Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation by Vladimir Jurišić, Jasmina Obradovic, Sonja Pavlović, Nataša Djordjevic

“…The accumulation of knowledge regarding SNPs lately suggests their significant and important role in the onset of carcinogenesis, the prediction of the onset of metastases, the response to therapy with TKI inhibitors, and the onset of toxic effects of the applied therapy. Based on this, we suggest further studies of the relationship of clinical significance to SNPs in patients with lung tumors.…”
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Determination of Heavy Metal Ions and Organic Pollutants in Water Samples Using Ionic Liquids and Ionic Liquid-Modified Sorbents by Minglei Tian, Luwei Fang, Xuemin Yan, Wei Xiao, Kyung Ho Row

“…Several governmental agencies are listing an increasing number of compounds as serious problems in water because of their toxicity, bioaccumulation, and persistence. In recent decades, there has been considerable research on developing analytical methods of heavy metal ions and organic pollutants from water. …”
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Immunotherapy in the Treatment of Metastatic Melanoma: Current Knowledge and Future Directions by Massimo Ralli, Andrea Botticelli, Irene Claudia Visconti, Diletta Angeletti, Marco Fiore, Paolo Marchetti, Alessandro Lambiase, Marco de Vincentiis, Antonio Greco

“…Immunotherapy is associated to a panel of dysimmune toxicities called immune-related adverse events that can affect one or more organs and may limit its use. …”
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“Lost in translation?” Animal research in the era of precision medicine by Hamideh Frühwein, Norbert W. Paul

“…Abstract Preclinical animal research has long been a cornerstone in evaluating the efficacy, toxicity, and safety of potential drug treatments before they proceed to human clinical trials. …”
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Mapping transcriptomic profiles of seminal vesiculitis and experimental verification by Chenkui Miao, Shaobo Zhang, Jiajin Wu, Meiling Bao, Zengjun Wang, Bianjiang Liu

“…We identified enriched Go Ontology terms, pathway maps, processes, toxicity, and metabolic networks of seminal vesiculitis. …”
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Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies by Justyna Paprocka, Marek Kijonka, Beata Rzepka, Maria Sokół

“…Melatonin efficacy, low toxicity, and ability to readily cross through the blood-brain barrier make it a promising molecule. …”
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Ionic Liquid‐Filled Polyamide Microcapsules Obtained by Interfacial Polymerization by Robin Scholl, Dominic Freudenmann

“…The IL‐filled microcapsules are obtained using a surfactant‐free synthesis process and inexpensive, low‐toxicity monomers and solvents and feature an exceptionally high core‐to‐shell weight ratio enabling a broad range of possible applications.…”
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Biosorption of Copper Ions by and Species by Sara Ghaed, Elham Khalilzadeh Shirazi, Reza Marandi

“…Compared with other alternatives, these metabolically inactive and nonliving biomasses of microbial or floral origins are cheaper and more effective in removing metallic elements, some of which are toxic and carcinogenic. The discharge of heavy metals, such as copper ions into wastewater is regarded as a serious threat to the environment. …”
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Discriminating Analysis of Metal Ions via Multivariate Curve Resolution–Alternating Least Squares Applied to Silver Nanoparticle Sensor by Andrea Rossi, Massimiliano Cuccioloni, Francesco Pellegrino, Rita Giovannetti, Eugenio Alladio

“…Heavy metals are life-threatening pollutions because of their great toxicity, long-term persistence in nature and their bioaccumulation in living organisms. …”
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Exploring the effects of perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) on silkworm from the insights of metabolome by Xing Zhang, Yifei Kong, Zihan He, Wenbin Yu, Wenjing Shao, Chengliang Gong, Wenlin Zhou, Xiaolong Hu

“…These findings suggest that PFOA and TBBP-A disrupt crucial metabolic processes in silkworms, indicating potential toxicity and prompting further investigation into their effects on human health and the environment. …”
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Research Progress on the Preparation, Physiological Activity and Action Mechanism of Plant Derived Bioactive Peptides by Sinan LI, Xi WANG, Yu AN, Jun YU, Kaiyuan XU, Jia WANG, Zhihui ZHANG, Meng WANG, Aqin WANG, Ying WANG, Lu ZHANG

“…Plant-derived BAPs come from a wide range of sources, are safe and non-toxic. At present, a large number of plant-derived BAPs have been identified by isolation and purification. …”
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Rising incidence of recreational ketamine use: Clinical cases and management in emergency settings by Sabrina Marongiu, Maarten van Eijk, Femke M.J. Gresnigt, Esther A. Croes, Eric J.F. Franssen

“…This trend has been accompanied by an increase in first aid incidents involving ketamine, often in combination with other substances such as alcohol or MDMA, leading to heightened toxicity. Acute intoxication with ketamine manifests through symptoms like agitation, hallucinations, nausea, tachycardia, and hypertension, while frequent use is associated with long-term complications, including ketamine-induced uropathy. …”
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In Vivo Inflammatory Effects of Ceria Nanoparticles on CD-1 Mouse: Evaluation by Hematological, Histological, and TEM Analysis by Anna Poma, Anna Maria Ragnelli, Joaquin de Lapuente, David Ramos, Miquel Borras, Pierpaolo Aimola, Mario Di Gioacchino, Sandro Santucci, Laura De Marzi

“…In this work, acute and subacute in vivo toxicity assays demonstrate no lethal effect of these NPs. …”
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Anti-Retroviral Strategies for AIDS and Related Diseases by Mark A Wainberg, Andre Dascal, Jack Mendelson

“…Although AZT therapy has been reasonably successful, it has not been free from toxicity. In addition, there have been several reports of isolation of AZT-resistant variants of HIV-1.…”
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Crystal structure and Hirshfeld surface analysis of the layered hybrid metal halide poly[bis(2-iodoethylammonium) [di-μ-iodido-diiodidogermanate(II)]] by Olesia I. Kucheriv, Mircea-Odin Apostu, Olena Prysiazhna, Vadim A. Potaskalov, Sergey O. Malinkin

“…The title compound is a germanium-based hybrid metal halide that represents a less-toxic alternative to more popular lead-based analogues in optoelectronic applications. {(2-IC2H4NH3)2[GeI4]}n is composed of infinite inorganic layers that are formed by [GeI6]4− octahedra connected in a corner-sharing manner with four equatorial I atoms. …”
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Different Genotypes of the Rare and Threatened Moss <i>Physcomitrium eurystomum</i> (Funariaceae) Exhibit Different Resilience to Zinc and Copper Stress by Djordje P. Božović, Marija V. Ćosić, Vladislav Kolarčik, Michal Goga, Claudio Varotto, Mingai Li, Aneta D. Sabovljević, Marko S. Sabovljević

“…The riparian habitat type of this species is often under the influence of contaminated water, and, therefore, we tested the influence of selected potentially toxic elements (PTEs), namely zinc and copper, on the development, physiological features, and survival of the species on two different accessions (German and Croatian). …”
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Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries by Cheng Ji

“…Potential mechanisms that trigger the alcoholic ER stress response are directly or indirectly related to alcohol metabolism, which includes toxic acetaldehyde and homocysteine, oxidative stress, perturbations of calcium or iron homeostasis, alterations of S-adenosylmethionine to S-adenosylhomocysteine ratio, and abnormal epigenetic modifications. …”
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Current Pharmacologic Approaches for Prevention and Treatment of Bronchopulmonary Dysplasia by Kristen Tropea, Helen Christou

“…Contributing factors include ventilator-induced lung injury, exposure to toxic oxygen levels, and infection. Several preventive and therapeutic strategies have been developed with variable success. …”
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Geriatric Chest Imaging: When and How to Image the Elderly Lung, Age-Related Changes, and Common Pathologies by J. Gossner, R. Nau

“…Pathologies with a special relevance for the elderly patient are discussed in detail: pneumonia, aspiration pneumonia, congestive heart failure, chronic obstructive pulmonary disease, the problem of overlapping heart failure and chronic obstructive pulmonary disease, pulmonary drug toxicity, incidental pulmonary embolism pulmonary nodules, and thoracic trauma.…”
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Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation by Ricardo Londono, Vijay S. Gorantla, Stephen F. Badylak

“…Despite recent progress in vascularized composite allotransplantation (VCA), limitations including complex, high dose immunosuppression regimens, lifelong risk of toxicity from immunosuppressants, acute and most critically chronic graft rejection, and suboptimal nerve regeneration remain particularly challenging obstacles restricting clinical progress. …”
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