Antiplasmodial and Cytotoxic Activities of Extracts of Selected Medicinal Plants Used to Treat Malaria in Embu County, Kenya by Bibianne Waiganjo, Gervason Moriasi, Jared Onyancha, Nelson Elias, Francis Muregi

“…Further focused studies geared towards isolation of active constituents and determination of in vivo toxicities to ascertain their safety are warranted.…”
Get full text

Human Serum Albumin and Human Serum Albumin Nanoparticles as Carriers of 10-(2′-Pyrimidyl)-3,6-diazaphenothiazine: In Vitro Spectroscopic Studies by Aleksandra Owczarzy, Karolina Kulig, Beata Morak-Młodawska, Małgorzata Jeleń, Tammam Muhammetoglu, Wojciech Rogóż, Małgorzata Maciążek-Jurczyk

“…Based on the data presented, it can be concluded that due to the high toxic effects of 10-Pyr-3,6-DAPT, a better carrier may be HSA-NPs.…”
Get full text

Concurrent versus sequential immunotherapy with chemoradiotherapy for unresectable stage III non-small-cell lung cancer: a retrospective study by Zhou Meng-Xi, Fan Wen-Jie, Zhang Ning, Zhu Li-Yang, Wang Hong-Yan

“…The incidence of any grade of pneumonitis was 43.1% and 38.3% in two groups, with grade 3 or higher in 7.8% and 8.5% of patients, respectively. Hematologic toxicity of any grade was observed in 29.4% and 34.0% of the two groups, with grade 3 or higher toxicity identified in 3.9% and 2.1% of patients, respectively.ConclusionsConcurrent immunotherapy combined with chemoradiotherapy demonstrated superior efficacy than sequential immunotherapy, with good safety and tolerability in patients with unresectable stage III NSCLC.…”
Get full text

Safety of vancomycin-loaded cement spacers for treating gram-positive periprosthetic joint infections in two-stage resection arthroplasty among patients with renal insufficiency by Yu-Chih Lin, Chih-Hsiang Chang, Chih-Chien Hu, Yung-Chieh Liang, Pang-Hsin Hsieh, Sheng-Hsun Lee, Sheng-Hsuan Lin

“…RI patients displayed higher peak blood vancomycin levels (1.23–5.43 mg/L) but remained below toxicity thresholds. The infection-free interval, aseptic revision rates, and bacterial profiles specific to gram-positive species showed no significant differences between the groups. …”
Get full text

Trifluridine-tipiracil in previously treated patients with oestrogen receptor-positive, HER2-negative metastatic breast cancer (BOOG 2019-01 TIBET trial): a single-arm, multicentre... by Niels A.D. Guchelaar, Ron H.J. Mathijssen, Maaike de Boer, Marlies L. van Bekkum, Joan B. Heijns, Birgit E.P.J. Vriens, Mandy M. van Rosmalen, Lonneke W. Kessels, Lisanne Hamming, Karin J. Beelen, Peter Nieboer, Susan M. van den Berg, Esther Oomen-de Hoop, Rhodé M. Bijlsma, Monique E.M.M. Bos

“…The safety profile of trifluridine-tipiracil aligned with expected toxicities and included leukopenia (n = 36, 69%), neutropenia (n = 43, 83%), and fatigue (n = 43, 83%). …”
Get full text

Facile Synthesis of Propranolol and Novel Derivatives by Vy Anh Tran, Nguyen Hai Tai Tran, Long Giang Bach, Trinh Duy Nguyen, Thi Thuong Nguyen, Tan Tai Nguyen, Thi Anh Nga Nguyen, The Ky Vo, Thu-Thao Thi Vo, Van Thuan Le

“…Herein, propranolol synthesis proceeded from 1-naphthol and isopropylamine under mild and less toxic conditions. Novel propranolol derivatives were designed by reactions of propranolol with benzoyl chloride, pyridinium chlorochromate, and n-butyl bromide through esterification, oxidation reduction, and alkylation, respectively. …”
Get full text

A Serious Case of Poisoning Caused by Oral Ingestion of Water-Soluble Fertilizer by Wei Ye, Shirong Lin, Chengquan Zheng, Chunshui Cao

“…Acute kidney injury occurred early, which showed that the toxicity could not be ignored. It was necessary to seek medical attention as soon as possible. …”
Get full text

Recent Natural Corrosion Inhibitors for Mild Steel: An Overview by Marko Chigondo, Fidelis Chigondo

“…Inorganic and organic inhibitors are toxic and costly and thus recent focus has been turned to develop environmentally benign methods for corrosion retardation. …”
Get full text

Quantification of Eosinophilic Granule Protein Deposition in Biopsies of Inflammatory Skin Diseases by Automated Image Analysis of Highly Sensitive Immunostaining by Peter Kiehl, Katrin Falkenberg, Markus Vogelbruch, Alexander Kapp

“…Extracellular deposition of toxic eosinophilic granule proteins (EGPs), but not the presence of intact eosinophils, is crucial for their functional effect in situ. …”
Get full text

Chlorambucil-Induced Acute Interstitial Pneumonitis by Hammad Shafqat, Adam J. Olszewski

“…We performed a systematic review of literature and identified 13 other case reports of chlorambucil-induced pulmonary toxicity, particularly interstitial pneumonitis. No unifying risk factor could be discerned and the mechanism of injury remains unknown. …”
Get full text

Chemical Constituents, Antioxidant Activities, and Element Concentrations of Rusa Deer Velvet Antler Extracts by Chutima Limmatvapirat, Potcharet Rodhetbhai, Krittaphas Somsakraksanti, Pitcha Danpongprasert, Soranun Poonsub, Wantanwa Krongrawa, Sontaya Limmatvapirat, Maneerat Meepan

“…All extracts were composed of essential elements and had levels of toxic elements and microbial contaminants lower than the acceptable criteria set by ASEAN guidelines. …”
Get full text

Analysis of Hazard Area of Dispersion Caused by Leakage from Underground Gas-Storage Caverns in Salt Rock by Ya Yang, Shigang Yang, Zhan Li, Qin Fang, Jianhua Wu, Jiongwei Cai, Wensheng Sun

“…Furthermore, a sample underground gas-storage cavern in salt rock is examined with respect to the toxic threshold limit value and the upper and lower flammability limits. …”
Get full text

Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes by P. J. Simpson-Haidaris, S. J. Pollock, S. Ramon, N. Guo, C. F. Woeller, S. E. Feldon, R. P. Phipps

“…However, longer survival is accompanied by increased incidence of comorbidities due, in part, to drug side effects and toxicities. It is well accepted that inflammation and tumorigenesis are linked. …”
Get full text

A mild and scalable one-pot synthesis of N-substituted 2-aminobenzimidazoles via visible light mediated cyclodesulfurization by Tanawat Rerkrachaneekorn, Rose Malina Annuur, Soraya Pornsuwan, Mongkol Sukwattanasinitt, Sumrit Wacharasindhu

“…The key advantages of this method include the use of less toxic solvent in aqueous media, the elimination of photocatalyst, and a simple, practical setup (one-pot, open-flask, and ambient temperature). …”
Get full text

Strategies in the Surgical Management of Atrial Fibrillation by Leanne Harling, Thanos Athanasiou, Hutan Ashrafian, Justin Nowell, Antonios Kourliouros

“…An increased understanding of AF pathophysiology has led to enhanced pharmacological and medical therapies; however this is often limited by toxicity, variable symptom control, and inability to modulate the atrial substrate. …”
Get full text

Application of Bionanomaterials in Tumor Immune Microenvironment Therapy by Jiawei Wang, Yan Bao, Yandan Yao

“…However, the clinical utility of immunotherapy in cancer is limited by severe off-target toxicity, long processing time, limited efficacy, and extremely high cost. …”
Get full text

Synthesis, evaluation of the biological activity against Trypanosoma cruzi and Leishmania donovani. Preliminary in silico ADMET studies of 5-nitroimidazole derivatives by Miguel A. Rodríguez, Ali Mijoba, Nereida J. Parra-Giménez, Zuleyma Blanco, Katiuska Chávez, Alirica I. Suárez, Esteban Fernandez-Moreira, Hegira Ramírez, Jaime E. Charris

“…The structures of the synthesized hybrids were confirmed by spectral analysis FT-IR, 1H NMR, 13C NMR, MS, and by Elemental Analysis. The toxicity (ADME/Tox) assessment study were carried out to predict the molecular properties associated with pharmacokinetic aspects of novel compounds. …”
Get full text

Innovative approaches to asthma treatment: harnessing nanoparticle technology by Vanshika Goswami, Kushneet Kaur Sodhi, Chandra Kant Singh

“…It has been shown in studies that these drug delivery systems can greatly enhance targeting and bioavailability and decrease the toxicity of medication. Nanoparticle drug delivery systems offer improved therapeutic efficacy compared to conventional administration techniques. …”
Get full text

Attention-based deep learning for accurate cell image analysis by Xiangrui Gao, Fan Zhang, Xueyu Guo, Mengcheng Yao, Xiaoxiao Wang, Dong Chen, Genwei Zhang, Xiaodong Wang, Lipeng Lai

“…In comparative tests on drug-induced cardiotoxicity, mitochondrial toxicity classification, and compound classification, X-Profiler outperformed both DeepProfiler and CellProfiler, as two highly recognized and representative methods in this field. …”
Get full text

Numerical Simulations as Tool to Predict Chemical and Radiological Hazardous Diffusion in Case of Nonconventional Events by J.-F. Ciparisse, A. Malizia, L. A. Poggi, O. Cenciarelli, M. Gelfusa, M. C. Carestia, D. Di Giovanni, S. Mancinelli, L. Palombi, C. Bellecci, P. Gaudio

“…The aim of this paper is to show how CFD calculations can help to understand the time evolution of two possible CBRNe (Chemical-Biological-Radiological-Nuclear-explosive) events: (1) hazardous dust mobilization due to the interaction between a jet of air and a metallic powder in case of a LOVA (Loss Of Vacuum Accidents) that is one of the possible accidents that can occur in experimental nuclear fusion plants; (2) toxic gas release in atmosphere. The scenario analysed in the paper has consequences similar to those expected in case of a release of dangerous substances (chemical or radioactive) in enclosed or open environment during nonconventional events (like accidents or man-made or natural disasters).…”
Get full text