Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma by JinSong Li, GuanBo Zhang, Gang Li, Jie Zhang, Zhi Yang, Lin Yang, ShiJie Jiang, JiaXing Wang

“…Recently, immunotherapy has emerged as a crucial treatment modality for HCC, following surgery, locoregional therapies, and targeted therapies. This approach harnesses the body's immune system to target and eliminate cancer cells, potentially resulting in durable antitumor responses. …”
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Discussion on the mechanism of HER2 resistance in esophagogastric junction and gastric cancer in the era of immunotherapy by Yan Zhang, Wenxuan Fan, Fei Su, Xiaoling Zhang, Yunyi Du, Weiling Li, Yangjun Gao, Wenqing Hu, Jun Zhao

“…Furthermore, the review discusses the Novel therapeutic approaches, including the use of antibody-drug conjugates (ADCs) and combination therapies are assessed for their potential to enhance outcomes. …”
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Motor Function in Irritable Bowel Syndrome by Michael Camilleri

“…Most novel therapies under trial probably modulate both sensory and motor functions, and are discussed briefly. …”
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Vaccine adjuvants for immunotherapy: type, mechanisms and clinical applications by Nimeet Desai, Sherrin Gotru, Sagar Salave, Lalitkumar K. Vora

“…These emerging agents hold promise for enhancing immune responses while tailoring therapies to specific disease contexts, from cancer to infectious diseases. …”
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Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology by Kai Jin, Yi Huang, Hailong Che, Yihan Wu

“…The application of microbial therapies in cancer, intestinal diseases, and metabolic disorders underscores their significant potential. …”
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Hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age-related musculoskeletal diseases by Lixin Liu, Siwen Chen, Yantao Song, Longwei Cui, Yiman Chen, Jiangli Xia, Yibo Fan, Liqun Yang, Lina Yang

“…Recently, regenerative medicine has exhibited vast potential in age-related MSK, with mesenchymal stromal cells (MSCs) and their derived exosomes (Exos) therapies showing distinct advantages. However, these therapies face several limitations, including issues related to ensuring stability and effective distribution within the body. …”
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Wernicke Encephalopathy Related to Hyperemesis Gravidarum: A Retrospective Study of 12 Cases by Kaouthar Abouelbaqua, Houssam Rebahi, Nisrine Louhab, Najib Kissani, Ahmed Rhassane El Adib

“…Therefore, physicians must be vigilant in detecting early signs of WE to promptly provide a high dose of thiamin with targeted multimodal therapies as this could be lifesaving.…”
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Hypoglycemic Syndrome in a Patient with Proinsulin-Only Secreting Pancreatic Adenoma (Proinsulinoma) by Gian Paolo Fadini, Alberto Maran, Anna Valerio, Francesco Meduri, Mariarosa Pelizzo, Diego Miotto, Cristiano Lanza, Giuseppe Altavilla, Angelo Avogaro

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A Study to Assess the Prevalence of Depression among Alcoholics, among Patients, Admitted to Christian Institute of Health Sciences and Research, Dimapur, Nagaland by Nukshijungla Ao

“…The management of depressive symptoms through the adoption of various therapies such as psychotherapy, other alternative systems of therapies and recreational therapies are much recommended. …”
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Implication of IL-17 in Bone Loss and Structural Damage in Inflammatory Rheumatic Diseases by Benoit Le Goff, Béatrice Bouvard, Thierry Lequerre, Eric Lespessailles, Hubert Marotte, Yves-Marie Pers, Bernard Cortet

“…The prevention of structural damage by anti-IL-17A therapies has been demonstrated in several pivotal clinical trials. …”
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The McGill University Health Centre Cancer Pain Clinic: A Retrospective Analysis of an Interdisciplinary Approach to Cancer Pain Management by Jordi Perez, Sara Olivier, Emmanouil Rampakakis, Manuel Borod, Yoram Shir

“…This tailored approach includes pharmacological and nonpharmacological therapies offered concurrently in an interdisciplinary fashion. …”
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Novel trial designs: Master protocol trials by Priya Ranganathan, Vishal Deo, C. S. Pramesh, Mahesh P. Parmar

“…This article focuses on master protocol trials, which allow several therapies to be tested within a single larger trial.…”
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Diagnostic Evaluation and Management of Chronic Thromboembolic Pulmonary Hypertension: A Clinical Practice Guideline by Sanjay Mehta, Doug Helmersen, Steeve Provencher, Naushad Hirani, Fraser D Rubens, Marc De Perrot, Mark Blostein, Kim Boutet, George Chandy, Carole Dennie, John Granton, Paul Hernandez, Andrew M Hirsch, Karen Laframboise, Robert D Levy, Dale Lien, Simon Martel, Gerard Shoemaker, John Swiston, Justin Weinkauf

“…Many care gaps exist in the diagnosis and management of CTEPH patients including lack of awareness, incomplete diagnostic assessment, and inconsistent use of surgical and medical therapies.…”
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Trastuzumab Resistance: Role for Notch Signaling by Kinnari Mehta, Clodia Osipo

“…Here we review the many possible mechanisms of action that could contribute to resistance, and novel therapies to prevent or reverse the resistant phenotype. …”
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Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics by Haisong Li, Can Li, Cong Fu, Yizhuo Wang, Tingting Liang, Haitao Wu, Chenxi Wu, Chang Wang, Tianmeng Sun, Shuhan Liu

“…Additionally, we address the current challenges and future prospects for NP-based therapies in NET research, aiming to bridge the gap between nanotechnology and NET modulation for the development of novel therapeutic approaches. …”
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DKK1 and Its Receptors in Esophageal Adenocarcinoma: A Promising Molecular Target by Markos Despotidis, Orestis Lyros, Tatiana S. Driva, Panagiotis Sarantis, Emmanouil I. Kapetanakis, Adam Mylonakis, Andreas Mamilos, Stratigoula Sakellariou, Dimitrios Schizas

“…Despite the recent progress in targeted therapies and surgical approaches, the survival rates of esophageal adenocarcinoma patients remain poor. …”
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Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing by Margeaux Hodgson-Garms, Matthew J. Moore, Mikaël M. Martino, Kilian Kelly, Jessica E. Frith

“…The data and findings from this study will inform the optimum MSC source for particular applications and underpin further development of MSC therapies.…”
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Dihydroartemisinin inhibits EphA2/PI3K/Akt pathway-mediated malignant behaviors and vasculogenic mimicry in glioma stem cells by Huangde Fu, Shengtian Wu, Hechun Shen, Kai Luo, Zhongxiang Huang, Nankun Lu, Yaolin Li, Qian Lan, Yishun Xian

“…Conclusively, the current report provides evidence that DHA, PI3K/Akt/EphA2 blockage, and VM inhibition are promising therapies for glioma.…”
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Understanding Obesity and the Role of Pharmacological Treatments: Insights for Health and Fitness Enthusiasts by Agnieszka Starzyk, Piotr Charzewski

“…The integration of genetic diagnostics into clinical practice is critical to identifying appropriate candidates for these therapies and personalizing treatment plans to address the heterogeneous nature of obesity. …”
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The impact of climate change on the epidemiology of fungal infections: implications for diagnosis, treatment, and public health strategies by Mary E. George, Tonisha T. Gaitor, David B. Cluck, Andrés F. Henao-Martínez, Nicholas R. Sells, Daniel B. Chastain

“…Immediate action is required to develop policies, educational initiatives, and novel antifungal therapies, enhance early diagnostic capabilities, and address healthcare disparities to mitigate the growing burden of fungal infections.…”
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