Exclusive Cutaneous and Subcutaneous Sarcoidal Granulomatous Inflammation due to Immune Checkpoint Inhibitors: Report of Two Cases with Unusual Manifestations and Review of the Lit... by Narciss Mobini, Rummit Dhillon, Jason Dickey, Jordan Spoon, Kaviyon Sadrolashrafi

“…This enhanced immune response can induce autoimmune adverse effects in many organs. Although skin toxicities are the most common, sarcoidal inflammation with exclusive cutaneous involvement is a rare occurrence with only 6 cases reported to date. …”
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Evolution of Alzheimer’s Disease Therapeutics: From Conventional Drugs to Medicinal Plants, Immunotherapy, Microbiotherapy and Nanotherapy by Emma Ortiz-Islas, Pedro Montes, Citlali Ekaterina Rodríguez-Pérez, Elizabeth Ruiz-Sánchez, Talía Sánchez-Barbosa, Diego Pichardo-Rojas, Cecilia Zavala-Tecuapetla, Karla Carvajal-Aguilera, Victoria Campos-Peña

“…Among the therapeutic alternatives, immunotherapy stands out, employing monoclonal antibodies to specifically target and eliminate toxic proteins implicated in AD. Additionally, the use of medicinal plants is examined, as their synergistic effects among components may confer neuroprotective properties. …”
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Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer by Jiayi Zhang, Mingxuan Yao, Shiting Xia, Fancai Zeng, Qiuyu Liu

“…An overview of HIF-1-related drugs that are approved or in clinical trials is summarized, highlighting their potential capacity for targeting HIF-1 in cancer and cardiovascular toxicity related to cancer treatment. The review provides a comprehensive insight into HIF-1’s regulatory mechanism and paves the way for future research and therapeutic development.…”
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Effect of oxidizing agents on the treatment of a Colombian lead ore by alternative hydrometallurgical processes by Borda J., Salamanca I.D., Torres R.

“…The metallurgy of lead presents significant environmental and public health challenges due to its toxicity. This is why it has been necessary to develop hydrometallurgical processes as alternatives for obtaining metal with a more sustainable and environmentally safe approach. …”
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BETTER OUTCOME OF HIGH-DOSE CEFTAZIDIME IN HEMATO – ONCOLOGICAL PATIENTS WITH INFECTIONS CAUSED BY EXTENSIVELY DRUG-RESISTANT PSEUDOMONAS AERUGINOSA by Alzbeta Zavrelova, Jakub Radocha, Pavla Paterova, Pavel Zak, Benjamin Visek, Martin Sima

“…Conclusion: Ceftazidime in high doses is a very potent ATB for the treatment of XDR P. aeruginosa infections in neutropenic cancer with acceptable toxicity. …”
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Polystyrene microplastics disrupt adrenal steroid synthesis in male mice via mitochondrial dysfunction by Ying Xiong, Zhe Chen, Hanmin Xiang, Yi Liu, Yanlin Wang

“…The latter may represent a common mechanism underlying the multi-organ toxicity induced by PS-MPs in the body. Our findings would provide new insights for the development of more effective environmental protection measures and the reduction of plastic pollution.…”
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Ventilation and features of the lung environment dynamically alter modeled intrapulmonary aerosol exposure from inhaled electronic cigarettes by Liqiao Li, Haoxuan Chen, Yifang Zhu, Airi Harui, Michael D. Roth

“…Investigating how e-cig aerosols behave when inhaled into the dynamic environment of the lung is important for understanding vaping-related exposure and toxicity. A ventilated artificial lung model was developed to replicate the ventilatory and environmental features of the human lung and study their impact on the characteristics of inhaled e-cig aerosols from simulated vaping scenarios. …”
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Preconditioning by Hydrogen Peroxide Enhances Multiple Properties of Human Decidua Basalis Mesenchymal Stem/Multipotent Stromal Cells by T. Khatlani, D. Algudiri, R. Alenzi, A. M. Al Subayyil, F. M. Abomaray, E. Bahattab, A. S. AlAskar, B. Kalionis, M. F. El-Muzaini, M. H. Abumaree

“…These data show that DBMSCs resist a toxic environment, which adds to their potential as a candidate stem cell type for treating various diseases in hostile environments.…”
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Euglycemic diabetic ketoacidosis associated metabolic encephalopathy caused by dapagliflozin: a rare case report by Lulu Chu, Zhenhua Xi, Runzhi Ma, Weiliang Shi, Guoshen Yu

“…The precise pathogenesis of encephalopathy in EuDKA remains poorly understood, potentially resulting from the toxic consequences of electrolyte disturbances, ketosis, and acidosis.Testing the level of ketones is essential for unconscious patients who are taking SGLT-2 inhibitors.…”
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Mechanisms of ubiquitin-independent proteasomal degradation and their roles in age-related neurodegenerative disease by Taylor R. Church, Seth S. Margolis, Seth S. Margolis

“…Neurodegenerative diseases are characterized by the progressive breakdown of neuronal structure and function and the pathological accumulation of misfolded protein aggregates and toxic protein oligomers. A major contributor to the deterioration of neuronal physiology is the disruption of protein catabolic pathways mediated by the proteasome, a large protease complex responsible for most cellular protein degradation. …”
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Selective adsorptive removal and separation of harmful anionic dyes using mesoporous magnesium oxide-chitosan composite by Mudita Nagpal, Nidhi Sharma, Ankit Mittal

“…Synthesized composite, MCC has been shown to be excellent for adsorption of toxic anionic dyes, like Congo red (CR) and Indigo carmine (IC). …”
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Use of Magnetic Nanoparticles as Targeted Therapy: Theranostic Approach to Treat and Diagnose Cancer by Arif Malik, Tariq Tahir Butt, Sara Zahid, Fatima Zahid, Sulayman Waquar, Mahmood Rasool, Mahmood Husain Qazi, Aamer Mahmood Qazi

“…In practice, magnetic nanoparticles- (MNPs-) based systems following the application of Fe3O4 bound antitumor drug have shown an enhanced therapeutic index in comparison with conventional chemotherapy ensuring the significant decline in nanosystems’ toxicity. A number of improved strategies employing nanoparticle engineering have been in practice for upgrading selectivity of metastatic cells and to have direct access to poorly manageable tumor regions. …”
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Fever, Haematuria, and Acute Graft Dysfunction in Renal Transplant Recipients Secondary to Adenovirus Infection: Two Case Reports by J. Ramírez, I. C. Bostock, A. Martin-Onraët, S. Calleja, A. Sánchez-Cedillo, L. A. Navarro-Vargas, A. L. Noriega-Salas, O. Martínez-Mijangos, N. O. Uribe-Uribe, M. Vilatoba, B. Gabilondo, L. E. Morales-Buenrostro, J. Alberú

“…The immunosuppression dose was reduced, and ribavirin treatment was started, for which the patient quickly developed toxicity. Antiviral treatment allowed for transient response; however, a relapse occurred. …”
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E. coli Meningitis Presenting in a Patient with Disseminated Strongyloides stercoralis by Juliana B. Gomez, Yvan Maque, Manuel A. Moquillaza, William E. Anicama

“…He underwent a laparotomy, which ended up in a total colectomy and partial proctectomy due to toxic megacolon. Three days later the patient died in the intensive care unit due to septic shock. …”
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Thiazolidinone Steroids Impregnated Polyurethane Foams as a Solid Phase Extractant for the Extraction and Preconcentration of Cadmium(II) from Industrial Wastewater by Mohammad S. Tawfiq Makki, R. Mohammady Abdel-Rahman, K. Ommar Alfooty, Mohammad S. El-Shahawi

“…The cyclic voltammetry of compound II showed two well defined irreversible redox couples and suggested its possible use as complexing agent in stripping voltammetric determination of trace concentrations of toxic metal ions in wastewater.…”
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Water‐Soluble, Spin‐Cast‐Based Crystalline Poly(Methacrylic Acid) Film as a Reversible Li‐Ion Battery Anode by Minjin Son, Hyeongjun Kim, Minju Lee, Jonggeon Na, Sang Kyu Kwak, Seok Ju Kang

“…Nevertheless, challenges such as the use of toxic aprotic solvents and the irreversible consumption of Li ions during the initial cycle need to be addressed to improve their performance. …”
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The role of size in PEGylated liposomal doxorubicin biodistribution and anti‐tumour activity by Saba Dadpour, Amin Mehrabian, Mahdieh Arabsalmani, Elaheh Mirhadi, Anis Askarizadeh, Mohammad Mashreghi, Mahmoud Reza Jaafari

“…Abstract The size of nanoliposome‐encapsulated drugs significantly affects their therapeutic efficacy, biodistribution, targeting ability, and toxicity profile for the cancer treatment. In the present study, the biodistribution and anti‐tumoral activity of PEGylated liposomal Doxorubicin (PLD) formulations with different sizes were investigated. …”
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Impact of polyvinyl chloride nano-plastics on the biochemical status of Oreochromis niloticus under a predicted global warming scenario by Ahmed Mohamed Soliman, Ayman S. Mohamed, Amr A. Abdel-Khalek, Shereen R. Badran

“…The fish groups were subjected to three distinct temperatures (30, 32, and 34 °C) and subsequently separated into two groups: 0 and 10 mg/L of PVC-NPs, as it is expected that these temperatures may modify their chemical properties, which can influence their absorption and toxicity in fish. After 4 days, the biochemical response of fish exposed to PVC-NPs and elevated temperatures showed a significant increase in the levels of plasma total proteins, albumin, globulin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine, and uric acid. …”
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Enhancing food waste compost quality with nutrient amendments by John Nkansah, Samson Oduro-Kwarteng, Helen Essandoh, Richard Kuffuor

“…In all treatments, the C/N ratio reduced significantly, while concentrations of heavy metals (Pb and Zn) were within the acceptable international limits. Toxicity of composts to cucumber (Cucumis sativus) was ascertained. …”
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Environmental behavior of per- and polyfluoroalkyl substances (PFASs) and the potential role of biochar for its remediation: a review by Haiyan Wang, Haiyan Zhang, Lizhi He, Jie Wang, Shuo Wang, Xiaoyu Shi, Xiaokai Zhang, Hailong Wang, Feng He

“…Abstract Per- and polyfluoroalkyl substances (PFASs), commonly known as ‘‘forever chemicals’’, are persistent organic pollutants that are widely distributed in the environment. Due to their toxicity and resistance to degradation, PFASs are classified as emerging contaminants, and increasing attention is being paid to their remediation. …”
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