Targeting BCMA in multiple myeloma: designs, challenges, and future directions by Yi Hu, Yuetao Xie, Xiaodong Wang, Lufeng Yang, He Geng, Zugang Yi, Yao Zhang, Lin Ma, Fang Chen

“…It critically addresses emerging challenges such as antigen escape and toxicity profiles, which have surfaced alongside therapeutic advances. …”
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Cytotoxicity Potentials of Eleven Bangladeshi Medicinal Plants by Amina Khatun, Mahmudur Rahman, Tania Haque, Md. Mahfizur Rahman, Mahfuja Akter, Subarna Akter, Afrin Jhumur

“…All the extracts showed potent to moderate cytotoxicity ranging from LC50 2 to 115 µg/mL. The highest toxicity was shown by Hygrophila spinosa seeds (LC50=2.93 µg/mL) and the lowest by Litsea glutinosa leaves (LC50=114.71 µg/mL) in comparison with standard vincristine sulphate (LC50=2.04 µg/mL). …”
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Repurposing brucine as a chemopreventive agent in mammary gland carcinoma: Regulating lactate transport through MCT-4 by Asma Khatoon Zaidi, Anurag Kumar, Rohit Kumar, Jyoti Singh, Sneha Yadav, Archana Bharti Sonkar, Dharmendra Kumar, Neeraj Kumar Shrivastava, Mohd Nazam Ansari, Abdulaziz S. Saeedan, Gaurav Kaithwas

“…After in-depth analysis, 900 molecules were shortlisted based on Lipinski's rule, optimal molecular weight, binding energy, hydrogen bonding, and ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties that render them viable MCT-4 inhibitors. …”
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Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances by Chong Ning, Yuhan Jiao, Jiaqi Wang, Weiwei Li, Jingqiu Zhou, Yi-Chieh Lee, Dik-Lung Ma, Chung-Hang Leung, Rugang Zhu, Hui-Min David Wang

“…Natural substances have the characteristics of low toxicity and few side effects and may be key to the development of diabetic health products and preventive treatments. …”
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Ozone/Thiosulfate-Assisted Leaching of Cu and Au from Old Flotation Tailings by Stefan Trujić, Miroslav P. Popović, Vesna Conić, Miloš Janošević, Filip Alimpić, Dragoljub Bajić, Ana Milenković-Anđelković, Filip Abramović

“…Flotation tailings are an important secondary mineral resource; however, they might pose a potential environmental threat due to containing toxic metals. Therefore, proper leaching reagent selection is required. …”
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Identifying common pathways for doxorubicin and carfilzomib-induced cardiotoxicities: transcriptomic and epigenetic profiling by Conagh Kelly, Dylan J. Kiltschewskij, Angeline J.W. Leong, Tatt Jhong Haw, Amanda J. Croft, Lohis Balachandran, Dongqing Chen, Danielle R. Bond, Heather J. Lee, Murray J. Cairns, Aaron L. Sverdlov, Doan T. M. Ngo

“…Abstract Cancer therapy-related cardiovascular toxicity (CTR-CVT) is now recognised as one of the leading causes of long-term morbidity and mortality in cancer patients. …”
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Recent Advances in the Pathogenesis of Syndromic Autisms by A. Benvenuto, B. Manzi, R. Alessandrelli, C. Galasso, P. Curatolo

“…Metabolic and mitochondrial defects may have toxic effects on the brain cells, causing neuronal loss and altered modulation of neurotransmission systems. …”
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The Peptide Vaccine Combined with Prior Immunization of a Conventional Diphtheria-Tetanus Toxoid Vaccine Induced Amyloid β Binding Antibodies on Cynomolgus Monkeys and Guinea Pigs by Akira Yano, Kaori Ito, Yoshikatsu Miwa, Yoshito Kanazawa, Akiko Chiba, Yutaka Iigo, Yoshinori Kashimoto, Akira Kanda, Shinji Murata, Mitsuhiro Makino

“…The peptide vaccination could be expected to reduce the brain Aβ peptides and their toxic effects via clearance of Aβ peptides by generated antibodies.…”
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Safety of oil from Schizochytrium limacinum (strain ATCC‐20889) for use in infant and follow‐on formula as a novel food pursuant to Regulation (EU) 2015/2283 by EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Helle Katrine Knutsen, Monika Neuhäuser‐Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Irene Nuin Garciarena, Emanuela Turla, Harry J. McArdle

“…., the QPS status of the source of the NF, the production process, the composition of the NF, the absence of marine biotoxins and viable cells in the NF, the Panel considers that there are no concerns with regard to the toxicity of the NF. The Panel concludes that the NF is safe under the proposed conditions of use.…”
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Muscle Relaxant and Sedative-Hypnotic Activities of Extract of Viola betonicifolia in Animal Models Supported by Its Isolated Compound, 4-Hydroxy Coumarin by Naveed Muhammad, Mohammad Saeed, Haroon Khan, Achyut Adhikari, Khalid Mohammed Khan

“…The whole plant of V. betonicifolia led to the isolation of 4-hydroxyl coumarin (4HC) which showed substantial safety profile in acute toxicity test. When challenged in Traction and Chimney tests, it showed significant (P<0.05) muscle relaxant effect in both muscle relaxant paradigms at 20 and 30 mg/kg during various assessment times. …”
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Efficiency of Removing Xylene Vapor from Air Utilizing Nano Graphene and Nano Graphene Oxide by Akram Tabrizi, Mostafa Jafarizaveh, Hamid Shirkhanloo, Farideh Golbabaeie

“…Introduction: Volatile organic compounds (VOCs) are hazardous toxic pollutants in the air, which are released from various industrial sources. …”
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Activation of Human Neutrophils by the Anti-Inflammatory Mediator Esenbeckia leiocarpa Leads to Atypical Apoptosis by Rafael de Liz, Heros Horst, Moacir Geraldo Pizzolatti, Tânia Silvia Fröde, Denis Girard

“…In this study, a crude hydroalcoholic extract (CHE) was used to evaluate the potential toxic or agonistic effect of E. leiocarpa in human neutrophils. …”
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Outcome of Very Late Relapse in Patients with Hodgkin's Lymphomas by Francesco Gaudio, Annamaria Giordano, Vincenzo Pavone, Tommasina Perrone, Paola Curci, Domenico Pastore, Mario Delia, Clara de' Risi, Alessandro Spina, Vincenzo Liso, Giorgina Specchia

“…The aim of this study is to report a single centre experience of the clinical characteristics, outcome, and toxicity of pts who experienced very late relapses, defined as relapses that occurred 5 or more years after the achievement of first complete remission. …”
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Activating PKC-ε induces HIV expression with improved tolerability. by Alivelu M Irrinki, Jasmine Kaur, Bally Randhawa, Ryan McFadden, Chelsea Snyder, Hoa Truong, Daniel Soohoo, Eric Hu, Helen Yu, Bernard P Murray, Bing Lu, Dmytro Kornyeyev, Ishak Darryl Irwan, Lan Nguyen, Yu-San Yang, Jean-Philippe Belzile, Uli Schmitz, Todd C Appleby, Brian Schultz, Jay Lalezari, Steven Deeks, Tomas Cihlar, Jeffrey P Murry

“…However, the clinical utility of PKCs for this application is limited due to toxicity, which is poorly understood. Our studies showed that PKC activation with multiple classes of agonists leads to widespread platelet activation, consistent with disseminated intravascular coagulation, at concentrations that were similar to those required for T-cell activation. …”
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New Insights on Quality, Safety, Nutritional, and Nutraceutical Properties of Honeydew Honeys from Italy by Andrea Mara, Federica Mainente, Vasiliki Soursou, Yolanda Picó, Iratxe Perales, Asma Ghorab, Gavino Sanna, Isabel Borrás-Linares, Gianni Zoccatelli, Marco Ciulu

“…The honeydew elements, conductivity, color, antioxidant properties, total polyphenol content, hydroxymethylfurfural, major and trace elements, toxic and rare earth elements, and pesticide residues were measured in 59 samples of honeydew honey from forest, eucalyptus, fir, oak, and citrus sources. …”
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Numerical analysis of collision mechanism that causes particle tribocharging in dry powder inhaler by Ryosuke Mitani, Muhammad Aiman bin Mohd Nor, Takuto Iinuma, Tatsuhiro Mori, Tomoaki Okuda

“…Abstract Chronic obstructive pulmonary disease (COPD) is induced by inhalation of toxic substances such as cigarettes and air pollution. …”
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Sonochemical synthesis of CQDs from coffee husk: Insights in aggregation mechanism, optimization and sustainability analysis by Alfonso Enrique Ramírez Sanabria, Santiago Urbano Narváez, Johnny Vilard Gutiérrez Portilla, Gerardo Andres Torres Rodríguez

“…A green methodology for the synthesis of carbon quantum dots (CQDs) from coffee husk without the use of any toxic solvents is proposed in this work. Sonochemical exfoliation of biochar, obtained from the thermal carbonization of coffee husk (from a certified coffee seeds) at low temperature in an air-restricted atmosphere, is described as an alternative procedure for the sustainable production of CQDs. …”
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Effect of 3-hydrazinylquinoxaline-2-thiol hydrogel on skin wound healing process in diabetic rats by Jehan Barakat Alamre, Huda Alkreathy, Ahmed S. Ali, Abdelbagi Alfadil, Sahar S. Alghamdi

“…In silico study indicated a favorable drug-like properties and toxicity profile. The present work showed that 3-hydrazinylquinoxaline-2-thiol holds great potential for the treatment of diabetic wounds.…”
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Three months of weekly rifapentine plus isoniazid for TB prevention among people with HIV by R. Borse, B. Randive, S. Mattoo, P. Malik, H. Solanki, A. Gupta, R.E. Chaisson, V. Mave, N. Suryavanshi

“…Of these, 20 (4%) discontinued TPT due to toxicity,17 (3.8%) lost to follow-up, one (0.2%) had breakthrough rifampicin-sensitive TB, and 464 (92%) completed 3 HP TPT. …”
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Environmental high temperature (heat stroke) causes articular cartilage damage in vivo and in vitro by Sun yingfei, Yang feng, Ma haoning

“…Therefore, in our current work, we studied the damage of heat toxicity on chondrocytes in vitro. The results showed that heatstroke reduced the cell activity of chondrocytes and triggered a decrease in mitochondrial membrane potential and oxidative stress response. …”
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