Lipids as key biomarkers in unravelling the pathophysiology of obesity-related metabolic dysregulation by Anis Adibah Osman, Siok-Fong Chin, Lay-Kek Teh, Noraidatulakma Abdullah, Nor Azian Abdul Murad, Rahman Jamal

“…This study was aimed to discern unique metabolite signatures in obese and lean individuals using liquid chromatography-mass spectrometry quadruple time-of-flight (LC-MS/Q-TOF), with the goal of elucidating their roles in obesity. …”
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Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma by Yuan Yao, Yiyi Yan, Vera J. Suman, Allan B. Dietz, Courtney L. Erskine, Anastasios Dimou, Svetomir N. Markovic, Svetomir N. Markovic, Robert R. McWilliams, Heather N. Montane, Matthew S. Block, Matthew S. Block

“…Pembrolizumab (200 mg/kg every 3 weeks) was combined with ibrutinib, administered orally at the dose assigned at the time of registration (140 mg daily, 280 mg daily, and 420 mg daily). …”
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KATALIKŲ BAŽNYČIOS KAITA LIETUVOJE TRANSFORMACIJŲ LAIKOTARPIU by Valdas Pruskus

“…CHANGES OF CATHOLIC CHURCH IN LITHUANIA IN TIME OF TRANSFORMATIONS Valdas Pruskus Summay After the restoration of independence of Lithuania, changing of Catholic Church as an institution was predetermined by two most important factors. …”
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Effects of Physical Exercise Breaks on Executive Function in a Simulated Classroom Setting: Uncovering a Window into the Brain by Qian Yu, Zhihao Zhang, Sebastian Ludyga, Kirk I. Erickson, Boris Cheval, Meijun Hou, Dominika M. Pindus, Charles H. Hillman, Arthur F. Kramer, Ryan S. Falck, Teresa Liu‐Ambrose, Jin Kuang, Sean P. Mullen, Keita Kamijo, Toru Ishihara, David A. Raichlen, Matthew Heath, David Moreau, André O. Werneck, Fabian Herold, Liye Zou

“…Linear mixed models identified significant positive effects of exercise conditions on behavioral reaction time (RT), error rate, and inverse efficiency score (β = −2.62, −0.19, −3.04: ps < 0.05). …”
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Model-Based Variation-Aware Optimization for Offset Calibration and Pre-Sensing in DRAM Sense Amplifiers by Dongyeong Kim, Geon Kim, Suyeon Kim, Jewon Park, Sinwook Kim, Hyeona Seo, Chaehyuk Lim, Sowon Kim, Juwon Lee, Jeonghyeon Yun, Hyerin Lee, Jinseok Park, Yongbok Lee, Seungchan Lee, Myoungjin Lee

“…While HSPICE simulations combining Monte Carlo (MC) and binary search methods require numerous iterations for single design point verification, our model significantly reduces design time by effectively narrowing the region of interest through pre-optimization using statistical characteristics. …”
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Small RNA CjNC110 regulates the activated methyl cycle to enable optimal chicken colonization by Campylobacter jejuni by Brandon Ruddell, Alan Hassall, Orhan Sahin, Paul J. Plummer, Qijing Zhang, Amanda J. Kreuder

“…Critically, this work for the first time reveals regulation of L-methionine (L-met) production within the activated methyl cycle (AMC) by small RNA (sRNA) CjNC110 as a key factor driving C. jejuni optimal chicken colonization. …”
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KiKli Fit: Insights into the Development and Practice of a Physical Activity Program in Pediatric Cancer by Lisa Hillebrech, Lars Rehbein, Ann Christin Schneider, Sara Müller, Christina Schindera, Katharina Eva, Valentin Benzing

“…Building on this, a PA program was designed and implemented over 1.5-years. During this time, various formal and informal assessments were conducted to ensure quality assurance. …”
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Spatial and temporal heterogeneity of soil respiration in a bare-soil Mediterranean olive grove by S. Aranda-Barranco, S. Aranda-Barranco, P. Serrano-Ortiz, P. Serrano-Ortiz, A. S. Kowalski, A. S. Kowalski, E. P. Sánchez-Cañete, E. P. Sánchez-Cañete

“…The results indicate that <span class="inline-formula"><i>R</i>_{s  Under-Tree}</span> was 3 times higher than <span class="inline-formula"><i>R</i>_s Alley</span> in the annual computations. …”
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The role of artificial intelligence and machine learning in predicting and combating antimicrobial resistance by Hazrat Bilal, Muhammad Nadeem Khan, Sabir Khan, Muhammad Shafiq, Wenjie Fang, Rahat Ullah Khan, Mujeeb Ur Rahman, Xiaohui Li, Qiao-Li Lv, Bin Xu

“…In addition, AI-based clinical decision support systems in real-time guide healthcare professionals to improve prescribing of antibiotics. …”
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Multi-observatory Study of Young Stellar Energetic Flares (MORYSEF): No Evidence for Abnormally Strong Stellar Magnetic Fields after Powerful X-Ray Flares by Konstantin V. Getman, Oleg Kochukhov, Joe P. Ninan, Eric D. Feigelson, Vladimir S. Airapetian, Abygail R. Waggoner, L. Ilsedore Cleeves, Jan Forbrich, Sergio A. Dzib, Charles J. Law, Christian Rab, Daniel M. Krolikowski

“…We explore the empirical power-law relationship between X-ray luminosity ( L _X ) and total surface magnetic flux (Φ), established across solar magnetic elements, time- and disk-averaged emission from the Sun, older active stars, and pre-main-sequence (PMS) stars. …”
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Recent advances of photodiagnosis and treatment for head and neck squamous cell carcinoma by Yining Zhang, Zhenfang Li, Chengchi Zhang, Chengying Shao, Yanting Duan, Guowan Zheng, Yu Cai, Minghua Ge, Jiajie Xu

“…Optical technology offers distinctive possibilities for early preoperative diagnosis, intraoperative real-time visualization of tumor margins, sentinel lymph node biopsies, phototherapy. …”
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Experimental use of mycobacterial antigens in tuberculin skin test on water buffalo by Alessandra Martucciello, Federica Signorelli, Piera Mazzone, Francesco Grandoni, Giovanna Cappelli, Lucia Boccia, Giuseppe Parente, Monica Cagiola, Maria Beatrice Boniotti, Esterina De Carlo, Francesco Napolitano, Giorgio Galiero

“…Negative subjects also exhibited a skin response to PPDB at 24 and 48 h, but it became completely negative at 72 h, the prescribed reading time. In the positive buffaloes, the kinetics of skin responses showed that the strongest response was to PPDB at 24h, with some subjects becoming doubtful at 72 and 96 h. …”
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Steroids In caRdiac Surgery (SIRS) trial: acute kidney injury substudy protocol of an international randomised controlled trial by Michael Walsh, Salim Yusuf, Chirag Parikh, Jessica Vincent, P J Devereaux, Francois Lamontagne, Matthew T V Chan, Richard Whitlock, Meaghan Cuerden, Amit X Garg, Andre Lamy, Daniel I Sessler, Kevin Teoh, Ainslie Hildebrand, Yunxia Zuo, Pallav Shah, Seyed Hesameddin Abbasi, Mackenzie Quantz, Jean-Pierre Yared, Nicolas Noiseux, Georgios Tagarakis, Antoine Rochon, Janice Pogue, Abbas Salehiomran

“…Introduction Steroids In caRdiac Surgery trial (SIRS) is a large international randomised controlled trial of methylprednisolone or placebo in patients undergoing cardiac surgery with the use of a cardiopulmonary bypass pump. At the time of surgery, compared with placebo, methylprednisolone divided into two intravenous doses of 250 mg each may reduce the risk of postoperative acute kidney injury (AKI).Methods and analysis With respect to the study schedule, over 7000 substudy eligible patients from 81 centres in 18 countries were randomised in December 2013. …”
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4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain by Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang

“…After 12 weeks of surgery, the efficacy of 4-OI treatment on PTOA in mice was evaluated using MRI, micro-CT, histological analysis, and quantitative real-time polymerase chain reaction. Finally, we utilized network pharmacology analysis to predict the mechanism of 4-OI in treating PTOA synovitis and conducted preliminary validation. …”
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Long-Term Therapeutic Effects of ²²⁵Ac-DOTA-E[c(RGDfK)]₂ Induced by Radiosensitization via G2/M Arrest in Pancreatic Ductal Adenocarcinoma by Mitsuyoshi Yoshimoto, Kohshin Washiyama, Kazunobu Ohnuki, Ayano Doi, Miki Inokuchi, Motohiro Kojima, Brian W. Miller, Yukie Yoshii, Anri Inaki, Hirofumi Fujii

“…Meanwhile, the γH2AX expression induced by 5 or 10 kBq/mL of ²²⁵Ac-DOTA-RGD₂ alone decreased over time. <b>Conclusions</b>: These findings highlight the potential of using ²²⁵Ac-DOTA-RGD₂ in the treatment of intractable pancreatic cancers, as its ability to induce G2/M cell cycle arrest enhances radiosensitization, resulting in notable growth inhibition.…”
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F. NIETZSCHE: VALIOS SIEKTI GALIOS PRINCIPAS by Arūnas Mickevičius

“…With respect to the genesis of power or its generation, the will to power determines the relation between forces, but in its own turn is determined by the activity of these forces. It is at the same time both determined and determiner. Nietzschean „slave“ and „master“ moralities are based upon active and reactive forces. …”
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Chemical Composition of Mexicali Propolis and Its Effect on Gastric Repair in an Indomethacin-Induced Gastric Injury Murine Model by Pilar Dominguez-Verano, Nadia Jacobo-Herrera, Andrés Castell-Rodríguez, Octavio Canales-Alvarez, Maria Margarita Canales-Martinez, Marco Aurelio Rodriguez-Monroy

“…The chemical composition was analysed using HPLC—TOF—MS (High—Performance Liquid Chromatography—Time—Of—Flight Mass Spectrometry) and GC—MS (Gas Chromatography–Mass Spectrometry), and a total of 52 compounds were identified. …”
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Impacts of Sandstorms on Chemistries of Ambient PAHs in a Small City in North China by Zhiyong Li, Zhen Zhai, Jixiang Liu, Lan Chen, Zhuangzhuang Ren, Chen Liu, Ziyi Zhan, Ziyuan Yue, Wenjia Zhu, Jihong Wei, Huiying Gao, Songtao Guo

“…SSP exhibited a slightly high average PAH concentrations of 10.3 ng m−3 than 9.16 ng m−3 in the NSSP. At the same time, the average PM2.5 concentrations obviously increased from 60.7 µg m−3 to 75.2 µg m−3. …”
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Anti-phenolic glycolipid antibodies in Mycobacterium bovis infected cattle by Zijie Zhou, Anouk van Hooij, J. Hessel M. van Dijk, Nina Musch, Louise Pierneef, Hamza Khalid, Kees Franken, Thomas Holder, Neil Watt, Anita L. Michel, Jeroen D.C. Codée, Martin Vordermeier, Paul L.A.M. Corstjens, Elisabeth M.D.L. van der Heijden, Jayne C. Hope, Annemieke Geluk

“…This study shows for the first time that anti M. bovis PGL antibodies can be detected in infected cattle: anti-M. bovis PGL IgM is a highly specific, but moderately sensitive biomarker for M. bovis infection in cattle, showing potential for differentiate infected from vaccinated animals (DIVA). …”
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Study of the relationships of polymorphisms of the folate cycle genes with the levels of homocysteine and folic acid as risk factors of cardiovascular disorders in the post-covid p... by A.A. Shuprovych, O.V. Zinych, N.M. Kushnareva, K.P. Komisarenko

“…Polymorphisms of the genes: methylenetetrahydrofolate reductase (677C>T and 1298A>C), methionine synthase-reductase (66A>G) and methionine synthase (2756A>G) were determined by real time polymerase chain reaction. For each of the named polymorphisms, the examined patients were divided into 3 groups according to the nucleotide alleles in the corresponding position: 1) homozygous dominant, 2) heterozygous and 3) homozygous recessive. …”
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