Maytansinoids in cancer therapy: advancements in antibody–drug conjugates and nanotechnology-enhanced drug delivery systems by Matteo Perra, Ines Castangia, Matteo Aroffu, Federica Fulgheri, Rita Abi-Rached, Maria Letizia Manca, Hernán Cortés, María Luisa Del Prado-Audelo, Carla Nomura-Contreras, Alejandra Romero-Montero, Dietrich Büsselberg, Gerardo Leyva-Gómez, Javad Sharifi-Rad, Daniela Calina

“…Preclinical and clinical studies show that AMCs, including FDA-approved drugs like Kadcyla and Elahere, effectively inhibit tumor growth while reducing systemic toxicity. Key developments include improved synthesis methods, linker chemistry and payload design. …”
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Removal of Cd (II) from Aqueous Media by Adsorption onto Chemically and Thermally Treated Rice Husk by María Camila Hoyos-Sánchez, Angie Carolina Córdoba-Pacheco, Luis Fernando Rodríguez-Herrera, Ramiro Uribe-Kaffure

“…Chemically and thermally treated rice husks were evaluated as a potential decontaminant of toxic Cd (II) in aqueous media. Rice husk (RH), a by-product from rice milling, was chemically treated with HCl and NaOH. …”
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Phytochemical fingerprinting of phytotoxins as a cutting-edge approach for unveiling nature’s secrets in forensic science by Nabil Zakaria, Ashraf S. A. El-Sayed, Mostafa G. Ali

“…This study explores the dynamic intersection of phytochemistry and forensic science, highlighting how the unique phytochemical profiles of toxic plants and their secondary metabolites, serve as distinctive markers for forensic investigations. …”
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Construction of Two mCherry Plasmids (pXG-mCherry) for Transgenic Leishmania: Valuable Tools for Future Molecular Analysis by Andrés Vacas, Conor Sugden, Óscar Velasco-Rodriguez, Miriam Algarabel-Olona, José Peña-Guerrero, Esther Larrea, Celia Fernández-Rubio, Paul A. Nguewa

“…Current treatments are toxic and poorly effective due to the acquisition of resistance within Leishmania populations. …”
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Deconjugation of Bile Acids with Immobilized Genetically Engineered Lactobacillus plantarum 80(pCBH1) by M. L. Jones, C. Martoni, H. Chen, W. Ouyang, T. Metz, S. Prakash

“…However, bile acids can be toxic when produced in pathologically high concentrations in hepatobileary and other diseases. …”
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Reversion of Hormone Treatment Resistance with the Addition of an mTOR Inhibitor in Endometrial Stromal Sarcoma by J. Martin-Liberal, C. Benson, C. Messiou, C. Fisher, I. Judson

“…Response has been maintained for more than 2 years with minimal toxicity and treatment is ongoing. Conclusion. This case suggests that the resistance to the hormone manipulation in ESS can be reversed by the addition of an mTOR pathway inhibitor. …”
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Air pollution modifies colonisation factors in beneficial symbiont Snodgrassella and disrupts the bumblebee gut microbiome by Hannah R. Sampson, Natalie Allcock, Eamonn B. Mallon, Julian M. Ketley, Julie A. Morrissey

“…Exposure of adult Bombus terrestris to non-toxic black carbon particulates significantly increased viable bacteria on MRS agar and 16S absolute abundance of beneficial bacteria Bombilactobacillus in Post-treated bumblebees compared to Pre-treated, demonstrating disruption of the bumblebee gut microbiome. …”
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Arsenic Contamination of Groundwater: A Review of Sources, Prevalence, Health Risks, and Strategies for Mitigation by Shiv Shankar, Uma Shanker, Shikha

“…The paper also critically reviews the As led human health risks, its uptake, metabolism, and toxicity mechanisms. The paper provides an overview of the state-of-the-art knowledge on the alternative As free drinking water and various technologies (oxidation, coagulation flocculation, adsorption, and microbial) for mitigation of the problem of As contamination of groundwater.…”
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Emergency Evacuation of Hazardous Chemical Accidents Based on Diffusion Simulation by Jiang-Hua Zhang, Hai-Yue Liu, Rui Zhu, Yang Liu

“…The recent rapid development of information technology, such as sensing technology, communications technology, and database, allows us to use simulation experiments for analyzing serious accidents caused by hazardous chemicals. Due to the toxicity and diffusion of hazardous chemicals, these accidents often lead to not only severe consequences and economic losses, but also traffic jams at the same time. …”
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NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication by Hyeonseo Park, Tejal V. Patil, Jieun Lee, Hojin Kim, Seong-Jun Cho, Ki-Taek Lim

“…Our research proposes a platform that not only effectively addresses antibiotic-resistant infections but also contributes to advancements in wound healing therapies by enabling controlled antibacterial action with minimal toxicity.…”
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The Brain-Heart Connection in Takotsubo Syndrome: The Central Nervous System, Sympathetic Nervous System, and Catecholamine Overload by Xiaopu Wang, Junyu Pei, Xinqun Hu

“…Specifically, stress can activate the SNS and lead to the over-release of catecholamine, which have toxic effects on myocardial tissue when present at excessive levels. …”
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Sensitive and Simultaneous Determination of Hydroquinone and Catechol in Water Using an Anodized Glassy Carbon Electrode with Polymerized 2-(Phenylazo) Chromotropic Acid by Miao Zhang, Chuang-ye Ge, Ya-feng Jin, Liang-bin Hu, Hai-zhen Mo, Xiao-bo Li, Hao Zhang

“…Hydroquinone (HQ) and catechol (CT) are considered as environmental pollutants with high toxicity. We have developed a simple electrochemical sensor using an anodized glassy carbon electrode modified with a stable 2-(phenylazo) chromotropic acid- (CH-) conducting polymer (PCH/AGCE). …”
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Ranitidine bismuth citrate: A review by N Chiba, RH Hunt, ABR Thomson

“…Bismuth levels do not appear to rise to toxic levels.…”
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Strategies to Overcome Intrinsic and Acquired Resistance to Chemoradiotherapy in Head and Neck Cancer by Tycho de Bakker, Anouk Maes, Tatiana Dragan, Philippe Martinive, Sébastien Penninckx, Dirk Van Gestel

“…Research is ongoing on how to improve the tumor response to treatment and limit normal tissue toxicity. A major limitation in that regard is the growing occurrence of intrinsic or acquired treatment resistance in advanced cases. …”
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Biosynthesis of α MnO2 nanorods using Coleus amboinicus leaf extract and its adsorption performance of Pb(II) from aqueous solutions. by Rejani Padmavathiamma, Rani Pillai

“…Heavy metals are known to be toxic for living organisms even if they are present at low levels. …”
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Oral Cavity Squamous Cell Carcinoma: Impact of Clear Margin Distance on Locoregional Control in Patients Undergoing Postoperative Radiotherapy by Erkan Topkan MD, Efsun Somay PhD, Ugur Selek MD

“…We congratulate Lang and colleagues for their study investigating the impact of resection margin (RM) size on locoregional control (LC) outcomes, overall survival (OS), progression-free survival (PFS), and treatment-related toxicity in 162 patients with oral cavity squamous cell carcinoma (OCSCC) who received postoperative radiotherapy (PORT).1 In this study, 77 (47.5%), 22 (13.6%), and 63 (38.9%) patients had involved (5 mm) RM, respectively. …”
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Synthesis and Catalytic and Biological Activities of Silver and Copper Nanoparticles Using Cassia occidentalis by Manjul Gondwal, Geeta Joshi nee Pant

“…The AgNPs showed lower haemolysis (1.7%) exhibiting lesser toxicity as compared to CuNPs. The CuNPs have better catalytic ability for the reduction of 4-nitrophenol and 2-nitrophenol as compared to AgNPs.…”
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Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers? by M. W. Saif, B. Fallon, K. N. Syrigos

“…Radiological response, duration of response and toxicities were evaluated. Results. In both cases, the targeted agents were able to control the disease for a short duration, but due to the deterioration in performance status and fatigue the agents were discontinued. …”
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Isolation and Characterization of 89K Pathogenicity Island-Positive ST-7 Strains of Streptococcus suis Serotype 2 from Healthy Pigs, Northeast China by Shujie Wang, Peng Liu, Chunyu Li, Yafang Tan, Xuehui Cai, Dongsheng Zhou, Yongqiang Jiang

“…Streptococcus suis is a swine pathogen which can also cause severe infection, such as meningitis, and streptococcal-like toxic shock syndrome (STSS), in humans. In China, most of the S. suis infections in humans were reported in the southern areas with warm and humid climates, but little attention had been paid to the northern areas. …”
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Mitoxantrone and acquired Long-QT Syndrome. Case presentation. by Brandy Viera Valdés, Lázaro Enrique De la Cruz Aviléz

“…After an exclusion diagnosis we concluded that there could be an association with the use of this drug caused by its toxic effects for the cardiac system. Mitoxantrone interferes in ionic transportation through cellular membrane, delays the exit of potassium from the cells and acts in the functioning of ATP asa Na/K altering the ventricular repolarization; however, it is not on the list of drugs that enlarge the QT interval. …”
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