ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis by Marina B.R. de Santana, Giulia O. Miranda, Lucas P. Carvalho

“…One way to potentially overcome SbV resistance may be a combined therapeutic strategy involving anti-Leishmania drugs administered together with ABC transporter inhibitors; however, toxicity poses a major challenge to the adoption of this approach.…”
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Autophagy-associated signal pathways of functional foods for chronic diseases by Jinfeng Xie, Jiling Liang, Ning Chen

“…Once the cells are in the stress environment, the induced autophagy will accelerate the clearance of cellular damaged or toxic protein aggregates or dysfunctional cellular organelles to maintain homeostasis in cells. …”
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Relapsing Malaria: A Case Report of Primaquine Resistance by Christopher Dijanic, Jillian Nickerson, Sunita Shakya, Amanda Dijanic, Marilyn Fabbri

“…We think of relapse occurring because of parasitic resistance or poor compliance secondary to drug toxicities. However, in patients with repeated treatment failure, we must consider CYP-450 mutations affecting drug metabolism as an important cause of relapse. …”
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Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches by Dong Li, Aixin Li, Hairui Zhou, Xi Wang, Peng Li, Sheng Bi, Yang Teng

“…Although the DIM is the current focus of the study, the proposed approaches could be applied to other toxicity assessments and facilitate the safety evaluation.…”
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Assessment of Hair Aluminum, Lead, and Mercury in a Sample of Autistic Egyptian Children: Environmental Risk Factors of Heavy Metals in Autism by Farida El Baz Mohamed, Eman Ahmed Zaky, Adel Bassuoni El-Sayed, Reham Mohammed Elhossieny, Sally Soliman Zahra, Waleed Salah Eldin, Walaa Yousef Youssef, Rania Abdelmgeed Khaled, Azza Mohamed Youssef

“…Environmental exposure to these toxic heavy metals, at key times in development, may play a causal role in autism.…”
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Quercetin Protects Primary Human Osteoblasts Exposed to Cigarette Smoke through Activation of the Antioxidative Enzymes HO-1 and SOD-1 by Karl F. Braun, Sabrina Ehnert, Thomas Freude, José T. Egaña, Thilo L. Schenck, Arne Buchholz, Andreas Schmitt, Sebastian Siebenlist, Lilianna Schyschka, Markus Neumaier, Ulrich Stöckle, Andreas K. Nussler

“…The aim of this study was to investigate whether Quercetin, a naturally occurring antioxidant, can protect osteoblasts from the toxic effects of smoking. Human osteoblasts exposed to cigarette smoke medium (CSM) rapidly produced ROS and their viability decreased concentration- and time-dependently. …”
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Significant Removal of Harmful Compounds in Mainstream Cigarette Smoke Using Carbon Nanotubes Mixture Prepared by Catalytic Pyrolysis by Shun Zhou, Min Ning, Yaping Zhang, Qing He, Xiaofeng Wang, Dongliang Zhu, Song Guo, Ningning Hong, Yuan Hu

“…After introducing 15 mg of CNTM into cigarette filter, some of the most important harmful compounds including tar, nicotine, benzo[a]pyrene (B[a]P) and phenolic compounds were more efficiently adsorbed in comparison with using commercial activated carbon, which can be related to the relatively bigger pore volume and a geometric confinement of CNT in CNTM for some toxic compounds in cigarette smoke. In particular, CNTs have a strong chemisorption capacity for B[a]P or phenolic compounds due to the π–π interactions between benzene rings.…”
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Quinoline and Quinazoline Alkaloids against COVID-19: An In Silico Multitarget Approach by Esraa M. O. A. Ismail, Shaza W. Shantier, Mona S. Mohammed, Hassan H. Musa, Wadah Osman, Ramzi A. Mothana

“…Among seventy-one tested compounds, twenty-three were selected for molecular docking based on their pharmacokinetic and toxicity profiles. The results identified a number of potential inhibitors. …”
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Sepsis and Pleural Empyema Caused by Streptococcus pyogenes after Influenza A Virus Infection by Fumihiro Ochi, Hisamichi Tauchi, Toshihiro Jogamoto, Hiromitsu Miura, Tomozo Moritani, Kozo Nagai, Eiichi Ishii

“…Streptococcus pyogenes (also referred to as group A streptococci, GAS) causes severe invasive diseases such as bacteremia, necrotizing fasciitis, pneumonia, osteomyelitis, septic arthritis, and toxic shock syndrome in children. However, there are only a few reports on pleural empyema caused by GAS in children. …”
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A Comparative Cytotoxic Evaluation of Acrylamide and Diacetone Acrylamide to Investigate Their Suitability for Holographic Photopolymer Formulations by Dervil Cody, Alan Casey, Izabela Naydenova, Emilia Mihaylova

“…Diacetone acrylamide exhibits a significantly lower toxicity profile in comparison to acrylamide at all exposure times. …”
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Antibiotic, Pesticide, and Microbial Contaminants of Honey: Human Health Hazards by Noori Al-Waili, Khelod Salom, Ahmed Al-Ghamdi, Mohammad Javed Ansari

“…Many cases of infant botulisms have been attributed to contaminated honey. Honey may be very toxic when produced from certain plants. Ingestion of honey without knowing its source and safety might be problematic. …”
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Synthesis and Characterization of Pd/La₂O₃/ZnO Catalyst for Complete Oxidation of Methane, Propane and Butane by Ralitsa Velinova, Nina Kaneva, Georgi Ivanov, Daniela Kovacheva, Ivanka Spassova, Silviya Todorova, Genoveva Atanasova, Anton Naydenov

“…Noble metal-based catalysts are widely employed to remove toxic compounds from gas mixtures. The objective of the present study was the synthesis of a palladium-containing catalyst deposited on a support modified with La₂O₃ zinc oxide. …”
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Application of Purified Botulinum Type A Neurotoxin to Treat Experimental Trigeminal Neuropathy in Rats and Patients with Urinary Incontinence and Prostatic Hyperplasia by Yoshizo Matsuka, Teruhiko Yokoyama, Yumiko Yamamoto, Tomonori Suzuki, Ni Nengah Dwi Fatmawati, Atsushi Nishikawa, Tohru Ohyama, Toshihiro Watanabe, Takuo Kuboki, Atsushi Nagai, Keiji Oguma

“…Type A neurotoxin (NTX) of Clostridium botulinum was purified by a simple procedure using a lactose gel column. The toxicity of this purified toxin preparation was retained for at least 1 year at −30°C by supplementation with either 0.1% albumin or 0.05% albumin plus 1% trehalose. …”
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Vermicomposting of Vegetable Wastes Using Cow Dung by K. Muthukumaravel, A. Amsath, M. Sukumaran

“…Municipal solid wastes are mainly from domestic and commercial areas containing recyclable toxic substances, compostable organic matter and others. …”
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Endothelin receptor antagonists (ERAs) can potentially be used as therapeutic drugs to reduce hypertension caused by small molecule tyrosine kinase inhibitors (TKIs) by Qingjian He, Junling Lin, Chanjuan Mo, Guodong Li, Jianzhong Lu, Qiyin Sun, Lijun Cao, Haojian Gan, Quan Sun, Jiafang Yao, Shengyi Lian, WenJuan Wang

“…Among these drugs, vascular endothelial growth factor (VEGF) inhibitors, particularly novel small molecule tyrosine kinase inhibitors (TKIs), are extensively employed as VEGF inhibitors; however, they are also associated with a higher incidence of complications, with hypertension being the most prevalent cardiovascular toxic side effect. Currently, it is widely accepted that TKIs-induced hypertension involves multiple mechanisms including dysregulation of the endothelin (ET) axis, reduced bioavailability of nitric oxide (NO), imbalance in NO-ROS equilibrium system, vascular rarefaction, and activation of epithelial sodium calcium channels; nevertheless, excessive activation of ET system appears to be predominantly responsible for this condition. …”
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Comparative analysis: PVC and concrete panels and traditional masonry by Iara Lima da Silva, Renata de Oliveira Gomes

“…However, it presents challenges such as the emission of toxic gases in fire situations and limited suppliers, which can increase costs. …”
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Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome by Chilakamarti V. Ramana

“…However, they play an important role in many cellular processes including trans-differentiation into type I cells as well as repair of lung injury in response to toxic chemicals and respiratory pathogens. Transcription factors are the regulatory proteins dynamically modulating DNA structure and gene expression. …”
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Sedum alfredii Hance: A cadmium and zinc hyperaccumulating plant by Mingying Liu, Ying Feng, Miao Wang, Xinglin Sun, Chen Yinfei Qi, Xiaoe Yang, Dayi Zhang

“…The hyperaccumulating ecotype Sedum alfredii Hance is one of few Cd hyperaccumulators with Cd contents in leaves and stems up to 9000 mg/kg (dry weight, DW) and 6500 mg/kg (DW) respectively without displaying significant toxicity symptoms as reported in 2004. Numerous studies have been conducted to uncover the mystery of its hypertolerance and hyperaccumulation using high-throughput sequencing, biochemical and molecular techniques, mainly pointing to the root-microorganism interaction, restrained Cd storage in roots, efficient root-shoot translocation, effective cellular detoxification, and phloem-mediated metal remobilization. …”
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Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus by Md. Sakib Hossen, Siew Hua Gan, Md. Ibrahim Khalil

“…It has several important biological effects and has a relatively low toxicity. Recent studies using animal models have confirmed that melittin has significant glucose and lipid lowering activities by acting on several mechanistic pathways. …”
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Improving lithium-sulfur battery performance using a polysaccharide binder derived from red algae by Dóra Zalka, Alen Vizintin, Alexey Maximenko, Zoltán Pászti, Zoltán Dankházi, Kristóf Hegedüs, Lakshmi Shiva Shankar, Róbert Kun, Karel Saksl, Andrea Straková Fedorková, Pál Jóvári

“…Electrode slurries are prepared without the toxic solvent N-methyl-2-pyrrolidone, using only water as a solvent and dispersant, making the process potentially scalable and cost-effective. …”
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