Natural Products: Insights into Leishmaniasis Inflammatory Response by Igor A. Rodrigues, Ana Maria Mazotto, Verônica Cardoso, Renan L. Alves, Ana Claudia F. Amaral, Jefferson Rocha de Andrade Silva, Anderson S. Pinheiro, Alane B. Vermelho

“…Leishmaniasis is a vector-borne disease that affects several populations worldwide, against which there are no vaccines available and the chemotherapy is highly toxic. Depending on the species causing the infection, the disease is characterized by commitment of tissues, including the skin, mucous membranes, and internal organs. …”
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Arsenic, Antimony, Chromium, and Thallium Speciation in Water and Sediment Samples with the LC-ICP-MS Technique by Magdalena Jabłońska-Czapla

“…Chemical speciation is a very important subject in the environmental protection, toxicology, and chemical analytics due to the fact that toxicity, availability, and reactivity of trace elements depend on the chemical forms in which these elements occur. …”
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Phytosynthesis of Titanium Dioxide Nanoparticles Using King of Bitter Andrographis paniculata and Its Embryonic Toxicology Evaluation and Biomedical Potential by S. Rajeshkumar, J. Santhoshkumar, Leta Tesfaye Jule, Krishnaraj Ramaswamy

“…The phytosynthesis TiO2 shows the antioxidant and antidiabetic activities. Similarly, toxicity studies have demonstrated the hatching and viability LD 50 value of TiO2 250 μg/L. …”
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Insulin Blocks Glutamate-Induced Neurotoxicity in Differentiated SH-SY5Y Neuronal Cells by Madhavan Nampoothiri, Neetinkumar D. Reddy, Jessy John, Nitesh Kumar, Gopalan Kutty Nampurath, Mallikarjuna Rao Chamallamudi

“…Thus, we examined the neuroprotective effect of insulin on glutamate-induced toxicity on differentiated SH-SY5Y neuronal cells. …”
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Preliminary in vitro evaluation of the anti-proliferative activity of guanylhydrazone derivatives by França Paulo H. B., Da Silva-Júnior Edeildo F., Aquino Pedro G. V., Santana Antônio E. G., Ferro Jamylle N. S., De Oliveira Barreto Emiliano, Do Ó Pessoa Cláudia, Meira Assuero Silva, De Aquino Thiago M., Alexandre-Moreira Magna S., Schmitt Martine, De Araújo-Júnior João X.

“…Among them, 7 was less toxic to non-tumor cells. Finally, obtained data suggest that guanylhydrazones may be regarded as potential lead compounds for the design of novel anticancer agents.…”
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Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression by Idris Yakubu, Abdolreza Haririan, Stephen Bartlett, Tracy Sparkes

“…Renal transplantation between monozygous identical twins provides an opportunity to utilize minimal immunosuppression to maintain stable allograft function, thereby alleviating the toxicities of immunosuppressive therapy. Despite monozygosity, there is a possibility of discordant protein presentation in identical twins that could trigger alloimmune response and lead to graft injury. …”
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Antibiotic Treatment of Dogs and Cats during Pregnancy by Marcela Rebuelto, María Elena Loza

“…The risk to the fetus is a result of the ability of a drug to reach the fetal circulation and to produce toxic effects. The placenta functions as a barrier that protects the fetus due to the presence of transporters and metabolising enzymes; however, during pregnancy, the presence and activity of both enzymes and transporters may change. …”
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Metal Content in Dandelion (Taraxacum officinale) Leaves: Influence of Vehicular Traffic and Safety upon Consumption as Food by Agnese Giacomino, Mery Malandrino, Maria Laura Colombo, Sergio Miaglia, Pietro Maimone, Sebastiano Blancato, Eleonora Conca, Ornella Abollino

“…Taraxacum officinale leaves growing spontaneously in meadows and along the streets are traditionally picked up and eaten in Italy as salad, so it is important to know the concentrations of potentially toxic elements contained in them from the point of view of food safety. …”
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Simultaneously Recovering High-Purity Chromium and Removing Organic Pollutants from Tannery Effluent by Jie Zong, Yan-Chun Li, Kang Hu

“…Chromium pollution is a serious issue because of carcinogenic toxicities of the pollutants and low recovery rate of chromium because of the presence of organic, such as protein and fat. …”
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In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta by Cyboran-Mikołajczyk Sylwia, Csonka Ákos, Molnar Joseph, Szabó Diana, Oszmiański Jan, Kleszczyńska Halina

“…They effectively protected the red blood cells from oxidative damage, but were not toxic to lymphoma cells and did not affect their multidrug resistance. …”
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Speciation and historical invasions of the Asian black-spined toad (Duttaphrynus melanostictus) by Christophe Dufresnes, Daniel Jablonski, Johanna Ambu, Vishal Kumar Prasad, Kumudani Bala Gautam, Rachunliu G. Kamei, Stephen Mahony, Sylvia Hofmann, Rafaqat Masroor, Bérénice Alard, Angelica Crottini, Devin Edmonds, Annemarie Ohler, Jianping Jiang, Janak R. Khatiwada, Sandeep Kumar Gupta, Amaël Borzée, Leo J. Borkin, Dmitriy V. Skorinov, Daniel A. Melnikov, Konstantin D. Milto, Evgeny L. Konstantinov, Sven Künzel, Tomasz Suchan, Dmitriy V. Arkhipov, Alexei V. Trofimets, Tan Van Nguyen, Chatmongkon Suwannapoom, Spartak N. Litvinchuk, Nikolay A. Poyarkov

“…Combining continental-wide genomic and DNA-barcoding analyses, we reconstructed the historical biogeography of the Asian black-spined toad (Duttaphrynus melanostictus), a toxic commensal amphibian that currently threatens two biodiversity hotspots through biological invasions (Wallacea and Madagascar). …”
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Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs by Torić Jelena, Marković Ana Karković, Brala Cvijeta Jakobušić, Barbarić Monika

“…The biggest issue concerning the chemotherapeutics is their toxicity on normal cells and persisting side effects. …”
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Distant Ureteral Metastasis from Colon Adenocarcinoma: Report of a Case and Review of the Literature by Ferakis Nikolaos, Anastasopoulos Panagiotis, Bouropoulos Konstantinos, Samaras Vassilios, Poulias Iraklis

“…The patient died 6 months later due to toxic megacolon during chemotherapy. The differential diagnosis of ureteral adenocarcinoma, especially in patients with previous history of colon adenocarcinoma, should include the possibility of distant metastasis from the primary colonic tumor.…”
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The Role of Cytokines in Nephrotic Syndrome by Elham Ahmadian, Yalda Rahbar Saadat, Elaheh Dalir Abdolahinia, Milad Bastami, Mohammadali M. Shoja, Sepideh Zununi Vahed, Mohammadreza Ardalan

“…Thus, the introduction of distinctive cytokines as novel biomarkers of SRNS enables both preventions of drug-related toxicity and earlier switch to more effective therapies. …”
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A Case of Repeat Kidney Transplant Intolerant to Multiple First-line Immunosuppressive Agents Mycophenolate Mofetil, Azathioprine, and Calcineurin Inhibitors by Puneet Arora, Rajan Duggal, Deepak Garg, Tarique Naseem

“…The case highlights the need for newer immunosuppressive drugs and protocols that are more effective and less toxic.…”
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Preclinical advance in nanoliposome-mediated photothermal therapy in liver cancer by Lixuan Tang, Xiao Yang, Liwen He, Chaogeng Zhu, Qingshan Chen

“…Although traditional treatment methods such as surgery, radiotherapy, and chemotherapy have increased the survival rate of patients, their efficacy remains unsatisfactory owing to the nonspecific distribution of drugs, high toxicity, and drug resistance of tumor tissues. In recent years, the application of nanotechnology in the medical field has opened a new avenue for the treatment of liver cancer. …”
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Hybrid optimal control for HIV multi-drug therapies: A finite set control transcription approach by Divya Thakur, Belinda Marchand

“…An STI treatment strategy may be beneficial in lowering the risk of HIV mutating to drug-resistant strains, and could provide patients with respite from toxic side effects of HAART. A shorter treatment period is considered compared to previous studies and the solution to the HIV STI problem is obtained via the Finite Set Control Transcription (FSCT) formulation. …”
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Hemin Augments Growth and Hemoglobinization of Erythroid Precursors from Patients with Diamond-Blackfan Anemia by Eitan Fibach, Memet Aker

“…In erythroid precursors derived from DBA patients, hemin significantly stimulated growth and hemoglobinization. Thus, heme toxicity is unlikely to play a role in the pathophysiology of most DBA cases. …”
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Chronic Exposure to Arsenic in Drinking Water Causes Alterations in Locomotor Activity and Decreases Striatal mRNA for the D2 Dopamine Receptor in CD1 Male Mice by Claudia Leticia Moreno Ávila, Jorge H. Limón-Pacheco, Magda Giordano, Verónica M. Rodríguez

“…This study provides evidence for the use of dopamine receptor D2 as potential target of arsenic toxicity in the dopaminergic system.…”
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A three-dimensional mouse liver organoid platform for assessing EDCs metabolites simulating liver metabolism by Ji Hyun Moon, Hyun-Soo Roh, Young Jae Park, Hyun Ho Song, Jieun Choi, Da Woon Jung, Soo Jin Park, Ho Jin Park, So-Hyeon Park, Da-Eun Kim, Gahee Kim, Joong-Hyuck Auh, Dong Ha Bhang, Hong Jin Lee, Do Yup Lee

“…Hepatic metabolism is an important process for evaluate the potential activity and toxicity of endocrine disrupting chemicals (EDCs) metabolites. …”
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