3D-Printed PCL-Based Scaffolds with High Nanosized Synthetic Smectic Clay Content: Fabrication, Mechanical Properties, and Biological Evaluation for Bone Tissue Engineering by Furtado ASA, Cunha MHS, Sousa LMR, Brito GC, Verde TFCL, Filgueiras LA, Sobral-Silva LA, Santana MV, Sousa GF, Santos FEP, Mendes AN, Figueredo-Silva J, Maia Filho ALM, Marciano FR, Vasconcellos LMR, Lobo AO

“…André SA Furtado,1,* Manuel HS Cunha,1,* Luciana MR Sousa,1 Guilherme C Brito,1 Thiago FCL Verde,1 Livia Alves Filgueiras,2 Leonardo A Sobral-Silva,3 Moisés V Santana,1 Gustavo F Sousa,1 Francisco EP Santos,4 Anderson N Mendes,2 José Figueredo-Silva,5 Antônio LM Maia Filho,5 Fernanda R Marciano,1,4 Luana MR Vasconcellos,3 Anderson O Lobo1 1Interdisciplinary Laboratory for Advanced Materials (LIMAV), Materials Science and Engineering Graduate Program (PPGCM), Federal University of Piauí (UFPI), Teresina, PI, Brazil; 2Laboratory of Innovation in Science and Technology, Department of Biophysics and Physiology, Federal University of Piauí, Teresina, PI, Brazil; 3Institute of Science and Technology, São Paulo State University (UNESP), São Paulo, SP, Brazil; 4Department of Physics, Federal University of Piauí (UFPI), Teresina, PI, Brazil; 5Biotechnology Research Center - State University of Piauí, Teresina, PI, Brazil*These authors contributed equally to this workCorrespondence: Anderson O Lobo, Interdisciplinary Laboratory for Advanced Materials, UFPI - Federal University of Piaui, Teresina, Brazil, Email lobo@ufpi.edu.brBackground: The 3D printing of macro- and mesoporous biomimetic grafts composed of polycaprolactone (PCL) infused with nanosized synthetic smectic clay is a promising innovation in biomaterials for bone tissue engineering (BTE). The main challenge lies in achieving a uniform distribution of nanoceramics across low to high concentrations within the polymer matrix while preserving mechanical properties and biological performance essential for successful osseointegration.Methods: This study utilized 3D printing to fabricate PCL scaffolds enriched with nanosized synthetic smectic clay (LAP) to evaluate its effects on structural, chemical, thermal, mechanical, and degradative properties, with a focus on in vitro biological performance and non-toxicity. …”
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Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration by Chun-Sheng Li, Yan Xu, Juan Li, Shu-Hao Qin, Shao-Wen Huang, Xue-Mei Chen, Yi Luo, Cheng-Tao Gao, Jian-Hui Xiao

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Editorial: Biodegradable polymers for biomedical applications - volume III by Liqun Yang, Jianshe Hu, Shuai Jiang

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Editorial: Recent advancements in RNA technologies, diagnostics, and therapeutics by Jaimie Marie Stewart, Yaroslava G. Yingling, Kirill A. Afonin, Florent Hubé, Naoyuki Kataoka

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Matrix Metalloproteinase‐Responsive Controlled Release of Self‐Assembly Nanoparticles Accelerates Heart Valve Regeneration In Situ by Orchestrating Immunomodulation by Xing Chen, Yunlong Wu, Peng Song, Liandong Feng, Ying Zhou, Jiawei Shi, Nianguo Dong, Weihua Qiao

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Advances in the application and research of biomaterials in promoting bone repair and regeneration through immune modulation by Li Liu, Hao Chen, Xue Zhao, Qing Han, Yongjun Xu, Yang Liu, Aobo Zhang, Yongyue Li, Weilong Zhang, Bingpeng Chen, Jincheng Wang

Subjects: “…Bone tissue engineering…”
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Phenotypic alterations in articulating joint cells: Role of mechanically loaded MSC secretome by Yann D. Ladner, Ursula Menzel, Keith Thompson, Angela R. Armiento, Martin J. Stoddart

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The role of polysaccharide-based biodegradable soft polymers in the healthcare sector by Zia Ullah Arif

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Editorial: The application of bioactive materials in bone repair by Yori Endo, Elena Giunta, Elena Giunta, Jessica Mroueh, William McCarthy, Nina Graf

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Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis by Da-Long Dong, Guang-Zhen Jin

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A platform for Bioengineering Tissue Membranes from cell spheroids by Quang Bach Le, Hariharan Ezhilarasu, Weng Wan Chan, Alok Tanala Patra, Priya Murugan, Shashaank Abhinav Venkatesh, Yean Kai Tay, Shin Ru Lim, Ahmad Amirul Abdul Rahim, Jia Sheng Zach Lee, Xuezhi Bi, Deepak Choudhury

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Decellularized Liver Matrices for Expanding the Donor Pool—An Evaluation of Existing Protocols and Future Trends by Marcin Morawski, Maciej Krasnodębski, Jakub Rochoń, Hubert Kubiszewski, Michał Marzęcki, Dominik Topyła, Kacper Murat, Mikołaj Staszewski, Jacek Szczytko, Marek Maleszewski, Michał Grąt

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Constructing Tissue-Engineered Dressing Membranes with Adipose-Derived Stem Cells and Acellular Dermal Matrix for Diabetic Wound Healing: A Comparative Study of Hypoxia- or Normoxia-Culture Modes by Wen Zhou, Xin Zhao, Xin Shi, Can Chen, Yanpeng Cao, Jun Liu

“…In the current study, we, respectively, culture adipose-derived stem cells (ADSCs) on an ADM membrane under a hypoxia or normoxia condition to construct two kinds of tissue-engineered dressing membranes (H-ADSCs/ADM and N-ADSCs/ADM) and then comparatively evaluated their efficacy on DFU healing using a diabetic rat model. …”
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Isolation of Viable Follicles from Cryopreserved Human Ovarian Tissue by Farnaz Tajbakhsh, Somayeh Tavana, Mohammad Kazemi Ashtiani, Naeimeh Sadat Abtahi, Leila Sadat Tahaei, Ashraf Moini, Rouhollah Fathi

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Employing Polymer and Gel to Fabricate Scaffold-like Cancellous Orthopedic Screw: Polycaprolactone/Chitosan/Hydroxyapatite by AmirHossein Badami, Javad Esmaeili, Hasan Mirtalaie

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Graphene oxide scaffolds promote functional improvements mediated by scaffold-invading axons in thoracic transected rats by Marta Zaforas, Esther Benayas, Raquel Madroñero-Mariscal, Ana Domínguez-Bajo, Elena Fernández-López, Yasmina Hernández-Martín, Ankor González-Mayorga, Elena Alonso-Calviño, Eduardo R. Hernández, Elisa López-Dolado, Juliana M. Rosa, Juan Aguilar, María C. Serrano

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Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization by Lili Zhang, Dineshi Sewvandi Thalakiriyawa, Jiawei Liu, Shengyan Yang, Yan Wang, Waruna Lakmal Dissanayaka

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Dentin-derived alveolar bone graft for alveolar augmentation: A systematic review by Dedy Agoes Mahendra, Kavanila Bilbalqish, Alexander Patera Nugraha, Arief Cahyanto, Kaushik Sengupta, Kamal Hanna, Asti Meizarini, Ninuk Hariyani

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Development of Prevascularized Synthetic Block Graft for Maxillofacial Reconstruction by Borvornwut Buranawat, Abeer Shaalan, Devy F. Garna, Lucy Di Silvio

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Engineering cardiology with miniature hearts by Xiaojun Xia, Miner Hu, Wenyan Zhou, Yunpeng Jin, Xudong Yao

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