Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2 by Yuchen Li, Jiayi Zhou, Tianxin Zhang, Xiaocong Li, Cheng Wu, Ziyi Zhao, Jianyuan Tang, Xiaoyu Tan, Qiongying Hu, Wenhao Liao

“…In conclusion, AS-IV could protect the kidney from heavy metal-induced toxicity and could be used as a nephroprotective agent.…”
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Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production by V. Bocci, G. Valacchi, F. Corradeschi, G. Fanetti

“…While the disinfectant activity of O3 is understandable, it is less clear how other biological effects can be elicited in human blood with practically no toxicity. On the other hand plasma and cells are endowed with a powerful antioxidant system so that a fairly wide range of O3 concentrations between 40 and 80μ g/ml per gram of blood (˜0.83-1.66 mM) are effective but not deleterious. …”
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Induced-volatolomics, a new research field in chemical biology by Blochouse, Estelle, Eid, Rony, Cannoni, Elsa, Châtre, Rémi, Geffroy, Claude, Opalinski, Isabelle, Papot, Sébastien, Poinot, Pauline

“…However, these imaging tools meet several bottlenecks related to either stability, background noise, limited penetration depth or systemic toxicity, pharmacokinetics, tissue distribution, and renal clearance.In parallel, novel volatile organic compound (VOC)-based probes have been proposed under the emerging paradigm of induced-volatolomics. …”
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Progress in the role of nanoparticles in the diagnosis and treatment of bone and joint tuberculosis by Yitong Ding, Baiyun Li, Yangfei Yi, Can Liu, Jie Wen, Jie Wen, Xiaohong Jian, Yufei Li

“…In therapeutic applications, nanomaterials prolong drug retention in bone tissue through targeted delivery, thereby decreasing medication frequency and minimizing toxic side effects, which significantly improves treatment efficacy. …”
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Experimental and computational studies of Schiff bases derived from 4-aminoantipyrine as potential antibacterial and anticancer agents by Johana Zúñiga-Miranda, Rebeca González-Pastor, Saskya E. Carrera-Pacheco, Cristina Rodríguez-Pólit, Carlos Barba-Ostria, Antonio Machado, Linda P. Guamán, Christian D. Alcivar-León, Jorge Heredia-Moya

“…Six compounds demonstrated anticancer activity, though some exhibited toxicity to non-tumor cells. Compounds 3b, 3f, and 3h showed notable anticancer potential, while 3f and 3h also exhibited strong antibacterial effects, with 3f being the most effective against multidrug-resistant bacteria strains. …”
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JNK and NADPH Oxidase Involved in Fluoride-Induced Oxidative Stress in BV-2 Microglia Cells by Ling Yan, Shengnan Liu, Chen Wang, Fei Wang, Yingli Song, Nan Yan, Shuhua Xi, Ziyou Liu, Guifan Sun

“…Excessive fluoride may cause central nervous system (CNS) dysfunction, and oxidative stress is a recognized mode of action of fluoride toxicity. In CNS, activated microglial cells can release more reactive oxygen species (ROS), and NADPH oxidase (NOX) is the major enzyme for the production of extracellular superoxide in microglia. …”
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Screening of Trace Elements in Hair of the Female Population with Different Types of Cancers in Wielkopolska Region of Poland by Bogusław Czerny, Krzysztof Krupka, Marcin Ożarowski, Agnieszka Seremak-Mrozikiewicz

“…Disturbance in the axis glucose-insulin and changes in concentrations of heavy metals and toxic elements were also noted. Conclusions. It seems safe to conclude that our results confirmed usefulness of hair element analysis in screening tests for the assessment of the biomarker of various cancer diseases in a female population.…”
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Universal antibacterial and anti-inflammatory treatment using chitosan-prussian blue nanozyme by Jian Wang, Jiayi Wang, Huayuan Zhou, Rui Ma, Zhou Fang, Jiawei Zhu, Zhejie Chen, Xinfeng Dai, Dali Wei, Jiabei Li, Yiting Jiang, Qian Xia, Xueliang Liu, Yu Yang

“…In conclusion, CS@PBs exhibited exceptional bactericidal capabilities, anti-inflammatory properties, and minimal toxicity, suggesting that they are promising candidates for a new generation of non-antibiotic antimicrobial agents for the treatment of bacterial infections.…”
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Methylobacterium populi VP2: Plant Growth-Promoting Bacterium Isolated from a Highly Polluted Environment for Polycyclic Aromatic Hydrocarbon (PAH) Biodegradation by Valeria Ventorino, Filomena Sannino, Alessandro Piccolo, Valeria Cafaro, Rita Carotenuto, Olimpia Pepe

“…The use of microorganisms to accelerate the natural detoxification processes of toxic substances in the soil represents an alternative ecofriendly and low-cost method of environmental remediation compared to harmful incineration and chemical treatments. …”
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Monitoring and management of adverse effects associated with trastuzumab deruxtecan: a UAE-specific consensus by Emad Dawoud, Fathi Azribi, Aref Chehal, Shaheenah Dawood, Syed Hammad Tirmazy, Dina Hamza, Hassan Jaafar, Hussam Marashi

“…Despite the inherent specificity of an ADC, the risk of off-site toxicity exists and is an essential component while assessing the risk-benefit ratio of the treatment. …”
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Degradation of aflatoxins in weakly alkaline conditions by Natalie Sandlin, Jiu Lee, Marco Zaccaria, Marek Domin, Babak Momeni

“…The AF degradation was shown to occur through lactone ring opening, a known cause of AF toxicity. Further analysis also provided a putative structure of the AFG2 degradation byproduct. …”
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C9ORF72 poly-PR induces TDP-43 nuclear condensation via NEAT1 and is modulated by HSP70 activity by Diksha Agnihotri, Chi-Chang Lee, Po-Chao Lu, Ruei-Yu He, Yung-An Huang, Hung-Chih Kuo, Joseph Jen-Tse Huang

“…Summary: The toxicity of C9ORF72-encoded polyproline-arginine (poly-PR) dipeptide is associated with its ability to disrupt the liquid-liquid phase separation of intrinsically disordered proteins participating in the formation of membraneless organelles, such as the nucleolus and paraspeckles. …”
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Life cycle assessment of laboratory-scale chitosan production: comparison of high-pressure processing-assisted and conventional methods by Bashir Bashiri, Ana Cristina De Aguiar Saldanha Pinheiro, Silvia Tappi, Pietro Rocculi, Aleksei Kaleda, Raivo Vilu

“…Conventional chemical extraction methods of chitosan are harsh, require strong acids and bases, and produce toxic waste products. High-pressure processing (HPP)-assisted chemical extraction of chitosan has the potential to result in a higher production yield. …”
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Antibacterial properties of substituted phenethylamine-based β-lactam derivatives in oral infections by Merve Yildirim, Elif Aksakal, Taha Yasin Bayram, Eda Irmak, Harun Gun, Bunyamin Ozgeris, Arzu Gormez

“…Moreover, antibiotic resistance is developing in these pathogenic bacteria, limiting treatment options. β-lactam antibiotics are particularly important due to their broad spectrum and selective toxicity. In this study, novel phenethylamine-based β-lactam derivatives were synthesized, and their antibacterial activities against oral pathogens were investigated. …”
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Application of therapeutical nanoparticles with neutrophil membrane camouflaging for inflammatory plaques targeting against atherosclerosis by Ningnannan Zhang, Tianzhu Zhang, Jintang Feng, Jian Shang, Beibei Zhang, Qingyang Dong, Zhang Zhang, Chunyang Sun

“…A biosafety assessment indicated that the biomimetic NNPST induced no noticeable toxicity in the body. This approach of neutrophil membrane-camouflaged nanoparticles offers new opportunities to various therapeutic agents for on-demand delivery in neutrophil-involved inflammatory diseases.…”
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Natural Enrichment of Trace Elements in Surface Horizons of Calcareous Soils (La Mancha, Spain) by Sandra Bravo Martín-Consuegra, Jose A. Amorós Ortíz-Villajos, Caridad Pérez-de-los-Reyes, Francisco J. García Navarro, Rolando Ruedas Luna, Raimundo Jiménez Ballesta

“…Soil quality does not indicate toxicity although surficial enrichment suggests a weak threat from consuming crops.…”
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Malachite Green Removal by Activated Potassium Hydroxide Clove Leaf Agrowaste Biosorbent: Characterization, Kinetic, Isotherm, and Thermodynamic Studies by Dyan Hatining Ayu Sudarni, Uyiosa Osagie Aigbe, Kingsley Eghonghon Ukhurebor, Robert Birundu Onyancha, Heri Septya Kusuma, Handoko Darmokoesoemo, Otolorin Adelaja Osibote, Vincent Aizebeoje Balogun, Bernadeta Ayu Widyaningrum

“…Although several approaches have been explored for the removal of dyes and other toxic materials from water as well as the entire environment, notwithstanding, researchers/scientists are still pursuing novel, low-cost, and eco-friendly biosorbents for the effective removal of such contaminants. …”
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Preclinical assessment of splicing modulation therapy for ABCA4 variant c.768G>T in Stargardt disease by Dyah W. Karjosukarso, Femke Bukkems, Lonneke Duijkers, Tomasz Z. Tomkiewicz, Julia Kiefmann, Andrei Sarlea, Sander Bervoets, Irene Vázquez-Domínguez, Laurie L. Molday, Robert S. Molday, Mihai G. Netea, Carel B. Hoyng, Alejandro Garanto, Rob W. J. Collin

“…No major safety concerns regarding off-targets, immunostimulation and toxicity are observed in transcriptomics analysis, cytokine stimulation assays in human primary immune cells, and cytotoxicity assays. …”
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Sequentially Activated Smart DNA Nanospheres for Photoimmunotherapy and Immune Checkpoint Blockade by Yu Chen, Yu Guo, Wen Cheng, Jiahao Fan, Jiacheng Li, Jiajia Song, Xiaohai Yang, Kemin Wang, Jin Huang

“…These results indicate that NS significantly enhance antitumor immune responses, synergistically improve antitumor efficacy, and reduce systemic toxicity. This study broadens the application of DNA nanomaterials in precision drug delivery and tumor therapy.…”
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Evaluation of GABAergic Transmission Modulation as a Novel Functional Target for Management of Multiple Sclerosis: Exploring Inhibitory Effect of GABA on Glutamate-Mediated Excitot... by Ankit A. Gilani, Ranjeet Prasad Dash, Mehul N. Jivrajani, Sandeep Kumar Thakur, Manish Nivsarkar

“…An excess release of glutamate leads to the activation of ionotropic and metabotropic receptors, thus resulting in accumulation of toxic cytoplasmic Ca2+ and cell death. However, it has been observed that gamma-aminobutyric acid-A (GABAA) receptors located in the nerve terminals activate presynaptic Ca2+/calmodulin-dependent signaling to inhibit depolarization-evoked Ca2+ influx and glutamate release from isolated nerve terminals, which suggest a potential implication of GABAA receptor in management of MS. …”
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