Foudroyant Course of an Extensive Clostridium septicum Gas Gangrene in a Diabetic Patient with Occult Carcinoma of the Colon by Maximilian Hartel, Asad Kutup, Axel Gehl, Jozef Zustin, Lars G. Grossterlinden, Johannes M. Rueger, Wolfgang Lehmann

“…After an incubation period of 5–48 hours, a very painful swelling is accompanied by a rapidly spreading toxic-infectious clinical picture ultimately leading to septic shock and multiple organ failure. …”
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Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary Results by M. Pracht, J. Edeline, L. Lenoir, M. Latournerie, H. Mesbah, O. Audrain, Y. Rolland, B. Clément, J. L. Raoul, E. Garin, E. Boucher

“…Patients were evaluated every 3 to 6 months for response, survival, and toxicity. Mean follow-up was 13.0 months (2.2–50.6). …”
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Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy by Sunil Kumar, Monu Kumar Shukla, Abhishek Kumar Sharma, Gururaj K. Jayaprakash, Rajiv K. Tonk, Dinesh K. Chellappan, Sachin Kumar Singh, Kamal Dua, Faheem Ahmed, Sanjib Bhattacharyya, Deepak Kumar

“…NMs are being modified to overcome issues, such as toxicity, lack of selectivity, increase drug capacity, and bioavailability, for a wide spectrum of cancer therapies. …”
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Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway by Xinzhang Chen, Xu Lin

“…Trimethyl tin (TMT) is a good stabilizer for plastic products but is also a toxic environmental pollutant. Selenium has good antioxidant and anti-inflammatory properties and has been widely used in the poultry industry. …”
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Allogeneic CD33-directed CAR-NKT cells for the treatment of bone marrow-resident myeloid malignancies by Yan-Ruide Li, Ying Fang, Siyue Niu, Yichen Zhu, Yuning Chen, Zibai Lyu, Enbo Zhu, Yanxin Tian, Jie Huang, Valerie Rezek, Scott Kitchen, Tzung Hsiai, Jin J. Zhou, Pin Wang, Wanxing Chai-Ho, Sunmin Park, Christopher S. Seet, Caspian Oliai, Lili Yang

“…These cells also show minimal off-tumor toxicity, reduced graft-versus-host disease and cytokine release syndrome risks, and resistance to allorejection, highlighting their substantial therapeutic potential for treating myeloid malignancies.…”
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Combined effects of pollution and bacterial infection in Sabella spallanzanii (Gmelin, 1971) by M. Dara, F. Bertini, C. La Corte, L. Bisanti, M. Staropoli, J. Vizioli, D. Parrinello, M. Cammarata, M. G. Parisi

“…Methylmercury is one of the most dangerous and toxic pollutants in marine environments, capable of bioaccumulating and being biomagnified within the food web with consequences for marine organisms. …”
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Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway by Charmy Twala, Sibusiso Malindisa, Chamone Munnik, Selisha Sooklal, Monde Ntwasa

“…We show that Ezetimibe inhibits the growth of several cancer cell lines at concentrations that are not toxic to a normal cell line. Conclusions: Thus, Ezetimibe is probably active against cancers that overexpress Mdm2. …”
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An Overview: Organophosphate Flame Retardants in the Atmosphere by Hsin-Chieh Kung, Yen-Kung Hsieh, Bo-Wun Huang, Nicholas Kiprotich Cheruiyot, Guo-Ping Chang-Chien

“…Lastly, atmospheric transformations of some OPFRs have been reported as more toxic and persistent than parent compounds, indicating additional risk. …”
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Enhancement of the Adsorptive Properties of a Desert Salsola Vermiculata Species by Noureddine Benderdouche, Benaouda Bestani, Baghdad Benstaali, Zoubir Derriche

“…These results showed that the activated plant could prove to be very useful in removing toxic substances from wastewater.…”
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RETRACTED ARTICLE: Fabrication of a magnetic alginate-silk fibroin hydrogel, containing halloysite nanotubes as a novel nanocomposite for biological and hyperthermia applications by Reza Eivazzadeh-Keihan, Zahra Sadat, Hooman Aghamirza Moghim Aliabadi, Fatemeh Ganjali, Amir Kashtiaray, Milad Salimi Bani, Samira Komijani, Mohammad Mahdi Ahadian, Nabi salehpour, Reza Ahangari Cohan, Ali Maleki

“…Moreover, the synthesized SA hydrogel/SF/HNTs/Fe3O4 nanobiocomposite does not demonstrate toxicity toward HEK293T normal cell line after 48 and 72 h. …”
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GSH/pH-responsive copper-based cascade nanocomplexes inducing immunogenic cell death through cuproptosis/ferroptosis/necroptosis in oral squamous cell carcinoma by Yi Sun, Enze Li, Wenzhao Zhong, Zhaoming Deng, Ziyao Zhou, Ka Hong Wong, Xiangwei Li

“…The study demonstrates that PC@B-H achieves a 92.3 % tumor growth inhibition rate with minimal systemic toxicity, offering a promising avenue for enhancing the efficacy of OSCC treatment through combined cell death pathways and immune activation.…”
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Prednisone inhibits osteosarcoma cell by regulating the Wnt/β-catenin signaling pathway by Yo Zhang, Hongmei Zhang, Shanshan Yang, Xiufeng Gao, Wenhao Guo

“…The results showed prednisone could inhibit the proliferation in osteosarcoma cells and exhibit lower proliferation toxicity towards normal bone cells compared to cisplatin by 17.5% (p<0.001). …”
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New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis by Zezheng Gao, Qingwei Li, Xuemin Wu, Xuemin Zhao, Linhua Zhao, Xiaolin Tong

“…Chinese herbs have been traditionally used to treat diabetes, with minimal side and toxic effects. Here, we reviewed monomers such as berberine, ginsenoside, M. charantia extract, and curcumin and herbal formulae such as Gegen Qinlian Decoction, Danggui Liuhuang Decoction, and Huanglian Wendan Decoction. …”
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Sesquiterpene Lactones as Promising Anti-Glioblastoma Drug Candidates Exerting Complex Effects on Glioblastoma Cell Viability and Proneural–Mesenchymal Transition by Andrey V. Markov, Arseny D. Moralev, Kirill V. Odarenko

“…Sesquiterpene triterpenoids (STLs) and their semi-synthetic analogs are considered as a promising source of novel anti-tumor agents due to their low systemic toxicity and multi-target pharmacological effects on key processes associated with tumor progression. …”
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DNA methylation and immune evasion in triple-negative breast cancer: challenges and therapeutic opportunities by Wen-yu Cai, Xin-xian Cai, Yi-ran Fei, Rui Ye, Ding-ming Song, Dan Hu, Wan-wan Zhang, Ming-fei Xia, Xiao-xiao Yang

“…We discuss the underlying mechanisms that enable these therapeutic synergies, preclinical and clinical evidence supporting the approach, and the challenges posed by tumor heterogeneity, drug resistance, and toxicity. Finally, we explore the potential for personalized treatment strategies incorporating multi-omics data to optimize therapeutic outcomes. …”
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The Effects of Microplastic Pollution on Marine Organisms and its Impact on Human Health: A Review by Aran Akbari, Jalil Jaafari

“…The accumulation of MPs in marine organisms consumed as human food has dangerous consequences for human health, leading to physical and chemical toxic effects. This study examines the effects of MPs and related contaminants on some of the most important marine organisms (plankton, bivalves, corals, fish, seabirds, and marine mammals) and also assesses the risks of human exposure to MPs through edible marine organisms.…”
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Genetic Variations of Glutathione S-Transferase Influence on Blood Cadmium Concentration by Nitchaphat Khansakorn, Waranya Wongwit, Prapin Tharnpoophasiam, Bunlue Hengprasith, Lerson Suwannathon, Suwannee Chanprasertyothin, Thunyachai Sura, Sming Kaojarern, Piyamit Sritara, Jintana Sirivarasai

“…This study indicated that polymorphisms of GSTP1 combined with GSTT1 and/or GSTM1 deletion are likely to influence on individual susceptibility to cadmium toxicity.…”
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Severe Diltiazem Poisoning Treated with Hyperinsulinaemia-Euglycaemia and Lipid Emulsion by Nadine Monteiro, Joana Silvestre, João Gonçalves-Pereira, Camila Tapadinhas, Vitor Mendes, Pedro Póvoa

“…CCB poisoning is associated with significant cardiovascular toxicity and is potentially fatal. Currently, there is no specific antidote and the treatment of CCB poisoning is supportive; however, this supportive therapy is often insufficient. …”
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Assessment of Halonitromethanes Formation Potentials Under Different Disinfection Scenarios in Low SUVA Water by Sehnaz Sule Kaplan-Bekaroglu, Sebnem Genisoglu, Cihan Ozgur

“…The main objective of this project is to investigate the formation of halonitromethanes, an emerging class of disinfection by-products (DBPs) identified in drinking waters in recent years, which are currently unregulated but highly toxic. Halonitromethanes formation potentials tests were investigated under five different disinfection conditions in Egirdir Lake with low specific ultraviolet absorbance (SUVA) value. …”
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An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity by Chun-Bing Chen, Riichiro Abe, Ren-You Pan, Chuang-Wei Wang, Shuen-Iu Hung, Yi-Giien Tsai, Wen-Hung Chung

“…., maculopapular exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS), or Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Current pharmacogenomic studies have made important strides in the prevention of some drug hypersensitivity through the identification of relevant genetic variants, particularly for genes encoding drug-metabolizing enzymes and human leukocyte antigens (HLAs). …”
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