Initial treatment of steroid-sensitive idiopathic nephrotic syndrome in children with mycophenolate mofetil versus prednisone: protocol for a randomised, controlled, multicentre tr... by Burkhard Toenshoff, Martin Konrad, Steffen Luntz, Anja Sander, Peter F Hoyer, Rasmus Ehren, Marcus R Benz, Jorg Doetsch, Alexander Fichtner, Jutta Gellermann, Dieter Haffner, Britta Höcker, Bärbel Kästner, Markus J Kemper, Uwe Querfeld, Lutz T Weber

“…Despite being effective, this treatment is associated with pronounced glucocorticoid-associated toxicity due to high-dose prednisone administration over a prolonged period of time. The aim of the INTENT study (Initial treatment of steroid-sensitive idiopathic nephrotic syndrom in children with mycophenolate mofetil versus prednisone: protocol for a randomised, controlled, multicentre trial) is to show that an alternative treatment regimen with mycophenolic acid is not inferior regarding sustainment of remission, but with lower toxicity compared with treatment with glucocorticoids only.Methods and design The study is designed as an open, randomised, controlled, multicentre trial. 340 children with a first episode of steroid-sensitive nephrotic syndrome and who achieved remission by a standard prednisone regimen will be enrolled in the trial and randomised to one of two treatment arms. …”
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Spatiotemporal range dynamics and conservation optimization for endangered medicinal plants in the Himalaya by Fu-Lv Liu, Winnie Wanjiku Mambo, Jie Liu, Guang-Fu Zhu, Raees Khan, Abdullah, Shujaul Mulk Khan, Lu Lu

“…However, our understanding of species distribution across space and time under climate change scenarios, as well as effective conservation planning for these medicinal plants in the Himalaya, remains limited. …”
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Satisfactory Evaluation of Call Service Using AI After Ureteral Stent Insertion: Randomized Controlled Trial by Ukrae Cho, Yong Nam Gwon, Seung Ryong Chong, Ji Yeon Han, Do Kyung Kim, Seung Whan Doo, Won Jae Yang, Kyeongmin Kim, Sung Ryul Shim, Jaehun Jung, Jae Heon Kim

“…MethodsOverall, 28 patients (aged 20-70 years) who underwent ureteral stent insertion for the first time without a history of psychological illness were consecutively included. …”
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Tasquinimod suppresses tumor cell growth and bone resorption by targeting immunosuppressive myeloid cells and inhibiting c-MYC expression in multiple myeloma by Marie Törngren, Rong Fan, Eline Menu, Helena Eriksson, Karin Vanderkerken, Andrew Chantry, Hatice Satilmis, Niels Vandewalle, Emma Verheye, Philip Vlummens, Anke Maes, Catharina Muylaert, Elke De Bruyne, Holly Evans, Nathan De Beule, Dirk Hose, Ken Maes, Karine Breckpot, Kim De Veirman

“…We aimed to gain more insights into its mechanisms of action both on the myeloma cells and the immune microenvironment.Methods We analyzed the effects of tasquinimod on MM cell viability, cell proliferation and downstream signaling pathways in vitro using RNA sequencing, real-time PCR, western blot analysis and multiparameter flow cytometry. …”
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Aides à la navigation, pratique de la navigation et construction des paysages maritimes en Atlantique du Nord-Est : quelques éléments de réflexion by Pascal Arnaud

“…They have been observed for a longer time, are sometimes still preserved, and have been described in texts as being endless repetitions of the lighthouse of Alexandria (Egypt). …”
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Oral Administration of 17α-Methyltestosterone Increased Male Percentage of Freshwater Crayfish Cherax quadricarinatus by O. Carman, M.Y. Jamal, . Alimuddin

“…., 25, 50, 75, 100 and 150 mg/kg diet or diet containing no MT as control, 3 times daily for 30 days.  After MT-treatment, crayfish were fed frozen Chironomus sp.  …”
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Mental health in public safety personnel with workplace injuries requiring surgery: a longitudinal population-wide administrative data study in Manitoba, Canada by Tracie O Afifi, Jitender Sareen, Dan Chateau, Alyson Mahar, Jordan Nantais, James Bolton, Allen Kraut, Sarvesh Logsetty, Thomas Turgeon, Brenda Comaskey, Justin Gawaziuk, Rae Spiwak, Lauren Burton, Anthony Wightman, Jai Sareen, Natalie Mota

“…After adjusting, there were no significant differences in rates between the two cohorts; however, the significant group × care interaction term for depression suggests a greater risk for PSP compared with GenPop over time.Conclusions Our findings indicate that, compared with a matched cohort, PSP have an increased risk of depression from the pre-injury to post-injury period following a traumatic physical workplace injury. …”
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DFT and molecular docking analyses of the effects of solvent polarity and temperature on the structural, electronic, and thermodynamic properties of p-coumaric acid: Insights for a... by Umer Sherefedin, Abebe Belay, Kusse Gudishe, Alemu Kebede, Alemayehu Getahun Kumela, Tadesse Lemma Wakjira, Dereje Gelanu, Tesfaye Feyise, Jebel Haji Mahamud, Abdulkerim Abdela, Kebede Shankute Gizew

“…The thermal analysis also revealed that increasing the temperature from 100 K to 1000 K led to higher enthalpy, heat capacity, and entropy, along with a decrease in Gibbs free energy values due to enhanced molecular vibrations, contributing to the degradation and instability of p-CA. Time-dependent DFT (TDDFT) analysis revealed that solvent polarity influenced UV–Vis absorption and excited-state dipole moments, leading to significant changes in electronic transitions. …”
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Promising Directions in Chemical Processing of Methane from Coal Industry. Part 4. Long-term Stability Test by Е.V. Matus, O.V. Tailakov, O.B. Sukhova, A.V. Salnikov, O.A. Stonkus, M.A. Kerzhentsev, S.R. Khairulin, Z.R. Ismagilov

“…Long-term catalytic tests have shown high parameters of the methane tri-reforming process, which were stable over the time of operation. At a temperature of 800 ᵒC, after 100 h of process using the Ce0.2Ni0.8O1.2/Al2O3 catalyst, the hydrogen yield was 85% at a methane conversion of 80%. …”
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Investigating the Role of Artificial Intelligence Enablers and Companies' Readiness in Adopting an Artificial Intelligence-integrated Customer Relationship Management System by Soheila Mohammadzadeh Vanestan, Rahim Abedi

“…In terms of existing limitations such as time and financial limitations as well as human resources required for quick response and establishing online communication, the use of communication and response programs based on artificial intelligence seems to be an efficient and effective alternative that can improve the financial and non-financial performance of the organization.…”
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Penerapan Model Technology Readiness Index untuk Mengukur Tingkat Kesiapan Mahasiswa dalam Penerimaan Sistem E-Polvot by M Khairul Anam, Fransiskus Zoromi, Soni, Torkis Nasution, Khusaeri Andesa

“…However, in the BEM elections, some students are unable to exercise their voting rights due to time constraints set by the election committee. The election process offers three types of lecture schedules: regular daytime from 08:00 to 17:00, evening lectures from 17:45 to 09:30, and non-regular lectures held during weekends for distance or online learning. …”
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Lattes/Lattara (Hérault), comptoir étrusque du littoral languedocien by Éric Gailledrat, Ariane Vacheret

“…Equipped with a fortification, this initial core was then adjacent to a vast indigenous settlement located less than 1 km away, in the place known as La Cougourlude, which testifies to the vitality of trade maintained with the Greco-Etruscan world at that time. This highly stratified site, with levels in parts preserved beneath the phreatic level, is first and foremost known for the late phases of the Iron Age, whereas the earlier levels have only been investigated to a limited extent. …”
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Establishing a radiomics model using contrast-enhanced ultrasound for preoperative prediction of neoplastic gallbladder polyps exceeding 10 mm by Dong Jiang, Yi Qian, Yijun Gu, Ru Wang, Hua Yu, Zhenmeng Wang, Hui Dong, Dongyu Chen, Yan Chen, Haozheng Jiang, Yiran Li

“…CEUS has a high accuracy rate in diagnosing the benign or malignant nature of gallbladder space-occupying lesions, which can significantly reduce the preoperative waiting time for related examinations and provide more reliable diagnostic information for clinical practice. …”
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Assessment of Environmental Hazards and Vulnerability of The Rud–E-Shur, Rud-E-Shirin and Rud-E-Minab International Wetland Using the DPSIR Model by Hengameh Safa Eisini, Saber Ghasemi, Afshin Danehkar, Mohsen Dehghani Ghanateghestani, Hossein Parvaresh

“…These forests are valueable due to the having sensitive biophysical resources, breeding important and biodiversity. At the same time, they are in the rank of one of the most important marine sensitive areas and need proper management. …”
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Integrated metabolome and transcriptome analysis reveals potential mechanism during the bud dormancy transition of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsi... by Huan Guan, Huan Guan, Yuhuan Zhao, Yuhuan Zhao, Qing Chen, Qianqian Zhang, Qianqian Zhang, Pengpeng Yang, Pengpeng Yang, Shuying Sun, Shuying Sun, Guilin Chen, Guilin Chen

“…In summary, these results provide insights into the novel regulatory mechanism of the transition of endo- to ecodormancy in underground buds of AMM and offer new analytical strategies for breaking dormancy in advance and shortening breeding time.…”
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Preservation of cellular structure via immersion fixation in brain banking by Macy Garrood, Emma L. Thorn, Adam Goldstein, Allison Sowa, William Janssen, Alyssa Wilson, Claudia S. López, Raakhee Shankar, Erin S. Stempinski, Kurt Farrell, John F. Crary, Andrew T. McKenzie

“…However, there are questions about the quality of preservation using this method, as formaldehyde takes a relatively long period of time to penetrate a large organ such as the human brain. …”
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An analytical method for the desorption superposition effect in commingled production of coalbed methane and its application: A case study of the Xiaotun mine field in western Guiz... by Chen GUO, Yan JI, Chenyi ZHAO, Lingling LU, Xinhang YU, Junzhe GAO, Houqiang LI, Xuyang ZHANG, Xiang WANG, Hongbin HE, Runhan ZHANG

“…The well-controlled desorption capacities and their time-varying curves indicate that gas desorption capacities peaked in the case of the synchronous desorption of all pay intervals within the respective desorption systems. …”
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Establishing rabbit critical-size bone defects to evaluate the bone-regeneration potential of porous calcium phosphate ceramics by Wei Lei, Yan Wu, Yan Wu, Hao Yuan, Ping He, Jingqi Wu, Jingrong Chen, Yuxiao Liu, Hongmei Zhang, Joost D. de Bruijn, Xuerong Xiang, Ping Ji, Huipin Yuan, Huipin Yuan, Mingzheng Li

“…This study offers two rabbit CSDs models for evaluating bone-regeneration strategies (including bone substitution), and the overall data obtained in the current study indicate the possibility of repairing CSDs with CaP ceramics demonstrating improved bone-forming ability given adequate implantation time.…”
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Unequal ageing: the quality of life of senior citizens in the EU before and after COVID-19. A multidimensional approach by Elżbieta Roszko-Wójtowicz, Klaudia Przybysz, Agnieszka Stanimir

“…The research seeks to answer the following question: How has the quality of life among seniors in the EU evolved over time, and how has the COVID-19 pandemic affected this trajectory? …”
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Benefits, limits, and risks of ChatGPT in medicine by Jonathan A. Tangsrivimol, Jonathan A. Tangsrivimol, Erfan Darzidehkalani, Hafeez Ul Hassan Virk, Zhen Wang, Zhen Wang, Jan Egger, Michelle Wang, Sean Hacking, Benjamin S. Glicksberg, Markus Strauss, Markus Strauss, Chayakrit Krittanawong, Chayakrit Krittanawong

“…Studies show significant efficiency gains, including 70% reduction in administrative time for discharge summaries and achievement of medical professional-level performance on standardized tests (60% accuracy on USMLE, 78.2% on PubMedQA). …”
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