Influence of Chronic Alcohol Use on Osteoblastic Differentiation of Bone Marrow Cells, Bone Properties, and Hepatic and Renal Morphology of Rats by Michelle Cardoso de Sousa, Mariana Raquel da Cruz Vegian, Matheus Alves Biserra, Bruno César Almeida Costa, Samira Esteves Afonso Camargo, Sigmar de Mello Rode, Carolina Judica Ramos, Luciane Dias de Oliveira, Luana Marotta Reis de Vasconcellos

“…Chronic alcohol exposure can affect the osteoblastic activity and the proliferation and differentiation of cells due to its toxic effect, which can affect negatively bone repair and bone microarchitecture. …”
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Single‐egg comet assay: A protocol to quantify DNA damage in natural bioarchives by Rejin Salimraj, Alessio Perotti, Marcin W. Wojewodzic, Dagmar Frisch

“…Abstract The comet assay (CA), originally developed as toxicity test, quantifies DNA integrity from DNA distribution across an electric field. …”
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Characterization of mineral composition of leaves and flowers of wild-growing Sambucus nigra by Qazimi Bujar, Stafilov Trajče, Andonovska Katerina Bačeva, Tašev Krste, Geskovski Nikola, Dragusha Shpend, Koraqi Hyrije, Ejupi Valon

“…The concentration of heavy metals and toxic elements (Pb, Cd, and Hg) was within the permissible concentrations according to Eur. …”
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The Role of Air Pollution and Olfactory Dysfunction in Alzheimer’s Disease Pathogenesis by Louise Odendaal, Hazel Quek, Carla Cuní-López, Anthony R. White, Romal Stewart

“…AD is recognised for its characteristic deposition of toxic proteins within the brain, leading to a steady deterioration of cognitive capabilities, memory failure, and, ultimately, death. …”
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Disseminated Exfoliative Dermatitis Associated with All-Transretinoic Acid in the Treatment of Acute Promyelocytic Leukemia by Yonal Ipek, Dogru Hulya, Aktan Melih

“…All-trans retinoic acid (ATRA) is a subgroup of the retinoid family, which induces complete remission (CR) in APL by causing differentiation and apoptosis in immature malignant promyelocytes rather than inducing cell death by cytotoxicity (Warrell et al. (1993), Liu et al. (2000), and Cassinat et al. (2001)). ATRA-associated toxicity consisting of headache, fever, weakness, fatigue, dry skin, dermatitis, gastrointestinal disorders, and hypertriglyceridemia has been shown to be mild (Kurzrock et al. (1993)). …”
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Health and Safety Considerations of Fermented Sausages by Askild Holck, Lars Axelsson, Anette McLeod, Tone Mari Rode, Even Heir

“…Over the last years, eating fermented sausages has been associated with potential health hazards due to their high contents of saturated fats, high NaCl content, presence of nitrite and its degradation products such as nitrosamines, and use of smoking which can lead to formation of toxic compounds such as polycyclic aromatic hydrocarbons. …”
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Successful Treatment of Cisplatin Overdose with Plasma Exchange by Yasuhiro Yamada, Yoshiaki Ikuta, Kisato Nosaka, Nobutomo Miyanari, Naoko Hayashi, Hiroaki Mitsuya, Hideo Baba

“…On day 4, he experienced frank cisplatin toxicities and emergency plasma exchange was initiated. …”
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Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review by Guangcan Chen, Tengyang Huang, Yifeng Dai, Xia Huo, Xijin Xu

“…Persistent organic pollutants (POPs) are pervasive organic chemicals with significant environmental and ecological ramifications, extending to adverse human health effects due to their toxicity and persistence. The intestinal mucosal barrier, a sophisticated defense mechanism comprising the epithelial layer, mucosal chemistry, and cellular immunity, shields the host from external threats and fosters a symbiotic relationship with intestinal bacteria. …”
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Rutin attenuates zearalenone-induced ferroptosis of endometrial stromal cells in piglets through the p53 signaling pathway by Chenlong Wang, Chuangjiang Chen, MengYa Wang, Sajid Ur Rahman, Bin Wei, Hongyan Ding, Wanyue Huang, Xichun Wang

“…Zearalenone (ZEA) is an environmentally widespread mycotoxin capable of posing a serious threat to food safety and public health, and porcine endometrial stromal cells (ESCs) are particularly sensitive to the toxic effects of ZEA. We hypothesized that Rutin, a flavonoid antioxidant, could significantly alleviate ZEA-induced ferroptosis through the p53 signaling pathway. …”
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Fatty Acid Accumulation and Resulting PPARα Activation in Fibroblasts due to Trifunctional Protein Deficiency by Masato Wakabayashi, Yuji Kamijo, Takero Nakajima, Naoki Tanaka, Eiko Sugiyama, Tian Yangyang, Takefumi Kimura, Toshifumi Aoyama

“…To examine fatty acid accumulation and its toxic effects in cells, we analyzed skin fibroblasts from six patients with mitochondrial trifunctional protein deficiency, who had abnormalities in the second through fourth reactions in fatty acid β-oxidation system. …”
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Efficacy of Nivolumab in a Patient with Metastatic Renal Cell Carcinoma and End-Stage Renal Disease on Dialysis: Case Report and Literature Review by Jawaher Ansari, Muhammad Ali, Ashraf Farrag, Arwa M. Ali, Abdulaziz Alhamad

“…In addition, there is uncertainty regarding drug dosing/pharmacokinetics, lack of safety and efficacy data, and potential for increased toxicity when using targeted therapy or immunotherapy for the management of patients with mRCC on dialysis. …”
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Research and application of advanced oxidation technology for low carbon and harmless treatment of hospital wastewater by XIONG Zhaokun, GU Lingyun, WANG Xinhao, CHEN Kexin, LAI Bo*

“…However, the high cost, substantial energy consumption, and the potential generation of additional toxic by-products limit the widespread application of advanced oxidation technologies in practical engineering. …”
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Physicochemical Characterization and Asymmetric Catalytic Properties of New Biobased Organocatalytic Surfactants by Elliot Calbrix, Pascale de Caro, Sophie Thiebaud-Roux, Christine Cecutti, Emeline Vedrenne

“…However, conventional solvents are often toxic and dangerous for the environment, and an interesting alternative is to replace them by water. …”
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Analysis of Slow-Released Fertilisers as a Source of Microplastics by Vladimir Isakov, Elena Vlasova, Vladislav Forer, Jose Kenny, Sergey Lyulin

“…Therefore, the solution to the problem of increasing the efficiency of agricultural production through the use of fertilisers with slow or controlled release of nutrients leads to environmental pollution by microplastics remaining in the soil after fertiliser application, which are also capable of adsorbing from the soil various toxic pollutants.…”
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Hepatic Differentiation of Murine Disease-Specific Induced Pluripotent Stem Cells Allows Disease Modelling In Vitro by Reto Eggenschwiler, Komal Loya, Malte Sgodda, Francoise André, Tobias Cantz

“…In this study, we focused on three murine models for metabolic liver disorders: the copper storage disorder Wilson's disease (toxic-milk mice), tyrosinemia type 1 (fumarylacetoacetate-hydrolase deficiency, FAH−/− mice), and alpha1-antitrypsin deficiency (PiZ mice). …”
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Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects by Dileep G. Nair, Ralf Weiskirchen

“…The use of advanced in vitro systems that closely mimic human physiology, such as organ-on-a-chip models like gut–liver-on-a-chip, can be crucial in improving drug efficacy while minimizing toxicity. Additionally, the adaptation of these technologies has the potential to significantly reduce both the time and cost associated with obtaining safe drug approvals, all while adhering to the 3Rs principle (replacement, reduction, refinement). …”
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Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer by Brock J. Sishc, Janapriya Saha, Elizabeth M. Alves, Lianghao Ding, Huiming Lu, Shih-Ya Wang, Katy L. Swancutt, James H. Nicholson, Angelica Facoetti, Arnold Pompos, Mario Ciocca, Todd A. Aguilera, Michael D. Story, Anthony J. Davis

“…These findings suggest that PDAC tumors with HR pathway mutations or high replication stress are more likely to benefit from CIRT while minimizing normal tissue toxicity.…”
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Renal Tubular Acidosis an Adverse Effect of PD-1 Inhibitor Immunotherapy by Sandy El Bitar, Chanudi Weerasinghe, Elie El-Charabaty, Marcel Odaimi

“…The widespread use of these agents resulted in increasing incidence of renal immune-related adverse events. Reported renal toxicity described so far includes acute interstitial nephritis, minimal change disease, and immune complex glomerulonephritis. …”
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Effect of Adsorption Characteristics of Rhodamine 6G Dye Solution in Fe3O4 Magnetic Nanoparticles on Fluorescence Quantum Yield by Suwaphit Phoemphoonthanyakit, Panpailin Seeharaj, Pattareeya Damrongsak, Kitsakorn Locharoenrat

“…We believe that our study makes a significant contribution to the literature because Fe3O4 magnetic nanoparticles were found to be able to quench rhodamine 6G dye molecules, which will aid in eliminating toxic and hazardous pollutants from dye wastewater, which are otherwise detrimental to the environment and human health.…”
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Oncolytic Virotherapy for Hematological Malignancies by Swarna Bais, Eric Bartee, Masmudur M. Rahman, Grant McFadden, Christopher R. Cogle

“…The ideal ex vivo purging agent would selectively target the contaminating cancer cells while spare normal stem and progenitor cells and would be applied quickly without toxicities to the recipient. One agent which meets these criteria is oncolytic viruses. …”
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