Antibacterial, Antifungal and Cytotoxic Properties as well as Molecular Docking Evaluation of Green Synthesized Silver Nanoparticles by Mojgan Taebi, Mahnaz Amiri, Niloofar Rashidi, Mahsa Sistani, Sanaz Hadizadeh, Razieh Razavi, Ali Reza Farzinnejad, Meysam Ahmadi Zeidabadi, Somayeh Karami Mohajeri

“…The utilization of silver nanoparticles (AgNPs) in diverse fields, including medicine, is on the rise, leading to the development of a non-toxic and environmentally friendly synthesis method. …”
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Procyanidin A1 and its digestive products alleviate acrylamide-induced IPEC-J2 cell damage through regulating Keap1/Nrf2 pathway by Fangfang Yan, Qun Lu, Chengming Wang, Rui Liu

“…Importantly, there was no difference between A1 and D-A1 treated groups, indicating that A1 can tolerate gastrointestinal digestion and may be a potential compound to limit the toxicity of ACR.…”
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Randomized Phase II Study of Docetaxel plus Personalized Peptide Vaccination versus Docetaxel plus Placebo for Patients with Previously Treated Advanced Wild Type EGFR Non-Small-Ce... by Koichi Takayama, Shunichi Sugawara, Yasuo Saijo, Makoto Maemondo, Atsushi Sato, Shinzo Takamori, Taishi Harada, Tetsuro Sasada, Tatsuyuki Kakuma, Junji Kishimoto, Akira Yamada, Masanori Noguchi, Kyogo Itoh, Yoichi Nakanishi

“…Results. PPV related toxicity was grade 2 or less skin reaction. The median PFS for placebo arm and PPV arm was 52 days and 59 days, respectively. …”
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Hepatoprotective effect anti-inflammatory and antioxidant Ganoderma lucidum ethanol extract on rats exposed to Plumbum acetate by Hernayanti, Laksana Agung, Saryono, Jehloh Latifah

“…Plumbum (Pb) is a toxic heavy metal that pollutes the environment and endangers human health. …”
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Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition by Zhenying Diao, Youcheng Liang, Yong Liu, Dou Zhang, Long Qiu, Jianbo Sun, Qiaoyou Lu, Yanlei Liu, Daxiang Cui, Ting Yin

“…In vivo photoacoustic imaging-guided, GNBs-Cur achieved effective tumor elimination through mild-photothermal chemotherapy without systemic toxicity. Overall, this work provides a new therapeutic modality paradigm for potential NSCLC treatment on the basis of synergistic therapies.…”
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Phase I trial on the safety of olprinone for low central venous pressure management aimed at haemorrhage control during open and laparoscopic hepatectomy: a study protocol by Katsuhiko Uesaka, Yuya Miura, Teiichi Sugiura, Ryo Ashida, Katsuhisa Ohgi, Mihoko Yamada, Shimpei Otsuka, Yoshiyasu Kato, Takuya Oyakawa, Eiji Ando, Sunao Tamai

“…The trial employs a 3+3 cohort study design to determine the maximum tolerated dose (MTD) and identify dose-limiting toxicities. The study also assesses the trends in CVP and circulatory dynamics using the FloTrac System, alongside safety evaluations. …”
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Chrysoeriol ameliorates hyperglycemia by regulating the carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats by Baskaran Krishnan, Abirami Ramu Ganesan, Ravindran Balasubramani, Dinh Duc Nguyen, Soon Woong Chang, Shaoyun Wang, Jianbo Xiao, Balamuralikrishnan Balasubramanian

“…Thus, chrysoeriol found to be non-toxic with potential regulation on glycemic control and upregulation of the carbohydrate metabolic enzymes.…”
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Assessment of Heavy Metal Contamination in Paddy Field Soils: A Case Study in Ranau Valley, Sabah, Malaysia by Ahmad Damanhuri Nadrah, Harun Siti Norliyana, Abd Rahim Sahibin

“…Several metals, including Mn, Ni, and Cr, exceeded established soil toxicity thresholds, particularly in areas influenced by ultrabasic rocks and agricultural practices. …”
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Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro by Divya S. Varghese, Shama Parween, Mustafa T. Ardah, Bright Starling Emerald, Suraiya A. Ansari

“…Human embryonic stem cells (hESCs) are being used extensively in array of studies to understand different mechanisms such as early human embryogenesis, drug toxicity testing, disease modeling, and cell replacement therapy. …”
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Development and Validation of a GC-MS Method for the Detection and Quantification of Clotiapine in Blood and Urine Specimens and Application to a Postmortem Case by Giulio Mannocchi, Flaminia Pantano, Roberta Tittarelli, Miriam Catanese, Federica Umani Ronchi, Francesco Paolo Busardò

“…There is little published data on the therapeutic and toxic concentrations of this drug. Aims. The aim of the present study is the development and validation of a method that allows the detection and quantification of clotiapine in blood and urine specimens by gas chromatography-mass spectrometry (GC-MS). …”
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Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity by A. Rodriguez-Barbero, E. Bosque, L. Rivas-Cabaero, M. Arévalo, J. M. López-Novoa

“…The present results suggest a role for PAF in the gentamicininduced nephro-toxicity.…”
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<i>Epigynum auritum</i>-Derived Near-Infrared Carbon Dots for Bioimaging and Antimicrobial Applications by Wenfeng Shi, Jiahui Li, Junmei Pu, Guiguang Cheng, Yaping Liu, Shanshan Xiao, Jianxin Cao

“…The NIR-CDs exhibited minimal toxicity, excellent biocompatibility, and high penetrability in both in vivo and in vitro environments, making them ideal luminescent probes for bioimaging applications. …”
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Electrostatic properties of human germlines and biodistribution of small biologics by Leticia Maria De Souza Cordeiro, Kelley Christine Atkinson, Argin Aivazian, Patrick Frank Joyce, Fang Jia, Alessandro Mascioni

“…Antibody fragments intended for use as vectors of cytotoxic payloads (e.g. antibody-drug conjugates, radiotherapy) can accumulate at clearance organs like kidneys and liver, where they can cause dose-limiting toxicities. Renal and hepatic uptakes are known to be affected by protein electrostatics, which promote protein internalization through pinocytosis. …”
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Atomic Force Microscopy (AFM) nanomechanical characterization of micro- and nanoplastics to support environmental investigations in groundwater by Massimiliano Galluzzi, Michele Lancia, Chunmiao Zheng, Viviana Re, Valter Castelvetro, Shifeng Guo, Stefano Viaroli

“…Micro and nanoplastic (MNP) pollution is a severe environmental issue, posing potential risks to environmental and human health due to the intrinsic toxicity of plastic particles and their capacity to adsorb other pollutants. …”
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Photothermal inactivation of methicillin‐resistant Staphylococcus aureus : anti‐biofilm mediated by a polypyrrole–carbon nanocomposite by Niloufar Behzadpour, Neda Akbari, Naghmeh Sattarahmady

“…To indicate the biocompatibility and toxic effect of the nanocomposite without and with laser irradiation, the authors counted the number of CFUs and compared it to an untreated sample. …”
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Antibacterial Screening of Gunnera perpensa-Mediated Silver Nanoparticles by Naazlene Patel, Kabange Kasumbwe, Viresh Mohanlall

“…The biosynthesis of nanoparticles has become quite popular and has been proposed as an alternative over the tedious, expensive, and toxic physical and chemical methods of synthesis due to its cost-effectiveness and ecofriendliness. …”
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Hydrogen sulfide removal from biogas using chemical absorption technique in packed column reactors by M.B. Kulkarni, P.M. Ghanegaonkar

“…The toxicity and corrosion potential of hydrogen sulfide in raw biogas underlines the need for biogas purification. …”
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Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i> by Julia Tortajada-Pérez, Andrea del Valle Carranza, Cristina Trujillo-del Río, Mar Collado-Pérez, José María Millán, Gema García-García, Rafael Pascual Vázquez-Manrique

“…In the nervous system of any animal, including mammals and invertebrates, lipid oxidation can disturb the delicate balance of cellular homeostasis, leading to oxidative stress, the build-up of toxic by-products, and protein misfolding, key factors in neurodegenerative diseases. …”
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Synthesis, Structural Characterization, and Preclinical Efficacy of a Novel Paclitaxel-Loaded Alginate Nanoparticle for Breast Cancer Treatment by Ahmed A. Markeb, Nagwa A. El-Maali, Douaa M. Sayed, Amany Osama, Mohamed A. Y. Abdel-Malek, Amen H. Zaki, Mostafa E. A. Elwanis, James J. Driscoll

“…Taken together, our results demonstrate that PTX-ALG nanoparticles represent an innovative, nanoscale delivery system for the administration of anticancer agents that may avoid the adverse toxicities with enhanced antitumor effects to improve the treatment of breast cancer patients.…”
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Visceral Leishmaniasis Clinical Management in Endemic Districts of India, Nepal, and Bangladesh by Megha Raj Banjara, Siddhivinayak Hirve, Niyamat Ali Siddiqui, Narendra Kumar, Sangeeta Kansal, M. Mamun Huda, Pradeep Das, Suman Rijal, Chitra Kumar Gurung, Paritosh Malaviya, Byron Arana, Axel Kroeger, Dinesh Mondal

“…Physician awareness of renal or liver toxicity as Miltefosine side effects was lower in Bangladesh. …”
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