Microglial Lyzl4 Facilitates β‐Amyloid Clearance in Alzheimer's Disease by Jie Pan, Jie Zhong, Ji Geng, Jane Oberhauser, Shihua Shi, Jun Wan

“…Despite a wealth of research on the toxicity of Aβ and its role in synaptic damage, the mechanisms facilitating Aβ clearance are not yet fully understood. …”
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Soil Assessment along Toposequences in Rural Northern Nigeria: A Geomedical Approach by Lena Hartmann, Marvin Gabriel, Yuanrong Zhou, Barbara Sponholz, Heinrich Thiemeyer

“…Case numbers of endemic Ca-deficiency rickets (CDR) have been reported to be alarmingly rising among children of subsistence farms in developing countries within the last 30 years. Fluoride toxicities in the environment are known to not be related to the disease. …”
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Effects of Low Concentration of Glyphosate-Based Herbicide on Genotoxic, Oxidative, Inflammatory, and Behavioral Meters in Danio rerio (Teleostei and Cyprinidae) by Eduardo Bortolon Ribas, Gustavo Colombo Dal-Pont, Ariana Centa, Marcos Otávio Bueno, Ricardo Cervini, Rosana Claudio Silva Ogoshi, Claudriana Locatelli

“…The objective of this work was to evaluate the toxicity of a glyphosate-based herbicide (GBH) in zebrafish (Danio rerio). …”
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Evaluating the stability and efficacy of fractal-fractional models in reproductive cancer apoptosis with ABT-737 by Kottakkaran Sooppy Nisar, M. Sivashankar, S. Sabarinathan, C. Ravichandran, V. Sivaramakrishnan

“…Conventional cancer therapies, such as chemotherapy and radiation therapy, often encounter issues like toxicity and resistance, primarily due to their inability to effectively differentiate between cancerous and normal cells. …”
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The Current Status of Atmospheric Micro/Nanoplastics Research: Characterization, Analytical Methods, Fate, and Human Health Risk by Hsin-Chieh Kung, Chien-Hsing Wu, Nicholas Kiprotich Cheruiyot, Justus Kavita Mutuku, Bo-Wun Huang, Guo-Ping Chang-Chien

“…Since most polymers are inert, the adverse health risks include endocytosis and accumulation in the liver and spleen. However, most of the toxic effects of these contaminants are related to surface-bound compounds, including heavy metals and persistent organic pollutants. …”
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Network pharmacology: a crucial approach in traditional Chinese medicine research by Yiyan Zhai, Liu Liu, Fanqin Zhang, Xiaodong Chen, Haojia Wang, Jiying Zhou, Keyan Chai, Jiangying Liu, Huiling Lei, Peiying Lu, Meiling Guo, Jincheng Guo, Jiarui Wu

“…The application of network pharmacology in TCM is widespread, covering areas such as identifying the material basis of TCM efficacy, unraveling mechanisms of action, and evaluating toxicity, safety, and novel drug development. However, challenges remain, such as the lack of standardized data collection across databases and insufficient consideration of processed herbs in research. …”
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Methane detection approach based on THz wave absorber by Alireza Barati Haghverdi, Ilghar Rezaei, Amir Ali Mohammad Khani, Toktam Aghaee

“…The second scenario considers the sample (probably toxic polluted air) in the middle layer and also in free space. …”
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Identification of plastic waste generation and composition to reduce environmental disaster risk (case study: Public facility sources in Padang City) by Ruslinda Yenni, Fahrunisa Gebi, Ayu Lestari Resti, Gunawan Hendra, Amin Muhammad

“…The degradation of plastic waste in aquatic environments can result in microplastics that threaten marine life, while the incineration of plastic waste produces toxic gases harmful to health. This study aims to identify the generation and composition of plastic waste as an initial step in reducing environmental disaster risks. …”
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Green synthesis of CuO nanoparticles from Cucurbita maxima leaf extract; a platinum free counter electrode for dye sensitized solar cells by Emma Panzi Mukhokosi, Stephen Tenywa, Nandipha L. Bothab, Shohreh Azizi, Mathapelo Pearl Seopela, Malik Maaza

“… Green synthesis of metal oxides has attracted attention as the latest technology in synthesizing metal oxide nanoparticles due to its simplicity, cheapness, non-toxicity and its ability for large scale production. …”
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Harnessing light-activated gallium porphyrins to combat intracellular Staphylococcus aureus using an in vitro keratinocyte infection model by Klaudia Szymczak, Michał Rychłowski, Lei Zhang, Joanna Nakonieczna

“…This study is the first to analyze aPDI toxicity in real time within an infection model, demonstrating that this method is neither cytotoxic nor phototoxic.…”
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Polystyrene nanoplastics promote the blood-brain barrier dysfunction through autophagy pathway and excessive erythrophagocytosis by Eun-Hye Kim, Seung Mi Baek, Han Jin Park, Yiying Bian, Han Young Chung, Ok-Nam Bae

“…Our study will help to understand the cardiovascular toxicity of nano-sized plastics.…”
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MOF-derived intelligent arenobufagin nanocomposites with glucose metabolism inhibition for enhanced bioenergetic therapy and integrated photothermal-chemodynamic-chemotherapy by Lihua Chen, Jiaying Yang, Lingyu Jia, Xiaolu Wei, Huijun Wang, Zhuo Liu, Shan Jiang, Pengyue Li, Yanyan Zhou, Hongjie Wang, Nan Si, Baolin Bian, Qinghe Zhao, Haiyu Zhao

“…To overcome the poor bioavailability and toxicity of arenobufagin (ArBu), a MOF-derived intelligent nanosystem, ZIAMH, was designed to facilitate energy deprivation by simultaneous interventions of glycolysis, OXPHOS and TCA cycle. …”
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Applications of cell penetrating peptide-based drug delivery system in immunotherapy by Jing-Jing Du, Ru-Yan Zhang, Shangchi Jiang, Shanshan Xiao, Yiting Liu, Yongheng Niu, Wen-Xiang Zhao, Dongyuan Wang, Dongyuan Wang, XianShi Ma

“…Besides, inappropriate chemical modification can lead to membrane disruption and nonspecific toxicity. In this paper, we first reviewed recent advances in the CPP applications for cancer therapy via covalent or non-covalent manners. …”
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Hypoglycemic natural products with in vivo activities and their mechanisms: a review by Wenyi Ma, Longgao Xiao, Haiyang Liu, Xiaojiang Hao

“…Natural products (NPs) are a reservoir of diverse structures and bioactivities with low toxicity and less side effects. And some of them show effects on diabetic complications, which is a significant idea for drug development. …”
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Assessing Risk of Fumonisin Contamination in Maize Using Near-Infrared Spectroscopy by Cecile Levasseur-Garcia, Sylviane Bailly, Didier Kleiber, Jean-Denis Bailly

“…Fumonisins are major mycotoxins found worldwide in maize and maize products. Because of their toxicity for both human and animals, European Union regulations were created to fix the maximal fumonisin B1 and B2 content allowed in foods and feeds. …”
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Anesthetic-Induced Oxidative Stress and Potential Protection by Cheng Wang, Xuan Zhang, Fang Liu, Merle G. Paule, William Slikker, Jr.

“…Prolonged exposure of developing mammals to general anesthetics affects the N-methyl-D-aspartate (NMDA)–type glutamate or γ-aminobutyric acid (GABA) receptor systems and enhances neuronal toxicity. Stimulation of immature neurons by NMDA antagonists or GABA agonists is thought to increase overall nervous system excitability and may contribute to abnormal neuronal cell death during development. …”
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Nanotherapeutics for Meningitis: Enhancing Drug Delivery Across the Blood-Brain Barrier by Hitaishi Sharma, Kannan Badri Narayanan, Shampa Ghosh, Krishna Kumar Singh, Prarthana Rehan, Aparajita Dasgupta Amist, Rakesh Bhaskar, Jitendra Kumar Sinha

“…Despite their potential, more studies are needed to ensure the safety and efficacy of NP-based drug delivery systems focusing on critical aspects such as toxicity, immunogenicity, and pharmacokinetics. Therefore, this review addresses current treatment strategies and innovative nanoparticle approaches, and it discusses future directions for efficient and targeted meningitis therapies.…”
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Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps by Drake W. Phelps, Ashley M. Connors, Giuliano Ferrero, Jamie C. DeWitt, Jeffrey A. Yoder

“…For PFASs where innate immune data are available, results are equivocal, raising additional questions about common mechanisms or pathways of toxicity, but highlighting that the innate immune system within several species can be perturbed by exposure to PFASs. …”
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Simultaneous Determination of Cr, As, Se, and Other Trace Metal Elements in Seawater by ICP-MS with Hybrid Simultaneous Preconcentration Combining Iron Hydroxide Coprecipitation an... by Akihide Itoh, Masato Ono, Kota Suzuki, Takumi Yasuda, Kazuhiko Nakano, Kimika Kaneshima, Kazuho Inaba

“…Nevertheless, the present method would have possibility to develop as the analytical method to determine comprehensively most metal elements in all standard and guideline values in quality standard in environmental water in Japan, that is, most toxic metal elements in environmental water.…”
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Authentication of Processed Epimedii folium by EA-IRMS by Fengyan He, Mengyi Li, Yi He, Zhe Dong, Jin Cao, Zhong Dai, Shuangcheng Ma

“…Processing of crude drug is a key character of traditional Chinese medicine (TCM), which could enhance the efficacy and/or reduce the toxicity of crude drugs to fulfill different requirements of TCM clinical practice. …”
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