HIV-Associated Hodgkin's Lymphoma: Prognosis and Therapy in the Era of cART by Caron A. Jacobson, Jeremy S. Abramson

“…Despite these significant advances, HIV-HL patients remain at increased risk for treatment-related toxicities and drug-drug interactions which require careful attention and supportive care to insure the safe administration of therapy. …”
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TOXICOLOGIC CHARACTERISTICS OF THE PREVENTIVE IODINE-CONTAINING PREPARATION “VANGTSEYOD” by T. V. Kruchinkina, Yu. A. Gavrilov, G. A. Gavrilova

“…Studies of the preparation safety performed on white mice showed that “Vangtseyod” does not have acute toxicity. It’s inclusion into mice diet at 1.0 and 2.0 g/kg dose during two months did not induce any signs of chronic intoxication as 100% mice of experimental group survived in comparison with the control group (57%). …”
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The Challenge of Recurrent Hepatitis C Virus in Liver Transplant Recipients by Paul J Marotta

“…Interferon-based antiviral therapy is challenging to use in this patient population because of significant toxicity. Nevertheless, these agents have some efficacy, and pegylated interferons, which are now being used more frequently, achieve superior response rates. …”
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A Pharmacological and Toxicological Profile of Silver as an Antimicrobial Agent in Medical Devices by Alan B. G. Lansdown

“…Silver sulphide or silver selenide precipitates, bound lysosomally in soft tissues, are inert and not associated with an irreversible toxic change. Argyria and argyrosis are the principle effects associated with heavy deposition of insoluble silver precipitates in the dermis and cornea/conjunctiva. …”
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Linezolid and serotonin syndrome by Haytham A. Wali

“…The Hunter Serotonin Toxicity Criteria have superior sensitivity and specificity over the Sternbach Criteria for diagnosis. …”
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Organic Alternatives to Quantum Dots for Intraoperative Near-Infrared Fluorescent Sentinel Lymph Node Mapping by Shunsuke Ohnishi, Stephen J. Lomnes, Rita G. Laurence, Andrew Gogbashian, Giuliano Mariani, John V. Frangioni

“…However, because of concerns over potential toxicity, organic alternatives to QDs will be required for initial clinical studies. …”
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Motion – Cyclo-oxygenase-2 Selective Nonsteroidal Anti-Inflammatory Drugs are as Safe as Placebo for the Stomach: Arguments Against the Motion by Andreas Maetzel

“…Selectivity for the COX-2 isoform affords protection against upper gastrointestinal toxicity possibly at the expense of the cardioprotective effect of traditional NSAIDs. …”
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Neonicotinoid Analysis in Sunflower (Helianthus annuus) Honey Samples Collected around Tekirdag in Turkey by Nurullah Ozdemir, Mustafa Necati Muz

“…In recent years, the widespread use of neonicotinoids in agricultural areas has caused environmental pollution due to its lower toxicity to mammals. Honey bees, which are considered as biological indicators of environmental pollution, can carry these pollutants to the hives. …”
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A Review of Chemical Variability and Metal Contamination of Herbaceous Plants in Terms of Health Safety—A Case Study of <i>Tanacetum vulgare</i> L. by Anna Turek

“…Stress factors to which plants are subjected may result in a decrease in their biological activity or toxic effects (as in the case of <i>Tanacetum vulgare</i> L.). …”
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Transcriptional Regulators of Claudins in Epithelial Tight Junctions by Niamat Khan, Abdul R. Asif

“…Human gastrointestinal tract is covered by a monolayer of specialized epithelial cells that constitute a protective barrier surface to external toxic and infectious agents along with metabolic and digestive functions. …”
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Acute Renal Failure due to a Tobramycin and Vancomycin Spacer in Revision Two-Staged Knee Arthroplasty by Ronak A. Patel, Hayden P. Baker, Sara B. Smith

“…The advantage to this approach is that antibiotic impregnated spacers provide supratherapeutic levels in the joint without toxic accumulation in serum. However, it remains important for physicians and pharmacists to be aware of antibiotic associated complications in knee revisions. …”
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Plasmapheresis for Pembrolizumab-Induced Hepatitis in a Patient with Squamous Cell Carcinoma and Prior Orthotopic Liver Transplantation by Sanaa Al-Nattah, Kusum Lata Sharma, Matthew Caldis, Erin Spengler, William N. Rose

“…Pembrolizumab is one such medication. While severe toxicities are very rare, mild immune-mediated reactions with a variety of end organ injuries are among the most commonly encountered adverse events attributed to these medications. …”
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Genotoxicity Studies of Titanium Dioxide Nanoparticles (TiO2NPs) in the Brain of Mice by Hanan R. H. Mohamed, Nahed A. Hussien

“…Recently, various studies referred to their toxic potential on various organs using different treatment route. …”
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HPRNA: Predicting synergistic drug combinations for angina pectoris based on human pathway relationship network algorithm. by Mengyao Zhou, Mengfan Xu, Xiangling Zhang, Xiaochun Xing, Yang Li, Guanghui Wang, Guiying Yan

“…Over the years, synergistic drug combinations therapies have attracted widespread attention due to its advantages of overcoming drug resistance, increasing treatment efficacy and decreasing toxicity. Compared to lengthy medical drugs experimental screening, mathematical models and algorithms show great potential in synergistic drug combinations prediction. …”
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Biochemical analysis to study wild-type and polyglutamine-expanded ATXN3 species. by Grégoire Quinet, María Cristina Paz-Cabrera, Raimundo Freire

“…The main hallmark of SCA3 is the expansion of a polyglutamine tract located in the C-terminal of Ataxin-3 (or ATXN3) protein, that triggers the mis-localization and toxic aggregation of ATXN3 in neuronal cells. The propensity of wild type and polyglutamine-expanded ATXN3 proteins to aggregate has been extensively studied over the last decades. …”
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Harnessing nanotechnology for enhanced epilepsy management by V. Manasa, J. Joysa Ruby, Himadri Priya Gogoi, S. Vignesh, P. H. Anjaneya, Akhil

“…Nanocarrier systems—such as nanoparticles, micelles, and liposomes—enhance drug specificity for brain delivery, improving the therapeutic efficacy and reducing off-target toxicity. New developments in nanocarrier systems for AEDs, including phenytoin, phenobarbital, carbamazepine, and valproate, demonstrate increased brain penetration, solubility, and controlled drug release, offering promising benefits in epilepsy management. …”
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Recent Updates on Induced Pluripotent Stem Cells in Hematological Disorders by Methichit Wattanapanitch

“…So far, many iPSC-derived disease models have led to the discovery of novel pathological mechanisms as well as new drugs in the pipeline that have been tested in the iPSC-derived cells for efficacy and potential toxicities. Furthermore, recent advances in genome editing technology in combination with the iPSC technology have provided a versatile platform for studying stem cell biology and regenerative medicine. …”
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Synthesis of Pure Micro- and Nanopyrite and Their Application for As (III) Removal from Aqueous Solution by Guobao Chen, Zhangfu Zhu, Yong Qin

“…Arsenic is one of the materials that has a worldwide concern because of its high toxicity and chronic effects on human health. The existence of arsenic as As (III) is about 56 times poisonous as As (V) and more difficult to process. …”
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Nanomaterials based biosensors applied for detection of aflatoxin B1 in cereals: a review by Loyce Namanya, Emma Panzi Mukhokosi, Ediriisa Mugampoza

“…It causes immune-suppressive effects, raising the risk of mutagenicity, carcinogenicity, teratogenicity, hepatotoxicity, and embryonic toxicity, as well as increasing illness and death. …”
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AM3, an Oral BRM: Protective Agent against Iatrogenic Bone-Marrow and Liver Damage in Breast Cancer Patients under Conventional Adjuvant Radiochemotherapy by Vicente G Villarrubia, Paula Marquez, Jose Cobo, Guillermo J Sada

“…Besides these hematological effects, AM3 palliated subclinical hepatic toxicity due to combined radio-chemotherapy. Finally, studies on acute-phase reactants, such as C-reactive protein, IgA. and factors B, C'3, and C'5 of the complement system, suggest that a modulation of hepatic inflammatory responses by AM3 appears to be essential for clinical effects described.…”
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