Neoadjuvant pembrolizumab-carboplatin-paclitaxel in locally advanced squamous cell carcinoma of the oral cavity: A case report and literature review by Abdulrahman Hesham, Fawaz AlOtaibi, D. David Kim, Yousef Alshamrani, Joao Hyppolito, Katie Jubala

“…Clinical trials are essential to investigate the viability of this potentially less toxic and more convenient combined therapy in patients with advanced squamous cell carcinoma of the oral cavity.…”
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In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide by Laura V. Ashton, Robert L. Callan, Sangeeta Rao, Gabriele A. Landolt

“…These results suggest that NTZ and TIZ are effective against CIV and may be useful for treatment of canine influenza in dogs but further investigation of the in vivo efficacy against CIV as well as the drug's potential for toxicity in dogs is needed.…”
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Lymphomatoid granulomatosis with rare manifestations. Case report by Pedro Rosales Torres, Pedro León Acosta

“…Patient information: 44-year-old male, with a health history and no toxic habits, who began with respiratory symptoms, dermatological lesions, constitutional syndrome and flaccid paraplegia. …”
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Chronic immune-related adverse events arising from immune checkpoint inhibitors: an update by Douglas B Johnson, Kylie Fletcher

“…Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, improving outcomes for many patients. However, toxicities termed immune-related adverse events (irAEs) are limitations of these revolutionary treatments. …”
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Dual-drug loaded chondroitin sulfate embolization beads enhance TACE therapy for HCC by integrating embolization, chemotherapy, and anti-angiogenesis by Jin-Xin Huang, Rui Yang, Huan Long, Jie Kong, Guo-Qiang Shao, Fei Xiong

“…We have developed chondroitin sulfate microspheres (CMs) capable of encapsulating both the cytotoxic drug idarubicin (Ida) and the vascular inhibitor Lenvatinib (Len), thereby achieving a triple therapeutic effect on liver cancer: embolic starvation, drug toxicity, and efficient inhibition of neovascularization.…”
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Genetic Variations Affect Chemotherapy Outcomes: A Role of the Spindle-assembly Checkpoint by Sinjini Sarkar, Ranita Pal, Trisha Choudhury, Manisha Vernekar, Partha Nath, Vilas D. Nasare

“…In addition, genetic polymorphisms in BUB3 (rs11248416 and rs11248419) were significantly linked to chemotherapy-related toxicities, with rs11248416 showing a negative impact on the patient’s physical quality of life.…”
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Chinchorro culture: An analysis from the learning perspective by Liliana Pedraja-Rejas, Emilio Rodríguez-Ponce, Camila Muñoz-Fritis, Miguel-Ángel Garrido-Tamayo, Javier Vélez, David Laroze

“…Regarding the topics addressed, three main areas of study were found: 1) pathologies and toxicity, 2) life, society and cultural interactions, and 3) funerary traditions and mummification. …”
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Enhancing hepatocellular carcinoma therapy with DOX-loaded SiO2 nanoparticles via mTOR-TFEB pathway autophagic flux inhibition by Huanyu Chen, Jun Liu, Zhichao Cao, Jiajia Li, Hong Zhang, Qianqian Yang, Jian Cheng, Yuxian Shen, Kewu He

“…Abstract Chemotherapeutic drugs often fail to provide long-term efficacy due to their lack of specificity and high toxicity. To enhance the biosafety and reduce the side effects of these drugs, various nanocarrier delivery systems have been developed. …”
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Bacterial Infections, DNA Virus Infections, and RNA Virus Infections Manifest Differently in Neutrophil Receptor Expression by Esa-Matti Lilius, Jari Nuutila

“…Treating viral illnesses or noninfective causes of inflammation with antibiotics is ineffective and contributes to the development of antibiotic resistance, toxicity, and allergic reactions, leading to increasing medical costs. …”
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Chiral recognition of some D and L-amino acids by microcrystalline cellulose assisted diffusion-ordered NMR spectroscopy by Bowen Han, Jing He, Shaohua Huang

“…Microcrystalline cellulose has been gradually gained more and more interest owing to its wide compatibility, surface area, excellent separation efficiency, non-toxicity, cost-effective, and mechanical stability in many fields. …”
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Studies on Dyeing Performance of Novel Acid Azo Dyes and Mordent Acid Azo Dyes Based on 2,4-Dihydroxybenzophenone by Bharat C. Dixit, Hitendra M. Patel, Dhirubhai J. Desai, Ritu B. Dixit

“…Results of bactericidal studies of chrome pretreated fibers revealed that the toxicity of mordented dyes against bacteria is fairly good. …”
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Autoantibodies and Liver Disease: Uses and Abuses by Marilyn V Zeman, Gideon M Hirschfield

“…In the continued absence of pathognomonic serum markers, diagnosis requires evaluation of laboratory investigations and, frequently, a liver biopsy – all of which need to be interpreted in the correct clinical context, with an emphasis on exclusion of viral infections, drug toxicity and metabolic disease. However, clear diagnosis is important for appropriate and timely therapy. …”
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FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors by Levi Makala, Salvatore Di Maro, Tzu-Fang Lou, Sharanya Sivanand, Jung-Mo Ahn, Betty S. Pace

“…To determine the physiological relevance of these compounds, studies in primary erythroid progenitors confirmed that JMA26 and JMA33 activated HbF synthesis at levels comparable to FK228 with low cellular toxicity. These data support our lead compounds as potential therapeutic agents for further development in the treatment of SCD.…”
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Fabrication of Cu–Zn–Sn–S–O Thin Films by the Electrochemical Deposition Method and Application to Heterojunction Cells by Kai Yang, Masaya Ichimura

“…A new multinary semiconductor Cu2ZnSnS4−𝑥O𝑥 (CZTSO), which does not contain toxic elements and expensive rare metals, was fabricated by the electrochemical deposition (ECD) method. …”
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Unique Optoelectronic Properties and Applications of Lead‐Free Perovskites and Derivatives by Mingbian Li, Weijun Li, Haotong Wei

“…The pursuit of lead‐free alternatives to lead halide perovskites has gained significant momentum due to the environmental concerns associated with lead toxicity. The adverse effects of lead on human health and the environment have prompted a shift toward developing sustainable and eco‐friendly perovskite materials for various optoelectronic devices. …”
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Cellulose nanofiber reinforced curcumin-infused calcium phosphate silicate cement for various bone-tissue engineering application by Xiu Guo Lu, Xiu Guo Lu, Sha Li Meng, Sha Li Meng, Qiu Jing Zhou, Qiu Jing Zhou, Tao Wu, Tao Wu, Xing Tian Gong, Qiong Wu

“…Biological assessments reveal a pronounced cytotoxic effect on osteosarcoma cells while maintaining minimal toxicity toward pre-osteoblasts, highlighting CPSC-Cur’s potential as a promising material for repairing bone defects following cancer removal.ConclusionThis study lays the groundwork for future investigations into CPSC-Cur’s in vivo efficacy and its role in the clinical treatment of bone cancer.…”
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Ca OXALATES IN LICHEN GENUS CLADONIA ON DUMPS OF THE SUGUR COPPER DEPOSIT (SOUTH URALS) by E.E. Artemenko, M.A. Rassomakhin, P.V. Khvorov, K.A. Filipрova

“…The samples of lichens and substrate are studied by scanning electron microscopy, energy-dispersion microanalysis, X-ray phase analysis and inductively coupled plasma mass spectrometry. The contents of toxic elements (Cu, Zn, Pb, Cd, Sn, Sb, Se, As, Te) of substrate and lichen thalli exceed their average contents in the Earth’s crust, whereas their contents in thalli are lower than in substrate (except for Cd). …”
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Recent Advances in Chitosan-Based Metal Nanocomposites for Wound Healing Applications by Kai Wang, Su Pan, Zhiping Qi, Peng Xia, Haotian Xu, Weijian Kong, Hongru Li, Pan Xue, Xiaoyu Yang, Chuan Fu

“…Chitosan (CS) has been extensively studied as a natural polymer, in the field of wound repair, due to its useful properties, which include a lack of toxicity and stimulation, excellent biological affinity, degradability, and promotion of collagen deposition. …”
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Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors by Fersing Cyril, Mathias Fanny

“…Glasdegib, an oral Hedgehog pathway inhibitor, showed satisfactory response rates associated with moderate toxicity and less early mortality than standard induction regimens in this population. …”
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Neratinib and the Role of Anti‐HER2 Therapy in Salivary Duct Carcinoma by Martina Napolitano, Lucia Trudu, Enrica Martinelli, Chiara Santini, Massimo Dominici, Federica Bertolini

“…Even with central nervous system involvement at diagnosis, a durable clinical response was obtained with a PFS of 11 months and no significant toxicities to manage. Best response observed during tratment was partial response. …”
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