<i>Ex Vivo</i> Regional Gene Therapy Compared to Recombinant BMP-2 for the Treatment of Critical-Size Bone Defects: An In Vivo Single-Cell RNA-Sequencing Study by Arijita Sarkar, Matthew C. Gallo, Jennifer A. Bell, Cory K. Mayfield, Jacob R. Ball, Mina Ayad, Elizabeth Lechtholz-Zey, Stephanie W. Chang, Osamu Sugiyama, Denis Evseenko, Jay R. Lieberman

“…However, the cellular and transcriptional mechanisms regulating the response to these two strategies for BMP-2 mediated bone regeneration are largely unknown. Here, for the first time, we performed single-cell RNA sequencing (10x Genomics) of hematoma tissue in six rats with critical-sized femoral defects that were treated with either regional gene therapy or rhBMP-2. …”
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Ecological problem identification based on spatial and temporal dynamics of ecosystem quality: A case study by Rui Zhang, Huamin Liu, Zhichao Xu, Xinchuan Zhao, Lu Wen, Yi Zhuo, Lixin Wang

“…The study found that: (1) Resource utilization efficiency varies among ecosystems in Bayannur, with human activities significantly impacting local ecosystems; (2) Ecological quality shows substantial variation over time and across regions. While ecological conditions have improved in some areas over recent decades, severe degradation persists in the northwest. …”
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The Effect of the Concurrent Use of Angiotensin-Converting Enzyme Inhibitors or Receptor Blockers on Toxicity and Outcomes in Patients Treated with Radiotherapy: A Systematic Revie... by Wan-Chuen Liao, Hala Shokr, Corinne Faivre-Finn, Clare Dempsey, Kaye Janine Williams, Li-Chia Chen

“…Differences in the median survival time, recurrence, and death rates were also calculated. …”
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Insights Into Antimicrobial Resistance From Dental Students in the Asia–Pacific Region by Saba Ghafoor, Gabriela Salvadori, Shiho Kino, Vy Thi Nhat Nguyen, Tam Thi-Thanh Nguyen, Miho Ishimaru, Antônio Pedro Ricomini-Filho, Cassiano Kuchenbecker Rösing, Dileep De Silva, Jun Aida, Belinda Farias Nicolau, Ratilal Lalloo, Roger Junges

“…Final-year students presented a mean (SEM) level of confidence to prescribe antibiotics of 6.01 (0.14) on a scale from 1 to 10, whilst 59.7% and 56.8% indicated feeling pressured to prescribe by patients or when lacking time, respectively. Final-year students participating in research activities assigned a higher priority to AMR compared to their peers not involved in research (mean [SEM] 8.6 [0.19] vs 7.81 [0.16]; P = .01). …”
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Complementary Embryonic and Adult Cell Populations Enhance Myocardial Repair in Rat Myocardial Injury Model by Sergio Li Calzi, Todd Cook, Domenico G. Della Rocca, Juan Zhang, Vinayak Shenoy, Yuanqing Yan, Andrew Espejo, Anandharajan Rathinasabapathy, Max H. Jacobsen, Tatiana Salazar, George E. Sandusky, Lynn C. Shaw, Keith March, Mohan K. Raizada, Carl J. Pepine, Michael J. Katovich, Maria B. Grant

“…Six-week-old female Sprague-Dawley rats underwent permanent left anterior descending (LAD) coronary artery ligation and received intramyocardial injection of either saline, Isl-1+ cells, CD90+ cells, or a combination of Isl-1+ and CD90+ cells, at the time of infarction. Cells were delivered transepicardially to the peri-infarct zone. …”
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Legal Disputes of Emigrant Periodical Publishers from the End of the 19th Century to 1904 by Remigijus Misiūnas

“…Evaluating the causes of the cases, it is possible to discuss the complicated perception of the satirical genre within the emigrant community of that time. On one hand, the hyperbolization of problems and ills in the emigrant life attracted readers with engaging texts, but on the other, it was interpreted as propaganda for a dissolute lifestyle and rejection of religious norms, dismissing the satirical aspect. …”
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Physicochemical characterization of biodegradable polymer polyhydroxybutyrate from halophilic bacterium local strain Halomonas elongata by W.O.S. Rizki, E. Ratnaningsih, D.G.T. Andini, S. Komariah, A.T. Simbara, R. Hertadi

“…The effect of incubation time, sodium chloride concentration, nitrogen, and carbon sources were evaluated via gas chromatography to enhance its productivity. …”
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The Epidemiological Characteristics of Coronavirus Disease (COVID-19) in Halabja Province/Kurdistan –Iraq by Osama Hamid Shareef, Othman Abdulrahman Mohammed, Dashty Aziz Ghafor, Ari Shareef Ali, Hardi Rafat Baqi, Ali Aziz Ali, Aryan Mahmood Faraj, Syamand Ahmed Qadir, Ali Muhi Aldeen Omar Aljabary

“…Samples were obtained nasopharyngeal using a sterilized swab following WHO guidelines and then the real time PCR (RT-PCR) machine was used for analysis. …”
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Risk of hemorrhagic fever with renal syndrome associated with meteorological factors in diverse epidemic regions: a nationwide longitudinal study in China by Nan Chang, Wenzhong Huang, Yanlin Niu, Zhihu Xu, Yuan Gao, Tingting Ye, Zihao Wang, Xiaohui Wei, Yuming Guo, Qiyong Liu

“…The associations between meteorological variables and HFRS incidence were investigated using a time-stratified case-crossover design combined with distributed lag nonlinear modeling for each epidemic category. …”
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Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria Region by Giovanni Matera, Maria Teresa Loria, Cinzia Peronace, Tatiana Catanzariti, Pio Settembre, Aida Giancotti, Angelo G. Lamberti, Giorgio S. Barreca, Luisa Galati, Gessica Dodaro, Maria Mazzitelli, Alessio Strazzulla, Carlo Torti, Angela Quirino, Maria Carla Liberto, Alfredo Focà

“…Echinococcosis diagnosis was based on imaging, serological investigations, and molecular assay. Indeed, real-time PCR indicated the presence of G2/G3 genotypes of Echinococcus granulosus complex. …”
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Resurgence of Mumps among Lower Socioeconomic Class of Children in Ahmedabad: A Cross-sectional Study of 115 Cases in a Tertiary Care Center by Dipti V Patel, Zeel Patel, Snehal V Patel, Pooja Gandhi, Gayatri Parmar, Param S Patel

“…Conclusion: It is high time that the Indian Academy of Pediatrics and the Government of India join hands to include MMR in place of MR in the National Immunization Schedule (NIS) and conduct a mass campaign for the MMR vaccine, although three doses of MMR in the 2023 Indian Academy of Pediatrics (IAP) Advisory Committee on Vaccines and Immunization Practices (ACVIP) recommendation. …”
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Challenges and Opportunities for Data Sharing Related to Artificial Intelligence Tools in Health Care in Low- and Middle-Income Countries: Systematic Review and Case Study From Tha... by Aprajita Kaushik, Capucine Barcellona, Nikita Kanumoory Mandyam, Si Ying Tan, Jasper Tromp

“…In Thailand, inconsistent data systems, limited staff time, low health data literacy, complex and unclear policies, and cybersecurity issues were important data-sharing challenges. …”
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Global, regional and national burden of neuroblastoma and other peripheral nervous system tumors, 1990 to 2021 and predictions to 2035: visualizing epidemiological characteristics... by Chaoyan Yue, Qi Zhang, Fenyong Sun, Qiuhui Pan

“…Findings: This study reported the disease burden of neuroblastoma and other peripheral nervous system tumors in GBD 2021 database for the first time. Globally, the incidence and mortality of neuroblastoma have increased year by year from 1990 to 2021, especially in regions with low SDI, such as South Asia and sub-Saharan Africa, where the burden of disease has increased significantly. …”
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Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cel... by Graciela Ruiz, Heriberto A. Valencia-González, Delia Pérez-Montiel, Felipe Muñoz, Rodolfo Ocadiz-Delgado, Jorge Fernández-Retana, Carlos Pérez-Plasencia, Osbaldo Reséndis-Antonio, Patricio Gariglio, Alejandro García-Carrancá

“…To our knowledge, this is the first time that the expression of OSKM-N is described to induce one of the main characteristics of the cancer stem cell, the tumorigenicity. …”
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A Study of the Relationship between the Polymorphism and Mutation of rs682429 and rs3781590 in the LRP5 Gene and Bone Metabolism in Postmenopausal Type 2 Diabetic Women in Xinjiang by Jun Li, SiYuan Li, HuiRong Zhao, JiaJia Li, Shuang Wang, YanQiu Shi

“…Calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), and clinical biochemical data were determined; haemoglobin A1c (HbA1c) was measured by HPLC; BMD of the femoral neck, hip, and lumbar spine (L1-4) was measured by dual-energy X-ray (DEXA); and the rs682429 and rs3781590 polymorphisms of the LRP5 gene were detected by time-of-flight mass spectrometry (TOF MS). Results. (1) The rs682429 polymorphism of the LRP5 genotype distribution was statistically significant (P<0.05) in group B compared with group A. (2) The triglycerides (TG) of women with the CT/TT genotype (mutant type) were higher than those of women with the CC genotype (wild type) (2.37±1.30 vs. 1.52±0.83, P<0.05) at the rs3781590 site of the LRP5 gene in group D. (3) Multiple linear regression analysis showed that TG (β=0.034, P<0.05) and body mass index (BMI) (β=0.013, P<0.05) were the influencing factors of BMD (L1-4) in T2DM patients. …”
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Im Niemandsland zwischen strengem Satz und Historismus. Zur Krise der Kontrapunktlehre im mittleren 19. Jahrhundert by Florian Edler

“…The influence of the music of his time on Bellermann’s method can be observed in an example from his book Der Contrapunkt, which may be interpreted as the outer voices of a modified Tristan citation.…”
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Application of Minimally Invasive Oral Swab Samples for qPCR-Based Sexing in Neognathae Birds by Maria-Carmen Turcu, Anamaria Ioana Paștiu, Lucia-Victoria Bel, Anca-Alexandra Doboși, Dana Liana Pusta

“…The objective of the present study was to demonstrate rapid, effective, and precise identification of sex in birds through quantitative real-time PCR (qPCR) using samples obtained via a minimally invasive technique (oral swabs). …”
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Sports and Games Union Policy by Kabale University

“…Such values as untiring work ethic-hard work endurance , perseverance , discipline ,leadership, how to follow , communication commitment time management , reliability, sportsmanship , responsibility , confidence character, creativity , socialization, motivation unselfishness/teamwork, self-awareness and alertness, how to handle adversity of losses and how to accept winning and losing graciously , among many other values are what sports help to instill into the participating athlete.…”
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Developing an effective teaching model in order to improve the educational level of schools by Mehdi Mohammadi, fardin Abdollahy, Rafigh Hasani

“…In explaining the findings of this research, it can be said that the optimal classroom management mentioned by the interviewees includes: classroom preparation, planning, parents' participation in their children's education process, welcoming students' interaction with each other, the ability to communicate with problematic students, continuous and formative evaluation, respecting the order of the teacher while teaching, having a lesson plan, having a logical order in teaching, on time attendance control, strictness on time, removing communication barriers while teaching, providing a learning environment, and human relations governing the classroom atmosphere. …”
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The learning process of physical education lessons in education through virtual education by mahyar yarahmadi, Habib Honari, Meysam Shabaninia

“…Theoretical Framework Virtual training Educational systems are among the institutions that are fundamentally on the path of these changes, in such a way that the quality and manner of teaching and learning have changed; focusing on the human being as an active learner and diminishing the limitations caused by time and space, e-learning has been proposed as a new paradigm in this category (Geller et al, 2018). …”
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