L-Citrulline in Neonates: From Bench to Bed Side by Dwayne Mascarenhas, Atefeh Mohammadi, Randa Higazy, Julijana Ivanovska, Estelle Gauda, Bonny Jasani

“…While L-CIT shows promise in the treatment of various neonatal conditions, adequately powered studies to evaluate the safety and efficacy of L-CIT supplementation post-surgical NEC and BPD ± PH in the extremely preterm population are needed to translate this novel therapy to clinical practice.…”
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Mitigation of doxorubicin-induced liver toxicity in mice breast cancer model by green tea and Moringa oleifera combination: Targeting apoptosis, inflammation, and oxidative stress by Abdulrahman H. Laftah, Nawfal Alhelfi, Sadeq K. Al Salait, Ammar B. Altemimi, Mohammad Reza Tabandeh, Efstathia Tsakali, Jan F.M. Van Impe, Ahmed A. Abd El-Maksoud, Tarek Gamal Abedelmaksoud

“…Histopathological evaluation showed that highly-dose therapy reduced hepatocyte degradation, inflammatory cell infiltration, localized necrosis, and blood vessel congestion. …”
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Genetic markers of children asthma: predisposition to disease course variants by M. V. Smolnikova, Ed. W. Kasparov, M. A. Malinchik, K. V. Kopylova

“…The results obtained will supplement information on the prevalence of polymorphic variants of the cytokine genes in the Russian population and in asthma patients with different disease courses, which is likely to be used in order to shape a plan for Public Health Authority to prevent the development of severe uncontrolled asthma and to optimize personalized therapy.…”
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An adenoviral vector encoding an inflammation-inducible antagonist, HMGB1 Box A, as a novel therapeutic approach to inflammatory diseases by Kari Ann Shirey, John Joseph, Lynda Coughlan, Haye Nijhuis, Alan W. Varley, Jorge C. G. Blanco, Stefanie N. Vogel

“…We hypothesized that gene therapy platforms could be useful in these cases if the production of an anti-inflammatory protein reflects the intensity and duration of the inflammatory condition. …”
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Feasibility of a videoconferencing-based parent-mediated intervention: a mixed-method pilot study by Marie-Maude Geoffray, Marie-Maude Geoffray, Maeva Bourgeois-Mollier, Maud Maleysson-Baste, Natacha Gallifet, Sara Dochez, Sara Dochez, Gaelle Bonis, Agathe Jay, Lucie Jurek, Lucie Jurek

“…Pre-school Autism Communication Therapy (PACT), a parent-mediated intervention, empowers parents to facilitate their child’s development. …”
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Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs by Khushboo Agrawal, Viswanath Das, Natálie Táborská, Ján Gurský, Petr Džubák, Marián Hajdúch

“…While the effects of these epi-drugs alone or in combination with other anticancer therapies are well described, the influence of stromal cells and their secretome on cancer cell response to these agents remain elusive. …”
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Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory by Jeyanthan Charles James, Hannah Schulze, Nadine Siems, Christian Prehn, Daniel R. Quast, Nadine Trampe, Ralf Gold, Simon Faissner

“…The present results should be considered to optimize treatment algorithms for therapy and rehabilitation programs of PCS patients with neurologic symptoms.…”
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Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: implications for the involvement of pirin by Bardees M. Foda, Bardees M. Foda, Annika E. Baker, Annika E. Baker, Annika E. Baker, Łukasz Joachimiak, Marzena Mazur, Richard R. Neubig, Richard R. Neubig, Richard R. Neubig

“…AimOvercoming therapy resistance is critical for effective melanoma control. …”
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In vitro Antibacterial Effect of Reduning Combined with Polymyxin on Carbapenem Resistant Klebsiella pneumoniae by Shangguan ZF, Chen HL, Li YF, Shi N, Mao QF

“…Zui-Fei Shangguan,1 Hong-Lei Chen,2 Yi-Fan Li,3 Na Shi,4 Qi-Fen Mao2 1Department of Clinical Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, 310006, People’s Republic of China; 2Department of Clinical Laboratory, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, People’s Republic of China; 3College of Laboratory Medicine and College of Bioengineering, Hangzhou Medical University, Hangzhou, Zhejiang, 311399, People’s Republic of China; 4Medical Laboratory, Second Sanatorium of Air Force Healthcare Center for Special Services, Hangzhou, Zhejiang, 310007, People’s Republic of ChinaCorrespondence: Qi-Fen Mao, Department of Clinical Laboratory, Tongde Hospital of Zhejiang Province, 234#, Gucui Road, Hangzhou, Zhejiang, 310012, People’s Republic of China, Email maoqifen@alu.zcmu.edu.cnObjective: This study aimed to investigate the status of carbapenem-resistant strains of Klebsiella pneumoniae isolated from the Department of Microbiology, Zhejiang Tongde Hospital between September 2023 and February 2024, and to examine the in vitro antibacterial effect of Reduning combined with polymyxin on carbapenem-resistant Klebsiella pneumoniae (CRKP), which may provide evidence on the application of Reduning in the clinical anti-infective therapy.Methods: A total of 50 different isolates of CRKP were collected, and the minimum inhibitory concentrations (MIC) of polymyxin, Reduning and polymyxin plus Reduning were measured with microbroth dilution method. …”
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Acceptability and Preliminary Effects of Intensive Brief Trauma-Focused PTSD Treatment for Refugees by Petter Tinghög, Lina Vågbratt, Julia Jennstål, Maria Bragesjö, Niklas Möller

“…Method: Ten participants were enrolled in the study and received ITT over five consecutive weekdays comprising Eye Movement Desensitization and Reprocessing Therapy (EMDR), prolonged exposure (PE), and physical activity (PA). …”
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INNOVATIVE STRATEGIES IN THE USE OF VITAMIN E AND ROSEMARY AS ANTIMICROBIAL AGENTS FOR ENHANCING THE SAFETY AND PRESERVATION OF MINCED POULTRY MEAT DURING REFRIGERATION by S. M. Farhan, H. M. Alnori, S. I. Yousif, N. Mirzan, S. Abdulateef, N. M. Jebril, A. A. Al-Azzami, O. A. Saeed, B. F. Sulaiman, S. Y. Sardary

“…There were no significant differences in reductions in E. coli and psychrophilic bacteria between the vitamin E therapy and the control group. The findings indicate that rosemary extracts, especially in alcoholic form, function as potent antibacterial agents that preserve the quality of minced fowl during storage, potentially extending shelf life and reducing spoilage. …”
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Gastric cancer liver metastases in China: a real-world, multicentre, prospective, observational cohort study protocol by Yi Liu, Lin Chen, Hongqing Xi, Zhida Chen, Tingting Lu, Yunhe Gao, Gan Zhang, Haiya Zhang

“…The patients' general information, medical history, imaging results, laboratory tests, surgical and systemic therapy details will be recorded and subjected to analysis. …”
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Nursing of a patient with chemotherapy-induced oral ulcer treated with Traditional Chinese Medicine mouthwash combined with moxibustion (中药含漱疗法联合艾灸治疗化疗相关性口腔溃疡1例的护理)... by LI Fang (李芳), LIU Shuhong (刘书红), ZHAO Yanan (赵亚楠), ZHAO Yan (赵燕)

“…Traditional Chinese Medicine mouthwash therapy combined with moxa stick moxibustion after embrocation using ginger is effective to relieve chemotherapy-induced oral ulcers and improve patient quality of life. …”
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Gut microbiota remodeling drived by dietary millet protein prevents the metabolic syndrome by Shuhua Shan, Ruopeng Yin, Jiangying Shi, Lizhen Zhang, Jiaqi Zhou, Qinqin Qiao, Xiushan Dong, Wenjing Zhao, Zhuoyu Li

“…Metabolites derived from gut microbes play essential roles in MetS prevention and therapy. Here, we focused on the inhibitory effect of the extract of millet bran protein (EMBP) on a high-fat diet (HFD)-induced MetS, aiming to identify gut microbiota and their metabolites that involve in the anti-MetS activity of EMBP. …”
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Infusion of Autologous Retrodifferentiated Stem Cells into Patients with Beta-Thalassemia by Ilham Saleh Abuljadayel, Tasnim Ahsan, Huma Quereshi, Shakil Rizvi, Tamseela Ahmed, Sabiha Mirza Khan, Jawaid Akhtar, Ghazi Dhoot

“…Current treatment of this disease involves regular blood transfusion and adjunct chelation therapy to lower blood transfusion–induced iron overload. …”
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Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, Brazil by Joao Leandro Paula Ferreira, Rosangela Rodrigues, Andre Minhoto Lança, Valeria Correia de Almeida, Simone Queiroz Rocha, Taisa Grotta Ragazzo, Denise Lotufo Estevam, Luis Fernando de Macedo Brigido

“…Seventy-six percent of genomes (13/17) with TDR carried a nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance mutation, mostly K103N/S (9/13, 69%), potentially compromising the preferential first-line therapy suggested by the Brazilian HIV Treatment Guideline that recommends efavirenz-based combinations. …”
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Cryo-Imaging and Software Platform for Analysis of Molecular MR Imaging of Micrometastases by Mohammed Q. Qutaish, Zhuxian Zhou, David Prabhu, Yiqiao Liu, Mallory R. Busso, Donna Izadnegahdar, Madhusudhana Gargesha, Hong Lu, Zheng-Rong Lu, David L. Wilson

“…This mouse-to-cells multiscale and multimodality platform should uniquely enable more informative and accurate studies of metastatic cancer imaging and therapy.…”
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Was It an Adrenocortical Adenoma or an Adrenocortical Carcinoma? Limitation of the Weiss Scoring System in Determining the Malignant Potential of Adrenocortical Tumor: Report on Tw... by Cheuk-Lik Wong, Chun-Kit Fok, Yuk-Kit Chan, Vicki Ho-Kee Tam, Lai-Ming Fung

“…The patient had progressive disease despite mitotane therapy and succumbed 7 years after initial presentation. …”
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The Women in ORTHopaedics Program Offers Early Exposure to Orthopaedic Surgery for Young Women. A Pre- and Post-Event Survey Comparison by Marianna Hsu, BSc candidate, Hayley Spurr, MB, BCh, BAO, FRCSC, Anthony P. Cooper, MBChB, FRCSC, Emily K. Schaeffer, PhD

“…Additionally, it provided insights into the multitude of career options available in Orthopaedics apart from surgery, including physiotherapy, occupational therapy, nursing, research, and biomedical engineering. …”
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The effects of circuit hydraulic weight interval training on body composition and progression of resistance in recreationally exercising pre- and postmenopausal women: an 18-week q... by Małgorzata Socha, Paulina Ćwieląg, Waldemar Andrzejewski

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