Multi-Omics on Traditional Medicinal Plant of the Genus <i>Aconitum</i>: Current Progress and Prospect by Ting Wang, Cai Rangji, Wenbin Liu, Jing Ma, Ruichen Zhou, Liang Leng, Yi Zhang

“…Despite their medicinal potential, the toxicity of most DAs restricts the direct use of <i>Aconitum</i> in traditional medicine, necessitating complex processing before use. …”
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Enhanced tumor self-targeting of lemon-derived extracellular vesicles by embedding homotypic cancer cell membranes for efficient drug delivery by Lu-Yao Yang, Guo-Wu Liang, Bing-Jie Cai, Ke-Min Xu, Yu-Jie Zhao, Xiao-Ting Xie, Yu-Lin Zhang, Chao-Qing Li, Guo-Jun Zhang

“…After intravenous injection, LEVBD could efficiently and selectively home to homologous tumor sites even under competition from heterologous tumors and significantly inhibit tumor growth without any observable toxic side effects. The doping of homologous cancer cell membranes provides a paradigm for the precise delivery of drug delivery vehicles using plant-derived vesicles as the backbone. …”
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Biological Effects of Medicinal Plants on Induced Periodontitis: A Systematic Review by Jefferson Soares de Oliveira, Moara e Silva Conceição Pinto, Lucas de Araújo de Bastos Santana, Antonione Santos Bezerra Pinto, David di Lenardo, Daniel Fernando Pereira Vasconcelos

“…None of the studies described the possible toxic effects associated with the administration of the plant material to animals and whether they could prevent damage to organs caused by systemic effect of induced periodontitis. …”
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Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes by Zongheng Wang, Zhipeng Hou, Shuguang Zhang, Shuangyi Ren, Liqun Yang, Qianshi Zhang

“…IntroductionCancer remains one of the deadliest diseases worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used chemotherapeutic agents in clinical practice today, but its effectiveness is often hampered by rapid drug metabolism and systemic toxicity. To address these limitations, the development of novel drug delivery systems for sustained drug release is essential to improve therapeutic outcomes.MethodsThis study aimed to develop a poly(trimethylene carbonate) (PTMC) membrane capable of sustained drug release of 5-FU to enhance its antitumor activity. …”
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3D printed lactic acid bacteria hydrogel: cell release kinetics and stability by Yifei Liu, Xintao Yin, Xiudong Xia, Zhen Liu, Lifei Chen, Mingsheng Dong

“…In this study, a new type of 3D printed living biological hydrogel was developed by integrating lactic acid bacteria (LAB) into biocompatible and non-toxic polymer materials. Interestingly, the living materials loaded with LAB can be freeze-dried and reused for more than 100 times. …”
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Evaluation of Mango Byproduct Extracts as Antioxidant Against Pb-Acetate-Induced Oxidative Stress and Genotoxicity in Mice by Makawy Aida I. El, Ashoush Ihab S., Abd-Elmoneim Omaima M.

“…Two doses of both extracts (50 and 100 mg/kg) were used to evaluate their role against the toxicity of Pb-acetate (500 ppm). Mice given mango extracts with Pb-acetate had significantly lower plasma MDA, AST and ALT and higher glutathione than mice given Pb-acetate alone. …”
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Arsenic Transfer from As-Rich Sediments to River Water in the Presence of Biofilms by Diego Martiñá Prieto, Verónica Martín-Liñares, Verónica Piñeiro, María Teresa Barral

“…This fact is of toxicological relevance due to the usually higher mobility and toxicity of the reduced AsIII species. Control systems exhibited higher As mobility in water, in sulphate solution, and in weak acid medium and higher bioavailability in diffusive gradient in thin films (DGT) devices. …”
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In Vitro Investigation of Potential Anti-Diabetic Activity of the Corm Extract of Hypoxis Argentea Harv. Ex Baker by Akinrinde Akinleye, Koekemoer Trevor, Venter Maryna Van De, Bradley Graeme

“…In this study, we investigated the effects of non-toxic concentrations (12.5-100 μg mL-1) of the aqueous extract of H. argentea (HAA) corms on glucose uptake, pancreatic beta cell proliferation, and adipocyte differentiation. …”
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Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro by Rudolfová Petra, Hanušová Veronika, Skálová Lenka, Bártíková Hana, Matoušková Petra, Boušová Iva

“…Moreover, EGCG at 25 μmol L-1 increased the viability of isolated hepatocytes and significantly protected these cells against DOX-induced toxicity and ROS production. Consumption of EGCG during DOX therapy seems to be safe and beneficial, since EGCG does not decrease DOX anticancer efficacy and could ameliorate DOX hepatotoxicity…”
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Imatinib Mesylate Effectiveness in Chronic Myeloid Leukemia with Additional Cytogenetic Abnormalities at Diagnosis among Black Africans by Tolo Diebkilé Aïssata, Duni Sawadogo, Clotaire Nanho, Boidy Kouakou, N'dogomo Meité, N'Dhatz Emeuraude, Ayémou Roméo, Sekongo Yassongui Mamadou, Paul Kouéhion, Konan Mozart, Gustave Koffi, Ibrahima Sanogo

“…Death was related in 40% to hematologic toxicity and in 30% to acutisation. The median survival was 40 months.…”
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Hepatic Steatosis Aggravates Vascular Calcification via Extracellular Vesicle‐Mediated Osteochondrogenic Switch of Vascular Smooth Muscle Cells by Zhao‐Lin Zeng, Zhi‐Bo Zhao, Qing Yuan, Shi‐Qi Yang, Zhen‐Xing Wang, Zuo Wang, Shi‐Yu Zeng, An‐Qi Li, Qian Chen, Guo‐Qiang Zhu, Xin‐Hua Xiao, Guang‐Hua Luo, Hai‐Yan Luo, Jiao‐Yang Li, Xu‐Yu Zu, Hui Xie, Jiang‐Hua Liu

“…Steatotic hepatocytes are found to release more EVs, which are able to reach the vascular tissue, be taken up by vascular smooth muscle cells (VSMCs), and promote their osteogenic differentiation. Within these toxic vesicles, a protein cargo is identified called lectin galactoside‐binding soluble 3 binding protein (Lgals3bp) that acted as a potent inducer of osteochondrogenic transformation in VSMCs. …”
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Influence of physicochemical factors on the interaction of metallic nanoparticles with immune system cells by Sinai G. Gutiérrez-Cruz, Alejandro Muñoz-Diosdado, Ramón A. Gutiérrez-Calleja, Octavio Rodríguez-Cortés, Ana E. Ortiz-Reyez, Raúl Flores-Mejía

“…Concentration also plays a critical role; high concentrations may trigger toxic responses, while low concentrations may act beneficially. …”
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Development of Environmental Action Plans for Adaptation to Climate Change: A Perspective of Air Quality Management by Han-Shi Chen, Kei-Iong Tam, Yu-Lin Zhao, Lan Yuan, Weiyi Wang, Merrisa Lin, Pen-Chi Chiang

“…Abstract The impacts of climate change on air quality (tropospheric ozone pollution, particulate matter pollution, atmospheric deposition effect, and extreme weather events) greatly threaten most creatures on the earth who need to breathe fresh and non-toxic air. To respond to the impacts of climate change concerning air, many countries have proposed corresponding adaptation plans to reduce these impacts. …”
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Optimal Pest Control Strategies with Cost-effectiveness Analysis by Ihza Rizkia Fitri, Farida Hanum, Ali Kusnanto, Toni Bakhtiar

“…The risk of environmental hazards induced by toxic chemicals alongside the rapid development of chemical resistance by insects entails more resilient, sustainable, and ecologically sound approaches to chemical methods of control. …”
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Critical potassium concentrations for the initial cultivation of Cedrela fissilis Vell by Nonato Junior Ribeiro dos Santos, José Zilton Lopes Santos, Sulianne Idalior Paião Rosado, Tainah Manuela Benlolo Brabosa, Mylena Rêgo Panza, Marcelo Tavares Nunes, Josinaldo Lopes Araújo Rocha

“…This study aimed to determine the critical level of K deficiency and toxicity for the initial cultivation of cedar. We grew Cedrela fissilis seedlings in a nutrient solution under the effect of five concentrations of K (0, 1, 2, 5, and 8 mmol L-1) in a completely randomized design with five replications. …”
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Clinical and morphological features of salmonellosis in cows and calves affected by heat stress by L. I. Drozdova, E. N. Shilova, I. A. Shkuratova, M. V. Ryaposova

“…In calves, the disease was accompanied by septic signs, severein toxication, hyperthermia (40.5–41.0 °C), severed ehydration (morethan 7%) and death. …”
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Biological evaluation and interaction mechanism of beta-site APP cleaving enzyme 1 inhibitory pentapeptide from egg albumin by Zhipeng Yu, Sijia Wu, Wenzhu Zhao, Long Ding, David Shiuan, Fuping Zheng, Jianrong Li, Jingbo Liu

“…To find natural products for the treatment of Alzheimer's disease, absorption, distribution, metabolism, excretion and toxicity (ADMET) properties and in vitro BACE1 inhibitory activity of the peptides isolated from egg albumin were evaluated. …”
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Case of acute drug-induced hepatitis after halothane anesthesia by I. Yu. Pirogova, Ye. V. Berestova, O. Yu. Bastrikov, Ye. B. Kovaleva, T. P. Petukhova, M. V. Guseva, I. A. Gubina, I. V. Rezepin, S. P. Sinitsyn

“…Biotransformation of volatile anesthetics can result in production of toxic metabolites and metabolic by-products, resulting in damage of the liver and kidneys. …”
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Protein and Metalloprotein Distribution in Different Varieties of Beans (Phaseolus vulgaris L.): Effects of Cooking by Aline P. Oliveira, Geyssa Ferreira Andrade, Bianca S. O. Mateó, Juliana Naozuka

“…The cooking of the grains is imperative, due to reduction of the effect of some toxic and antinutritional substances, as well as increase of protein digestibility. …”
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Recrudescence of Plasmodium malariae after Quinine by Irfanali R. Kugasia, Farhana K. Polara, Hussein Assallum

“…We propose that the indolence of some of the Plasmodium malariae trophozoites in the blood can shield them from the effect of the toxic effects of antimalarials and enable them to produce recrudescence later. …”
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