Effectiveness of Fewer Falls, an online group-based self-management fall prevention programme for people with multiple sclerosis: protocol of a randomised controlled trial by Maria Flink, Charlotte Ytterberg, Kristina Gottberg, Marie Kierkegaard, Susanna Tuvemo Johnson, Elizabeth Walker Peterson, Ulrika Meijer, Johanna Bylinder

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Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applications by Zhenglin He, Yishuo Ji, Yutong Yuan, Tianfang Liang, Chenglin Liu, Yiping Jiao, Yimeng Chen, Yiming Yang, Liang Han, Liang Han, Yue Hu, Yue Hu, Xianling Cong, Xianling Cong, Xianling Cong

“…In this review, we provide a comprehensive analysis of the role of miRNAs in EC, emphasizing their mechanisms in tumorigenesis, their potential as diagnostic and prognostic biomarkers, and their influence on resistance to therapy. We elucidate how miRNAs modulate oncogenic pathways and tumor suppressor genes, influencing EC cell behavior and treatment outcomes. …”
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Antiparkinsonian activity of selective MAO-B inhibitors of different chemical structures by Vladimir N. Fedorov, Mikhail K. Korsakov, Anton A. Shetnev, Sergey S. Petukhov, Nikita N. Volkhin, Vladimir P. Vdovichenko, Anastasia A. Khokhlova, Salavat Sh. Suleymanov

“…Introduction: Parkinson’s disease (PD) is a chronic neurodegenerative disease of the central nervous system, the pathogenesis of which is associated with the death of dopaminergic neurons of the midbrain substantia nigra. The mainstay of therapy for PD is levodopa. However, in the initial stages of PD or in case of levodopa intolerance, MAO B inhibitors are used. …”
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Healthcare Practitioners’ perspectives on paediatric burns management at Korle Bu Teaching Hospital, Ghana by Alberta A. Rockson, Natalie Benjamin-Damons, Sonti Imogene Pilusa

“…Methodology: This study employed a qualitative research approach utilizing Focus Group Discussion (FGD) with 15 participants from various disciplines, including Plastic Surgery, Medicine, Anaesthetics, Physiotherapy, Occupational Therapy, Dietetics, Nursing, Pharmacy, Clinical Psychology, Public Health Nursing and. …”
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Disrupted HIV care during COVID-19 pandemic associated with increased disabilities among people living with HIV in Belize by Tracy M. Quetzal, Wei-Cheng Lo, Ya-Wen Chiu, Hung-Yi Chiou

“…A cross-sectional study was conducted at the Western Regional Hospital and Southern Regional Hospital between August and October 2021 among people living with HIV in Belize aged ≥ 21 years and on antiretroviral therapy. A self-reported questionnaire captured data on demographic and clinical characteristics (gender, age, ethnicity, marital status, employment, education, CD4 count, and viral load), COVID-19-affected HIV care behaviors, and disability across six domains (physical, cognitive, and mental-emotional symptoms and impairments; uncertainty; difficulties carrying out day-to-day activities; and social inclusion challenges) using the Short-Form HIV Disability Questionnaire. …”
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Developing a medication-safety self-assessment tool for rural primary care units - a case from Finnish Lapland by Päivi Sova, Ercan Celikkayalar, Sami Sneck, Anna-Riia Holmström

“…Abstract Background In rural areas, primary care faces several challenges, and medication therapy is one of the most complex processes in primary care. …”
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Prevention and Reversal of Diabetes by All-Trans Retinoid Acid and Exendin-4 in NOD Mice by Jyuhn-Huarng Juang, Yang-Hau Van, Chien-Hung Kuo, Mei-Yin Lin, Ying-Hsiu Liu, Han-Ying Chang

“…Thus, we hypothesized that ATRA and exendin-4 combination therapy would prevent and reverse autoimmune diabetes. …”
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Burden and challenges in managing TB infection among people with occupational exposure to silica in India by B. Kalottee, P. Mahajan, A. Nuken, D. Nair, P. Thekkur, A.M.V. Kumar, V. Rai, M. Parmar, H. Solanki, R. Rao, S.K. Mattoo, R. Kumar

“…Of these 160 individuals eligible for TB preventive therapy (TPT), 153 (96%, 95% CI 92–98) were initiated on TPT and 124 (81%, 95% CI 74–88) completed TPT. …”
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Real-world clinical experience with secukinumab in psoriatic arthritis: an observational study and a literature review by Eleonora Celletti, Giulio Gualdi, Emanuela Sabatini, Francesco Cipollone, Fabio Lobefaro, Paolo Amerio

“…An observational study was conducted on adult subjects with PsA and comorbidities, treated with secukinumab after prior therapy with conventional disease-modifying anti-rheumatic drugs or biological agents that were discontinued due to lack of efficacy or adverse drug reactions. …”
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Role of CX3CL1/CX3CR1 Signaling Axis Activity in Osteoporosis by Piotr Wojdasiewicz, Pawel Turczyn, Barbara Dobies-Krzesniak, Justyna Frasunska, Beata Tarnacka

“…Therefore, it seems justified to continue research which would precisely determine its role in the metabolism of the bone tissue as one of the most promising targets in osteoporosis therapy.…”
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Current update on surgical management for spinal tuberculosis: a scientific mapping of worldwide publications by Romaniyanto Romaniyanto, Muhana Fawwazy Ilyas, Aldebaran Lado, Daffa Sadewa, Daffa Sadewa, Dykall Naf'an Dzikri, Enrico Ananda Budiono, Enrico Ananda Budiono

“…Despite antitubercular drug therapy being the primary treatment, surgical intervention is often required in cases of spinal instability or neurological complications. …”
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Statin prescriptions and progression of advanced fibrosis risk in primary care patients with MASLD by Andrew D Schreiner, William P Moran, Jingwen Zhang, Patrick D Mauldin, Justin Marsden, Mulugeta Gebregziabher, Chelsey A Petz, David G Koch, Chloe Bays

“…We developed Cox regression models for the time to a high-risk FIB-4 score with statin therapy as the primary covariate and adjusting for baseline fibrosis risk, demographic and comorbidity variables.Results The cohort of 1238 patients with MASLD was followed for a mean of 3.3 years, with 47% of patients receiving a prescription for a statin, and 18% of patients progressing to a high-risk FIB-4. …”
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Safety during surgical resection of the sclera in patients with primary and secondary glaucoma by A.Yu. Kazantzeva, E.A. Korchuganova

“…All patients received topical maximally tolerated antihypertensive therapy before surgery (on average, 4 drugs individually and in the form of fixed combinations). …”
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Mesenchymal Stem/Stromal Cells Derived from Induced Pluripotent Stem Cells Support CD34pos Hematopoietic Stem Cell Propagation and Suppress Inflammatory Reaction by Mohsen Moslem, Irina Eberle, Iuliia Weber, Reinhard Henschler, Tobias Cantz

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Clinical features and outcomes of pseudolithiasis induced by ceftriaxone in Chinese children: a single-center observational study by Chen Jin, Chen Jin, Wen-Li Xiu, Wen-Li Xiu, Yao Liu, Yao Liu, Xi-Wei Hao, Qian Dong, Qian Dong

“…Data on treatment regimens, gallbladder imaging findings, and serum biochemical parameters post-CTX therapy were analyzed. Patients were classified into PL (n = 34) and non-PL (n = 151) groups based on imaging findings.ResultsPL was diagnosed in 18.4% of patients treated with CTX, primarily through ultrasound, which revealed hyperechoic material within the gallbladder. …”
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Development and validation of a nomogram-based risk prediction model for carbapenem-resistant Klebsiella pneumoniae in hospitalized patients by Tingting Xu, Yuxin Shi, Xiongjing Cao, Lijuan Xiong

“…ABSTRACT Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses one of the major challenges in clinical anti-infective therapy worldwide. This retrospective cohort study at a tertiary general hospital in Wuhan aimed to identify risk factors for hospital-acquired CRKP infections among 1,113 patients. …”
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Use of Autologous Mesenchymal Stem Cells Derived from Bone Marrow for the Treatment of Naturally Injured Spinal Cord in Dogs by Euler Moraes Penha, Cássio Santana Meira, Elisalva Teixeira Guimarães, Marcus Vinícius Pinheiro Mendonça, Faye Alice Gravely, Cláudia Maria Bahia Pinheiro, Taiana Maria Bahia Pinheiro, Stella Maria Barrouin-Melo, Ricardo Ribeiro-dos-Santos, Milena Botelho Pereira Soares

“…Our results indicate that MSC are potential candidates for the stem cell therapy following spinal cord injury.…”
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The Efficacy of Madeira Vine Leaf Extract Combined with Turmeric Rhizome Extract Gel Topically on Second-Degree Burn Wound in Albino Rats by Mirza Atikah Madarina Hisyam, Wiwik Misaco Yuniarti, Sis Wisnuarti Theresia, Ira Sari Yudaniayanti, Bambang Sektiari Lukiswanto, Sri Agus Sudjarwo, Thomas Valentinus Widiyatno

“…The burn wound was performed on the right gluteus of rats, and the therapy was applied twice a day topically, starting after the burn wounds were made. …”
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Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis by Xiaoyu Huang, Zhouao Zhang, Zhouyi Wang, Tiancheng Luo, Mingjin Yang, Xinyan Guo, Xue Du, Tianyu Ma, Yong Zhang

“…However, targeted B-cell therapy such as rituximab may result in long-term peripheral B cell clearance and allow for the survival of plasma cells, contributing to frequent infections and relapses. …”
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Myocarditis in malaria—current evidence and future directions: a literature review by Gbolahan Olatunji, Emmanuel Kokori, Ikponmwosa Jude Ogieuhi, Olumide Akinmoju, Oluwatobi Omoworare, Doyin Olatunji, David Timilehin Isarinade, God-dowell O. Odukudu, Israel Charles Abraham, Samuel Owolabi, Jamil Nasrallah, Emmanuel Egbunu, Babafemi Oluwadarasimi Jaiyeoba, Ismaila Ajayi Yusuf, Olawale Olanisa, Nicholas Aderinto

“…Treatment outcomes underscore the efficacy of timely antimalarial therapy, advocating for integrated approaches to patient care. …”
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