Chloroquine Inhibits Dengue Virus Type 2 Replication in Vero Cells but Not in C6/36 Cells by Kleber Juvenal Silva Farias, Paula Renata Lima Machado, Benedito Antônio Lopes da Fonseca

“…Our results showed that a dose of 50 μg/ml of chloroquine was not toxic to the cells and induced a statistically significant inhibition of virus production in infected Vero cells when compared to untreated cells. …”
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Improvement of yield and nutrient composition of orchardgrass in soils with increased nickel concentration by inoculation with Bacillus strains by Buntić Aneta, Stajković-Srbinović Olivera, Pešić Mila, Dinić Zoran, Milinković Mira, Knežević Magdalena

“…The pollution of soil by potentially toxic trace elements (PTE) is increasing every year and has become a serious problem worldwide. …”
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Quantitative analysis of povidone-iodine thin films by X-ray photoelectron spectroscopy and their physicochemical properties by Sa Anongtip, Sawatdee Somchai, Phadoongsombut Narubodee, Buatong Wilaiporn, Nakpeng Titpawan, Sritharadol Rutthapol, Srichana Teerapol

“…The cytotoxicity study confirmed that the PVP-I spray had lower toxic effects on keratinocytes and fibroblasts compared to the commercial PVP-I solution. …”
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Self-propelled ferroptosis nanoinducer for enhanced cancer therapy by Wenxin Xu, Hao Tian, Yanzhen Song, Hanfeng Qin, Junbin Gao, Yichi Chen, Weichang Huang, Lin Lin, Haixin Tan, Yicheng Ye, Xiaoting Zhang, Daniela A Wilson, Guang Yang, Fei Peng, Yingfeng Tu

“…However, the development of ferroptosis-based nanotherapeutics is generally hindered by the limited penetration depth in tumors, poor active pharmaceutical ingredient (API) loading content and the systemic toxicity. Herein, self-propelled ferroptosis nanoinducers composed of two endogenous proteins, glucose oxidase and ferritin, are presented to show enhanced tumor inhibition via ferroptosis while maintaining high API and biocompatibility. …”
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Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice by Meng Li, Min Xu, Jichang Li, Lili Chen, Dongwei Xu, Ying Tong, Jianjun Zhang, Hailong Wu, Xiaoni Kong, Qiang Xia

“…Mechanistically, Alda-1 treatment enhanced ALDH2 activity and subsequently reduced the accumulation of reactive aldehydes and toxic protein adducts, which result in decreased hepatocyte apoptosis and mitochondrial dysfunction. …”
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Formation of hybrid carriers based on albumin and polyoxometalate for targeted drug delivery by M.O. Tonkushina, I.D. Gagarin, V.R. Gavrilyuk, K.A. Piunov, A.A. Ostroushko

“…Polyoxometalates are able to bind both proteins and molecules of certain drugs to obtain water-soluble products without the use of toxic reagents and organic solvents. The regulation of the experimental conditions allows to control the size of the particles formed in solution. …”
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Interference of a phytoconstituent from Nymphaea lotus-derived ligand N-acetyl glucosamine with signaling receptors in diabetes mellitus development: A targeted computational analy... by Sunday Amos Onikanni, Tran Nhat-Phong Dao, Adewale Oluwaseun Fadaka, Halliru Zailani, Oluwafemi Shittu Bakare, Omolola Esther Amos, Ashwil Klein, Valens Munyembaraga, Morenike Grace Ajayi, Adebola Iyabode Akinjokun, Babatunji Emmanuel Oyinloye, Leandro Miranda-Alves

“…Molecular docking studies, toxicity prediction, examination of drug depiction, and Molecular Dynamics Simulation (MDs) of the ligands with the identified receptor target were conducted using the Schrödinger platform. …”
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Mineralization of Quinoline by BDD Anodes: Variable Effects and Its Effluent Characteristics by C. R. Wang, J. Wang, X. G. Ma, H. Li, S. Z. Zhang

“…The specific oxygen uptake rate was used to assess effluent toxicity, and the value gradually reduced with decreasing effluent organic concentration with mean value of 5.51, 4.19, and 2.20 mgO2 g−1MLSS at electrolysis time of 15, 30, and 45 min, respectively. …”
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Identification of natural and anthropogenic factors in the spatial pattern of Pb in the surface soil of the Nanliu River Basin by Xu Liu, Zhongfang Yang, Huading Shi, Tiansheng Wu, Tao Yu, Bo Li, Lei Wang, Yuxiang Shao, Zexin He, Minghui Xie, Chenning Deng

“…The identification of source in potentially toxic elements (PTEs) in watershed soils is crucial for environmental management. …”
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Involuntary intoxication caused by vaping the synthetic cannabinoid ADB-BUTINACA: A case report by Elise M.A. Slob, Maryam Lyousoufi, Sharif Pasha, Erik B. Wilms

“…Clinicians should be aware that besides the harmful effects of nicotine and toxic metals in e-cigarettes, e-cigarettes may also contain synthetic cannabinoids or other recreational drugs including new psychoactive substances (NPS), which can cause involuntary intoxication with potentially severe adverse effects. …”
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Comprehensive study on impact of hydrogen peroxide decomposition on the crucial parameters of OSM-type energetic materials by Mateusz Polis, Agnieszka Stolarczyk, Konrad Szydło, Magdalena Fabin, Mateusz Pytlik, Barbara Lisiecka, Tomasz Jarosz

“….% hydrogen peroxide (HP) and not containing toxic compounds, and therefore is environmentally friendly. …”
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The Effects of Subchronic Exposure to Metribuzin on Danio rerio by Lucie Plhalova, Stanislava Stepanova, Eva Praskova, Lucie Chromcova, Lenka Zelnickova, Lenka Divisova, Misa Skoric, Vladimira Pistekova, Iveta Bedanova, Zdenka Svobodova

“…The effects of subchronic exposure to metribuzin on fish growth and the development of histopathological changes in selected organs (gill, kidney, liver) and on activity of some biochemical markers (CYP450, EROD) in Danio rerio were investigated during a 28-day toxicity test. Juvenile growth tests were performed on D. rerio according to OECD method number 215. …”
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Water Quality of Urban Streams: The Allium cepa Seeds/Seedlings Test as a Tool for Surface Water Monitoring by Camila Gonçalves Athanásio, Daniel Prá, Alexandre Rieger

“…The Pedras stream receives mixed industrial and urban wastewater, while the Lajeado and Preto streams receive wastewater predominantly domestic in nature, which may partially explain the difference in toxicity among the samples. Moreover, the Allium cepa seeds/seedlings were shown to be extremely sensitive in detecting the genotoxicity of environmental water samples and can be applied as the first tool for environmental health hazard identification and prediction.…”
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Mitigation PFHxA-induced neurotoxicity in Carassius auratus brain cells by selenium-enriched Bacillus subtilis via the BDNF/PI3K/AKT/GSK-3β pathway by Yu-ting Lu, Zheng-yao Guo, Lei Guo, Yu-hua He, Li-ming Liu, Xue Jiao, Yue-hong Li

“…Our previous studies have shown that selenium-rich Bacillus subtilis can not only alleviate the cause of brain damage by perfluorohexanoic acid (PFHxA) in Carassius auratus via the intestinal axis of the brain, but its metabolites can also alleviate PFHxA toxicity. This study further explores the potential mechanism through in vitro experiments. …”
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Bioconversion of municipal organic solid waste in to compost using Black Soldier Fly (Hermetia Illucens) by Priscilla Addo, Sampson Oduro-Kwarteng, Samuel Gyasi, Esi Awuah

“…The nutrients were extremely high in the compost to the extent that can cause phyto-toxicity. Post-treatment of the compost is needed to make BSFL compost viable for the market.…”
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Epoxidation of Ethylene by Whole Cell Suspension of Methylosinus trichosporium IMV 3011 by Jia-Ying Xin, Ning Xu, Sheng-Fu Ji, Yan Wang, Chun-Gu Xia

“…Thus, exhaustion of reductant and the inhibition of toxic products make it difficult to accumulate epoxyethane continuously. …”
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Effect of In Vitro Exposure of Corticosteroid Drugs, Conventionally Used in AMD Treatment, on Mesenchymal Stem Cells by Raffaele Nuzzi, Monica Gunetti, Deborah Rustichelli, Barbara Roagna, Francesca Fronticelli Bardelli, Franca Fagioli, Ivana Ferrero

“…Dexamethasone was the least toxic corticosteroid used in this study. ARPE-19 seemed to help cells preserve the typical MSC morphology. …”
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Effects of Zearalenone on IL-2, IL-6, and IFN-γ mRNA Levels in the Splenic Lymphocytes of Chickens by Y. C. Wang, J. L. Deng, S. W. Xu, X. Peng, Z. C. Zuo, H. M. Cui, Y. Wang, Z. H. Ren

“…These compounds elicit a wide spectrum of toxic effects, including the capacity to alter normal immune function. …”
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Determination of Interesting Toxicological Elements in PM2.5 by Neutron and Photon Activation Analysis by Pasquale Avino, Geraldo Capannesi, Francesco Lopez, Alberto Rosada

“…In this way, trace elements in airborne particulate have a preeminent position due to toxic element presence affecting the biological systems. …”
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Jasmonic acid improves cadmium tolerance in rice (Oryza sativa) by reducing the production of nitric oxide by Ji Bo Yang, Hao Yu Wang, Jing Huang, Chuan Jin Shan, Jing Yan, Chong Wei Zhong, Die Hu, Qiang Zhang, Ren Fang Shen, Xiao Fang Zhu, Da Li Zeng

“…In this study, exposure to Cd stress rapidly elevated endogenous JA concentrations in rice roots, meanwhile, a mutant coleoptile photomorphogenesis 2 (cpm2) which produces less JA, was more sensitive to Cd stress than its wild type (WT). JA mitigated Cd toxicity by decreasing Cd absorption in root cell wall and shoot, which was achieved by up-regulating the expression of the Cd-chelation and efflux-related genes such as OsHMA3, OsABCG36 and OsCAL1; down-regulating the transcript level of the Cd uptake and translocation-related genes, including OsHMA2, OsCCX2, OsNRAMP1/5, and OsZIP5/7. …”
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