Carvacrol acetate activated Nrf2 modulates mitophagy for the treatment of neurocyte oxidative stress induced by chlorpyrifos by Hong-Ling Zhou, Bei-Bei Wang, Xu-Li Fan, Xiao-Min Zhang, Ying Song

“…Moreover, PC12 cells treated with Nrf2 inhibitors failed to exhibit any improvement in survival rate when treated with CAA after a toxic insult. Furthermore, ROS and MDA levels were not significantly reduced, SOD enzyme activity did not increase, and mitochondrial membrane potential and mtDNA copy number did not improve. …”
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Novel role of FTO in regulation of gut–brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure by Ruonan Chen, Xiaoqin Chai, Yunxiao Zhang, Tianxiu Zhou, Yinyin Xia, Xuejun Jiang, Bo Lv, Jun Zhang, Lixiao Zhou, Xin Tian, Ruonan Wang, Lejiao Mao, Feng Zhao, Hongyang Zhang, Jun Hu, Jingfu Qiu, Zhen Zou, Chengzhi Chen

“…However, there is no specific treatment for its toxic effects due to the uncovered mechanisms. We previously revealed that exposure to arsenic increased the level of m6A via down-regulation of FTO, which might serve as a potential target for intervention against arsenic-related disorders. …”
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Organ-specific immune-related adverse events and prognosis in cancer patients receiving immune checkpoint inhibitors by Xinyue Han, Yingcui Chen, Hong Xie, Yuekai Zhang, Yu Cui, Yaping Guan, Weiwei Nie, Qi Xie, Jisheng Li, Baocheng Wang, Bicheng Zhang, Jun Wang

“…Furthermore, only skin or endocrine toxicities were associated with improved OS and PFS. …”
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The Frequency of <i>DPYD</i> c.557A>G in the Dominican Population and Its Association with African Ancestry by Mariela Guevara, Carla González de la Cruz, Fernanda Rodrigues-Soares, Ernesto Rodríguez, Caíque Manóchio, Eva Peñas-Lledó, Pedro Dorado, Adrián LLerena

“…The <i>DPYD</i> genotype is linked to variability in enzyme activity, 5-FU elimination, and toxicity. Approximately 10–40% of patients treated with fluoropyrimidines develop severe toxicity. …”
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Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

“…Novel engineered IL-2 agonists strive to increase the therapeutic window of aldesleukin (human IL-2) by increasing selectivity toward effector over regulatory T cells and reducing dose-limiting toxicities. Here we describe ANV419, an IL-2/anti-IL2 antibody fusion protein designed for selective IL-2 receptor βγ (IL-2 Rβγ) activation by sterically hindering IL-2 from binding to IL-2 Rα. …”
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Systematic Review and Network Meta-Analysis on Treating Hormone Receptor-Positive Metastatic Breast Cancer After CDK4/6 Inhibitors by Neha Pathak, Abhenil Mittal, Sudhir Kumar, Chitrakshi Nagpal, Eitan Amir, Partha Haldar, Bharath B. Gangadharaiah, Akash Kumar, Ashutosh Mishra, Atul Batra

“…In the HER2-low population, a similar efficacy and different toxicity spectrum was seen. In AKT-altered tumors, capivasertib was less toxic than alpelisib. …”
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Advancing treatment choices: CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer by Paola Zagami, Angela Esposito, Beatrice Taurelli Salimbeni, Pier Paolo Maria Berton Giachetti, Roberta Scafetta, Matteo Lambertini, Massimo Di Maio, Giuseppe Curigliano, Carmen Criscitiello, Saverio Cinieri

“…Recently, the Italian Medicines Agency (AIFA) approved the possibility of switching between CDK4/6i for unacceptable toxicity. This study explores oncologists' experiences and future perspectives on CDK4/6 inhibitor switching following this new approval. …”
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Comprehensive analysis of histophysiology, transcriptomics and metabolomics in goslings exposed to gossypol acetate: unraveling hepatotoxic mechanisms by Jun Yu, Jun Yu, Haiming Yang, Jian Wang, Zixin Huang, Shi Chen, Hongchang Zhao, Jun Wang, Zhiyue Wang

“…Although the general toxicity of free gossypol is well-known, its specific effects on the liver—the primary site where it accumulates—are less thoroughly studied, particularly at the molecular level. …”
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Assessment of Biological Activity, Total Phenolic Content, and Cytotoxicity of Ethyl Acetate Extracts from an Endophytic Fungus, Lasiodiplodia pseudotheobromae IBRL OS-64 by Mohd Taufiq Mat Jalil, Nurul Aili Zakaria, Mohd Fakharul Zaman Raja Yahya, Sharifah Aminah Syed Mohamad, Darah Ibrahim

“…Therefore, the present study suggests that the fraction extract could be an effective pharmaceutical agent and safe for drug development due to its low toxicity. …”
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Intraperitoneal paclitaxel for patients with primary malignant peritoneal mesothelioma: a phase I/II dose escalation and safety study—INTERACT MESO by Job P van Kooten, Jacobus W A Burger, Cornelis Verhoef, Joachim G J V Aerts, Eva V E Madsen, Alexandra R M Brandt-Kerkhof, Stijn L W Koolen, Ron H J Mathijssen, Michelle V Dietz, Niels A D Guchelaar

“…Systemic uptake will be limited, likely resulting in less toxicity. The aim of the INTERACT MESO trial is to determine the maximum tolerable dose of intraperitoneal paclitaxel monotherapy in patients with MPM. …”
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Astaxanthin-loaded brain-permeable liposomes for Parkinson’s disease treatment via antioxidant and anti-inflammatory responses by Thai-Duong Nguyen, Shristi Khanal, Eunhee Lee, Jinsol Choi, Ganesh Bohara, Nikesh Rimal, Dong-Young Choi, Soyeun Park

“…In vitro, Lf-ASX-LPs reduced cell loss by 20.1% and oxygen species by 30.0%, ameliorated the reduction in mitochondrial membrane potential under 1-methyl-4-phenylpyridinium-induced toxicity by 40.1%, and reduced extracellular nitric oxide levels under lipopolysaccharide-induced toxicity by 32.0%, indicating cytoprotective and antioxidant effects. …”
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The XIAP inhibitor AZD5582 improves the treatment effect of microwave ablation on hepatocellular carcinoma by Wenhui Wang, Fuyuan Wu, Zhe Wu, Mengfan Zhang, Qiang Lu

“…Finally, AZD5582 drug toxicity was detected to confirm its feasibility.ResultsXIAP protein expression is significantly increased in recurrent hepatocellular carcinoma tissues of patients who previously received microwave ablation therapy. …”
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Chemical Composition, Source Appointment and Health Risk of PM2.5 and PM2.5-10 during Forest and Peatland Fires in Riau, Indonesia by Sepridawati Siregar, Nora Idiawati, Puji Lestari, Abiyu Kerebo Berekute, Wen-Chi Pan, Kuo-Pin Yu

“…Clearly, more attention should be devoted to reducing the noncarcinogenic and carcinogenic health risks caused by particulate-bound toxic elements through inhalation exposure.…”
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Determinants of Virologic Failure among Adult HIV Patients on First-Line Antiretroviral Therapy at Waghimra Zone, Northern Ethiopia: A Case-Control Study by Abrham Emagnu, Zenahebezu Abay, Abera Balcha Bulti, Yaregal Animut

“…This study showed that poor adherence to treatment, longer duration on ART, experiencing drug toxicity, older age, and recent CD4 <200 cell/mm³ are factors that increase the risk of virologic failure.…”
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In Vitro Antibacterial and Antioxidant Activities, Pharmacokinetics, and In Silico Molecular Docking Study of Phytochemicals from the Roots of Ziziphus spina-christi by Hadush Gebrehiwot, Urgessa Ensermu, Aman Dekebo, Milkyas Endale, Tariku Nefo Duke

“…Furthermore, the organ toxicity predictions showed that all the compounds exhibit no hepatotoxicity and cytotoxicity effects and stigmasterol (5) affords drug-likeness protocols. …”
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Assessing molecular changes underlying isopropylated phenyl phosphate (IPP)-induced larval sensorimotor response deficits in zebrafish by Sunil Sharma, Alfredo Rojas, Abhishek Gour, Rosemaria Serradimigni, Connor Leong, Abhisheak Sharma, Subham Dasgupta

“…Notably, these impacts occur at concentrations within environmental relevance where overt toxic morphological phenotypes are not recorded. …”
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Biochar Derived from Domestic Sewage Sludge: Influence of Temperature Pyrolysis on Biochars’ Chemical Properties and Phytotoxicity by Rahma Inès Zoghlami, Sarra Hechmi, Rihab Weghlani, Naceur Jedidi, Mohamed Moussa

“…The raw sewage sludge and the produced biochars have been analyzed to determine their volatile organic matter (VOM), mineral content (MC), nutrients’ level (total nitrogen TN, available phosphorus P, and potassium K), alkalinity (pH), and salinity (electrical conductivity EC and Na). The toxic effect of biochars derived from SS has been evaluated through the analysis of trace metals (Pb, Cr, Cd, Cu, and Zn) and their toxicity by measuring root elongation inhibition (REI). …”
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Association of genetically proxied cancer-targeted drugs with cardiovascular diseases through Mendelian randomization analysis by Chuchun Fang, Xuewei Liu, Chen Yu, Songlin Li, Xueying Liu, Shifeng Qiu, Hongbin Liang, Caiwen Ou, Jiancheng Xiu

“…These findings underscore the delicate balance between cardiovascular toxicity risk and the benefits of cancer-targeted therapy.…”
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Regulation of adipocyte differentiation and lipid metabolism by novel synthetic chromenes exploring anti-obesity and broader therapeutic potential by Kewalin Inthanon, Natthawut Wong-a-nan, Srisulak Dheeranupattana, Andres Garcia Guerra, Neal M. Davies, Chatchai Kesornpun, Sasithorn Sangher, Prasat Kittakoop

“…Among them, 14 chromenes demonstrated a lack of toxicity to pre-adipocytes (PAs) and mature adipocytes (MAs) of 3T3-L1 cells. …”
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Cocoa pod husk wastes derived biochar for overcoming potassium deficiency in organic agriculture by Murali Gopal, Elain Apshara S., Sathyaseelan Neenu, Alka Gupta

“…An ecotoxicity assay using earthworms indicated no acute toxicity, although earthworms took longer to acclimatize to the cocoa pod husk biochar compared to coconut residue biochar. …”
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