Safety and Efficacy of Subcutaneous Rituximab in Previously Untreated Patients with CD20+ Diffuse Large B-Cell Lymphoma or Follicular Lymphoma: Results from an Italian Phase IIIb S... by Mario Petrini, Gianluca Gaidano, Andrea Mengarelli, Ugo Consoli, Armando Santoro, Anna Maria Liberati, Marco Ladetto, Vincenzo Fraticelli, Attilio Guarini, Donato Mannina, Paola Ferrando, Paolo Corradini, Pellegrino Musto, Caterina Stelitano, Dario Marino, Andrea Camera, Marco Murineddu, Roberta Battistini, Giuseppe Caparrotti, Mauro Turrini, Luca Arcaini, Simone Santini, Manuela Cerqueti, Andres J. M. Ferreri, Nicola Cantore, Alessandro Inzoli, Giovanni Cardinale, Benedetto Ronci, Giorgio La Nasa, Stefano Massimi, Gianfranco Gaglione, Valentina Barbiero, Maurizio Martelli

“…Two patients with DLBCL (2.8%) and 6 with FL (7.0%) discontinued rituximab due to TEAEs. 65.2% and 69.7% of patients with DLBCL and 67.9% and 73.6% of patients with FL had complete response (CR) and CR unconfirmed, respectively. The median time to events (EFS, PFS, and OS) was not estimable due to the low rate of events. …”
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Molecular and cellular aspects of the impact of secondary metabolites from common barberry and hybrid goat’s rue on the HeLa cell line by E. Yu. Zlatnik, Ya. S. Enin, O. N. Burov, E. S. Bondarenko, A. B. Sagakyants, D. S. Kutilin, Yu. V. Dzigunova, O. G. Ishonina, E. V. Shalashnaya, N. D. Ushakova

“…The level of copy number variation and expression of genes responsible for apoptosis were assessed by real-time PCR (RT-PCR). In total, three substances were studied, with two concentrations (4 and 12 μg/ml) and two exposures (24 and 72 hours) for each of them.Results. …”
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Analysis of the Effect of Human Type I Collagen-Derived Peptide on Bone Regenerative Capacity and Comparison with Various Collagen Materials In Vivo by Tatsunori Asakura, Tran Thi Thuy Diep, Yuta Ueda, Aoi Yamada, Takahiro Tsuzuno, Naoki Takahashi, Masayuki Miyata, Koichi Tabeta, Masaki Nagata, Ken Matsuda

“…In vitro experiments included the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), adhesion, and migration assays, and a real-time polymerase chain reaction using rapidly expanding cells (RECs) to explore the mechanisms of Cellnest’s bone regenerative capacity. …”
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Parents' perception of the promotion of physical activity as part of the Purzelbaum project in Swiss daycare centers by Bianca Celine Schmidli, Claudio R. Nigg

“…Parents from Purzelbaum daycare centers are more likely to feel that PA is part of everyday life (mpb=3.83, SD=.41; mnpb=3.60, SD=.63; p=.023), that it is highly valued (mpb=3.70, SD=.54; mnpb=3.21, SD=.74; p<.001) and that the children can be physically active at any time in the daycare center (mpb=3.61, SD=.54; mnpb=3.36, SD=.77; p=.034). …”
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Dechlorination of selected polychlorinated biphenyl congeners using metal-impregnated pulverized shrimp shell catalyst from waste by D.B. Aviantara, F. Suciati, G. Hadiko, N.S. Indrasti, M. Yani

“…The chlorines from polychlorinated biphenyl congeners were removed using a heterogeneous catalyst synthesized via microwave-assisted impregnation of zinc metal onto pulverized shrimp shell waste.METHODS: The five polychlorinated biphenyl congeners were dechlorinated through treatments combination of time (1–4 hours), heat (150–250 degree celsius), and catalyst proportion (1–5 percent weight/weight basis). …”
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Case based Reasoning Prediksi Waktu Studi Mahasiswa Menggunakan Metode Euclidean Distance dan Normalisasi Min-Max by Henni Endah Wahanani, Made Hanindia Prami Swari, Fawwaz Ali Akbar

“…Abstract One of the reasons for the length of study time for students of the Informatics study program of UPN "Veteran" Jawa Timur is the difficulty of monitoring the progressy, given the large number of students and academics do not have an accurate method to map students who are predicted to experience delays. …”
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Axonal regeneration and innervation ratio following supercharged end-to-side nerve transfer by Leopold Harnoncourt, Martin Schmoll, Christopher Festin, Laurenz Pflaum, Markus Breuss, Johanna Klepetko, Dominik C. Dotzauer, Florian J. Jaklin, Udo Maierhofer, Philipp Tratnig-Frankl, Oskar C. Aszmann, Oskar C. Aszmann

“…IntroductionPeripheral nerve injuries often result in incomplete recovery, particularly after the occurrence of proximal lesions, owing to the extended reinnervation time as well as consequent reductions in the regeneration supportive factors and muscle recovery potential. …”
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Effect of Zhan Zhuang Qigong on upper limb static tremor and aerobic exercise capacity in patients with mild-to-moderate Parkinson’s disease: study protocol for a randomised contro... by Hang Su, Xiaoyu Jiang, Limin Wang, Linlin Zhang, Qing Wang, Xihua Liu, Xiaoming Xi, Yuxiao Chen, Xinjie Qu, Haihao Cao, Wenyu Sun, Guoming Chen, Huifen Liu, Jiahui Jiang, Hongyan Bi

“…The intervention group received conventional medicine plus Zhan Zhuang Qigong exercises five times a week at 30 min each time, over an 8-week period. …”
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Mycobiota composition through the ripening of artisanal soft cheeses ‘Torta del Casar’ and ‘Queso de la Serena’ monitored by high-throughput sequencing by Almudena V. Merchán, Ángel Carlos Román, Santiago Ruiz-Moyano, María Vázquez-Hernández, Catalina M. Cabañas, María José Benito

“…The Protected Designation of Origin and the ripening time factors do not significantly influence the fungal diversity between different cheese samples, suggesting that minor changes in manufacturing practices between the type of cheeses have a negligible impact on mycobiota composition. …”
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Breaking the biofilm barrier: Juglone derivatives as dual-action inhibitors and anti-quorum sensing agents by Muhammad Abdullah Bhatti, Atif Ali Khan Khalil, Sayed Muhammad Ata Ullah Shah Bukhari, Faisal Hanif, Mi-Jeong Ahn, Sumra Wajid Abbasi, Nazir Ahmed Lone, Wen-Jun Li, Wasim Sajjad

“…The untreated MRSA exhibited quorum sensing signals of N-Butanoyl-l-homoserine lactone (C4-HSL) with retention time 3.6 min and of N-hexanoyl-l-Homoserine lactone (C6-HSL) at 5.8 minutes’ vs the treated with MRSA where no peaks were observed. …”
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Molecular identification of chitinase and its function in growth of Odontobutis potamophila by Siyu Lu, Lin Du, Ting Zhang, Dan Wang, Jinjuan Wan, Guoxing Liu, Yuning Hu, Yu Xu, Zhiqiang Xu, Xuguang Li

“…Phylogenetic analyses suggest that OpCht has appeared in the teleost-specific monophyletic branches (CHIO). Quantitative real-time PCR analyses showed that OpCht was mainly expressed in stomach, liver, intestine and increased significantly during the period of juvenile. …”
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Safety and efficacy of filgotinib in patients with rheumatoid arthritis: final results of the DARWIN 3 long-term extension study by Arthur Kavanaugh, Paul Emery, René Westhovens, Mark C Genovese, Kevin L Winthrop, Rieke Alten, Dick de Vries, Lorenzo Dagna, Patrick Verschueren, Maria Greenwald, Regina Cseuz, Robin Besuyen, Vikas Modgill, Ly Huong Le

“…Disease response assessed using non-responder imputation plateaued at LTE week 12 before slowly declining over time, with overall American College of Rheumatology (ACR)20/50/70 response rates of 26.9%/20.2%/14.7% at week 396.Conclusion Filgotinib was well tolerated in patients with RA for up to 8 years. …”
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Impairment of myocardial perfusion correlates with heart failure severity in patients with non‐compaction cardiomyopathy by Andraz Cerar, Martina Jaklic, Sabina Frljak, Gregor Poglajen, Gregor Zemljic, Barbara Guzic Salobir, Maja Dolenc Novak, Monika Stalc, Rok Zbacnik, Mirta Kozelj

“…In all patients, we have determined left ventricular end‐diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), and global longitudinal strain (GLS) by echocardiography. At the same time, serum levels of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) have been measured, and myocardial single‐photon emission computed tomography at rest and on stress was used to define significant myocardial ischemia defined as summed difference score ≥ 2. …”
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Profile of the grain physical traits and physicochemical properties of selected Malaysian rice landraces for future use in a breeding program by Site Noorzuraini Abd Rahman, Rosimah Nulit, Faridah Qamaruz Zaman, Khairun Hisam Nasir, Mohd Hafiz Ibrahim, Mohd Ramdzan Othman, Nur Idayu Abd Rahim, Nor Sufiah Sebaweh

“…The alkali spreading value showed that most of the rice landraces require an intermediate cooking time. The gel consistency exhibited a wide range, varying from soft to hard. …”
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Exploring the Feasibility of a 5-Week mHealth Intervention to Enhance Physical Activity and an Active, Healthy Lifestyle in Community-Dwelling Older Adults: Mixed Methods Study by Kim Daniels, Sharona Vonck, Jolien Robijns, Kirsten Quadflieg, Jochen Bergs, Annemie Spooren, Dominique Hansen, Bruno Bonnechère

“…In addition, incorporating wearable device integration and predictive analytics could provide real-time health data, optimizing activity recommendations and health monitoring. …”
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Emergence of Carbapenem-Resistant <i>bla</i>_POM-1 Harboring <i>Pseudomonas otitidis</i> Isolated from River Water in Ghana by Frederick Ofosu Appiah, Samiratu Mahazu, Isaac Prah, Taira Kawamura, Yusuke Ota, Yohei Nishikawa, Mitsunori Yoshida, Masato Suzuki, Yoshihiko Hoshino, Toshihiko Suzuki, Tomoko Ishino, Anthony Ablordey, Ryoichi Saito

“…In this study, for the first time, we characterized <i>P. otitidis</i> from Densu river water in Ghana. …”
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Genetic Variation Analysis of Hsp101 Gene in Common Wild Rice and Asian Cultivated Rice Germplasm Resources by Yue LIU, Liqun JIANG, Shuwei LYU, Bingrui SUN, Chen LI, Qing LIU, Hang YU

“…It was speculated that the genetic differentiation time of Xian rice was earlier than that of Geng rice, and the genetic differences between Xian rice and Geng rice at the Hsp101 locus may be associated with the natural heat stress of their respective ecological environments.…”
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Patient Voices: Multimethod Study on the Feasibility of Implementing Electronic Patient-Reported Outcome Measures in a Comprehensive Cancer Center by Cinzia Brunelli, Sara Alfieri, Emanuela Zito, Marco Spelta, Laura Arba, Linda Lombi, Luana Caselli, Augusto Caraceni, Claudia Borreani, Anna Roli, Rosalba Miceli, Gabriele Tine', Ernesto Zecca, Marco Platania, Giuseppe Procopio, Nicola Nicolai, Luigi Battaglia, Laura Lozza, Morena Shkodra, Giacomo Massa, Daniele Loiacono, Giovanni Apolone

“…However, there are barriers to implementation related to the time and cognitive effort required to complete the questionnaires. …”
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School-to-work and school-to-university transition and health inequalities among young adults: a scoping review by Matthias Richter, Nico Dragano, Benjamin Wachtler, Stephanie Hoffmann, Max Herke, Katharina Diehl, Marvin Reuter, Paula Mayara Matos Fialho, Maria-Inti Metzendorf, Wiebke Schüttig, Christian Deindl, Sarah Schleberger, Claudia R Pischke

“…To be able to draw a picture of the development of various health outcomes over time, we focused on longitudinal studies. Forty-six prospective studies mapping health-related outcomes during STWT were identified. …”
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Genetic selection for postweaning growth rate shows no relevant negative impact on reproductive performance in breeding rabbit does by P.J. Marín-García, E. Martínez-Paredes, L. Ródenas, T. Larsen, M. Cambra-López, E. Blas, J.J. Pascual

“…Using rabbit as a model, this study has evaluated for the first time how genetic selection for growth rate has affected feed efficiency, resource allocation, blood traits, reproductive performance and survival during five reproductive cycles in rabbit does. …”
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