Antibacterial Activity of Selected Essential Oil Components and Their Derivatives: A Review by Vuyolwethu Khwaza, Blessing A. Aderibigbe

“…Furthermore, this review highlights recent advancements in developing derivatives of these EO components, which have shown improved antibacterial activity with reduced toxicity. By summarizing recent studies, this review reveals the potential of these natural compounds and their derivatives as promising candidates for pharmaceuticals, food preservation, and as alternatives to synthetic antibiotics in combating bacterial resistance.…”
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Altered Gene Expression, Mitochondrial Damage and Oxidative Stress: Converging Routes in Motor Neuron Degeneration by Luisa Rossi, Cristiana Valle, Maria Teresa Carrì

“…Here we discuss which may be the links that make pathways apparently as different as altered gene expression, mitochondrial damage, and oxidative stress converge to generate a similar motoneuron-toxic phenotype.…”
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Severe Gastrooesophageal Reflux Disease Associated with Foetal Alcohol Syndrome by N. K. Sujay, Matthew Jones, Emma Whittle, Helen Murphy, Marcus K. H. Auth

“…Prenatal alcohol exposure may have adverse effects on the developing foetus resulting in significant growth restriction, characteristic craniofacial features, and central nervous system dysfunction. The toxic effects of alcohol on the developing brain are well recognised. …”
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Advanced graphene oxide synthesis for arsenic removal from groundwater in Mexico and Colombia by J.P. Rodríguez-Caicedo, D.R. Joya-Cárdenas, A. Gallegos-Muñoz, M.R. Abraham-Juárez, M. Zapata-Torres, C.E. Damián-Ascencio, A. Saldaña-Robles

“…Additionally, the synthesis process reduced toxic by-products, demonstrating sustainability for industrial-scale applications. …”
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Gelatin Nanoemulsion-Based Co-Delivery of Terbinafine and Essential Oils for Treatment of <i>Candida albicans</i> Biofilms by Muhammad Aamir Hassan, Sadaf Noor, Jungmi Park, Ahmed Nabawy, Maitri Dedhiya, Robin Patel, Vincent M. Rotello

“…Eugenol and methyl eugenol/terbinafine T-GNEs had an additive efficacy, while carvacrol (CT-GNE) worked synergistically with terbinafine, providing effective antifungal treatment with minimal mammalian cell toxicity. Confocal microscopy demonstrated that CT-GNE penetrated the dense <i>C. albicans</i> biofilm and disrupted the fungal cell membrane. …”
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Harnessing macroalgae for heavy metal phytoremediation: A sustainable approach to aquatic pollution control by Ali Akbar Said, Nur Lestari Aisyah, Rizki Fazli Rahmad, Gunawan Gunawan

“…This review explores the potential of macroalgae in heavy metal phytoremediation, focusing on their ability to absorb and sequester toxic metals from contaminated aquatic environments. …”
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Cutaneous Manifestation Maple Syrup Urine Disease: Case Report by Gabriel Alejandro Díaz Bernal, Mányeles Brito Vázquez, Magdalena de la Caridad Guirado Espinosa

“…The case of a transitional male is presented, who at 10 days after birth presented with neonatal seizures, associated with metabolic acidosis and cerebral edema, increased levels of amino acids in urine, skin lesions suggestive of dysmetabolic acrodermatitis that were colonized by staphylococcus which caused lethal staphylococcal toxic shock at 2 years of age. The patient was diagnosed with maple syrup urine disease. …”
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Therapeutic drug monitoring of atypical antipsychotic drugs by Grundmann Milan, Kacirova Ivana, Urinovska Romana

“…It can help in monitoring adherence, dose adjustment, minimizing the risk of toxicity and in cost-effectiveness in the treatment of psychiatric disorders. …”
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Phosphorus Flame Retardants for Polymeric Materials from Gallic Acid and Other Naturally Occurring Multihydroxybenzoic Acids by Bob A. Howell, Kendahl L. Oberdorfer, Eric A. Ostrander

“…Moreover, degradation of derivatives does not yield toxic products. Gallic acid (3,4,5-trihydroxybenzoic acid) is found widely in nature and has long been touted for its medicinal qualities. 3,5-Dihydroxybenzoic acid is also produced by several plants, most notably buckwheat. …”
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Distribution of dye-decolorizing peroxidase (DyP) genes among bacteria based on the NCBI database by Mustafa Irfan, Suharjono, Ardyati Tri, Jatmiko Yoga Dwi

“…Synthetic textile dyes, such as anthraquinones, are durable and persistent to microbial degradation, making them toxic to the environment. Certain bacteria have been reported to possess dye-decolorizing peroxidase (DyP) enzymes, which show potential for degrading anthraquinones. …”
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Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival by Gil-Ran Kim, Kyung-Ho Nam, Je-Min Choi

“…Belatacept, a modified version of cytotoxic T lymphocyte antigen-4 immunoglobulin with increased binding affinity for its ligand, has emerged as a viable alternative to traditional CNIs due to its lower toxicity profile. Despite these benefits, belatacept is associated with a higher rate of acute rejection, which presents a challenge for long-term graft survival. …”
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Teaching an old dog new tricks: re-engineering IL-2 for immuno-oncology applications by Mario Sznol, Naiyer Rizvi

“…Interleukin-2 has become a prominent focus of preclinical and clinical investigation, because of its known clinical activity, the important role of this cytokine in immune biology, and the ability to engineer variant proteins with potentially improved antitumor immunomodulatory activity and reduced toxicity. Bempegaldesleukin, the first of the modified IL-2 agents to reach phase 3 evaluation in combination with an anti-PD-1, did not improve outcome for patients with metastatic melanoma and renal carcinoma. …”
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Anticorrosion Nanocrystalline Beta Zeolite Thin Film for Advanced Applications by Maha Saud M. Al-subaie, Aisha Mahmood A. Al-Turkustani, Rosilda Selvin, Saedah Rwede Al-Mhayawi

“…The present study demonstrated that the nanozeolite coating can be a potential alternative for toxic and carcinogenic chromate coating.…”
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Varying Presentations of Multisystem Inflammatory Syndrome Temporarily Associated with COVID-19 by Jasmina Krikilion, Lisa Nuyttens, Siel Daelemans, Karlien François, Reiner Mauel, Daniel De Wolf, Gerlant van Berlaer

“…Initially, children seemed minimally affected, but there were reports of cases similar to (atypical) Kawasaki disease or toxic shock syndrome, and evidence emerges about a complication named paediatric inflammatory multisystem syndrome temporarily associated with SARS-CoV-2 (PIMS-TS) or multisystem inflammatory syndrome in children (MIS-C). …”
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Biomarkers of Acute Kidney Injury by Jeffrey C. Sirota, Jelena Klawitter, Charles L. Edelstein

“…Acute kidney injury (AKI) is a common problem in both the inpatient and outpatient setting and often results from drug toxicities. Traditional methods of identifying AKI, through measurement of blood urea nitrogen and serum creatinine, are problematic in that they are slow to detect decreases in glomerular filtration rate (GFR) and are influenced by a variety of factors that are not related to GFR changes. …”
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Bulky Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Treated with Yttrium-90 Ibritumomab Tiuxetan by Shinobu Tamura, Tokuji Ikeda, Toshio Kurihara, Yoshiteru Kakuno, Hideki Nasu, Yoshio Nakano, Koichi Oshima, Tokuzo Fujimoto

“…The abnormal shadow on her pulmonary images was significantly reduced two months later, and she had no symptoms without nonhematological toxicities. She has had no progression for 18 months. …”
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Characterization of Fly Ash Generated from Matla Power Station in Mpumalanga, South Africa by Olushola S. Ayanda, Olalekan S. Fatoki, Folahan A. Adekola, Bhekumusa J. Ximba

“…The results showed that the fly ash is alkaline and consists mainly of mullite (Al6Si2O13) and quartz (SiO2). Highly toxic metals As, Sb, Cd, Cr, and Pb as well as metals that are essential to health in trace amounts were also present. …”
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Advantages of using biofilms to obtain high-value molecules by microbial biotransformations by Nicoly Subtil de Oliveira, Romeu Cassiano Pucci da Silva Ramos, Rafaela Caldas de Paula, Matheus Gonçalves da Costa Pereira, Rosimeire Takaki Rosa, Luiz Fernando Bianchini, Edvaldo Antonio Ribeiro Rosa

“…However, microbial cells grown under a phenotype of biofilm can improve biotransformation bioprocesses once they form more biomass per volume, are more resistant to extreme conditions (pH, temperature, and toxic substances), remain active for extended periods, are less prone to cell washouts, and reduce re-inoculation demands, leading to increased production rates due to their unique physiological features. …”
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The Implications of Liver Biopsy Results in Patients with Myeloproliferative Neoplasms Being Treated with Ruxolitinib by Douglas Tremblay, Juan Putra, Alexander Vogel, Adam Winters, Ronald Hoffman, Thomas D. Schiano, Maria Isabel Fiel, John O. Mascarenhas

“…Ruxolitinib is increasingly being utilized for the treatment of myelofibrosis and polycythemia vera, but the potential for hepatic toxicity is poorly understood. We performed a retrospective review of hepatic damage occurring in patients with myeloproliferative neoplasms receiving ruxolitinib. …”
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Modern approaches to drug therapy of bladder cancer after first progression. by L. V. Bolotina, L. A. Koroleva

“…Cisplatin remains the basic drug for first line, but its use may be limited because of significant toxic reactions, that develop in a great number of patients. …”
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