Efficacy and Safety of High-dose versus Standard-dose Prazosin in Paediatric Scorpion Envenomation: A Single-blinded Randomised Controlled Study by Apoorva Gayatri Abbadi, Hidaytullah R Bijapure, Chandrika R Doddihal, Bhavana B Lakhkar, Y Rohith, VJ Prakash, Kumar BM Prasanna, Mallanagouda Patil

“…After the patient was haemodynamically stable for 24 hours shifted to a high-dependency unit. The time interval between sting and treatment, various vital parameters, duration of the PICU stay and hospital stay were noted. …”
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Efek Pengurangan Durasi Tidur terhadap Jumlah dan Hitung Jenis Leukosit pada Tikus Wistar by Wahyu Tri Novriansyah, Ellyza Nasrul, Rosfita Rasyid

“…</p><p>                            <strong>Kata kunci:</strong> <em>sleep deprivation</em>, leukosit, eosinofil, neutrofil, limfosit, monosit</p><p><strong><em> </em></strong></p><p><strong><em>Abstract</em></strong></p><p><em>Sleep Deprivation (SD) is a complete loss of sleep for a certain period or a shorter sleep duration than the</em><em> </em><em>optimal time required. Sleep deprivation affects the immune system as well as the disruption of circadian rhythms. …”
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Reflecting on the impact of the COVID pandemic on patient management and its subsequent influence on long-term outcomes: a case–control study in the field of esophago-gastric cance... by Mohamed Alasmar, Nadia Matias, Norah Ali M. Alhamed, Omneya Alwani, Brogan Rudge, Terngu David Moti, Muhammad Ossama Yassin Abdelwahab, Jennifer Stockton, Charef Raslan, Jess Cairney-Hill, Mohammad Altarawni, Bilal Alkhaffaf, on behalf Greater Manchester Oesophago-Gastric Service

“…Results A consistent demographic profile across these periods was maintained, but with a significant decrease in patient referrals during P1 (35.25% reduction from PP to P1 and 9.5% reduction from PP to P2), quicker ‘time to treatment’ during P1 (130.8 days in P1 vs 162 in PP and 178.9 in P2), and notable changes in treatment modalities. …”
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Contribution of flood early warning response measures in reducing flood effects in Kilosa District, Tanzania by Japhet Ringo, Shadrack Sabai, Anesi Mahenge

“…The responders to these warnings are the people in flood-prone areas at the individual and community (collective) levels, who then have to take voluntary or mandatory measures before and during flood events (onset time). Such measures include running, climbing on roofs or trees, informing others and moving to uplands (safe areas). …”
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Kontrol Level Kecepatan Kipas Melalui Deteksi Gestur Jari Tangan Menggunakan MediaPipe dan Faster-RCNN by Muhammad Aldi Fakhruddin, Heri Pratikno, Musayyanah, Weny Indah Kusumawati

“…In this study, an interaction control system was applied between the user and the computer to adjust the fan speed level automatically and in real time based on computer vision technology for deep learning through the detection of the shape of the right hand finger gesture and the left hand finger gesture using a webcam. …”
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Improved Constraints on the Vertical Profile of CH4 at Jupiter’s Mid- to High Latitudes, Using IRTF-TEXES and SOFIA-EXES Spectroscopy by James A. Sinclair, Thomas K. Greathouse, Rohini S. Giles, Matthew Richter, Maisie Rashman, Curtis de Witt, Julianne Moses, Vincent Hue, Pablo Rodríguez-Ovalle, Thierry Fouchet, Ananyo Bhattacharya, Bilal Benmahi, Glenn S. Orton, Leigh N. Fletcher, Patrick G. J. Irwin

“…We therefore conclude that the region poleward of the northern MAE is, at times, subject to enhanced vertical transport resulting from auroral energy deposition. …”
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Deep application of controlled-release urea increases the yield and saponin content of Panax notoginseng by regulating soil nitrate distribution by Yun-xia Su, Yun-xia Su, Yun-xia Su, Ping Zhao, Li-jie Jia, Li-jie Jia, Li-jie Jia, Yuan-feng Cao, Guan-ze Liu, Guan-ze Liu, Jun-wen Chen, Jun-wen Chen, Sheng-chao Yang, Sheng-chao Yang, Yan-li Zhou, Guang-qiang Long, Guang-qiang Long, Guang-qiang Long

“…The distribution depth of soil NO3⁻-N and plant roots increased with the depth of CRU application, with a high overlap in time and space, indicating P. notoginseng N uptake peaked when CRU was applied at a depth of 6 cm (R6). …”
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Des vestiges d’un possible aqueduc à Lyon, à l’angle des rues Appian et des Fossés-de-Trion by Tony Silvino

“…The site is located near the Point-du-Jour plain, close to the Saint-Irénée district, in the southern ridge of the Trion valley, with the Fourvière hill to the north-east and the plain of Sainte-Foy to the south-west. In ancient times, the site was located in the south-western suburbium of the colony of Lugdunum, a space occupied by a series of different activities, with housing, agricultural areas, areas with craft or commercial activities and even a necropolis. …”
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Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis a... by Christian Gluud, Marija Barbateskovic, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Mathias Maagaard, Sophie Juul, Johanne Juul Petersen, Caroline Barkholt Kamp, Mark Abie Horowitz, Kiran Kumar Katakam

“…The trials’ assessment time points were between 6 and 16 weeks after randomisation. …”
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A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms by Yuan Yan, Yuan Yan, Yuan Yan, Yiyao Wu, Yiyao Wu, Yiyao Wu, Yu Zhao, Yu Zhao, Yu Zhao, Yaguang Yang, Yaguang Yang, Yaguang Yang, Guangtao An, Guangtao An, Guangtao An, Zhidong Liu, Zhidong Liu, Zhidong Liu, Zhidong Liu, Dongli Qi, Dongli Qi, Dongli Qi

“…Starting from the disease-related mechanisms and pathophysiological characteristics of eye blue light injury, this article elucidates the pharmacological mechanisms of various drugs for treating eye blue light injury. At the same time, it reviews the research on in vitro cultured cell and animal model conditions for blue light injury eyes, in order to provide reference for subsequent blue light injury modeling experiments. …”
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Combining Innovative Bioink and Low Cell Density for the Production of 3D-Bioprinted Cartilage Substitutes: A Pilot Study by Christel Henrionnet, Léa Pourchet, Paul Neybecker, Océane Messaoudi, Pierre Gillet, Damien Loeuille, Didier Mainard, Christophe Marquette, Astrid Pinzano

“…The influence of the bioprinting process and chondrogenic differentiation on MSC metabolism, gene profiles, and extracellular matrix (ECM) production at two different MSC concentrations (1 million or 2 million cells/mL) was assessed on day 28 (D28) by using MTT tests, real-time RT-PCR, and histology and immunohistochemistry, respectively. …”
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Previous treatment decreases efficacy of pralsetinib in RET fusion-positive non-small-cell lung cancer by Lei Wang, Yafei You, Wenzhuo He, Yu Hou, Lan Li, Li Wang, Chang Jiang, Jiahong Yi, Yaoxiong Xia, Liangping Xia

“…A Cox regression model was performed to identify independent prognostic factors.ResultsA total of 28 patients were enrolled, and the median follow-up time was 18.1 months. The objective response rate and disease control rate of the whole cohort were 57.2% and 71.4%, respectively, and the median PFS and OS were 8.1 months [95% confidence interval (CI), 3.1–13.2] and 13.8 months (95% CI, 2.8–24.8), respectively. …”
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The quasi-continuous exhaust regime in JET by M. Faitsch, M. Dunne, E. Lerche, P. Lomas, I. Balboa, P. Bilkova, P. Bohm, A. Kappatou, D. Kos, B. Labit, S. Menmuir, O. Sauter, S. Silburn, E.R. Solano, H.J. Sun, A. Tookey, E. Viezzer, U. Stroth, JET Contributors, the EUROfusion Tokamak Exploitation Team

“…This contribution reports that for the first time the QCE regime was successfully achieved in JET with a metal wall. …”
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SARS-CoV-2 infections in pediatric and young adult recipients of chimeric antigen receptor T-cell therapy: an international registry report by Hongyan Liu, Colleen Callahan, Shannon L Maude, Kevin Owen McNerney, Rebecca M Richards, Paibel Aguayo-Hiraldo, Friso G Calkoen, Julie-An Talano, Amy Moskop, Adriana Balduzzi, Jennifer Krajewski, Hema Dave, Anant Vatsayan, Yimei Li, Kara Lynn Davis

“…While SARS-CoV-2 mortality rates of 33%–40% are reported in adult CAR T-cell recipients, outcomes in pediatric and young adult CAR T-cell recipients are limited.Methods We created an international retrospective registry of CAR T recipients aged 0–30 years infected with SARS-CoV-2 within 2 months prior to or any time after CAR T infusion. SARS-CoV-2-associated illness was graded as asymptomatic, mild, moderate, or severe COVID-19, or multisystem inflammatory syndrome in children (MIS-C). …”
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A Prospective, Crossover, Randomized, Double-Blind Clinical Study Comparing the Effectiveness and Ocular Comfort of 0.1% Hyaluronic Acid and 0.3% Hyaluronic Acid in Patients With D... by Kim SJ, Yoo WS, Kwon LH, Kim RB, Yoon HJ, Yoon KC

“…Patients aged > 19 years with DED level 2 or higher, corneal staining score > 1, and tear break-up time (TBUT) < 10s were included. Sixty patients were randomly assigned to two groups. …”
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Web-based mindfulness and skills-based distress reduction for patients with cancer: study protocol of the multicentre, randomised, controlled confirmatory intervention trial Reduct by Dirk Schadendorf, Peter Martus, Stephan Zipfel, Yesim Erim, Alexander Bäuerle, Martin Teufel, Caterina Schug, Johanna Graf, Wolfgang Bethge, Andreas Dinkel, Anja Neumann, Jasmin Steinbach, Jana Heinen, Julia Barbara Krakowczyk, Mirjam Damerau, Sebastian Dries, Anja Mehnert-Theuerkauf, Mitra Tewes, Jörg Wiltink, Alexander Wünsch

“…The proposed trial incorporates four distinct measurement time points: the baseline assessment before randomisation, a post-treatment assessment and 3 and 6 month follow-up assessments. …”
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PD-1-expressing macrophages and CD8 T cells are independent predictors of clinical benefit from PD-1 inhibition in advanced mesothelioma by Solange Peters, Urania Dafni, Panagiota Zygoura, Sanjay Popat, Mary O'Brien, Rolf A Stahel, Alessandra Curioni-Fontecedro, Georges Coukos, Amy Roy, Riyaz Shah, Krisztian Homicsko, James Spicer, Stephen P Finn, David Gilligan, Maxim Norkin, Stephanie Tissot, Nicholas Shakarishvili, Anthony Pope, Patricia Fisher, Sylvie Rusakiewicz, Ekaterina Fortis, Nesa Marti, Roswitha Kammler

“…This data provides evidence for the first time for the existence of PD-1+macrophages in mesothelioma and their clinical relevance for immune checkpoint blockade.…”
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Chemical Characterization and Antimicrobial Activity of Essential Oils and Nanoemulsions of <i>Eugenia uniflora</i> and <i>Psidium guajava</i> by Rebeca Dias dos Santos, Breno Noronha Matos, Daniel Oliveira Freire, Franklyn Santos da Silva, Bruno Alcântara do Prado, Karolina Oliveira Gomes, Marta Oliveira de Araújo, Carla Azevedo Bilac, Letícia Fernandes Silva Rodrigues, Izabel Cristina Rodrigues da Silva, Lívia Cristina Lira de Sá Barreto, Claudio Augusto Gomes da Camara, Marcilio Martins de Moraes, Guilherme Martins Gelfuso, Daniela Castilho Orsi

“…The NE of <i>P. guajava</i> demonstrated low MIC (1.26 mg/mL) and MBC (11.35 mg/mL) values for <i>C. krusei</i>. The time–growth inhibition assay also suggests the effectiveness of the NE against the tested pathogens <i>S. aureus</i> and <i>E. coli</i>, highlighting its potential as a novel alternative therapeutic agent.…”
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Prognostic value of intraductal carcinoma subtypes and postoperative radiotherapy for localized prostate cancer by Fang Cao, Qing Li, Tianyu Xiong, Yingjie Zheng, Tian Zhang, Mulan Jin, Liming Song, Nianzeng Xing, Yinong Niu

“…Screening cases with pathological results of intraductal carcinoma, subtyping was completed by a pathologist, grouped by intraductal carcinoma (+/-; pattern 1/ 2) and treatment regimen (RP + PORT / RP only), Kaplan-Meier curves were plotted based on the time to biochemical recurrence-free and overall survival of the patients, and Cox regression analyses were performed. …”
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A UV to X-Ray View of Soft Excess in Type 1 Active Galactic Nuclei. I. Sample Selection and Spectral Profile by Shi-Jiang Chen, Jun-Xian Wang, Jia-Lai Kang, Wen-Yong Kang, Hao Sou, Teng Liu, Zhen-Yi Cai, Zhen-Bo Su

“…We show that a cutoff power law could uniformly characterize both types of soft excesses, with a median E _cut of 1.40 keV for po-like and 0.14 keV for bb-like. For the first time, we report a robust and quantitative correlation between the SE profile and SE strength (the ratio of SE luminosity to that of the primary power-law continuum in 0.5–2.0 keV), indicating that stronger soft excess is more likely to be po-like, or effectively has a higher E _cut . …”
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