AutoLDP: An accurate and efficient artificial intelligence-based tool for automatic labeling of digital pathology by Yingnan Zhao, Huifen Ye, Jing Yang, Su Yao, Maohua Lv, Zhihong Chen, Yunrui Ye, Qingru Hu, Cheng Lu, Zaiyi Liu, Ke Zhao, Zhihua Chen

“…We used the accuracy and processing time to validate our method using two validation sets. …”
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Unveiling the toxicity of JWH-018 and JWH-019: Insights from behavioral and molecular studies in vivo and vitro by Fenghua Zhou, Yan Shi, Sujun Tan, Xiaoli Wang, Weicheng Yuan, Shuqi Tao, Ping Xiang, Bin Cong, Chunling Ma, Di Wen

“…In the present study, we aimed to investigate the toxicity and underlying mechanisms of indole SCs JWH-018 and JWH-019 in mice (C57BL/6, male, 6–8 weeks old), zebrafish (AB strain, male, 4–5 months old) and modified human embryonic kidney (HEK) 293 T cells, using behavioral, pharmacokinetic, pharmacological approaches, and molecular docking. JWH-018 induced time- and dose-dependent cannabinoid-like effects in mice (administration dosages: 0.02, 0.1, and 0.5 mg/kg, i.p.), and yielded dose-dependent anxiogenic effects and lower aggression behavior in zebrafish (administration dosages: 0.01, 0.05, and 0.25 µg/g, i.p.), unlike JWH-019. …”
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Basic Molecular Biology, Metabolic and Immunological Mechanisms of Fecal Microbiota Transplantation by O. V. Goloshchapov, A. V. Beynarovich, A. B. Chukhlovin, R. V. Klementeva, A. A. Shcherbakov, E. A. Bakin, I. K. Golubovskaya, N. D. Ventslovayte, O. S. Yudintseva, M. V. Gorchakova, V. E. Karev, M. A. Kucher, M. A. Suvorova, E. V. Svetkina, G. G. Rodionov, V. V. Gostev, S. V. Sidorenko, I. S. Moiseev, A. D. Kulagin

“…To monitor the basic effects of FMT, we performed targeted DNA sequencing of 16S rRNA gene (V3–V4) using MiSeq platform as well as multiplex real-time PCR, MS/gas chromatography technique, immunophenotyping of blood lymphocytes, histological and immunohistochemical techniques.Clinical case. …”
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Un outil éthique, automatisé et totalement autonome pour étudier la cognition chez les primates by Jonas Fizet, Adam Rimele, Thierry Pebayle, Jean Christophe Cassel, Christian Kelche, Helene Meunier

“…Les tâches mises en place dans cette étude ciblent l’attention et le contrôle inhibiteur (5-Choice Serial Reaction Time), la mémoire visuelle à court terme (Delayed Matching to Sample) et la mémoire de travail (Self Order Spatial Search). …”
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Editorial by Pieter Vanhuysse, Antony Mason, Jörg Tremmel, Markus Rutsche, Maria Lenk

“…But if intra-familial transfers of cash and, crucially, time, are taken into account, this pro-elderly bias flips over entirely. …”
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Journal of Health and Social Sciences: A reputable, DOAJ-indexed, free, open access journal by Francesco Chirico

“…Thanks to the combined efforts of some of the editorial board members and authors, our journal published 79 high-quality manuscripts from 2016 to 2018 (39 original articles, 10 commentaries, 5 reviews and 25 other types of manuscripts, including 25 works from developing countries and 54 from developed countries). In a time when it is difficult to give voice to voiceless people, JHSS provides room for discussions and views from researchers from poor and disadvantages countries on issues that have a significant health impact on all people, from climate change to other themes in global public health. …”
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Climate change policies reduce air pollution and increase physical activity: Benefits, costs, inequalities, and indoor exposures by Sean Beevers, Nosha Assareh, Andrew Beddows, Gregor Stewart, Mike Holland, Daniela Fecht, Yunzhe Liu, Anna Goodman, Heather Walton, Christian Brand, Dimitris Evangelopoulos, Dylan Wood, Tuan Vu, David Dajnak

“…By 2040 under BNZP, relative to BAU, the buildings sector was predicted to be three times more effective at reducing PM2.5 than road transport. …”
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Adverse events in the nervous system associated with blinatumomab: a real-world study by Wen Gao, Jingwei Yu, Yifei Sun, Zheng Song, Xia Liu, Xue Han, Lanfan Li, Lihua Qiu, Shiyong Zhou, Zhengzi Qian, Xianhuo Wang, Huilai Zhang

“…Concomitant use of medication for age, musculoskeletal system, genitourinary system, and sexual hormones were independent risk factors for NST, and age was an independent protective factor for fatal NST. The median time to onset (TTO) for neurological events was 3 days (range, 1 ~ 21). …”
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Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics f... by Aliosha I. Figueroa-Valdés, Patricia Luz-Crawford, Yeimi Herrera-Luna, Nicolás Georges-Calderón, Cynthia García, Hugo E. Tobar, María Jesús Araya, José Matas, Darío Donoso-Meneses, Catalina de la Fuente, Jimena Cuenca, Eliseo Parra, Fernando Lillo, Cristóbal Varela, María Ignacia Cádiz, Rolando Vernal, Alexander Ortloff, Gino Nardocci, Verónica Castañeda, Catalina Adasme-Vidal, Maximiliano Kunze-Küllmer, Yessia Hidalgo, Francisco Espinoza, Maroun Khoury, Francisca Alcayaga-Miranda

“…The unique detection of sEV signals within the knee joint over time highlights its safety profile by confirming the retention of sEV in the joint. …”
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Topographie et restitution du chantier de l’aqueduc d’Arles (Bouches-du-Rhône) by Robert Fabre, Philippe Leveau, Vincent Dumas

“…The eastern branch dates from the time of Augustus. At the beginning of the 2nd century AD, it was assigned to supply the Barbegal mills while the other branch was extended into the Durance valley. …”
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Midostaurin shapes macroclonal and microclonal evolution of FLT3-mutated acute myeloid leukemia by Romane Joudinaud, Augustin Boudry, Laurène Fenwarth, Sandrine Geffroy, Mikaël Salson, Hervé Dombret, Céline Berthon, Arnaud Pigneux, Delphine Lebon, Pierre Peterlin, Simon Bouzy, Pascale Flandrin-Gresta, Emmanuelle Tavernier, Martin Carre, Sylvie Tondeur, Lamya Haddaoui, Raphael Itzykson, Sarah Bertoli, Audrey Bidet, Eric Delabesse, Mathilde Hunault, Christian Récher, Claude Preudhomme, Nicolas Duployez, Pierre-Yves Dumas

“…Using a dedicated algorithm for FLT3-ITD detection, 189 FLT3-ITD microclones (allelic ratio [AR] of <0.05) and 225 macroclones (AR ≥ 0.05) were detected at both time points. At R/R disease, the rate of FLT3-ITD persistence was lower in patients treated with ICT + MIDO than in patients not receiving MIDO (68% vs 87.5%; P = .011). …”
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Constructing Identities: Amos Tutuola and the Ibadan Literary Elite in the wake of Nigerian Independence by Mackenzie Finley

“…The educated elite writers, such as Wole Soyinka and Chinua Achebe, who emerged from University College, Ibadan, during the same time period, will serve as a point of comparison. …”
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De l’agglomération antique de Cassinomagus au village de Chassenon (Charente) : un bilan des connaissances by Lucie Carpentier, Sandra Sicard

“…Excavations carried out in the eastern part of the site revealed traces of occupation dating back to the Second Iron Age, though it remains impossible to determine whether these vestiges correspond to the origins of the urban concentration that would become Cassinomagus, or whether they are merely indicative of the presence of marginal rural occupation at that time. The site remained occupied at the beginning of the 1st c. …”
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SGLT2-inhibitors in diabetic patients with severe aortic stenosis and cardiac damage undergoing transcatheter aortic valve implantation (TAVI) by Pasquale Paolisso, Marta Belmonte, Emanuele Gallinoro, Roberto Scarsini, Luca Bergamaschi, Leonardo Portolan, Matteo Armillotta, Giuseppe Esposito, Elisabetta Moscarella, Giovanni Benfari, Claudio Montalto, Monika Shumkova, Elayne Kelen de Oliveira, Francesco Angeli, Mateusz Orzalkiewicz, Margherita Fabroni, Nurcan Baydaroglu, Andrea Raffaele Munafò, Daniele Oreste D’Atri, Matteo Casenghi, Lucia Scisciola, Michelangela Barbieri, Raffaele Marfella, Felice Gragnano, Edoardo Conte, Dario Pellegrini, Alfonso Ielasi, Daniele Andreini, Martin Penicka, Jacopo Andrea Oreglia, Paolo Calabrò, Antonio Bartorelli, Carmine Pizzi, Tullio Palmerini, Marc Vanderheyden, Francesco Saia, Flavio Ribichini, Emanuele Barbato

“…Patients not treated with SGLT2i were more likely to progress to a worse EVCD stage over time (p = 0.018). At 2-year follow-up, SGLT2i use was associated with a lower rate of MACE, all-cause death, and HF hospitalization (p < 0.01 for all). …”
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RETRACTED: A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice by Shireen Mohammad, Sura Al Zoubi, Sura Al Zoubi, Debora Collotta, Nadine Krieg, Nadine Krieg, Bianka Wissuwa, Bianka Wissuwa, Gustavo Ferreira Alves, Gareth S. D. Purvis, Gareth S. D. Purvis, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Andrea Baragetti, Andrea Baragetti, Alberico Luigi Catapano, Alberico Luigi Catapano, Alberico Luigi Catapano, Egle Solito, Egle Solito, Elisabeth Zechendorf, Tobias Schürholz, Wilmar Correa-Vargas, Klaus Brandenburg, Sina M. Coldewey, Sina M. Coldewey, Massimo Collino, Muhammad M. Yaqoob, Lukas Martin, Lukas Martin, Christoph Thiemermann

“…We report here for the first time that patients with T2DM compared to healthy volunteers have elevated plasma levels of LL-37. …”
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Autologous osteoperiosteal transplantation achieves comparable repair effect and superior interface integration to autologous osteochondral transplantation in porcine osteochondral... by Shuai Yang, En Deng, Linxin Chen, Yanbin Pi, Anhong Wang, Linghui Dai, Hongjie Huang, Xiaoning Duan, Xin Fu, Jiying Zhang, Qinwei Guo, Weili Shi

“…Notably, AOPT consistently exhibited superior interface integration compared to AOCT at all time points. Conclusion: Both AOPT and AOCT demonstrate significant efficacy in promoting the repair of osteochondral defects in a porcine model. …”
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Single-Photon Detectors for Quantum Integrated Photonics by Thu Ha Dao, Francesco Amanti, Greta Andrini, Fabrizio Armani, Fabrizio Barbato, Vittorio Bellani, Vincenzo Bonaiuto, Simone Cammarata, Matteo Campostrini, Samuele Cornia, Fabio De Matteis, Valeria Demontis, Giovanni Di Giuseppe, Sviatoslav Ditalia Tchernij, Simone Donati, Andrea Fontana, Jacopo Forneris, Roberto Francini, Luca Frontini, Gian Carlo Gazzadi, Roberto Gunnella, Ali Emre Kaplan, Cosimo Lacava, Valentino Liberali, Leonardo Martini, Francesco Marzioni, Claudia Menozzi, Elena Nieto Hernández, Elena Pedreschi, Paolo Piergentili, Paolo Prosposito, Valentino Rigato, Carlo Roncolato, Francesco Rossella, Matteo Salvato, Fausto Sargeni, Jafar Shojaii, Franco Spinella, Alberto Stabile, Alessandra Toncelli, Gabriella Trucco, Valerio Vitali

“…Although single-photon detector fabrication has been established for some time, integrating detectors with waveguides using new materials with suitable structural and electronic properties, especially at telecommunication wavelengths, creates more compact source-line-detector systems. …”
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Nonacademic predictors of China medical licensing examination by Jie Sun, Yingying Xie, Ningnannan Zhang, Jingliang Cheng, Meiyun Wang, Bing Zhang, Wenzhen Zhu, Hui Zhang, Shijun Qiu, Xiaojun Xu, Yongqiang Yu, Tong Han, Zuojun Geng, Weihua Liao, Bo Gao, Wen Qin, Feng Liu, Meng Liang, Qiang Xu, Jilian Fu, Jiayuan Xu, Mengge Liu, Peng Zhang, Wei Li, Dapeng Shi, Caihong Wang, Xi-Nian Zuo, Quan Zhang, Feng Chen, Jiance Li, Zhihan Yan, Wen Shen, Yanwei Miao, Junfang Xian, Longjiang Zhang, Kai Xu, Zhaoxiang Ye, Jing Zhang, Guangbin Cui, Chunshui Yu, for the CHIMGEN Consortium

“…Body mass index (BMI) and working memory reaction time showed direct negative effects on GMKT performance. …”
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Serum NFL and neuropsychological performance over ∼8 years in women with and without HIV: a longitudinal repeated measures studyResearch in context by Deborah R. Gustafson, Xuantao Li, Alison E. Baird, Henrik Zetterberg, Kaj Blennow, Jinbing Zhang, Amanda Blair Spence, Pauline Maki, Anjali Sharma, Kathleen Weber, Recai Yucel

“…Interpretation: Higher levels and greater ∼8-year increases in sNFL were associated with poorer NP by domain in WLWH and WLWOH differentially over time. Funding: The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). …”
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Bidirectional effect modifications of temperature and PM2.5 on myocardial infarction morbidity and mortality in Beijing, China from 2007 to 2021 by Piaopiao Hu, Qinghui Zeng, Jie Chang, Moning Guo, Feng Lu, Yue Qi, Zhao Yang, Pingping Jia, Qiuju Deng, Jing Liu

“…Objectives: To investigate bidirectional effect modifications of temperature and PM2.5 on MI morbidity and mortality. Methods: A time-stratified case-crossover study was conducted utilizing high-resolution data of temperature and PM2.5, along with 498,077 MI cases from the citywide registry in Beijing, China from 2007 to 2021. …”
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