Assessment of platelet-to-white blood cell ratio on short-term mortality events in patients hospitalized with acute decompensated heart failure: evidence from a cohort study from J... by Xin Huang, Xin Huang, Xin Huang, Xin Huang, Maobin Kuang, Maobin Kuang, Maobin Kuang, Maobin Kuang, Jiajun Qiu, Jiajun Qiu, Jiajun Qiu, Jiajun Qiu, Chao Wang, Chao Wang, Chao Wang, Chao Wang, Guotai Sheng, Guotai Sheng, Yang Zou, Guobo Xie

“…Subgroup analysis showed that compared to subjects with reduced or moderately reduced ejection fraction, ADHF patients with preserved ejection fraction had a lower risk of short-term mortality associated with PWR (HR:0.99 vs. 0.98 vs. 0.87, P for interaction = 0.0067).ConclusionThis study reveals, for the first time, a negative correlation between the inflammatory marker PWR and all-cause mortality within 30 days of hospitalization in ADHF patients. …”
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The concerted actions of microRNA-29a and interferon-β modulate complete Freund's adjuvant-induced inflammatory pain by regulating the expression of type 1 interferon receptor, int... by Chien-Cheng Liu, Kuo-Chuan Hung, Yu-Yu Li, Eagle Yi-Kung Huang, Chin-Chen Chu, Lok-Hi Chow, Ping-Heng Tan

“…Results: Our results demonstrated elevated miR-29a expression (CFA 3 days: mean difference [95% confidence interval, CI]: 0.860 [0.657–1.062]; CFA 5 days: mean difference [95% CI]: 1.120 [0.917–1.322], P<0.001, n=6) and decreased IFNR1 expression (CFA 3 days: mean difference [95% CI]: −0.300 [−0.470 to −0.130]; CFA 5 days: mean difference [95% CI]: −0.330 [−0.515 to −0.145], P=0.004, n=6) from Days 3–5 post-CFA induction, with IFN-ß expression showing a significant increase from Day 2 (F [3.30, 16.5]=34.3 for factor time, P≤0.01, n=6). Treatment with an miR-29a inhibitor alleviated CFA-induced mechanical allodynia and thermal hyperalgesia by Day 5 (P<0.001, n=9), concomitant with upregulation of IFNR1 and ISG15 expression, and downregulation of p-ERK (IFNR1; CFA 5 days + miR-29a inhibitor vs CFA 5 days; mean difference [95% CI]: 30.00 [20.31–39.69]; ISG15 conjugates; CFA 5 days + miR-29a inhibitor vs CFA 5 days, mean difference [95% CI]: 1.000 [0.9144–1.086]; free ISG15, mean difference [95% CI]: 2.402 [2.171–2.633]; p-ERK; CFA 5 days + miR-29a inhibitor vs CFA 5 days, mean difference [95% CI]: −32.00 [−34.10 to −29.90], P<0.001, n=9). …”
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Studying the Oncolytic Activity of <i>Streptococcus pyogenes</i> Strains Against Hepatoma, Glioma, and Pancreatic Cancer <i>In Vitro</i> and <i>In Vivo</i> by Anna N. Tsapieva, Alexander N. Chernov, Nadezhda V. Duplik, Anastasiya O. Morozova, Tatiana A. Filatenkova, Mariia A. Suvorova, Elena Egidarova, Elvira S. Galimova, Kseniya Bogatireva, Alexander N. Suvorov

“…Methods: The <i>in vitro</i> oncolytic cytotoxic activity of GAS strains was studied against human glioma U251, pancreatic cancer PANC02, murine hepatoma 22a, and normal skin fibroblast cells using the MTT assay and the real-time xCELLigence system. A syngeneic mouse model of hepatoma and pancreatic cancer was used to evaluate the <i>in vivo</i> oncolytic effect of GAS strains. …”
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Comparison of outcome and toxicity of postoperative intensity‐modulated radiation therapy with two‐dimensional radiotherapy in patients with soft tissue sarcoma of extremities and... by Jianyang Wang, Yongwen Song, Xinfan Liu, Jing Jin, Weihu Wang, Zihao Yu, Yueping Liu, Ning Li, Hui Fang, Hua Ren, Yuan Tang, Yu Tang, Bo Chen, Ningning Lu, Shunan Qi, Shulian Wang, Yexiong Li

“…Results With a median follow‐up time of 58.1 months, 30 local recurrences, 66 distant metastases, and 40 deaths occurred. …”
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Resultados a corto y largo plazo tras trasplante cardíaco en pacientes con cardiopatías congénitas by Marta Molina, Elena Roselló, Manel Tauron, Juan F. Tabilo, Constanza Fernandez, Carla Gotsens, Exzequiel Pueblas, José Montiel, Sandra Casellas, Angela Irabien, Laura Corominas, Laura López, Sonia Mirabet, Antonino Ginel

“…There were no significant differences in extracorporeal circulation time, reoperation for bleeding, or hospital stay. …”
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Synergistical effect of CoIn alloy and oxygen vacancies over Co-In-Zr ternary catalysts boosting CO2 hydrogenation to methanol by Xueyang Jiang, Xiaoshen Li, Shaohui Xiong, Wei Liu, Jiayan Yan, Xiang Duan, Song Song, Qingpeng Cheng, Ye Tian, Xingang Li

“…Under the conditions of 300 °C and GHSV of 30,000 ml gcat-1 h-1, the catalyst with a Co: In: Zr molar ratio of 1: 2: 7 achieves the CO2 conversion of 10.2 %, the methanol selectivity of 81.5 %, and especially the methanol time-space yield up to 860 mg gcat-1 h-1, surpassing the majority of the state-of-the-art In-based catalysts. …”
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Potential and limitations of noise-based surface-wave tomography for numerical site effect estimation: a case study in the French Rhône valley by Lavoué, François, Froment, Bérénice, Gélis, Céline, Boué, Pierre,  Chaljub, Emmanuel, Stehly, Laurent, Beauprêtre, Sophie, De Martin, Florent,  Gisselbrecht, Loïc, Pilz, Marco, Moiriat, Denis, Cushing, Edward Marc

“…Estimating these site effects is important for seismic hazard assessment but can be difficult to do empirically due to the scarcity of site-specific field data in time and space, especially in low-to-moderate seismicity regions where the earthquakes needed for measuring the site effects have long return periods. …”
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Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS) by Parisa Riahi, Amir Hossein Saeidian, Albert Tenesa, Carolyn T. Hogan, Michael March, Kamran Guity, Mahmoud Amiri Roudbar, Asieh Zahedi, Maryam Zarkesh, Farideh Neshati, Mehdi Hedayati, Fereidoun Azizi, Hakon Hakonarson, Maryam S. Daneshpour, Mahdi Akbarzadeh

“…We conducted a Bayesian hierarchical meta-analysis for each time point to assess the validity of the increasing trend of the longitudinal association. …”
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Correlations between primary tumour location, biomarkers of inflammation and lung injury, and postoperative pulmonary complications in patients underwent laparoscopic colorectomy:... by Hui-xian Li, Li Che, Yuan Li, Tai-hang Wang, Fang-di Min, Lei Xu, Meng Wang, Zhao-xu Zheng, Shi-ning Qu, Fei Wang, Wei Tang, Shi-jing Wei, Yu-lin Sun, Hui Zheng, Tao Yan

“…A univariate Cox proportional hazards model revealed that sRAGE, ANG-2, IL-1β, and IL-6 levels were not correlated with the incidence of time-to-PPCs across the two cohorts (P&gt;0.05). …”
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Implementation of in utero laparotomy-assisted fetoscopic spina bifida repair in two centers in Latin America: rationale for this approach in this regionAJOG Global Reports at a Gl... by Jezid Miranda, PhD, Miguel A. Parra-Saavedra, PhD, William O. Contreras-Lopez, PhD, Cristóbal Abello, MD, Guido Parra, MD, Juan Hernandez, MD, Amanda Barrero, MD, Isabela Leones, MD, Adriana Nieto-Sanjuanero, MD, Gerardo Sepúlveda-Gonzalez, MD, Magdalena Sanz-Cortes, PhD

“…Results: The gestational age (GA) at the time of surgery was significantly higher in fetoscopic centers (26±1.27 weeks) compared to the MOMs trial (23.6±1.42 weeks) and traditional hysterotomy methods (25.4±1 weeks) (P<.001). …”
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Outcomes of endometrial cancer prevention strategies in patients with Lynch syndrome: a nationwide cohort study in the NetherlandsResearch in context by Ellis L. Eikenboom, Lotte van Leeuwen, Floris Groenendijk, Jorien M. Woolderink, Anne M. Van Altena, Monique E. Van Leerdam, Manon C.W. Spaander, Helena C. van Doorn, Anja Wagner, M.C. Breijer, A.S. Tjalsma, F. Vork, H.P.M. Smedts, J. van der Velden, M.M.A. Brood-van Zanten, J.E. van de Riet, A.L.M. Oei, H. Kessel, P.M.L.H. Vencken, M.P.L.M. Snijders, R.H.M. Hermans, A. Bouman, H.W. Ünsalan, A.M.G. van de Swaluw, G.M. Plaisier, H.C. van Doorn, K. van den Berg, W. Hofhuis, Y.A.J.M. Dabekausen, P.R. Kolk, H.T.C. Nagel, A.M.L.D. van Haaften-de Jong, A.C. van Hof, M. van den Hende, J. Kaijser, H.H. de Haan, R.A. Smit, M.W.G. Moonen-Delarue, J.J. Beltman, J.E. Martens, R. Kruitwagen, J.M. van der Ploeg, J.M. Woolderink, S.F.P.J. Coppus, M.J. Duk, M.J.A. Apperloo, C.M. Koopmans, C.C.M. Buis, H. van Meurs, E.C. Dul, B.B.J. Hermsen, A.M. van Altena, A. Baalbergen, A.A. van Ginkel-Terng, M. Baas, P. van Greunen, C.M.W.H. Smeets, H. Knipscheer, J.E. Martens, C. Schmeink, M.D. van der Laan, E.J.M. van Es, J.E.W. van Dijk, F.M.F. Rosier-van Dunné, H. Nijman, C.G. Gerestein, D. Boskamp, E.C.A.H. Scheers, M. Verbruggen, L.R. Bartelink, C.B.M. Kruijdenberg, J.M. Briët, B. Visschers, M. Engelen

“…Overall survival after endometrial carcinoma diagnosis was analyzed using Kaplan Meier time to event analyses, cumulative incidence was calculated after adjusting for competing risks (death and prophylactic hysterectomy). …”
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Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk by Núria Granel, Gemma Iserte, Concepció Bartres, Neus Llarch, Anna Pla, Víctor Sapena, Zoe Mariño, Sabela Lens, Ramón Vilana, Isabel Nuñez, Anna Darnell, Ernest Belmonte, Ángeles García-Criado, Alba Díaz, Marco Sanduzzi-Zamparelli, Carla Fuster, Sergio Muñoz-Martínez, Carmen Ayuso, Jordi Rimola, Alejandro Forner, Alexandre Soler, Ferran Torres, José Ríos, Jordi Bruix, Andrew M. Moon, Xavier Forns, María Reig

“…Results This prospective cohort included 182 patients with SVR after DAA in this first analysis through the 4 years of follow-up. At the time of SVR, 65.9% had cirrhosis, median BMI was 27.1 kg/m2, 74.2% were overweight or obese and 6.6% had an US with hepatic steatosis. …”
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Methicillin-Resistant <i>Staphylococcus aureus</i>: The Shifting Landscape in the United Arab Emirates by Syrine Boucherabine, Rania Nassar, Lobna Mohamed, Maya Habous, Anju Nabi, Riyaz Amirali Husain, Mubarak Alfaresi, Seema Oommen, Hamda Hassan Khansaheb, Mouza Al Sharhan, Handan Celiloglu, Mubarak Hussain Raja, Eman Abdelkarim, Nishi Ali, Salman Tausif, Victory Olowoyeye, Nelson Cruz Soares, Mahmood Hachim, Danesh Moradigaravand, Dean Everett, Elke Mueller, Stefan Monecke, Ralf Ehricht, Abiola Senok

“…Upward trends of CC1153 were observed along with rare CCs, such as CC121-MRSA and CC7-MRSA, with the latter being reported for the first time in the Arabian Gulf region. The presence of pandemic strains USA300 CC8-MRSA-[IVa + ACME1] and CC8-MRSA-IV strains were also observed, including variants lacking Panton–Valentine leukocidin (<i>pvl</i>) genes and missing <i>tst1</i> or enterotoxin genes. …”
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Les fours « à pain » dans les Gaules et les Germanies (ve s. av. J.-C.-ve s. apr. J.-C.), un regard technique by Nicolas Monteix, Camille Noûs

“…BC and in the last quarter of the 4th c. AD. At the same time, from the 4th to the 2nd c. BC, the size of the ovens gradually increased, subsequently stabilising and remaining constant until the 5th c. …”
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Editorial by Ann-Kristin Kölln, Antony Mason, Maria Lenk, Jörg Tremmel, Markus Rutsche

“…In other words, while younger people are disproportionately affected by political decisions, they are at the same time heavily underrepresented in organisations and processes leading to the decisions. …”
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Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade by Evan J Lipson, Ludmila Danilova, Elizabeth M Jaffee, Won Jin Ho, Mark Yarchoan, Yasser Ged, Jean Hoffman-Censits, Jennifer Durham, Sanjay Bansal, Chester Kao, Rajat Mohindra, Stephanie L Alden, Tanguy Y Seiwert, Soren Charmsaz, Howard L Li, Kabeer Munjal, Hua-Ling Tsai, Alexei Hernandez, Erin M Coyne, Rachel Garonce-Hediger, Laura Tang, Marina Baretti, Kathryn Howe, G Scott Chandler, Madelena Brancati, Aanika Warner, Ervin Griffin, Mari Nakazawa, Chris Thoburn, Jennifer Gizzi, Nicole E Gross, Elsa Hallab, Sarah S Shin, Aditi Guha

“…We evaluated the concentration of 37 cytokines and used cytometry by time of flight to characterize immune cell clusters and cell-surface expression markers at baseline and on-treatment.Results We enrolled 94 patients, of whom 30 (32%) were obese and 64 (68%) were non-obese. …”
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Association between social activities and risk of COVID-19 in a cohort of healthcare personnel by Holly Shoemaker, Haojia Li, Yue Zhang, Jeanmarie Mayer, Michael Rubin, Candace Haroldsen, Morgan M. Millar, Per H. Gesteland, Andrew T. Pavia, Lindsay T. Keegan, Jessica Marie Cole, Egenia Dorsan, Matthew Doane, Kristina Stratford, Matthew Samore

“…Mixed-effect logistic regression assessed the association between social behavior and outcomes, adjusting for baseline and time-dependent covariates. To account for missed surveys, we employed inverse probability-of-censoring weighting with a propensity score approach. …”
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New Insights into Duckweed as an Alternative Source of Food and Feed: Key Components and Potential Technological Solutions to Increase Their Digestibility and Bioaccessibility by Krisztina Takács, Rita Végh, Zsuzsanna Mednyánszky, Joseph Haddad, Karim Allaf, Muying Du, Kewei Chen, Jianquan Kan, Tian Cai, Péter Molnár, Péter Bársony, Anita Maczó, Zsolt Zalán, István Dalmadi

“…Duckweed has special properties: It is one of the fastest-growing plants in the world (in freshwater), multiplying its mass in two days, so it can cover a water surface quickly even in filtered sunlight (doubling its biomass in 96 hours). During this time, it converts a lot of carbon dioxide into oxygen. …”
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Jinbei oral liquid for idiopathic pulmonary fibrosis: a randomized placebo-controlled trial by Aijun Zhang, Kangkang Han, Fangfang Chen, Xiao Chen, Jun Wang, Yikai Niu, Zhaoqiu Hu, Chunyan Zheng, Liping Han, Zhaoqing Meng, Liangzong Zhang, Qingcui Xu, Cuixiang Yu, Wei Zhang, Quanguo Li, Ningning Tao, Weixiang Kong, Fei Liu, Min Wang, Juanjuan Jiang, Honglin Li, LongBin Pang, Huaichen Li

“…Over a 26-week period, patients received the active treatment or placebo three times daily, in a 1:1 ratio. This clinical study uses a randomized method, with a cycle of every 4 patients. …”
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A Meta-Synthesis of the Integrated Model of Customer Value co-Destruction and Value co-Creation by Zohreh Dehdashti Shahrokh, Vahid Nasehifar, Mohammad Reza Karimi Alavijeh, Yazdan Rahmatabadi

“…In this regard, it is possible to redefine both creation and destruction of customer value, and appropriate measures to reduce the wastage of financial, time and credit resources can be put on the agenda.  …”
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