Nanoplastics induces arrhythmia in human stem-cells derived cardiomyocytes by Shirley Pei Shan Chia, Jeremy Kah Sheng Pang, Winanto Winanto, Boon-Seng Soh

“…Further research is needed to fully elucidate the mechanisms underlying NP-induced toxicity and to develop strategies for mitigating their adverse effects. …”
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Biomolecule screen identifies several inhibitors of Salmonella enterica surface colonization by Joseph Headrick, Amital Ohayon, Shannon Elliott, Jacob Schultz, Erez Mills, Erik Petersen

“…In an effort to identify potential new inhibitors of S. enterica on abiotic surfaces, we developed a biomolecule screen of nutrient-type compounds because nutrients would have lower toxicity in animal facilities and bacterial nutrient utilization pathways might prove less susceptible to the development of bacterial resistance. …”
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Life Cycle Assessment of Biofuel Production from Sugarcane Bagasse by Nasri Nurul Farhana, Mohd Hanafiah Marlia, Harun Siti Norliyana, Chong Jing Wen, Hassan Faez M.

“…The findings revealed that biofuel production from sugarcane significantly impacts terrestrial ecotoxicity (10.44 kg 1,4-DCB), human non-carcinogenic toxicity (2.61 kg 1,4-DCB), and global warming (2.60 kg CO2 eq). …”
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Biodegradable and Stimuli-Responsive Nanomaterials for Targeted Drug Delivery in Autoimmune Diseases by Nargish Parvin, Sang Woo Joo, Tapas K. Mandal

“…By achieving localized and controlled release of anti-inflammatory and immunosuppressive agents, these systems minimize systemic toxicity and enhance therapeutic efficacy. We discuss the underlying mechanisms of stimuli-responsive nanomaterials, recent applications in treating diseases such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease, and the design considerations essential for clinical translation. …”
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Growth and bioactivity of Phellinus linteus in the mushroom farm, at different cultivation times by Jitchum Supapitch, Tabtimmai Lueacha, Phoohinkong Weerachon, Thumthanaruk Benjawan, Zhang Xiaoshuan, Suttisintong Khomson, Rungsardthong Vilai

“…Further studies of their toxicity on normal cells would benefit the application of PL extract.…”
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Levofloxacin-induced visual hallucinations: A case report and review of the literature by Valentina Raffaelli, Giulia Cantoni, Gabriella Nucera, Pietro Marino

“…., hypoglyvemia, dyselectrolytemia, diabetic ketoacidosis) or toxic ingestion were also excluded. However, the possibility of levofloxacin-induced acute psychosis was considered and, on day 3, levofloxacin was discontinued with a complete resolution of the patient’s visual hallucinations by her sixth day of hospitalization. …”
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In Silico Study of Alkaloids: Neferine and Berbamine Potentially Inhibit the SARS-CoV-2 RNA-Dependent RNA Polymerase by Rishab Marahatha, Asmita Shrestha, Kabita Sharma, Bishnu P. Regmi, Khaga Raj Sharma, Pramod Poudel, Ram Chandra Basnyat, Niranjan Parajuli

“…The QSAR analysis was conducted by using the way2drug/PASS online web resource, and the pharmacokinetics and toxicity properties of these alkaloids were predicted using pkCSM, SwissADME, and ProTox-II webserver. …”
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Targeting Shp2 as a therapeutic strategy for neurodegenerative diseases by Jiao Pang, Changqian Cen, Yuan Tian, Xingrui Cao, Liang Hao, Xueshu Tao, Zhipeng Cao

“…Shp2 is closely related to NDs-related pathogenic factors such as oxidative stress, mitochondrial dysfunction, excitatory toxicity, immune inflammation, apoptosis, and autophagy. …”
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Cystatin C-Based Equations Detect Hidden Kidney Disease and Poor Prognosis in Newly Diagnosed Patients with Multiple Myeloma by Francisco-Javier Cepeda-Piorno, Esther González-García, Alba Méndez-Gallego, Juan Torres-Varona, Vanesa García-Moreira, Christian Sordo-Bahamonde, Cristina AlberdiGarcía-del-Castillo, Elene Astobieta-Madariaga, Maria-Victoria Mateos-Manteca, Segundo González-Rodríguez

“…The IMWG criteria may underestimate kidney disease, mostly in women, which could affect the dose received as well as its toxicity. Altogether, our data suggest that equations that include CysC are more accurate to detect hidden kidney disease, as well as patients with more and worse prognostic factors, in newly diagnosed MM.…”
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Increased miRNA-375 causes oxidative damage but promotes apoptosis resistance and cell migration in the clam Ruditapes philippinarum by Ming Cong, Zhaoshun Li, Wenwen Tian, Yixian Yu, Yu Che, Jiasen Lv

“…Results showed that increased expression of miRNA-375 interfered with the expression levels of both its target genes and ammonia toxicity-related genes, which would probably lead to oxidative stress, migration of damaged cells, apoptosis resistance, and increased possibility of tumor formation. …”
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Metabolic and Genetic Determinants of Lipid Metabolism Disruption in Non-Alcoholic Fatty Liver Disease by O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko, D. A. Kovalevsky

“…The progression of NAFLD is associated with the powerful toxicity of lipids released in the liver parenchyma upon the loss of the cell biomembrane integrity.Conclusions. …”
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Adsorption of Cd (II) Using Chemically Modified Rice Husk: Characterization, Equilibrium, and Kinetic Studies by Javier Montalvo-Andía, Warren Reátegui-Romero, Alexis D. Peña-Contreras, Walter F. Zaldivar Alvarez, María E. King-Santos, Víctor Fernández-Guzmán, José Luis Guerrero-Guevara, Jhon E. Puris-Naupay

“…Cadmium (Cd) is a highly toxic heavy metal considered carcinogenic to humans. …”
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Peritoneal Nebulization of Ropivacaine during Laparoscopic Cholecystectomy: Dose Finding and Pharmacokinetic Study by Massimo Allegri, Martina Ornaghi, Catherine E. Ferland, Dario Bugada, Yash Meghani, Serena Calcinati, Manuela De Gregori, Federica Lovisari, Krishnaprabha Radhakrishnan, Maria Cusato, Stefano Scalia Catenacci, Marta Somaini, Guido Fanelli, Pablo Ingelmo

“…Plasma concentrations did not reach toxic levels in any patient, and no significant differences were observed between groups (P>0.05). …”
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Guanidines Conjugated with Cell-Penetrating Peptides: A New Approach for the Development of Antileishmanial Molecules by João Victor Marcelino de Souza, Natalia C. S. Costa, Maria C. O. Arruda Brasil, Luana Ribeiro dos Anjos, Renata Priscila Barros de Menezes, Eduardo Henrique Zampieri, Jhonatan Santos de Lima, Angela Maria Arenas Velasquez, Luciana Scotti, Marcus Tullius Scotti, Marcia A. S. Graminha, Eduardo R. Pérez Gonzalez, Eduardo Maffud Cilli

“…The bioconjugation between natural compounds with antimicrobial activity and cell-penetrating peptides could alleviate the resistance and toxicity of current treatments. This work aims to conjugate the cell penetration peptide TAT to the guanidine GVL1. …”
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Pseudogenization of the Slc23a4 gene is necessary for the survival of Xdh-deficient mice by Kazuki Terada, Tamaki Watanabe, Nobuhiro Yasuno, Toshio Ohtsubo, Shigeru Shibata, Kimiyoshi Ichida, Makoto Hosoyamada

“…Hypoxanthine or xanthine levels become excessive and thus toxic in Xdh(− / −) mice because enhancing the activity of hypoxanthine phosphoribosyl transferase (HPRT), which is an enzyme that uses hypoxanthine as a substrate, slightly increases the life span of these mice. …”
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Probabilistic assessment of the cumulative risk from dietary heavy metal exposure in Chongqing, China using a hazard-driven approach by Jiahui Chen, Jingrong Chen, Mintao Li, Ping Feng, Mei Qin, Ting Chen, Shuquan Luo, Jian Zhao, Xiaofeng Yan, Jinyao Chen, Xuemei Lian, Huadong Zhang, Jiao Huo

“…Neurotoxicity and nephrotoxicity were identified as the main toxic endpoints, and the final evaluation elements included were Pb, Cd, As, and Hg. …”
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Pomegranate Juices: Analytical and Bio-Toxicological Comparison of Pasteurization and High-Pressure Processing in the Development of Healthy Products by Francesco Cairone, Stefania Cesa, Irene Arpante, Simonetta Cristina Di Simone, Alejandro Han Mendez, Claudio Ferrante, Luigi Menghini, Antonello Filippi, Caterina Fraschetti, Gokhan Zengin, Simone Carradori, Marialucia Gallorini, Luisa Mannina, Mattia Spano

“…The potential inhibition of key enzymes of degenerative processes (cholinesterases, tyrosinase) and diabetes (amylase, glucosidase), the allelopathy toward <i>Cichorium intybus</i>, <i>Dicondra repens</i>, and <i>Diplotaxis tenuifolia</i>, and the in vivo toxicity on brine shrimp were also evaluated. The two different applied processing techniques analyzed impacted the bioactive compound’s preservation differently, modifying the phytocomplex profile. …”
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Larvicidal Evaluation against Aedes aegypti and Antioxidant and Cytotoxic Potential of the Essential Oil of Tridax procumbens L. Leaves by Lethicia B. Brandão, Lizandra L. Santos, Rosany L. Martins, Alex B. L. Rodrigues, Erica de M. Rabelo, Allan K. R. Galardo, Sheylla S. M. da S. de Almeida

“…In this way, it was possible to identify that the essential oil of the leaves of T. procumbens presented potential for the development of a natural larvicide, as well as antioxidant activity satisfactory to the radical DPPH and low toxicity to A. salina.…”
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Characteristics and treatment modes of industrial wastewater in new energy vehicles industrial park by LI Dian, WANG Xun, LIU Yingming

“…The pollutants of new energy vehicles wastewater was complex, toxic and difficult to be directly biodegraded. The wastewater mainly contained pollutants such as surfactants, mineral oil, phosphate and heavy metal. …”
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Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product by Afolabi C. Akinmoladun, Kehinde O. Oguntunde, Lawrence O. Owolabi, Omotayo B. Ilesanmi, Joan O. Ogundele, M.Tolulope Olaleye, Afolabi A. Akindahunsi

“…In this study, Trévo™, a nutraceutical and phytopharmaceutical product, was evaluated for beneficial effects in acetaminophen-induced hepatic toxicity in Wistar rats. Animals received Trévo™ (1.5 mL/kg, 3.0 mL/kg or 4.5 mL/kg) orally for 14 days. …”
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