assessing toxic effects that residual pollutants and the nZVI might have. …”
Get full text

Oxide-Based Nanocomposites for Food Packaging Application: A Review by Aisha Idris Ali, Munir Abba Dandago, Fatima Idris Ali, Genitha Immanuel, Jishnu Naskar

“…Nanoparticles migration from packaging, on the other hand, is a source of concern due to their potential toxicity in the human body and the environment. The purpose of this article therefore, was to review the available literature on the utilization of metal oxide-based nanoparticles to produce nanocomposites for food packaging application. …”
Get full text

Intravitreal Melphalan for Vitreous Seeds: Initial Experience in China by Xunda Ji, Peiyan Hua, Jing Li, Jiakai Li, Junyang Zhao, Peiquan Zhao

“…Intravitreal melphalan achieved a high local control rate for vitreous seeds without extraocular extension and with acceptable toxicity in Chinese retinoblastoma patients.…”
Get full text

Bi-targeting of thioredoxin 1 and telomerase by thiotert promotes cell death of myelodysplastic syndromes and lymphoma by Qiangan Jing, Yunyi Wu, Yanchun Li, Chaoting Zhou, Junyu Zhang, Jun Xia, Keyi Li, Yuhuan Shen, Hongfeng Yao, Xiangmin Tong, Jing Du, Lushan Yu, Ying Wang

“…Meanwhile, pharmacological administration of glutathione (GSH), N-acetylcysteine (NAC), and mitoquinone (MitoQ), or genetic overexpression of TRX1 or TERT in MDS and cells could dampen the toxicity caused by thiotert. Remarkably, the in vivo mouse model of MDS demonstrated that thiotert administration exhibited greater efficacy in tumor reduction compared to the conventional chemotherapy drug cytarabine. …”
Get full text

Long-term outcomes of LDR-brachytherapy for localized prostate cancer by Lauri Mäkelä, Anssi Pétas, Arto Mikkola, Harri Visapää

“…IntroductionThis retrospective study aims to evaluate the long-term efficacy and urinary toxicity of LDR-brachytherapy for localized prostate cancer.Materials and methods235 primary prostate cancer patients treated with LDR-brachytherapy and subsequently followed up in our center were included in this study. …”
Get full text